Wiring the Vascular Network with Neural Cues: A CNS Perspective
Open accessAbstract
The vascular and the nervous system are responsible for oxygen, nutrient, and information transfer and thereby constitute highly important communication systems in higher organisms. These functional similarities are reflected at the anatomical, cellular, and molecular levels, where common developmental principles and mutual crosstalks have evolved to coordinate their action. This resemblance of the two systems at different levels of complexity has been termed the "neurovascular link." Most of the evidence demonstrating neurovascular interactions derives from studies outside the CNS and from the CNS tissue of the retina. However, little is known about the specific properties of the neurovascular link in the brain. Here, we focus on regulatory effects of molecules involved in the neurovascular link on angiogenesis in the periphery and in the brain and distinguish between general and CNS-specific cues for angiogenesis. Moreover, we discuss the emerging molecular interactions of these angiogenic cues with the VEGF-VEGFR-Delta-like ligand 4 (Dll4)-Jagged-Notch pathway.
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Both cerebral angiogenesis and BBB formation require precise cues from various growth factors, guidance molecules and other factors such as microRNA, as well as fine tuning of intracellular signaling pathways and gene expression.
“Both cerebral angiogenesis and BBB formation require precise cues from various growth factors, guidance molecules and other factors such as microRNA, as well as fine tuning of intracellular signaling pathways and gene expression (22, 628, 682, 689).”
From Blood-Brain Barrier: From Physiology to Disease and Back (2019) · cites this paper as [628]
VEGF-VEGFR2-neuropilin1 signaling drives angiogenesis and vascular patterning.
“In general, the VEGF-VEGFR2-neuropilin1 signaling drives the angiogenesis and vascular patterning (628);”
From Blood-Brain Barrier: From Physiology to Disease and Back (2019) · cites this paper as [628]
Neural guidance molecules such as netrins and semaphorins also shape the growing cerebrovasculature and BBB functions.
“and neural guidance molecules such as netrins and semaphorins also shape the growing cerebrovasculature and BBB functions (22, 475, 596, 628).”
From Blood-Brain Barrier: From Physiology to Disease and Back (2019) · cites this paper as [628]
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The Neurovascular Unit Coming of Age: A Journey through Neurovascular Coupling in Health and Disease
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- Authors
- Wälchli, T., Wacker, A., Frei, K., Regli, L., Schwab, M. E., Hoerstrup, S. P., Gerhardt, H., & Engelhardt, B.
- Affiliations
- University of Zurich (CH)
- ETH Zurich (CH)
- University Hospital Zurich (CH)
- Max Delbrück Center (DE)
- University of Bern (CH)
- Corresponding author
- Wälchli, Thomas
- ORCID
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2015-07
- Volume
- 87
- Issue
- 2
- Pages
- 271-296
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W1504922538
- Cited by
- 178
- References
- 169
- Citations by year
- 2026: 10 · 2025: 14 · 2024: 21 · 2023: 15 · 2022: 23 · 2021: 25 · 2020: 13 · 2019: 18 · 2018: 16 · 2017: 15 · 2016: 6 · 2015: 1
- FWCI
- 1.21
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- Zurich Open Repository and Archive (University of Zurich) (acceptedVersion)
- BORIS (University Library Bern) (submittedVersion)
- MDC Repository (Max-Delbrueck-Center for Molecular Medicine) (submittedVersion)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
- Keywords
- angiogenesis, cerebral vasculature, vascular endothelial growth factor, VEGFR, DLL4, Jagged, Notch signaling, vascular development
- MeSH terms
- Animals, Central Nervous System, Cues, Humans, Neovascularization, Physiologic, Vascular Endothelial Growth Factor A
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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