Cited by 178Angiogenesis and VEGF in CancerBarrier Structure and Function StudiesAxon Guidance and Neuronal Signaling

Wiring the Vascular Network with Neural Cues: A CNS Perspective

Open access
Wälchli, Thomas, Wacker, Andrin, Frei, Karl, Regli, Luca, Schwab, Martin E., Hoerstrup, Simon P., Gerhardt, Holger, Engelhardt, Britta·2015·Neuron

Abstract

The vascular and the nervous system are responsible for oxygen, nutrient, and information transfer and thereby constitute highly important communication systems in higher organisms. These functional similarities are reflected at the anatomical, cellular, and molecular levels, where common developmental principles and mutual crosstalks have evolved to coordinate their action. This resemblance of the two systems at different levels of complexity has been termed the "neurovascular link." Most of the evidence demonstrating neurovascular interactions derives from studies outside the CNS and from the CNS tissue of the retina. However, little is known about the specific properties of the neurovascular link in the brain. Here, we focus on regulatory effects of molecules involved in the neurovascular link on angiogenesis in the periphery and in the brain and distinguish between general and CNS-specific cues for angiogenesis. Moreover, we discuss the emerging molecular interactions of these angiogenic cues with the VEGF-VEGFR-Delta-like ligand 4 (Dll4)-Jagged-Notch pathway.

Integrity signals

Registry

Crossref · 10.1016/j.neuron.2015.06.038

Cites

169 of 169 references verified0 citation errors · 0 not checkable

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  • Both cerebral angiogenesis and BBB formation require precise cues from various growth factors, guidance molecules and other factors such as microRNA, as well as fine tuning of intracellular signaling pathways and gene expression.

    “Both cerebral angiogenesis and BBB formation require precise cues from various growth factors, guidance molecules and other factors such as microRNA, as well as fine tuning of intracellular signaling pathways and gene expression (22, 628, 682, 689).”

    From Blood-Brain Barrier: From Physiology to Disease and Back (2019) · cites this paper as [628]

  • VEGF-VEGFR2-neuropilin1 signaling drives angiogenesis and vascular patterning.

    “In general, the VEGF-VEGFR2-neuropilin1 signaling drives the angiogenesis and vascular patterning (628);”

    From Blood-Brain Barrier: From Physiology to Disease and Back (2019) · cites this paper as [628]

  • Neural guidance molecules such as netrins and semaphorins also shape the growing cerebrovasculature and BBB functions.

    “and neural guidance molecules such as netrins and semaphorins also shape the growing cerebrovasculature and BBB functions (22, 475, 596, 628).”

    From Blood-Brain Barrier: From Physiology to Disease and Back (2019) · cites this paper as [628]

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Authors
Wälchli, T., Wacker, A., Frei, K., Regli, L., Schwab, M. E., Hoerstrup, S. P., Gerhardt, H., & Engelhardt, B.
Affiliations
  • University of Zurich (CH)
  • ETH Zurich (CH)
  • University Hospital Zurich (CH)
  • Max Delbrück Center (DE)
  • University of Bern (CH)
Corresponding author
Wälchli, Thomas
Venue
Neuron
Publisher
Elsevier BV
Published
2015-07
Volume
87
Issue
2
Pages
271-296
ISSN
0896-6273 (ISSN-L)
OpenAlex
W1504922538
Cited by
178
References
169
Citations by year
2026: 10 · 2025: 14 · 2024: 21 · 2023: 15 · 2022: 23 · 2021: 25 · 2020: 13 · 2019: 18 · 2018: 16 · 2017: 15 · 2016: 6 · 2015: 1
FWCI
1.21
Type
journal article
Language
en
Open access
Locations
  • Neuron (publishedVersion)
  • PubMed (publishedVersion)
  • Zurich Open Repository and Archive (University of Zurich) (acceptedVersion)
  • BORIS (University Library Bern) (submittedVersion)
  • MDC Repository (Max-Delbrueck-Center for Molecular Medicine) (submittedVersion)
  • Zurich Open Repository and Archive (University of Zurich) (submittedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
  • Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
Keywords
angiogenesis, cerebral vasculature, vascular endothelial growth factor, VEGFR, DLL4, Jagged, Notch signaling, vascular development
MeSH terms
Animals, Central Nervous System, Cues, Humans, Neovascularization, Physiologic, Vascular Endothelial Growth Factor A

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