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Mechanisms of Inhibition within the Telencephalon: “Where the Wild Things Are”
Open accessAbstract
In this review, we first provide a historical perspective of inhibitory signaling from the discovery of inhibition through to our present understanding of the diversity and mechanisms by which GABAergic interneuron populations function in different parts of the telencephalon. This is followed by a summary of the mechanisms of inhibition in the CNS. With this as a starting point, we provide an overview describing the variations in the subtypes and origins of inhibitory interneurons within the pallial and subpallial divisions of the telencephalon, with a focus on the hippocampus, somatosensory, paleo/piriform cortex, striatum, and various amygdala nuclei. Strikingly, we observe that marked variations exist in the origin and numerical balance between GABAergic interneurons and the principal cell populations in distinct regions of the telencephalon. Finally we speculate regarding the attractiveness and challenges of establishing a unifying nomenclature to describe inhibitory neuron diversity throughout the telencephalon.
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“By producing hyperpolarizing and/or shunting inhibition (Fishell and Rudy, 2011) close to the site of action potential generation, both types powerfully influence the output of their target neurons.”
From GABAergic Interneurons in the Neocortex: From Cellular Properties to Circuits (2016) · cites this paper as Fishell and Rudy, 2011
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Local GABA release can affect target cells as a result of changes in membrane potential through a local IPSP that will decrease with distance according to the cell’s cable properties, as well as changes in membrane resistance created by the local conductance change (shunting inhibition) (Fishell and Rudy, 2011).”
From GABAergic Interneurons in the Neocortex: From Cellular Properties to Circuits (2016) · cites this paper as Fishell and Rudy, 2011
Experimental — accuracy not yet measuredIn the citing paper
“Isocortical and hippocampal GABAergic interneuron types are similarly organized by their embryonic origins, firing characteristics and local connectivity patterns”
From A taxonomy of transcriptomic cell types across the isocortex and hippocampal formation (2021) · cites this paper as Fishell and Rudy, 2011
In the citing paper
“Cortical inhibitory cells exhibit varied morphology, physiological properties, connectivity patterns and biochemical composition, suggesting that they may contribute to distinct computational functions108,109.”
From Mechanisms underlying gain modulation in the cortex (2020) · cites this paper as [108]
In the citing paper
“L1 interneurons and VIP+ interneurons are characterized by robust expression of serotonin 3A receptors (5-HT3ARs)108”
From Mechanisms underlying gain modulation in the cortex (2020) · cites this paper as [108]
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References 223 · Cited by 233
Research works printed but not linked: 10
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Metadata
- Authors
- Fishell, G., & Rudy, B.
- Affiliations
- NYU Langone Health (US)
- Venue
- Annual Review of Neuroscience
- Publisher
- Annual Reviews
- Published
- 2011-07-21
- Volume
- 34
- Issue
- 1
- Pages
- 535-567
- ISSN
- 0147-006X (ISSN-L)
- 1545-4126
- PMC
- PMC3556485
- OpenAlex
- W2168311770
- Cited by
- 233
- References
- 223
- Citations by year
- 2026: 8 · 2025: 7 · 2024: 9 · 2023: 10 · 2022: 15 · 2021: 11 · 2020: 13 · 2019: 12 · 2018: 16 · 2017: 17 · 2016: 25 · 2015: 24 · 2014: 31 · 2013: 17 · 2012: 13
- FWCI
- 1.93
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Annual Review of Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (5r01ns030989-22)
- National Institute of Mental Health (R01MH068469, R01MH071679, R37MH071679)
- National Institute of Neurological Disorders and Stroke (2R01NS030989-18, R01-NS030989, R01NS045217, R01NS032993, R01NS039007, R01NS081297)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- inhibitory signaling, GABAergic interneurons, telencephalon, interneuron subtypes, hippocampus, somatosensory cortex, piriform cortex, striatum, amygdala, pallium, subpallium
- MeSH terms
- Animals, gamma-Aminobutyric Acid, Humans, Interneurons, Models, Neurological, Neural Inhibition, Telencephalon, Neurotransmitter Agents
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