Cited by 372Prion Diseases and Protein MisfoldingAlzheimer's disease research and treatmentsAmyotrophic Lateral Sclerosis Research

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Neurodegenerative Diseases: Expanding the Prion Concept

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Walker, Lary C., Jucker, Mathias·2015·Annual Review of Neuroscience

DOI 10.1146/annurev-neuro-071714-033828PMC PMC4803040

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Abstract

The prion paradigm has emerged as a unifying molecular principle for the pathogenesis of many age-related neurodegenerative diseases. This paradigm holds that a fundamental cause of specific disorders is the misfolding and seeded aggregation of certain proteins. The concept arose from the discovery that devastating brain diseases called spongiform encephalopathies are transmissible to new hosts by agents consisting solely of a misfolded protein, now known as the prion protein. Accordingly, “prion” was defined as a “proteinaceous infectious particle.” As the concept has expanded to include other diseases, many of which are not infectious by any conventional definition, the designation of prions as infectious agents has become problematic. We propose to define prions as “proteinaceous nucleating particles” to highlight the molecular action of the agents, lessen unwarranted apprehension about the transmissibility of noninfectious proteopathies, and promote the wider acceptance of this revolutionary paradigm by the biomedical community.

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Authors: Walker, L. C., & Jucker, M.
Affiliations: Emory University (US)
German Center for Neurodegenerative Diseases (DE)
ORCID: Walker, Lary C.
Jucker, Mathias
Venue: Annual Review of Neuroscience
Publisher: Annual Reviews
Published: 2015-07-08
Volume: 38
Issue: 1
Pages: 87-103
ISSN: 0147-006X (ISSN-L)
1545-4126
DOI: 10.1146/annurev-neuro-071714-033828
PMC: PMC4803040
OpenAlex: W2156606243
Cited by: 361
References: 174
Citations by year: 2026: 18 · 2025: 21 · 2024: 24 · 2023: 22 · 2022: 34 · 2021: 26 · 2020: 48 · 2019: 34 · 2018: 39 · 2017: 40 · 2016: 42 · 2015: 13
FWCI: 4.33
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Annual Review of Neuroscience (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
DZNE Pub (submittedVersion)
Funders: MetLife Foundation
Bundesministerium für Bildung und Forschung (01GI0705)
National Institutes of Health (RR000165, AG025688, OD11132, P51OD011132)
National Institute on Aging (AG 025688, R21AG040589, P50AG025688, AG040589)
National Center for Research Resources (RR000165, P51RR000165)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Prion Diseases and Protein Misfolding
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Health Sciences › Medicine › Clinical Neurology › Amyotrophic Lateral Sclerosis Research
Keywords: neurodegenerative diseases, protein misfolding, seeded aggregation, spongiform encephalopathy, prion protein, proteinopathies, transmissibility, age-related neurodegeneration, pathogenesis
MeSH terms: Animals, Humans, Prions, Neurodegenerative Diseases

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