Neurodegenerative Diseases: Expanding the Prion Concept

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Prions

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Novel Proteinaceous Infectious Particles Cause Scrapie

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Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade

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Adapting Proteostasis for Disease Intervention

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Neurodegenerative Tauopathies

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Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation

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Converging Mechanisms in ALS and FTD: Disrupted RNA and Protein Homeostasis

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Transmission and spreading of tauopathy in transgenic mouse brain

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The Amyloid State of Proteins in Human Diseases

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Lewy body–like pathology in long-term embryonic nigral transplants in Parkinson's disease

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Self-Propagating, Molecular-Level Polymorphism in Alzheimer's ß-Amyloid Fibrils

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Self-propagation of pathogenic protein aggregates in neurodegenerative diseases

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Exogenous α-Synuclein Fibrils Induce Lewy Body Pathology Leading to Synaptic Dysfunction and Neuron Death

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A cellular gene encodes scrapie PrP 27-30 protein

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Mutations in prion-like domains in hnRNPA2B1 and hnRNPA1 cause multisystem proteinopathy and ALS

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Propagation of Tau Pathology in a Model of Early Alzheimer's Disease

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Alzheimer’s Disease: The Challenge of the Second Century

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The topographical and neuroanatomical distribution of neurofibrillary tangles and neuritic plaques in the cerebral cortex of patients with Alzheimer's disease

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MAVS Forms Functional Prion-like Aggregates to Activate and Propagate Antiviral Innate Immune Response

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Propagation of Tau Misfolding from the Outside to the Inside of a Cell

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Eight prion strains have PrPSc molecules with different conformations

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100 years of Lewy pathology

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Molecular structural basis for polymorphism in Alzheimer's β-amyloid fibrils

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Intracerebral inoculation of pathological α-synuclein initiates a rapidly progressive neurodegenerative α-synucleinopathy in mice

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Tau pathology and neurodegeneration

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Molecular Structure of β-Amyloid Fibrils in Alzheimer’s Disease Brain Tissue

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A General Model of Prion Strains and Their Pathogenicity

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Functional Amyloids As Natural Storage of Peptide Hormones in Pituitary Secretory Granules

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Role of tau protein in both physiological and pathological conditions

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Trans-Synaptic Spread of Tau Pathology In Vivo

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Distinct Tau Prion Strains Propagate in Cells and Mice and Define Different Tauopathies

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Exogenous Induction of Cerebral ß-Amyloidogenesis Is Governed by Agent and Host

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Stress granules as crucibles of ALS pathogenesis

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Exogenous α-synuclein fibrils seed the formation of Lewy body-like intracellular inclusions in cultured cells

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The most infectious prion protein particles

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Neuronal activity regulates the regional vulnerability to amyloid-β deposition

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Prion-like spreading of pathological α-synuclein in brain

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Brain homogenates from human tauopathies induce tau inclusions in mouse brain

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The adaptor ASC has extracellular and 'prionoid' activities that propagate inflammation

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Cell-free Formation of RNA Granules: Bound RNAs Identify Features and Components of Cellular Assemblies

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C9orf72 repeat expansions cause neurodegeneration in Drosophila through arginine-rich proteins

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Predicting Regional Neurodegeneration from the Healthy Brain Functional Connectome

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Distinct α-Synuclein Strains Differentially Promote Tau Inclusions in Neurons

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Unconventional Viruses and the Origin and Disappearance of Kuru

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Lewy body extracts from Parkinson disease brains trigger α‐synuclein pathology and neurodegeneration in mice and monkeys

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Synthetic Tau Fibrils Mediate Transmission of Neurofibrillary Tangles in a Transgenic Mouse Model of Alzheimer's-Like Tauopathy

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Generating a Prion with Bacterially Expressed Recombinant Prion Protein

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The tip of the iceberg: RNA-binding proteins with prion-like domains in neurodegenerative disease

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Cell-to-cell transmission of pathogenic proteins in neurodegenerative diseases

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ALS motor phenotype heterogeneity, focality, and spread

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Pathogenic protein seeding in Alzheimer disease and other neurodegenerative disorders

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The physical basis of how prion conformations determine strain phenotypes

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Peripherally Applied Aβ-Containing Inoculates Induce Cerebral β-Amyloidosis

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A Neuronal Isoform of the Aplysia CPEB Has Prion-Like Properties

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Prion-like Polymerization Underlies Signal Transduction in Antiviral Immune Defense and Inflammasome Activation

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Mosaic Copy Number Variation in Human Neurons

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Prion-like Properties of Pathological TDP-43 Aggregates from Diseased Brains

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Amyotrophic lateral sclerosis—a model of corticofugal axonal spread

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Gain of function of mutant p53 by coaggregation with multiple tumor suppressors

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Small Misfolded Tau Species Are Internalized via Bulk Endocytosis and Anterogradely and Retrogradely Transported in Neurons

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A Unifying Role for Prions in Neurodegenerative Diseases

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Nomenclature 2014: Amyloid fibril proteins and clinical classification of the amyloidosis

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Alzheimer brain-derived tau oligomers propagate pathology from endogenous tau

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Identification of scrapie prion protein-specific mRNA in scrapie-infected and uninfected brain

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A novel in vivo model of tau propagation with rapid and progressive neurofibrillary tangle pathology: the pattern of spread is determined by connectivity, not proximity

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Prion-like propagation of mutant superoxide dismutase-1 misfolding in neuronal cells

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Chronic Wasting Disease

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Biology and Genetics of Prions Causing Neurodegeneration

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Transmission of multiple system atrophy prions to transgenic mice

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Advances in understanding the molecular basis of frontotemporal dementia

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Cytoplasmic penetration and persistent infection of mammalian cells by polyglutamine aggregates

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The genetics and neuropathology of amyotrophic lateral sclerosis

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Intercellular propagated misfolding of wild-type Cu/Zn superoxide dismutase occurs via exosome-dependent and -independent mechanisms

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The benefits and limitations of animal models for translational research in neurodegenerative diseases

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Prion-like acceleration of a synucleinopathy in a transgenic mouse model

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Evidence for Seeding of β-Amyloid by Intracerebral Infusion of Alzheimer Brain Extracts in β-Amyloid Precursor Protein-Transgenic Mice

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Preventing Alzheimer’s Disease

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Prions in Yeast

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Clinical and Biomarker Changes in Dominantly Inherited Alzheimer's Disease

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Purified and synthetic Alzheimer’s amyloid beta (Aβ) prions

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Iatrogenic Creutzfeldt-Jakob Disease, Final Assessment

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Transmissible spongiform encephalopathies

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