The DOI matches its Crossref record; 173 of the 173 references it cites were found in a registry or an index.
Endogenous and Exogenous Opioids in Pain
Open accessAbstract
Opioids are the most commonly used and effective analgesic treatments for severe pain, but they have recently come under scrutiny owing to epidemic levels of abuse and overdose. These compounds act on the endogenous opioid system, which comprises four G protein–coupled receptors (mu, delta, kappa, and nociceptin) and four major peptide families (β-endorphin, enkephalins, dynorphins, and nociceptin/orphanin FQ). In this review, we first describe the functional organization and pharmacology of the endogenous opioid system. We then summarize current knowledge on the signaling mechanisms by which opioids regulate neuronal function and neurotransmission. Finally, we discuss the loci of opioid analgesic action along peripheral and central pain pathways, emphasizing the pain-relieving properties of opioids against the affective dimension of the pain experience.
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Cites
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Self-citationEndogenous Pain Control Systems: Brainstem Spinal Pathways and Endorphin Circuitry
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BackgroundCrystal structure of the µ-opioid receptor bound to a morphinan antagonist
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Cited by
Dowdle, L. T., Borckardt, J. J., Back, S. E., Morgan, K., Adams, D., Madan, A., Balliet, W., & Hanlon, C. A. (2019) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2019.02.024 · Cited by 8
Gowrishankar, R., Hjort, M., Elerding, A. J., Shirley, S. E., Van Tilburg, J., Marcus, D. J., Senthilkumar, P., Abrera, K. A., Sumarli, D., Motovilov, K., et al. (2024) · doi:10.1101/2024.05.20.595035 · Cited by 3
Self-citation
Metadata
- Authors
- Corder, G., Castro, D. C., Bruchas, M. R., & Scherrer, G.
- Venue
- Annual Review of Neuroscience
- Publisher
- Annual Reviews
- Published
- 2018-07-08
- Volume
- 41
- Issue
- 1
- Pages
- 453-473
- ISSN
- 0147-006X (ISSN-L)
- 1545-4126
- OpenAlex
- W2806465603
- Cited by
- 502
- References
- 173
- FWCI
- 6.05
- Type
- journal article
- Language
- en
- Open access
- bronze
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