Endogenous opioid dynamics in the dorsal striatum sculpt neural activity to control goal-directed action
Open accessAbstract
Endogenous neuropeptides are uniquely poised to regulate neuronal activity and behavior across multiple timescales. Traditional studies ascribing neuropeptide contributions to behavior lack spatiotemporal precision. The endogenous opioid dynorphin is highly enriched in the dorsal striatum, known to be critical for regulating goal-directed behavior. However, the locus, the precise timescale, or functional role of endogenous dyn-KOR signaling on goal-directed behavior is unknown. Here, we report that local, time-locked dynorphin release from the dorsomedial striatum is necessary and sufficient for goal-directed behavior using a suite of high resolution modern approaches including in vivo two-photon imaging, neuropeptide biosensor detection, conditional deletions and time-locked optogenetic manipulations. We discovered that glutamatergic axon terminals from the basolateral amygdala evoke striatal dynorphin release, resulting in retrograde presynaptic GPCR inhibition during behavior. Collectively, our findings isolate a causal role for endogenous neuropeptide release at rapid timescales, and subsequent GPCR activity for tuning and promoting fundamental goal-directed behaviors.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The BLA sends a direct excitatory projection to the DMS.
“It sends a direct excitatory projection to the DMS30,31.”
From A dual-pathway architecture for stress to disrupt agency and promote habit (2025) · cites this paper as [31]
Cites
Gerfen, C. R., Engber, T. M., Mahan, L. C., Susel, Z., Chase, T. N., Monsma, F. J., & Sibley, D. R. (1990) · Science · doi:10.1126/science.2147780 · Cited by 2,967 · see citing works
Regulation of parkinsonian motor behaviours by optogenetic control of basal ganglia circuitry
Kravitz, A. V., Freeze, B. S., Parker, P. R. L., Kay, K., Thwin, M. T., Deisseroth, K., & Kreitzer, A. C. (2010) · Nature · doi:10.1038/nature09159 · Cited by 1,885 · see citing works
Modulation of Striatal Projection Systems by Dopamine
Gerfen, C. R., & Surmeier, D. J. (2011) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-061010-113641 · Cited by 1,700 · see citing works
The Role of the Dorsal Striatum in Reward and Decision-Making: Figure 1.
Balleine, B. W., Delgado, M. R., & Hikosaka, O. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.1554-07.2007 · Cited by 1,390 · see citing works
Baxter, M. G., & Murray, E. A. (2002) · Nature Reviews Neuroscience · doi:10.1038/nrn875 · Cited by 1,200 · see citing works
Dynorphin Is a Specific Endogenous Ligand of the κ Opioid Receptor
Chavkin, C., James, I. F., & D, A. G. M. (1982) · Science · doi:10.1126/science.6120570 · Cited by 1,171 · see citing works
The role of the dorsomedial striatum in instrumental conditioning
Yin, H. H., Ostlund, S. B., Knowlton, B. J., & Balleine, B. W. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.04218.x · Cited by 1,099 · see citing works
Neural responses during anticipation of a primary taste reward
O'Doherty, J. P., Deichmann, R., Critchley, H. D., & Dolan, R. J. (2002) · Neuron · doi:10.1016/s0896-6273(02)00603-7 · Cited by 1,076 · see citing works
Molecular mechanisms of opioid receptor-dependent signaling and behavior
Al-Hasani, R., & Bruchas, M. R. (2011) · Anesthesiology · doi:10.1097/aln.0b013e318238bba6 · Cited by 1,067 · see citing works
Self-citationNeuromodulation of neuronal circuits: back to the future
Marder, E. (2012) · Neuron · doi:10.1016/j.neuron.2012.09.010 · Cited by 904 · see citing works
Kelley, A. E., Domesick, V. B., & Nauta, W. J. H. (1982) · Neuroscience · doi:10.1016/0306-4522(82)90067-7 · Cited by 888 · see citing works
Neuropeptide Transmission in Brain Circuits
van den Pol, A. N. (2012) · Neuron · doi:10.1016/j.neuron.2012.09.014 · Cited by 810 · see citing works
Gremel, C. M., & Costa, R. M. (2013) · Nature Communications · doi:10.1038/ncomms3264 · Cited by 618 · see citing works
Hikosaka, O., Sakamoto, M., & Usui, S. (1989) · Journal of Neurophysiology · doi:10.1152/jn.1989.61.4.814 · Cited by 579 · see citing works
The dynorphin/kappa opioid system as a modulator of stress-induced and pro-addictive behaviors
Bruchas, M. R., Land, B. B., & Chavkin, C. (2010) · Brain Research · doi:10.1016/j.brainres.2009.08.062 · Cited by 544 · see citing works
Self-citationEndogenous and Exogenous Opioids in Pain
Corder, G. F., Castro, D. C., Bruchas, M. R., & Scherrer, G. (2018) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-080317-061522 · Cited by 511 · see citing works
Self-citationDifferential Innervation of Direct- and Indirect-Pathway Striatal Projection Neurons
Wall, N. R., De La Parra, M., Callaway, E. M., & Kreitzer, A. C. (2013) · Neuron · doi:10.1016/j.neuron.2013.05.014 · Cited by 489 · see citing works
Basal ganglia subcircuits distinctively encode the parsing and concatenation of action sequences
Jin, X., Tecuapetla, F., & Costa, R. M. (2014) · Nature Neuroscience · doi:10.1038/nn.3632 · Cited by 488 · see citing works
Basolateral to Central Amygdala Neural Circuits for Appetitive Behaviors
Kim, J., Zhang, X., Muralidhar, S., LeBlanc, S., & Tonegawa, S. (2017) · Neuron · doi:10.1016/j.neuron.2017.02.034 · Cited by 460 · see citing works
Transient stimulation of distinct subpopulations of striatal neurons mimics changes in action value
Tai, L.-H., Lee, A. M., Benavidez, N., Bonci, A., & Wilbrecht, L. (2012) · Nature Neuroscience · doi:10.1038/nn.3188 · Cited by 399 · see citing works
Dynorphin and the pathophysiology of drug addiction
Shippenberg, T. S., Zapata, A., & Chefer, V. I. (2007) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2007.06.011 · Cited by 387 · see citing works
Influence of Reward Expectation on Behavior-Related Neuronal Activity in Primate Striatum
Hollerman, J. R., Tremblay, L., & Schultz, W. (1998) · Journal of Neurophysiology · doi:10.1152/jn.1998.80.2.947 · Cited by 380 · see citing works
Goal-directed learning and obsessive-compulsive disorder
Gillan, C. M., & Robbins, T. W. (2014) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2013.0475 · Cited by 348 · see citing works
Altered striatal function in a mutant mouse lacking D1A dopamine receptors.
Drago, J., Gerfen, C. R., Lachowicz, J. E., Steiner, H., Hollon, T. R., Love, P. E., Ooi, G. T., Grinberg, A., Lee, E. J. K., & Huang, S.-P. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.26.12564 · Cited by 343 · see citing works
Molecular alterations in the neostriatum of human cocaine addicts
Hurd, Y. L., & Herkenham, M. A. (1993) · Synapse · doi:10.1002/syn.890130408 · Cited by 316 · see citing works
The basolateral amygdala in reward learning and addiction
Wassum, K. M., & Izquierdo, A. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.08.017 · Cited by 306 · see citing works
Hogarth, L. (2020) · Neuropsychopharmacology · doi:10.1038/s41386-020-0600-8 · Cited by 281 · see citing works
Reiner, A. J., & Anderson, K. D. (1990) · Brain Research Reviews · doi:10.1016/0165-0173(90)90003-7 · Cited by 272 · see citing works
Stress-induced reinstatement of cocaine seeking is mediated by the kappa opioid system
Redila, V. A., & Chavkin, C. (2008) · Psychopharmacology · doi:10.1007/s00213-008-1122-y · Cited by 234 · see citing works
Frontal cortex neuron types categorically encode single decision variables
Hirokawa, J., Vaughan, A., Masset, P., Ott, T., & Kepecs, Á. (2019) · Nature · doi:10.1038/s41586-019-1816-9 · Cited by 215 · see citing works
Simultaneous two-photon imaging and two-photon optogenetics of cortical circuits in three dimensions
Yang, W., Carrillo‐Reid, L., Bando, Y., Peterka, D. S., & Yuste, R. (2018) · eLife · doi:10.7554/elife.32671 · Cited by 209 · see citing works
Walker, B. M., Zorrilla, E. P., & Koob, G. F. (2010) · Addiction Biology · doi:10.1111/j.1369-1600.2010.00226.x · Cited by 202 · see citing works
Cocaine self-administration differentially alters mRNA expression of striatal peptides
Hurd, Y. L., Brown, E. E., Finlay, J. M., Fibiger, H. C., & Gerfen, C. R. (1992) · Molecular Brain Research · doi:10.1016/0169-328x(92)90058-j · Cited by 199 · see citing works
Ostlund, S. B., & Balleine, B. W. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.5472-07.2008 · Cited by 198 · see citing works
The Dopamine D1-D2 Receptor Heteromer Localizes in Dynorphin/Enkephalin Neurons
Perreault, M. L., Hasbi, A., Alijaniaram, M., Fan, T., Varghese, G. K., Fletcher, P. J., Seeman, P. M., O’Dowd, B. F., & George, S. R. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.159954 · Cited by 187 · see citing works
Corbit, L. H., & Janak, P. H. (2010) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2010.07153.x · Cited by 159 · see citing works
Cellular Sites for Dynorphin Activation of κ-Opioid Receptors in the Rat Nucleus Accumbens Shell
Svingos, A. L., Colago, E. E. O., & Pickel, V. M. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-05-01804.1999 · Cited by 157 · see citing works
Pan, W. X., Mao, T., & Dudman, J. T. (2010) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2010.00147 · Cited by 150 · see citing works
Namboodiri, V. M. K., Otis, J. M., van Heeswijk, K., Voets, E. S., Alghorazi, R. A., Rodriguez-Romaguera, J., Mihalas, S., & Stuber, G. D. (2019) · Nature Neuroscience · doi:10.1038/s41593-019-0408-1 · Cited by 150 · see citing works
Self-citationDynorphin Controls the Gain of an Amygdalar Anxiety Circuit
Crowley, N. A., Bloodgood, D. W., Hardaway, J. A., Kendra, A. M., McCall, J. G., Al‐Hasani, R., McCall, N. M., Yu, W., Schools, Z. L., Krashes, M. J., et al. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.02.069 · Cited by 149 · see citing works
Self-citationAn approximate line attractor in the hypothalamus encodes an aggressive state
Nair, A., Karigo, T., Yang, B., Ganguli, S., Schnitzer, M. J., Linderman, S. W., Anderson, D. J., & Kennedy, A. (2023) · Cell · doi:10.1016/j.cell.2022.11.027 · Cited by 143 · see citing works
Knoll, A. T., Muschamp, J. W., Daws, S. E., Ferguson, D., Dietz, D., Meloni, E. G., Carroll, F. I., Nestler, E. J., Konradi, C. L., & Carlezon, W. A. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.03.017 · Cited by 141 · see citing works
Mouse prefrontal cortex represents learned rules for categorization
Reinert, S., Hübener, M., Bonhoeffer, T., & Goltstein, P. M. (2021) · Nature · doi:10.1038/s41586-021-03452-z · Cited by 138 · see citing works
Direct and indirect dorsolateral striatum pathways reinforce different action strategies
Vicente, A. M., Galvão-Ferreira, P., Tecuapetla, F., & Costa, R. M. (2016) · Current Biology · doi:10.1016/j.cub.2016.02.036 · Cited by 137 · see citing works
Parkes, S. L., & Balleine, B. W. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.5071-12.2013 · Cited by 136 · see citing works
Tejeda, H. A., Wu, J., Kornspun, A. R., Pignatelli, M., Kashtelyan, V., Krashes, M. J., Lowell, B. B., Carlezon, W. A., & Bonci, A. (2017) · Neuron · doi:10.1016/j.neuron.2016.12.005 · Cited by 134 · see citing works
Architectural Representation of Valence in the Limbic System
Namburi, P., Al‐Hasani, R., Calhoon, G. G., Bruchas, M. R., & Tye, K. M. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2015.358 · Cited by 133 · see citing works
Self-citationShan, Q., Ge, M., Christie, M. J., & Balleine, B. W. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.0313-14.2014 · Cited by 122 · see citing works
Wee, S., Orío, L., Ghirmai, S., Cashman, J. R., & Koob, G. F. (2009) · Psychopharmacology · doi:10.1007/s00213-009-1563-y · Cited by 119 · see citing works
Hjelmstad, G. O., & Fields, H. L. (2003) · Journal of Neurophysiology · doi:10.1152/jn.01115.2002 · Cited by 119 · see citing works
Cho, Y., Monique Ernst, D., & Fudge, J. L. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.0170-13.2013 · Cited by 117 · see citing works
A Paranigral VTA Nociceptin Circuit that Constrains Motivation for Reward
Parker, K. E., Pedersen, C. E., Gomez, A. M., Spangler, S. M., Walicki, M. C., Feng, S., Stewart, S., Otis, J. M., Al‐Hasani, R., McCall, J. G., et al. (2019) · Cell · doi:10.1016/j.cell.2019.06.034 · Cited by 113 · see citing works
Self-citationTejeda, H. A., & Bonci, A. (2018) · Brain Research · doi:10.1016/j.brainres.2018.09.023 · Cited by 112 · see citing works
Al‐Hasani, R., Gowrishankar, R., Schmitz, G. P., Pedersen, C. E., Marcus, D. J., Shirley, S. E., Hobbs, T. G., Elerding, A. J., Renaud, S. J., Jing, M., et al. (2021) · Nature Neuroscience · doi:10.1038/s41593-021-00898-2 · Cited by 110 · see citing works
Self-citationPresynaptic long-term depression mediated by Gi/o-coupled receptors
Atwood, B. K., Lovinger, D. M., & Mathur, B. N. (2014) · Trends in Neurosciences · doi:10.1016/j.tins.2014.07.010 · Cited by 107 · see citing works
Bloem, B., Huda, R., Sur, M., & Graybiel, A. M. (2017) · eLife · doi:10.7554/elife.32353 · Cited by 99 · see citing works
Local D2- to D1-neuron transmodulation updates goal-directed learning in the striatum
Matamales, M., McGovern, A. E., Mi, J. D., Mazzone, S. B., Balleine, B. W., & Bertran‐Gonzalez, J. (2020) · Science · doi:10.1126/science.aaz5751 · Cited by 95 · see citing works
An endogenous opioid circuit determines state-dependent reward consumption
Castro, D. C., Oswell, C. S., Zhang, E. T., Pedersen, C. E., Piantadosi, S. C., Rossi, M. A., Hunker, A. C., Guglin, A., Morón, J. A., Zweifel, L. S., et al. (2021) · Nature · doi:10.1038/s41586-021-04013-0 · Cited by 95 · see citing works
Self-citationLowe, S. L., Wong, C. J., Witcher, J. W., Gonzales, C., Dickinson, G. L., Bell, R. L., Rorick‐Kehn, L. M., Weller, M., Stoltz, R. R., Royalty, J. E., et al. (2014) · The Journal of Clinical Pharmacology · doi:10.1002/jcph.286 · Cited by 91 · see citing works
Temporal upregulation of prodynorphin mRNA in the primate striatum after cocaine self‐administration
Fagergren, P., Smith, H. R., Daunais, J. B., Nader, M. A., Porrino, L. J., & Hurd, Y. L. (2003) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2003.02636.x · Cited by 88 · see citing works
A photoswitchable GPCR-based opsin for presynaptic inhibition
Copits, B. A., Gowrishankar, R., O’Neill, P., Li, J.-N., Girven, K. S., Yoo, J. J., Meshik, X., Parker, K. E., Spangler, S. M., Elerding, A. J., et al. (2021) · Neuron · doi:10.1016/j.neuron.2021.04.026 · Cited by 86 · see citing works
Self-citationGeneration of dynorphin knockout mice
Sharifi, N., Diehl, N. L., Yaswen, L. R., Brennan, M. B., & Hochgeschwender, U. (2001) · Molecular Brain Research · doi:10.1016/s0169-328x(00)00264-3 · Cited by 85 · see citing works
Coordinated Reductions in Excitatory Input to the Nucleus Accumbens Underlie Food Consumption
Reed, S. J., Lafferty, C. K., Mendoza, J. A., Yang, A. K., Davidson, T. J., Grosenick, L., Deisseroth, K. A., & Britt, J. P. (2018) · Neuron · doi:10.1016/j.neuron.2018.07.051 · Cited by 85 · see citing works
In vivo detection of optically-evoked opioid peptide release
Al‐Hasani, R., Wong, J. T., Mabrouk, O. S., McCall, J. G., Schmitz, G. P., Porter‐Stransky, K. A., Aragona, B. J., Kennedy, R. T., & Bruchas, M. R. (2018) · eLife · doi:10.7554/elife.36520 · Cited by 80 · see citing works
Self-citationVentral pallidostriatal pathway in the monkey: Evidence for modulation of basal ganglia circuits
Spooren, W. P. J. M., Lynd‐Balta, E., Mitchell, S., & Haber, S. N. (1996) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19960701)370:3 · Cited by 76 · see citing works
Corbit, L. H., Leung, B. K., & Balleine, B. W. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.3271-13.2013 · Cited by 75 · see citing works
Ironside, M., Amemori, K.-I., McGrath, C. L., Pedersen, M. L., Kang, M. S., Amemori, S., Frank, M. J., Graybiel, A. M., & Pizzagalli, D. A. (2020) · Biological Psychiatry · doi:10.1016/j.biopsych.2019.08.022 · Cited by 75 · see citing works
Ehrich, J. M., Phillips, P. E. M., & Chavkin, C. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2014.157 · Cited by 65 · see citing works
Piantadosi, S. C., Zhou, Z. C., Pizzano, C., Pedersen, C. E., Nguyen, T. K., Thai, S., Stuber, G. D., & Bruchas, M. R. (2023) · Neuron · doi:10.1016/j.neuron.2023.11.007 · Cited by 64 · see citing works
Self-citationRelease of endogenous dynorphin opioids in the prefrontal cortex disrupts cognition
Abraham, A. D., Casello, S. M., Schattauer, S. S., Wong, B. A., Mizuno, G. O., Mahe, K., Tian, L., Land, B. B., & Chavkin, C. (2021) · Neuropsychopharmacology · doi:10.1038/s41386-021-01168-2 · Cited by 62 · see citing works
Self-citationNygard, S. K., Hourguettes, N. J., Sobczak, G. G., Carlezon, W. A., & Bruchas, M. R. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.0953-16.2016 · Cited by 61 · see citing works
Self-citationUnlocking opioid neuropeptide dynamics with genetically encoded biosensors
Dong, C., Gowrishankar, R., Jin, Y., He, X. J., Gupta, A., Wang, H., Sayar, N., Flores, R. J., Mahe, K., Tjahjono, N., et al. (2024) · Nature Neuroscience · doi:10.1038/s41593-024-01697-1 · Cited by 61 · see citing works
Self-citationPeak, J. N., Chieng, B. C. H., Hart, G., & Balleine, B. W. (2020) · eLife · doi:10.7554/elife.58544 · Cited by 58 · see citing works
Competition between stochastic neuropeptide signals calibrates the rate of satiation
Zhang, S. X., Kim, A., Madara, J. C., Zhu, P. K., Christenson, L. F., Lutas, A., Kalugin, P. N., Jin, Y., Pal, A., Tian, L., et al. (2023) · doi:10.1101/2023.07.11.548551 · Cited by 56 · see citing works
Self-citationYoshida, K., Drew, M. R., Kono, A., Mimura, M., Takata, N., & Tanaka, K. F. (2021) · Neuropsychopharmacology · doi:10.1038/s41386-021-00990-y · Cited by 55 · see citing works
A neuronal mechanism for motivational control of behavior
Courtin, J., Bitterman, Y., Müller, S., Hinz, J., Hagihara, K. M., Müller, C. R., & Lüthi, A. (2022) · Science · doi:10.1126/science.abg7277 · Cited by 52 · see citing works
A stable, distributed code for cue value in mouse cortex during reward learning
Ottenheimer, D. J., Hjort, M. M., Bowen, A. J., Steinmetz, N. A., & Stuber, G. D. (2023) · eLife · doi:10.7554/elife.84604 · Cited by 36 · see citing works
Self-citationBloem, B., Huda, R., Amemori, K., Abate, A., Krishna, G., Wilson, A. L., Carter, C. W., Sur, M., & Graybiel, A. M. (2022) · Nature Communications · doi:10.1038/s41467-022-28983-5 · Cited by 34 · see citing works
An open-source platform for head-fixed operant and consummatory behavior
Gordon-Fennell, A., Barbakh, J. M., Utley, M. T., Singh, S., Bazzino, P., Gowrishankar, R., Bruchas, M. R., Roitman, M. F., & Stuber, G. D. (2023) · eLife · doi:10.7554/elife.86183 · Cited by 34 · see citing works
Self-citationMu, P., Neumann, P. A., Panksepp, J., Schlüter, O. M., & Dong, Y. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.09.014 · Cited by 33 · see citing works
Limoges, A., Yarur, H. E., & Tejeda, H. A. (2022) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2022.963691 · Cited by 33 · see citing works
Wang, H., Flores, R. J., Yarur, H. E., Limoges, A., Bravo-Rivera, H., Casello, S. M., Loomba, N., Enríquez-Traba, J., Arenivar, M. A., Wang, Q., et al. (2024) · Neuron · doi:10.1016/j.neuron.2024.03.015 · Cited by 25 · see citing works
Self-citationMotor thalamus supports striatum-driven reinforcement
Lalive, A. L., Lien, A. D., Roseberry, T. K., Donahue, C. H., & Kreitzer, A. C. (2018) · eLife · doi:10.7554/elife.34032 · Cited by 23 · see citing works
Kønig, A. B., Ciriachi, C., Gether, U., & Rickhag, M. (2019) · Neuroscience · doi:10.1016/j.neuroscience.2019.01.013 · Cited by 20 · see citing works
Dichotomous regulation of striatal plasticity by dynorphin
Yang, R., Lalchandani, R. R., Hwang, F.-J., Bloodgood, D. W., Kong, D., & Ding, J. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01885-0 · Cited by 14 · see citing works
Farahbakhsh, Z. Z., Song, K., Branthwaite, H. E., Erickson, K. R., Mukerjee, S., Nolan, S. O., & Siciliano, C. A. (2023) · Neuropsychopharmacology · doi:10.1038/s41386-023-01547-x · Cited by 13 · see citing works
Hjort, M. M., Gowrishankar, R., Tian, L., et al. (2024) · Neurophotonics · doi:10.1117/1.nph.11.3.033407 · Cited by 10 · see citing works
Self-citationRappleye, M., Gordon-Fennell, A., Castro, D. C., Matarasso, A. K., Zamorano, C. A., Stine, C., Wait, S. J., Lee, J. D., Siebart, J. C., Suko, A. V., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.06.01.494241 · Cited by 8 · see citing works
Self-citationDevelopment of a genetically encoded sensor for probing endogenous nociceptin opioid peptide releasePreprint
Zhou, X., Stine, C., Prada, P. O., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.05.26.542102 · Cited by 7 · see citing works
A dual-pathway architecture enables chronic stress to disrupt agency and promote habit formationPreprint
Giovanniello, J. R., Paredes, N., Wiener, A. J., Ramírez-Armenta, K., Oragwam, C., Uwadia, H. O., Yu, A. L., Lim, K. Y., Pimenta, J. S., Vilchez, G. E., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.10.03.560731 · Cited by 7 · see citing works
Kappa Opioid Receptors in Mesolimbic Terminals Mediate Escalation of Cocaine ConsumptionPreprint
Gordon-Fennell, L., Farero, R. D., Burgeno, L. M., Murray, N. L., Abraham, A. D., Soden, M. E., Stuber, G. D., Chavkin, C., Zweifel, L. S., & Phillips, P. E. M. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.12.21.572842 · Cited by 2 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
A dual-pathway architecture for stress to disrupt agency and promote habit
Giovanniello, J. R., Paredes, N., Wiener, A., Ramírez-Armenta, K., Oragwam, C., Uwadia, H. O., Yu, A. L., Lim, K., Pimenta, J. S., Vilchez, G. E., et al. (2025) · Nature · doi:10.1038/s41586-024-08580-w · Cited by 30 · see citing works
- Authors
- Gowrishankar, R., Hjort, M., Elerding, A. J., Shirley, S. E., Van Tilburg, J., Marcus, D. J., Senthilkumar, P., Abrera, K. A., Sumarli, D., Motovilov, K., Lau, V., Gordon-Fennell, A. A., Zhou, Z. C., Dong, C., Tian, L., Stuber, G. D., & Bruchas, M. R.
- Affiliations
- University of Washington (US)
- University of California, Davis (US)
- Max Planck Florida Institute for Neuroscience (US)
- Corresponding author
- Bruchas, Michael R.
- ORCID
- Venue
- bioRxiv (Cold Spring Harbor Laboratory)
- Publisher
- openRxiv
- Published
- 2024-05-20
- OpenAlex
- W4398175943
- Cited by
- 3
- References
- 91
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 1
- Type
- posted content
- Language
- en
- Open access
- green
- doi.org
- Licence
- cc-by-nc-nd
- Locations
- bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion, cc-by-nc-nd)
- SSRN Electronic Journal (acceptedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Keywords
- dorsal striatum, goal-directed behavior, kappa opioid receptor, neuropeptide release, basolateral amygdala, glutamatergic synapses, presynaptic inhibition
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review