The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
Endoplasmic Reticulum Stress in Nonalcoholic Fatty Liver Disease
Abstract
The underlying causes of nonalcoholic fatty liver disease are unclear, although recent evidence has implicated the endoplasmic reticulum in both the development of steatosis and progression to nonalcoholic steatohepatitis. Disruption of endoplasmic reticulum homeostasis, often termed ER stress, has been observed in liver and adipose tissue of humans with nonalcoholic fatty liver disease and/or obesity. Importantly, the signaling pathway activated by disruption of endoplasmic reticulum homeostasis, the unfolded protein response, has been linked to lipid and membrane biosynthesis, insulin action, inflammation, and apoptosis. Therefore, understanding the mechanisms that disrupt endoplasmic reticulum homeostasis in nonalcoholic fatty liver disease and the role of the unfolded protein response in the broader context of chronic, metabolic diseases have become topics of intense investigation. The present review examines the endoplasmic reticulum and the unfolded protein response in the context of nonalcoholic fatty liver disease.
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Endoplasmic Reticulum Stress: Its Role in Disease and Novel Prospects for Therapy
Schönthal, A. H. (2012) · Scientifica · doi:10.6064/2012/857516 · Cited by 353
Targeting fatty acid metabolism to improve glucose metabolism
Stinkens, R., Goossens, G. H., Jocken, J. W. E., & Blaak, E. E. (2015) · Obesity Reviews · doi:10.1111/obr.12298 · Cited by 183
The hepatokine Tsukushi is released in response to NAFLD and impacts cholesterol homeostasis
Mouchiroud, M., Camiré, É., Aldow, M., Caron, A., Jubinville, É., Turcotte, L., Kaci, I., Beaulieu, M.-J., Roy, C., Labbé, S. M., et al. (2019) · JCI Insight · doi:10.1172/jci.insight.129492 · Cited by 57
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Chen, Y., Yan, X., Wang, T., Deng, H., Deng, X., Xu, F., & Liang, H. (2023) · International Journal of Endocrinology · doi:10.1155/2023/2872408 · Cited by 6
Metadata
- Authors
- Pagliassotti, M. J.
- Venue
- Annual Review of Nutrition
- Publisher
- Annual Reviews
- Published
- 2012-08-21
- Volume
- 32
- Issue
- 1
- Pages
- 17-33
- ISSN
- 0199-9885 (ISSN-L)
- 1545-4312
- OpenAlex
- W2122957192
- Cited by
- 220
- References
- 16
- FWCI
- 1.55
- Type
- journal article
- Language
- en
- Open access
- closed
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