The DOI matches its Crossref record; 209 of the 209 references it cites were found in a registry or an index.
Hypoxia and Adipocyte Physiology: Implications for Adipose Tissue Dysfunction in Obesity
Abstract
Hypoxia develops in white adipose tissue in obese mice, resulting in changes in adipocyte function that may underpin the dysregulation that leads to obesity-associated disorders. Whether hypoxia occurs in adipose tissue in human obesity is unclear, with recent studies contradicting earlier reports that this was the case. Adipocytes, both murine and human, exhibit extensive functional changes in culture in response to hypoxia, which alters the expression of up to 1,300 genes. These include genes encoding key adipokines such as leptin, interleukin (IL)-6, vascular endothelial growth factor (VEGF), and matrix metalloproteinase-2 (MMP-2), which are upregulated, and adiponectin, which is downregulated. Hypoxia also inhibits the expression of genes linked to oxidative metabolism while stimulating the expression of genes associated with glycolysis. Glucose uptake and lactate release by adipocytes are both stimulated by hypoxia, and insulin sensitivity falls. Preadipocytes and macrophages in adipose tissue also respond to hypoxia. The hypoxia-signaling pathway may provide a new target for the treatment of obesity-associated disorders.
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“Adipocytes release proinflammatory factors such as IL-6 and macrophage migration inhibitory factor (12).”
From The ominous triad of adipose tissue dysfunction: inflammation, fibrosis, and impaired angiogenesis. (2017) · cites this paper as [12]
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The metabolic phenotype in obesity: Fat mass, body fat distribution, and adipose tissue function
Goossens, G. H. (2017) · Obesity Facts · doi:10.1159/000471488 · Cited by 8,481
PPARs in Obesity-Induced T2DM, Dyslipidaemia and NAFLD
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Metadata
- Authors
- Trayhurn, P.
- Affiliations
- University of Liverpool (GB)
- Corresponding author
- Trayhurn, Paul
- ORCID
- Trayhurn, Paul
- Venue
- Annual Review of Nutrition
- Publisher
- Annual Reviews
- Published
- 2014-07-17
- Volume
- 34
- Issue
- 1
- Pages
- 207-236
- ISSN
- 0199-9885 (ISSN-L)
- 1545-4312
- OpenAlex
- W2112850039
- Cited by
- 194
- References
- 207
- Citations by year
- 2026: 6 · 2025: 8 · 2024: 11 · 2023: 12 · 2022: 18 · 2021: 22 · 2020: 13 · 2019: 19 · 2018: 20 · 2017: 24 · 2016: 18 · 2015: 17 · 2014: 6
- FWCI
- 2.89
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annual Review of Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Keywords
- hypoxia, adipocytes, white adipose tissue, obesity, adipose tissue dysfunction, adipokines, leptin, adiponectin, interleukin-6, vascular endothelial growth factor, MMP-2, oxidative metabolism, glycolysis, glucose uptake, lactate release, insulin sensitivity, preadipocytes, macrophages, hypoxia signaling
- MeSH terms
- Animals, Energy Metabolism, Humans, Insulin Resistance, Macrophages, Models, Biological, Obesity, Cell Hypoxia, Adipogenesis, Hypoxia-Inducible Factor 1, Adipocytes, Brown, Adipocytes, White
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