Cited by 873Diet and metabolism studiesDietary Effects on HealthMetabolism and Genetic Disorders

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β-Hydroxybutyrate: A Signaling Metabolite

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Newman, John C., Verdin, Eric·2017·Annual Review of Nutrition

DOI 10.1146/annurev-nutr-071816-064916PMC PMC6640868

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Abstract

Various mechanisms in the mammalian body provide resilience against food deprivation and dietary stress. The ketone body β-hydroxybutyrate (BHB) is synthesized in the liver from fatty acids and represents an essential carrier of energy from the liver to peripheral tissues when the supply of glucose is too low for the body's energetic needs, such as during periods of prolonged exercise, starvation, or absence of dietary carbohydrates. In addition to its activity as an energetic metabolite, BHB is increasingly understood to have cellular signaling functions. These signaling functions of BHB broadly link the outside environment to epigenetic gene regulation and cellular function, and their actions may be relevant to a variety of human diseases as well as human aging.

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“13”
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“Histone hyperacet-ylation induces expression of several key regulatory proteins, including Foxo3a, the mammalian ortholog of the stress-responsive transcriptional factor DAF-16 that regulates lifespan in C. elegans (Shimazu et al. 2013; Newman and Verdin 2017).”
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Diet-mediated bioenergetic flux: a double-edged sword for health and diseases
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Genetic modulation of mitochondrial NAD+ regeneration does not prevent dopaminergic neuron dysfunction caused by mitochondrial complex I impairment
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Protective effects of β-hydroxybutyrate against N-methyl-D-aspartic acid-induced excitotoxic retinal injury in rats
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Influential
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Background
β-hydroxybutyrate suppresses pathological changes of blood-induced arthropathy in rats
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Double Blinded Clinical Study on D-Glyceric Acid, a Potential Novel Energy Metabolic Signaling MetabolitePreprint
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Self-citation

Authors: Newman, J. C., & Verdin, E.
Affiliations: Gladstone Institutes (US)
ORCID: Verdin, Eric
Venue: Annual Review of Nutrition
Publisher: Annual Reviews
Published: 2017-08-21
Volume: 37
Issue: 1
Pages: 51-76
ISSN: 0199-9885 (ISSN-L)
1545-4312
DOI: 10.1146/annurev-nutr-071816-064916
PMC: PMC6640868
OpenAlex: W2747163024
Cited by: 872
References: 163
Citations by year: 2026: 146 · 2025: 160 · 2024: 126 · 2023: 100 · 2022: 106 · 2021: 99 · 2020: 72 · 2019: 38 · 2018: 24 · 2017: 1
FWCI: 4.53
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.annualreviews.org/licenses/tdm (tdm)
Locations: Annual Review of Nutrition (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health
National Institute on Aging (K08AG048354)
National Institute of Diabetes and Digestive and Kidney Diseases (R24DK085610)
Topics: Health Sciences › Medicine › Physiology (medical) › Diet and metabolism studies
Health Sciences › Medicine › Physiology (medical) › Dietary Effects on Health
Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Metabolism and Genetic Disorders
Keywords: beta-hydroxybutyrate, ketone bodies, signal transduction, epigenetic regulation, energy metabolism, fasting, starvation, physical activity, nutritional stress, aging
MeSH terms: Aging, Animals, Humans, Liver, Starvation, Signal Transduction, 3-Hydroxybutyric Acid, Epigenesis, Genetic

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β-Hydroxybutyrate: A Signaling Metabolite

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