The genetics of ageing

Kenyon, Cynthia J.

doi:10.1038/nature08980

Cited by 2,739Genetics, Aging, and Longevity in Model OrganismsTelomeres, Telomerase, and SenescenceEvolution and Genetic Dynamics

The genetics of ageing

Kenyon, Cynthia J.·2010·Nature

DOI 10.1038/nature08980

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Abstract

The nematode Caenorhabditis elegans ages and dies in a few weeks, but humans can live for 100 years or more. Assuming that the ancestor we share with nematodes aged rapidly, this means that over evolutionary time mutations have increased lifespan more than 2,000-fold. Which genes can extend lifespan? Can we augment their activities and live even longer? After centuries of wistful poetry and wild imagination, we are now getting answers, often unexpected ones, to these fundamental questions.

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Genome wide expression profiling studies have identified several genes and biological pathways affected by aging.
“Genome wide expression profiling studies have identified several genes and biological pathways affected by aging (Bishop et al. 2010, Lopez-Otin et al. 2013, Kenyon 2010, Yankner et al. 2008).”
From miR‐186 is decreased in aged brain and suppresses <scp>BACE</scp>1 expression (2016) · cites this paper as Kenyon 2010
Mutations that reduce insulin/IGF-1 signaling decelerate degenerative aging and extend lifespan in many organisms, including mice and possibly humans.
“In vitro experiments show that mutations that reduce insulin/IGF-1 signaling have been shown to decelerate the degenerative aging process and extend lifespan in many organisms, including mice and possibly humans.”
From GHK and DNA: Resetting the human genome to health (2014) · cites this paper as [63]

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A Regulated Response to Impaired Respiration Slows Behavioral Rates and Increases Lifespan in Caenorhabditis elegans
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The Target of Rapamycin Pathway Antagonizes pha-4/FoxA to Control Development and Aging
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Caenorhabditis elegans lifespan extension caused by treatment with an orally active ROS-generator is dependent on DAF-16 and SIR-2.1
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Mitochondrial Oxidative Phosphorylation Is Defective in the Long-lived Mutant clk-1
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The Hallmarks of Aging
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Autophagy and Aging
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Ketone bodies as signaling metabolites
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Metformin retards aging in C. elegans by altering microbial folate and methionine metabolism
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The transcriptional landscape of age in human peripheral blood
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TOR Signaling and Rapamycin Influence Longevity by Regulating SKN-1/Nrf and DAF-16/FoxO
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Gut microbiome and aging: physiological and mechanistic insights
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NAD + Replenishment Improves Lifespan and Healthspan in Ataxia Telangiectasia Models via Mitophagy and DNA Repair
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Aging, Rejuvenation, and Epigenetic Reprogramming: Resetting the Aging Clock
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The metabolic footprint of aging in mice
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Mitohormesis: Promoting Health and Lifespan by Increased Levels of Reactive Oxygen Species (ROS)
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Molecular and physiological manifestations and measurement of aging in humans
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AMPK at the Nexus of Energetics and Aging
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Neurogenesis in the embryonic and adult brain: same regulators, different roles
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The quest to slow ageing through drug discovery
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A mitochondrial UPR-mediated metabolic checkpoint regulates hematopoietic stem cell aging
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Calorie restriction and sirtuins revisited
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A Review of the Role of Green Tea (Camellia sinensis) in Antiphotoaging, Stress Resistance, Neuroprotection, and Autophagy
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SIRT3 Reverses Aging-Associated Degeneration
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An Acetylation Switch of the NLRP3 Inflammasome Regulates Aging-Associated Chronic Inflammation and Insulin Resistance
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Autophagy Impairment in Muscle Induces Neuromuscular Junction Degeneration and Precocious Aging
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Ryanodine receptor oxidation causes intracellular calcium leak and muscle weakness in aging
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Autophagy and the cell biology of age-related disease
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The starvation hormone, fibroblast growth factor-21, extends lifespan in mice
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The first long-lived mutants: discovery of the insulin/IGF-1 pathway for ageing
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Pharmacological approaches to restore mitochondrial function
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Aged skeletal stem cells generate an inflammatory degenerative niche
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Inflammaging decreases adaptive and innate immune responses in mice and humans
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Towards a unifying, systems biology understanding of large-scale cellular death and destruction caused by poorly liganded iron: Parkinson’s, Huntington’s, Alzheimer’s, prions, bactericides, chemical toxicology and others as examples
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Pten positively regulates brown adipose function, energy expenditure, and longevity
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FOXO3: A Major Gene for Human Longevity - A Mini-Review
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Autophagy and Lipid Metabolism Coordinately Modulate Life Span in Germline-less C. elegans
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Metabolic regulation of stem cell function in tissue homeostasis and organismal ageing
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Small nucleoli are a cellular hallmark of longevity
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Cancer-Associated PIK3CA Mutations in Overgrowth Disorders
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Autophagy and the hallmarks of aging
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The Genetics of Aging: A Vertebrate Perspective
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Impaired Epidermal to Dendritic T Cell Signaling Slows Wound Repair in Aged Skin
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Cockayne syndrome: Clinical features, model systems and pathways
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Mitochondrial Dysfunction in Alzheimer’s Disease and the Rationale for Bioenergetics Based Therapies
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Nucleocytosolic depletion of the energy metabolite acetyl-coenzyme a stimulates autophagy and prolongs lifespan
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A Platform for Rapid Exploration of Aging and Diseases in a Naturally Short-Lived Vertebrate
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Aging Hallmarks: The Benefits of Physical Exercise
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Firefly luciferase mutants as sensors of proteome stress
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You Are What You Host: Microbiome Modulation of the Aging Process
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“Unlike worms, the effect of associated bacteria on Drosophila lifespan is less clear and may depend upon the precise composition of the microbiota population.”
BackgroundInfluential
Neurite Sprouting and Synapse Deterioration in the Aging Caenorhabditis elegans Nervous System
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“Aging appears to be a conserved feature of eukaryotic biology, affecting organisms as phylogenetically diverse as the single-celled Saccharomyces cerevisiae, the eutelic nematode Caenorhabditis elegans, mice, and humans (Kenyon 2010; Longo et al. 2012; Tissenbaum 2014).”
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Deep proteome analysis identifies age-related processes in C. elegans
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Authors: Kenyon, C. J.
Affiliations: University of California, San Francisco (US)
Corresponding author: Kenyon, Cynthia J.
ORCID: Kenyon, Cynthia J.
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2010-03-24
Volume: 464
Issue: 7288
Pages: 504-512
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/nature08980
OpenAlex: W2058484936
Cited by: 2,739
References: 104
Citations by year: 2026: 106 · 2025: 115 · 2024: 130 · 2023: 128 · 2022: 149 · 2021: 182 · 2020: 198 · 2019: 189 · 2018: 173 · 2017: 185 · 2016: 190 · 2015: 194 · 2014: 202 · 2013: 197 · 2012: 181
FWCI: 15.05
Type: journal article
Language: en
Update notices: erratum (2010-09-29)
Open access: closed
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
RePEc: Research Papers in Economics (submittedVersion)
Funders: Tokyo Center for Economic Research
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
Keywords: aging, lifespan extension, Caenorhabditis elegans, longevity genes, human lifespan
MeSH terms: Aging, Animals, Humans, Insulin, Insulin-Like Growth Factor I, Longevity, Transferases, Signal Transduction, Cell Respiration

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