The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
Inflammation in Alcoholic Liver Disease
Open accessAbstract
Frank Burr Mallory's landmark observation in 1911 on the histopathology of alcoholic liver disease (ALD) was the first identification of a link between inflammation and ALD. In this review, we summarize recent advances regarding the origins and roles of various inflammatory components in ALD. Metabolism of ethanol generates a number of metabolites, including acetate, reactive oxygen species, acetaldehyde, and epigenetic changes, that can induce inflammatory responses. Alcohol and its metabolites can also initiate and aggravate inflammatory conditions by promoting gut leakiness of microbial products, by sensitizing immune cells to stimulation, and by activating innate immune pathways, such as complement. Chronic alcohol consumption also sensitizes nonimmune cells, e.g., hepatocytes, to inflammatory signals and impairs their ability to respond to protective signals. Based on these advances, a number of inflammatory targets have been identified with potential for therapeutic intervention in ALD, presenting new opportunities and challenges for translational research.
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Cites
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Self-citationSelective depletion of macrophages reveals distinct, opposing roles during liver injury and repair
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Contribution of the Intestinal Microbiome and Gut Barrier to Hepatic Disorders
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Pathophysiological Aspects of Alcohol Metabolism in the Liver
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Alcoholic hepatitis: Translational approaches to develop targeted therapies
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Self-citationHepatocyte toll-like receptor 4 deficiency protects against alcohol-induced fatty liver disease
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Metadata
- Authors
- Wang, H. J., Gao, B., Zakhari, S., & Nagy, L. E.
- Venue
- Annual Review of Nutrition
- Publisher
- Annual Reviews
- Published
- 2012-08-21
- Volume
- 32
- Issue
- 1
- Pages
- 343-368
- ISSN
- 0199-9885 (ISSN-L)
- 1545-4312
- OpenAlex
- W2114405620
- Cited by
- 297
- References
- 17
- FWCI
- 3.37
- Type
- journal article
- Language
- en
- Open access
- green
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