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Cited by 180Diet, Metabolism, and DiseaseGastrointestinal motility and disordersBiochemical Analysis and Sensing Techniques

Intestinal Absorption of Fructose

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Ferraris, Ronaldo P., Choe, Jun-yong, Patel, Chirag R.·2018·Annual Review of Nutrition
DOI 10.1146/annurev-nutr-082117-051707PMC PMC6457363
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Abstract

Increased understanding of fructose metabolism, which begins with uptake via the intestine, is important because fructose now constitutes a physiologically significant portion of human diets and is associated with increased incidence of certain cancers and metabolic diseases. New insights in our knowledge of intestinal fructose absorption mediated by the facilitative glucose transporter GLUT5 in the apical membrane and by GLUT2 in the basolateral membrane are reviewed. We begin with studies related to structure as well as ligand binding, then revisit the controversial proposition that apical GLUT2 is the main mediator of intestinal fructose absorption. The review then describes how dietary fructose may be sensed by intestinal cells to affect the expression and activity of transporters and fructolytic enzymes, to interact with the transport of certain minerals and electrolytes, and to regulate portal and peripheral fructosemia and glycemia. Finally, it discusses the potential contributions of dietary fructose to gastrointestinal diseases and to the gut microbiome.

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  • Intestinal glucose absorption can be limited by the capacity of the intestinal glucose transport system (SGLT1).

    “However, intestinal glucose absorption can be limited by the capacity of the intestinal glucose transport system (SGLT1).”

    From Fructose co‐ingestion to increase carbohydrate availability in athletes (2019) · cites this paper as Ferraris et al. (2018)

    In “The Apical GLUT2 Hypothesis” (page unavailable), the review identifies SGLT1 as the primary transporter for glucose uptake across the intestinal apical membrane and reports that glucose failed to enter the mucosa in mice lacking SGLT1. That supports SGLT1’s importance, but the passages do not establish that its transport capacity limits glucose absorption. (LLM, conf=0.82)

    Experimental — accuracy not yet measured

  • Intestinal fructose uptake is not regulated by the same transport system as glucose, as it largely depends on GLUT5 as opposed to SGLT1 transporters.

    “Intestinal fructose uptake is not regulated by the same transport system, as it largely depends on GLUT5 as opposed to SGLT1 transporters.”

    From Fructose co‐ingestion to increase carbohydrate availability in athletes (2019) · cites this paper as Ferraris et al. (2018)

  • At rest, fructose is primarily absorbed across the apical membrane of intestinal enterocytes by GLUT5, whereas glucose is primarily absorbed by SGLT1.

    “At rest, fructose is primarily absorbed across the apical membrane of the intestinal enterocytes by transport protein GLUT5, whereas glucose is primarily absorbed across the apical membrane of the intestinal enterocytes by transport protein SGLT1 (please see Ferraris et al. (2018) for a comprehensive review on this topic).”

    From Fructose co‐ingestion to increase carbohydrate availability in athletes (2019) · cites this paper as Ferraris et al. (2018)

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Cited by

Sorted by citations

Authors
Ferraris, R. P., Choe, J.-Y., & Patel, C. R.
Affiliations
  • Rutgers, The State University of New Jersey (US)
  • Rosalind Franklin University of Medicine and Science (US)
  • Independent Drug Safety Consulting, Wilmington, Delaware 19803, USA;
ORCID
Ferraris, Ronaldo P.
Venue
Annual Review of Nutrition
Publisher
Annual Reviews
Published
2018-08-21
Volume
38
Issue
1
Pages
41-67
ISSN
  • 0199-9885 (ISSN-L)
  • 1545-4312
DOI
10.1146/annurev-nutr-082117-051707
PMC
PMC6457363
OpenAlex
W2800704834
Cited by
180
References
4
Citations by year
2026: 15 · 2025: 28 · 2024: 30 · 2023: 21 · 2022: 27 · 2021: 25 · 2020: 22 · 2019: 9 · 2018: 3
FWCI
2.27
Type
journal article
Language
en
Open access
Locations
  • Annual Review of Nutrition (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health (5r01dk091754-05)
  • National Institute of General Medical Sciences (R01GM123103)
  • National Institute of Diabetes and Digestive and Kidney Diseases (R01-DK091754)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
  • Health Sciences › Nursing › Nutrition and Dietetics › Biochemical Analysis and Sensing Techniques
Keywords
GLUT5, GLUT2, fructose transporter, glycemia, dietary fructose, gut microbiota, gastrointestinal diseases, fructose metabolism
MeSH terms
Animals, Biological Transport, Diet, Fructose, Gene Expression Regulation, Humans, Intestines

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