Role of Dietary Fructose and Hepatic De Novo Lipogenesis in Fatty Liver Disease
Open accessAbstract
Nonalcoholic fatty liver disease (NAFLD) is a liver manifestation of metabolic syndrome. Overconsumption of high-fat diet (HFD) and increased intake of sugar-sweetened beverages are major risk factors for development of NAFLD. Today the most commonly consumed sugar is high fructose corn syrup. Hepatic lipids may be derived from dietary intake, esterification of plasma free fatty acids (FFA) or hepatic de novo lipogenesis (DNL). A central abnormality in NAFLD is enhanced DNL. Hepatic DNL is increased in individuals with NAFLD, while the contribution of dietary fat and plasma FFA to hepatic lipids is not significantly altered. The importance of DNL in NAFLD is further established in mouse studies with knockout of genes involved in this process. Dietary fructose increases levels of enzymes involved in DNL even more strongly than HFD. Several properties of fructose metabolism make it particularly lipogenic. Fructose is absorbed via portal vein and delivered to the liver in much higher concentrations as compared to other tissues. Fructose increases protein levels of all DNL enzymes during its conversion into triglycerides. Additionally, fructose supports lipogenesis in the setting of insulin resistance as fructose does not require insulin for its metabolism, and it directly stimulates SREBP1c, a major transcriptional regulator of DNL. Fructose also leads to ATP depletion and suppression of mitochondrial fatty acid oxidation, resulting in increased production of reactive oxygen species. Furthermore, fructose promotes ER stress and uric acid formation, additional insulin independent pathways leading to DNL. In summary, fructose metabolism supports DNL more strongly than HFD and hepatic DNL is a central abnormality in NAFLD. Disrupting fructose metabolism in the liver may provide a new therapeutic option for the treatment of NAFLD.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Fructose alone more strongly induces DNL enzymes ACC1, FASN, and SCD1 compared to high-fat diets.
“Fructose enhances its own metabolism by upregulating ketohexokinase (KHK), which is elevated in MASLD; diets high in both fat and fructose worsen MASLD, but fructose alone more strongly induces DNL enzymes like ACC1, FASN, and stearoyl-CoA desaturase 1 (SCD1) compared to HFDs [13].”
From Hepatic Insulin Resistance and Steatosis in Metabolic Dysfunction-Associated Steatotic Liver Disease: New Insights into Mechanisms and Clinical Implications (2025) · cites this paper as [13]
Fructose enhances its own metabolism by upregulating ketohexokinase (KHK).
“Fructose enhances its own metabolism by upregulating ketohexokinase (KHK), which is elevated in MASLD; diets high in both fat and fructose worsen MASLD, but fructose alone more strongly induces DNL enzymes like ACC1, FASN, and stearoyl-CoA desaturase 1 (SCD1) compared to HFDs [13].”
From Hepatic Insulin Resistance and Steatosis in Metabolic Dysfunction-Associated Steatotic Liver Disease: New Insights into Mechanisms and Clinical Implications (2025) · cites this paper as [13]
KHK is elevated in MASLD.
“Fructose enhances its own metabolism by upregulating ketohexokinase (KHK), which is elevated in MASLD; diets high in both fat and fructose worsen MASLD, but fructose alone more strongly induces DNL enzymes like ACC1, FASN, and stearoyl-CoA desaturase 1 (SCD1) compared to HFDs [13].”
From Hepatic Insulin Resistance and Steatosis in Metabolic Dysfunction-Associated Steatotic Liver Disease: New Insights into Mechanisms and Clinical Implications (2025) · cites this paper as [13]
Patients with MASLD often show reduced hepatic ATP.
“Patients with MASLD often show reduced hepatic ATP [13].”
From Hepatic Insulin Resistance and Steatosis in Metabolic Dysfunction-Associated Steatotic Liver Disease: New Insights into Mechanisms and Clinical Implications (2025) · cites this paper as [13]
DAG buildup, not TG, is linked to hepatic IR via PKC activation.
“Importantly, DAG buildup, not TG, is linked to hepatic IR via PKC activation.”
From Hepatic Insulin Resistance and Steatosis in Metabolic Dysfunction-Associated Steatotic Liver Disease: New Insights into Mechanisms and Clinical Implications (2025) · cites this paper as [13]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Design and validation of a histological scoring system for nonalcoholic fatty liver disease†
Kleiner, D. E., Brunt, E. M., Van Natta, M., Behling, C., Contos, M. J., Cummings, O. W., Ferrell, L. D., Liu, Y., Torbenson, M. S., Unalp‐Arida, A., et al. (2005) · Hepatology · doi:10.1002/hep.20701 · Cited by 10,791 · see citing works
Sontrop, J. M., Dixon, S. N., Garg, A. X., Jiménez, I. B., Dohein, O., Huang, S. S., & Clark, W. F. (2013) · American Journal of Nephrology · doi:10.1159/000350377 · Cited by 5,903 · see citing works
Donnelly, K. L., Smith, C. I., Schwarzenberg, S. J., Jessurun, J., Boldt, M. D., & Parks, E. J. (2005) · Journal of Clinical Investigation · doi:10.1172/jci23621 · Cited by 3,604 · see citing works
Critical nodes in signalling pathways: insights into insulin action
Taniguchi, C. M., Emanuelli, B., & Kahn, C. R. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1837 · Cited by 2,760 · see citing works
Self-citationTriglyceride accumulation protects against fatty acid-induced lipotoxicity
Listenberger, L. L., Han, X., Lewis, S. E., Cases, S., Farese, R. V., Ory, D. S., & Schaffer, J. E. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0630588100 · Cited by 2,075 · see citing works
Risk of Cardiovascular Disease in Patients with Nonalcoholic Fatty Liver Disease
Targher, G., Day, C. P., & Bonora, E. (2010) · New England Journal of Medicine · doi:10.1056/nejmra0912063 · Cited by 1,907 · see citing works
Chalasani, N., Younossi, Z. M., Lavine, J. E., Diehl, A. M., Brunt, E. M., Cusi, K. J., Charlton, M., & Sanyal, A. J. (2012) · Gastroenterology · doi:10.1053/j.gastro.2012.04.001 · Cited by 1,773 · see citing works
Stanhope, K. L., Schwarz, J. M., Keim, N. L., Griffen, S. C., Bremer, A. A., Graham, J. L., Hatcher, B., Cox, C. L., Dyachenko, A., Zhang, W., et al. (2009) · Journal of Clinical Investigation · doi:10.1172/jci37385 · Cited by 1,765 · see citing works
Loomba, R. S., & Sanyal, A. J. (2013) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2013.171 · Cited by 1,696 · see citing works
Increasing Prevalence of the Metabolic Syndrome Among U.S. Adults
Ford, E. S., Giles, W. H., & Mokdad, A. H. (2004) · Diabetes Care · doi:10.2337/diacare.27.10.2444 · Cited by 1,488 · see citing works
Insulin Receptor Signaling in Normal and Insulin-Resistant StatesPreprint
Boucher, J., Kleinridders, A., & Kahn, C. R. (2014) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a009191 · Cited by 1,473 · see citing works
Self-citationA lipidomic analysis of nonalcoholic fatty liver disease
Puri, P., Baillie, R. A., Wiest, M. M., Mirshahi, F., Choudhury, J., Cheung, O., Sargeant, C., Contos, M. J., & Sanyal, A. J. (2007) · Hepatology · doi:10.1002/hep.21763 · Cited by 1,338 · see citing works
Michael, M. D., Kulkarni, R. N., Postic, C., Previs, S. F., Shulman, G. I., Magnuson, M. A., & Kahn, C. R. (2000) · Molecular Cell · doi:10.1016/s1097-2765(05)00015-8 · Cited by 1,296 · see citing works
Self-citationPostic, C., & Girard, J. R. (2008) · Journal of Clinical Investigation · doi:10.1172/jci34275 · Cited by 1,200 · see citing works
A causal role for uric acid in fructose-induced metabolic syndrome
Nakagawa, T., Hu, H., Zharikov, S. I., Tuttle, K. R., Short, R., Glushakova, O. Y., Ouyang, X., Feig, D. I., Block, E. R., Herrera-Acosta, J., et al. (2005) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00140.2005 · Cited by 1,104 · see citing works
Loss of stearoyl–CoA desaturase-1 function protects mice against adiposity
Ntambi, J. M., Miyazaki, M., Stoehr, J. P., Hong, L., Kendziorski, C. M., Yandell, B. S., Song, Y., Cohen, P., Friedman, J. M., & Attie, A. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.132384699 · Cited by 1,096 · see citing works
Lambert, J. E., Ramos–Roman, M. A., Browning, J. D., & Parks, E. J. (2014) · Gastroenterology · doi:10.1053/j.gastro.2013.11.049 · Cited by 1,069 · see citing works
Regulation of Hepatic Lipogenesis by the Transcription Factor XBP1
Lee, A., Scapa, E. F., Cohen, D. E., & Glimcher, L. H. (2008) · Science · doi:10.1126/science.1158042 · Cited by 978 · see citing works
Self-citationMechanisms of hepatic triglyceride accumulation in non-alcoholic fatty liver disease
Kawano, Y., & Cohen, D. E. (2013) · Journal of Gastroenterology · doi:10.1007/s00535-013-0758-5 · Cited by 968 · see citing works
Self-citationAdded sugar intake and cardiovascular diseases mortality among US adults
Yang, Q., Zhang, Z., Gregg, E. W., Flanders, W. D., Merritt, R., & Hu, F. B. (2014) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2013.13563 · Cited by 947 · cited 1× · see citing works
“Adolescents today consume 15 % of total calories from refined sugar and 10 % of population consumes 25 % or more of their total calories from refined sugar [6].”
BackgroundContinuous fatty acid oxidation and reduced fat storage in mice lacking acetyl-CoA carboxylase 2
Abu-Elheiga, L., Matzuk, M. M., Abo-Hashema, K. A. H., & Wakil, S. J. (2001) · Science · doi:10.1126/science.1056843 · Cited by 903 · see citing works
Fullerton, M. D., Galic, S., Marcinko, K., Sikkema, S., Pulinilkunnil, T., Chen, Z.-P., O'Neill, H. M., Ford, R. J., Palanivel, R., O'Brien, M., et al. (2013) · Nature Medicine · doi:10.1038/nm.3372 · Cited by 893 · see citing works
Fructose consumption as a risk factor for non-alcoholic fatty liver disease
Ouyang, X., Cirillo, P., Sautin, Y. Y., McCall, S. J., Bruchette, J. L., Diehl, A. M., Johnson, R. J., & Abdelmalek, M. F. (2008) · Journal of Hepatology · doi:10.1016/j.jhep.2008.02.011 · Cited by 862 · see citing works
Role for Stearoyl-CoA Desaturase-1 in Leptin-Mediated Weight Loss
Cohen, P., Miyazaki, M., Socci, N. D., Hagge-Greenberg, A., Liedtke, W., Soukas, A. A., Sharma, R., Hudgins, L. C., Ntambi, J. M., & Friedman, J. M. (2002) · Science · doi:10.1126/science.1071527 · Cited by 818 · see citing works
A Trial of Sugar-free or Sugar-Sweetened Beverages and Body Weight in Children
de Ruyter, J. C., Olthof, M. R., Seidell, J. C., & Katan, M. B. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1203034 · Cited by 814 · see citing works
Shimomura, I., Bashmakov, Y. K., Ikemoto, S., Horton, J. D., Brown, M. S., & Goldstein, J. L. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.24.13656 · Cited by 779 · see citing works
Sugar, Uric Acid, and the Etiology of Diabetes and Obesity
Johnson, R. J., Nakagawa, T., Sánchez‐Lozada, L. G., Shafiu, M., Sundaram, S. S., Le, M. T., Ishimoto, T., Sautin, Y. Y., & Lanaspa, M. A. (2013) · Diabetes · doi:10.2337/db12-1814 · Cited by 773 · see citing works
Kim, D., Kim, R. W., Kim, H. J., & Therneau, T. M. (2013) · Hepatology · doi:10.1002/hep.26156 · Cited by 772 · see citing works
The role of fructose in the pathogenesis of NAFLD and the metabolic syndrome
Lim, J. S., Mietus-Snyder, M., Valente, A., Schwarz, J.-M., & Lustig, R. H. (2010) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2010.41 · Cited by 771 · see citing works
Abdelmalek, M. F., Suzuki, A., Guy, C. D., Ünalp–Arida, A., Colvin, R., Johnson, R. J., & Diehl, A. M. (2010) · Hepatology · doi:10.1002/hep.23535 · Cited by 767 · see citing works
Decreased Survival of Subjects With Elevated Liver Function Tests During A 28-Year Follow-Up
Söderberg, C., Stal, P. I., Askling, J., Glaumann, H., Lindberg, G., Marmur, J., & Hultcrantz, R. W. (2009) · Hepatology · doi:10.1002/hep.23314 · Cited by 748 · see citing works
Fatty acid metabolism: Target for metabolic syndrome
Wakil, S. J., & Abu-Elheiga, L. A. (2009) · Journal of Lipid Research · doi:10.1194/jlr.r800079-jlr200 · Cited by 731 · see citing works
Uric Acid Induces Hepatic Steatosis by Generation of Mitochondrial Oxidative Stress
Lanaspa, M. A., Sánchez‐Lozada, L. G., Choi, Y.-J., Cicerchi, C., Kanbay, M., Roncal-Jiménez, C. A., Ishimoto, T., Li, N., Marek, G. W., Duranay, M., et al. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.399899 · Cited by 718 · see citing works
A Randomized Trial of Sugar-Sweetened Beverages and Adolescent Body Weight
Ebbeling, C. B., Feldman, H. A., Chomitz, V. R., Antonelli, T. A., Gortmaker, S. L., Osganian, S. K., & Ludwig, D. S. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1203388 · Cited by 699 · see citing works
Regulation of sterol regulatory element binding proteins in livers of fasted and refed mice
Horton, J. D., Bashmakov, Y. K., Shimomura, I., & Shimano, H. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.11.5987 · Cited by 669 · see citing works
Increased overall mortality and liver-related mortality in non-alcoholic fatty liver disease
Ong, J. P., Pitts, A., & Younossi, Z. M. (2008) · Journal of Hepatology · doi:10.1016/j.jhep.2008.06.018 · Cited by 636 · see citing works
“New” hepatic fat activates PPARα to maintain glucose, lipid, and cholesterol homeostasis
Chakravarthy, M. V., Pan, Z., Zhu, Y., Tordjman, K. M., Schneider, J. G., Coleman, T., TURK, J. W., & Semenkovich, C. F. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.04.002 · Cited by 545 · see citing works
Zelber‐Sagi, S., Nitzan, D., Goldsmith, R., Webb, M., Blendis, L. M., Halpern, Z., & Oren, R. (2007) · Journal of Hepatology · doi:10.1016/j.jhep.2007.06.020 · Cited by 545 · see citing works
Identification of a Physiologically Relevant Endogenous Ligand for PPARα in Liver
Chakravarthy, M. V., Lodhi, I. J., Yin, L., Malapaka, R. R. V., Xu, H. E., TURK, J. W., & Semenkovich, C. F. (2009) · Cell · doi:10.1016/j.cell.2009.05.036 · Cited by 534 · see citing works
Increased Hepatic CD36 Expression Contributes to Dyslipidemia Associated With Diet-Induced Obesity
Koonen, D. P. Y., Jacobs, R. L., Febbraio, M., Young, M. E., Soltys, C.-L. M., Ong, H., Vance, D. E., & Dyck, J. R. B. (2007) · Diabetes · doi:10.2337/db07-0907 · Cited by 514 · see citing works
Dissociation of Hepatic Steatosis and Insulin Resistance in Mice Overexpressing DGAT in the Liver
Monetti, M., Levin, M. C., Watt, M. J., Sajan, M. P., Marmor, S., Hubbard, B. K., Stevens, R. D., Bain, J. R., Newgard, C. B., Farese, R. V., et al. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.05.005 · Cited by 511 · see citing works
Sweetened beverage consumption, incident coronary heart disease, and biomarkers of risk in men
de Koning, L., Malik, V. S., Kellogg, M. D., Rimm, E. B., Willett, W. C., & Hu, F. B. (2012) · Circulation · doi:10.1161/circulationaha.111.067017 · Cited by 503 · see citing works
PKC-θ knockout mice are protected from fat-induced insulin resistance
Kim, J. K., Fillmore, J. J., Sunshine, M. J., Albrecht, B., Higashimori, T., Kim, D.-W., Liu, Z.-X., Soos, T. J., Cline, G. W., O’Brien, W. R., et al. (2004) · Journal of Clinical Investigation · doi:10.1172/jci200422230 · Cited by 500 · see citing works
Endoplasmic reticulum stress is reduced in tissues of obese subjects after weight loss
Gregor, M. F., Yang, L., Fabbrini, E., Mohammed, B. S., Eagon, J. C., Hotamisligil, G. S., & Klein, S. (2009) · Diabetes · doi:10.2337/db08-1220 · Cited by 488 · see citing works
Alterations in Liver ATP Homeostasis in Human Nonalcoholic Steatohepatitis
Cortez‐Pinto, H., Chatham, J. C., Chacko, V. P., Arnold, C., Rashid, A., & Diehl, A. M. (1999) · JAMA · doi:10.1001/jama.282.17.1659 · Cited by 487 · see citing works
Biddinger, S. B., Hernandez-Ono, A., Rask-Madsen, C., Haas, J. T., Alemán, J. O., Suzuki, R., Scapa, E. F., Agarwal, C., Carey, M. C., Stephanopoulos, G., et al. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2007.11.013 · Cited by 469 · see citing works
Self-citationPhysiological and molecular mechanisms involved in nutritional regulation of fatty acid synthesis
Hillgartner, F. B., Salati, L. M., & Goodridge, A. G. (1995) · Physiological Reviews · doi:10.1152/physrev.1995.75.1.47 · Cited by 459 · see citing works
Savage, D. B. (2006) · Journal of Clinical Investigation · doi:10.1172/jci27300 · Cited by 447 · see citing works
Charlton, M., Krishnan, A., Viker, K., Sanderson, S. O., Cazanave, S. C., McConico, A. L., Masuoko, H., & Gores, G. J. (2011) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00145.2011 · Cited by 444 · see citing works
Diraison, F., Moulin, P., & Beylot, M. (2003) · Diabetes & Metabolism · doi:10.1016/s1262-3636(07)70061-7 · Cited by 435 · see citing works
Regulation of acetyl-CoA carboxylase
Brownsey, R. W., Boone, A. N., Elliott, J. E., Kulpa, J. E., & Lee, W. M. (2006) · Biochemical Society Transactions · doi:10.1042/bst20060223 · Cited by 432 · see citing works
Thuy, S., Ladurner, R., Volynets, V., Wagner, S., Strahl, S., Königsrainer, A., Maier, K., Bischoff, S., & Bergheim, I. (2008) · Journal of NutriLife · doi:10.1093/jn/138.8.1452 · Cited by 432 · see citing works
Miyazaki, M., Flowers, M. T., Sampath, H., Chu, K., Otzelberger, C., Liu, X., & Ntambi, J. M. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.10.014 · Cited by 426 · see citing works
A high-fat, ketogenic diet induces a unique metabolic state in mice
Kennedy, A. R., Pissios, P., Otu, H., Xue, B., Asakura, K., Furukawa, N., Marino, F. E., Liu, F.-F., Kahn, B. B., Libermann, T. A., et al. (2007) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00717.2006 · Cited by 420 · see citing works
Consumption of added sugars is decreasing in the United States
Welsh, J. A., Sharma, A. J., Grellinger, L., & Vos, M. B. (2011) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.111.018366 · Cited by 420 · see citing works
Choi, C. S., Savage, D. B., Kulkarni, A., Yu, X. X., Liu, Z.-X., Morino, K., Kim, S., Distefano, A., Samuel, V. T., Neschen, S., et al. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m704213200 · Cited by 383 · see citing works
Kohli, R., Kirby, M., Xanthakos, S. A., Softic, S., Feldstein, A. E., Saxena, V., Tang, P., Miles, L., Miles, M. V., Balistreri, W. F., et al. (2010) · Hepatology · doi:10.1002/hep.23797 · Cited by 377 · see citing works
Self-citationMechanisms for the acute effect of fructose on postprandial lipemia
Chong, M. F., Fielding, B. A., & Frayn, K. N. (2007) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/85.6.1511 · Cited by 367 · see citing works
Parks, E. J., Krauss, R. M., Christiansen, M. P., Neese, R. A., & Hellerstein, M. K. (1999) · Journal of Clinical Investigation · doi:10.1172/jci6572 · Cited by 350 · see citing works
Regulation of Hepatic De Novo Lipogenesis in Humans
Hellerstein, M. K., Schwarz, J.-M., & Neese, R. A. (1996) · Annual Review of Nutrition · doi:10.1146/annurev.nu.16.070196.002515 · Cited by 349 · see citing works
High-fat and high-sucrose (western) diet induces steatohepatitis that is dependent on fructokinase
Ishimoto, T., Lanaspa, M. A., Rivard, C. J., Roncal-Jiménez, C. A., Orlicky, D. J., Cicerchi, C., McMahan, R. H., Abdelmalek, M. F., Rosen, H. R., Jackman, M. R., et al. (2013) · Hepatology · doi:10.1002/hep.26594 · Cited by 333 · see citing works
Presence and significance of microvesicular steatosis in nonalcoholic fatty liver disease
Tandra, S., Yeh, M. M., Brunt, E. M., Vuppalanchi, R., Cummings, O. W., Ünalp–Arida, A., Wilson, L., & Chalasani, N. (2010) · Journal of Hepatology · doi:10.1016/j.jhep.2010.11.021 · Cited by 328 · see citing works
Takayama, S., White, M. F., & Kahn, C. R. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)69090-8 · Cited by 317 · see citing works
Self-citationDiacylglycerol Activation of Protein Kinase Cε and Hepatic Insulin Resistance
Jornayvaz, F. R., & Shulman, G. I. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.03.005 · Cited by 315 · see citing works
Juárez, R. G. (2006) · Journal of Clinical Investigation · doi:10.1172/jci26991 · Cited by 298 · see citing works
Mao, J., DeMayo, F. J., Huiguang, L., Abu-Elheiga, L. A., Gu, Z., Shaiken, T. E., Kordari, P., Chirala, S. S., Heird, W. C., & Wakil, S. J. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0603115103 · Cited by 292 · see citing works
The role of the lipogenic pathway in the development of hepatic steatosis
Postic, C., & Girard, J. R. (2008) · Diabetes & Metabolism · doi:10.1016/s1262-3636(08)74599-3 · Cited by 287 · see citing works
Prevention of obesity in mice by antisense oligonucleotide inhibitors of stearoyl-CoA desaturase–1
Jiang, G., Li, Z., Liu, F., Ellsworth, K. P., Dallas-Yang, Q., Wu, M. S., Ronan, J., Esau, C., Murphy, C., Szalkowski, D., et al. (2005) · Journal of Clinical Investigation · doi:10.1172/jci23962 · Cited by 285 · see citing works
Taniguchi, C. M., Kondo, T., Sajan, M. P., Luo, J., Bronson, R. T., Asano, T., Farese, R. V., Cantley, L. C., & Kahn, C. R. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.04.005 · Cited by 282 · see citing works
Self-citationConsumption of Added Sugars and Indicators of Cardiovascular Disease Risk Among US Adolescents
Welsh, J. A., Sharma, A. J., Cunningham, S. A., & Vos, M. B. (2011) · Circulation · doi:10.1161/circulationaha.110.972166 · Cited by 269 · see citing works
Mutant mice lacking acetyl-CoA carboxylase 1 are embryonically lethal
Abu-Elheiga, L. A., Matzuk, M. M., Kordari, P., Oh, W. K., Shaiken, T. E., Gu, Z., & Wakil, S. J. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0505714102 · Cited by 263 · see citing works
Meier, J. J., Veldhuis, J. D., & Butler, P. C. (2005) · Diabetes · doi:10.2337/diabetes.54.6.1649 · Cited by 261 · see citing works
FATP2 is a hepatic fatty acid transporter and peroxisomal very long-chain acyl-CoA synthetase
Falcon, A., Doege, H., Fluitt, A. H., Tsang, B., Watson, N., Kay, M. A., & Stahl, A. (2010) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00226.2010 · Cited by 249 · see citing works
De novo lipogenesis in humans: metabolic and regulatory aspects
Hellerstein, M. (1999) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1600744 · Cited by 246 · see citing works
Adverse effects of dietary fructose.
Gaby, A. R. (2005) · PubMed · Cited by 245 · see citing works
Sugar-sweetened beverages and BMI in children and adolescents: reanalyses of a meta-analysis
Malik, V., Willett, W. C., & Hu, F. B. (2008) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2008.26980 · Cited by 244 · see citing works
Interplay between FGF21 and insulin action in the liver regulates metabolism
Emanuelli, B., Vienberg, S. G., Smyth, G., Cheng, C., Stanford, K. I., Arumugam, M., Michael, M. D., Adams, A. C., Kharitonenkov, A., & Kahn, C. R. (2014) · Journal of Clinical Investigation · doi:10.1172/jci67353 · Cited by 243 · see citing works
Self-citationChirala, S. S., Chang, H., Matzuk, M. M., Abu-Elheiga, L. A., Mao, J., Mahon, K., Finegold, M. J., & Wakil, S. J. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0931394100 · Cited by 242 · see citing works
Dietary Composition and Nonalcoholic Fatty Liver Disease
Solga, S. F., Alkhuraishe, A. R., Clark, J. M., TORBENSON, M., Greenwald, A., Diehl, A. M., & Magnuson, T. H. (2004) · Digestive Diseases and Sciences · doi:10.1023/b:ddas.0000043367.69470.b7 · Cited by 214 · see citing works
The role of fructose-enriched diets in mechanisms of nonalcoholic fatty liver disease
Nomura, K., & Yamanouchi, T. (2012) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2011.09.006 · Cited by 213 · see citing works
Wang, Q. A., Jiang, L., Wang, J., Li, S., Yu, Y., You, J., Zeng, R., Gao, X., Rui, L., Li, W., et al. (2008) · Hepatology · doi:10.1002/hep.22774 · Cited by 212 · see citing works
Liver ATP Synthesis Is Lower and Relates to Insulin Sensitivity in Patients With Type 2 Diabetes
Schmid, A. I., Szendroedi, J., Chmelik, M., Krššák, M., Moser, E., & Roden, M. (2011) · Diabetes Care · doi:10.2337/dc10-1076 · Cited by 212 · see citing works
Sevastianova, K., Santos, A., Kotronen, A., Hakkarainen, A., Makkonen, J., Silander, K., Peltonen, M., Romeo, S., Lundbom, J., Lundbom, N., et al. (2012) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.112.038695 · Cited by 211 · cited 1× · see citing works
“Conversely, following 6 months of a hypocaloric diet, the same subjects lost 25 % of liver fat and 4 % of body weight [48].”
BackgroundHormonal and nutritional regulation of SCD1 gene expression
Mauvoisin, D., & Mounier, C. (2010) · Biochimie · doi:10.1016/j.biochi.2010.08.001 · Cited by 211 · see citing works
Haas, J. T., Miao, J., Chanda, D., Wang, Y., Zhao, E., Haas, M. E., Hirschey, M. D., Vaitheesvaran, B., Farese, R. V., Kurland, I. J., et al. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.05.002 · Cited by 207 · see citing works
High fructose corn syrup and diabetes prevalence: A global perspective
Goran, M., Ulijaszek, S., & Ventura, E. (2013) · Global Public Health · doi:10.1080/17441692.2012.736257 · Cited by 201 · see citing works
Kornacker, M. S., & Lowenstein, J. (1965) · Biochemical Journal · doi:10.1042/bj0940209 · Cited by 198 · see citing works
Elovl6 promotes nonalcoholic steatohepatitis
Matsuzaka, T., Atsumi, A., Matsumori, R., Nie, T., Shinozaki, H., Suzuki‐Kemuriyama, N., Kuba, M., Nakagawa, Y., Ishii, K., Shimada, M., et al. (2012) · Hepatology · doi:10.1002/hep.25932 · Cited by 194 · see citing works
Differential effects of central fructose and glucose on hypothalamic malonyl–CoA and food intake
Cha, S. H., Wolfgang, M. J., Tokutake, Y., Chohnan, S., & Lane, M. D. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0809255105 · Cited by 191 · see citing works
Abdelmalek, M. F., Lazo, M., Horska, A., Bonekamp, S., Lipkin, E. W., Balasubramanyam, A., Bantle, J. P., Johnson, R. J., Diehl, A. M., & Clark, J. M. (2012) · Hepatology · doi:10.1002/hep.25741 · Cited by 190 · see citing works
Lustig, R. H., Mulligan, K. M., Noworolski, S. M., Tai, V., Wen, M., Erkin‐Cakmak, A., Gugliucci, A., & Schwarz, J. (2015) · Obesity · doi:10.1002/oby.21371 · Cited by 185 · see citing works
Lipoprotein Metabolism, Dyslipidemia, and Nonalcoholic Fatty Liver Disease
Fisher, E. A. A., & Cohen, D. E. (2013) · Seminars in Liver Disease · doi:10.1055/s-0033-1358519 · Cited by 179 · see citing works
Self-citationSilbernagel, G., Machann, J., Unmuth, S., Schick, F., Stefan, N., Häring, H. U., & Fritsche, A. (2011) · British Journal Of Nutrition · doi:10.1017/s000711451000574x · Cited by 172 · see citing works
Garbow, J. R., Doherty, J. M., Schugar, R. C., Travers, S., Weber, M. L., Wentz, A. E., Ezenwajiaku, N., Cotter, D. G., Brunt, E. M., & Crawford, P. A. (2011) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00539.2010 · Cited by 172 · see citing works
Temporal pattern of de novo lipogenesis in the postprandial state in healthy men1–3
Timlin, M. T., & Parks, E. J. (2005) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/81.1.35 · Cited by 170 · see citing works
Doege, H., Grimm, D., Falcon, A., Tsang, B., Storm, T. A., Xu, H., Ortegon, A. M., Kazantzis, M., Kay, M. A., & Stahl, A. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m803510200 · Cited by 170 · see citing works
Insulin signaling to hepatic lipid metabolism in health and disease
Leavens, K. F., & Birnbaum, M. J. (2011) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.3109/10409238.2011.562481 · Cited by 162 · see citing works
Marques-Lopes, I., Ansorena, D., Astiasarán, I., Forga, L., & Martínez, J. A. (2001) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/73.2.253 · Cited by 159 · see citing works
Liver transplantation and non-alcoholic fatty liver disease
Zezos, P. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i42.15532 · Cited by 156 · see citing works
Cox, C. L., Stanhope, K. L., Schwarz, J. M., Graham, J. L., Hatcher, B., Griffen, S. C., Bremer, A. A., Berglund, L., McGahan, J. P., Keim, N. L., et al. (2012) · Nutrition & Metabolism · doi:10.1186/1743-7075-9-68 · Cited by 155 · see citing works
ATP-Citrate Lyase Deficiency in the Mouse
Beigneux, A. P., Kosinski, C., Gavino, B. J., Horton, J. D., Skarnes, W. C., & Young, S. G. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m310512200 · Cited by 154 · see citing works
PKCδ regulates hepatic insulin sensitivity and hepatosteatosis in mice and humans
Bézy, O., Tran, T. T., Pihlajamäki, J., Suzuki, R., Emanuelli, B., Winnay, J., Mori, M. A., Haas, J. T., Biddinger, S. B., Leitges, M., et al. (2011) · Journal of Clinical Investigation · doi:10.1172/jci46045 · Cited by 148 · see citing works
Self-citationSITES OF INITIAL REMOVAL OF CHYLOMICRON TRIGLYCERIDE FATTY ACIDS FROM THE BLOOD*
Nestel, P. J., Havel, R. J., & Bezman, A. (1962) · Journal of Clinical Investigation · doi:10.1172/jci104648 · Cited by 145 · see citing works
The role of ATP citrate-lyase in the metabolic regulation of plasma lipids
PEARCE, N. J., Yates, J. W., Berkhout, T. A., Jackson, B., Tew, D. G., Boyd, H., Camilleri, P., Sweeney, P. J., Gribble, A. D., Shaw, A. N., et al. (1998) · Biochemical Journal · doi:10.1042/bj3340113 · Cited by 144 · see citing works
Jurczak, M. J., Lee, A., Jornayvaz, F. R., Lee, H., Birkenfeld, A. L., Guigni, B. A., Kahn, M., Samuel, V. T., Glimcher, L. H., & Shulman, G. I. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.316760 · Cited by 142 · see citing works
Hepatic De Novo Lipogenesis Is Present in Liver-Specific ACC1-Deficient Mice
Harada, N., Oda, Z., Hara, Y., Fujinami, K., Okawa, M., Ohbuchi, K., Yonemoto, M., Ikeda, Y., Ohwaki, K., Aragane, K., et al. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.01122-06 · Cited by 130 · see citing works
Diraison, F., & Beylot, M. (1998) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1998.274.2.e321 · Cited by 122 · see citing works
Ong, J. P., Pitts, A., & Younossi, Z. M. (2008) · Journal of Hepatology · doi:10.1016/s0168-8278(08)60008-2 · Cited by 119 · see citing works
Jin, R., Welsh, J. A., Le, N., Holzberg, J. R., Sharma, P., Martin, D. R., & Vos, M. B. (2014) · Nutrients · doi:10.3390/nu6083187 · Cited by 118 · see citing works
Gene knockout of Acc2 has little effect on body weight, fat mass, or food intake
Olson, D. P., Pulinilkunnil, T., Cline, G. W., Shulman, G. I., & Lowell, B. B. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0913492107 · Cited by 109 · see citing works
Asipu, A., Hayward, B. E., O’Reilly, J., & Bonthron, D. T. (2003) · Diabetes · doi:10.2337/diabetes.52.9.2426 · Cited by 109 · see citing works
Kaplan, R. S., Mayor, J. A., Johnston, N., & Oliveira, D. L. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)38309-7 · Cited by 108 · see citing works
Tsuchiya, H., Ebata, Y., Sakabe, T., Hama, S., Kogure, K., & Shiota, G. (2012) · Metabolism · doi:10.1016/j.metabol.2012.06.008 · Cited by 103 · see citing works
Low-carbohydrate ketogenic diets, glucose homeostasis, and nonalcoholic fatty liver disease
Schugar, R. C., & Crawford, P. A. (2012) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0b013e3283547157 · Cited by 102 · see citing works
Machado, R. M., Stefano, J. T., de Oliveira, C. P. M. S., de Mello, E. S., Ferreira, F. D., Nunes, V. S., de Lima, V. M. R., Quintão, E. C. R., Catanozi, S., Nakandakare, E. R., et al. (2010) · Journal of Nutrition · doi:10.3945/jn.109.117937 · Cited by 98 · see citing works
2-Hydroxy-N-arylbenzenesulfonamides as ATP-citrate lyase inhibitors
Li, J. J., Wang, H., Tino, J. A., Robl, J. A., Herpin, T. F., Lawrence, R. M., Biller, S. A., Jamil, H., Ponticiello, R., Chen, L., et al. (2007) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2007.03.017 · Cited by 94 · see citing works
Mager, D. R., Rivera‐Íñiguez, I., Gilmour, S. M., & Yap, J. Y. K. (2013) · Journal of Parenteral and Enteral Nutrition · doi:10.1177/0148607113501201 · Cited by 92 · see citing works
Abu-Elheiga, L. A., Wu, H., Gu, Z., BRESSLER, R. C., & Wakil, S. J. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.309559 · Cited by 84 · see citing works
Moon, Y.-A., Ochoa, C. R., Mitsche, M. A., Hammer, R. E., & Horton, J. D. (2014) · Journal of Lipid Research · doi:10.1194/jlr.m054353 · Cited by 83 · see citing works
Mordier, S. B., & Iynedjian, P. B. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.08.004 · Cited by 82 · see citing works
Jin, R., Le, N., Liu, S., Epperson, M., Ziegler, T. R., Welsh, J. A., Jones, D. P., McClain, C. J., & Vos, M. B. (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2012-1370 · Cited by 76 · see citing works
Did fat intake in the United States really decline between 1989-1991 and 1994-1996?☆☆☆★★★
Chanmugam, P., Guthrie, J. F., Cecilio, S., Morton, J. F., Basiotis, P. P., & Anand, R. S. (2003) · Journal of the American Dietetic Association · doi:10.1016/s0002-8223(03)00381-x · Cited by 75 · see citing works
Wang, Q. A., Li, S., Jiang, L., Zhou, Y., Li, Z., Shao, M., Li, W., & Liu, Y. (2010) · Journal of Lipid Research · doi:10.1194/jlr.m003335 · Cited by 68 · see citing works
Kohli, R., Pan, X., Malladi, P., Wainwright, M. S., & Whitington, P. F. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m701759200 · Cited by 67 · see citing works
Papandreou, D., Karabouta, Z., Pantoleon, A., & Rousso, I. (2012) · Appetite · doi:10.1016/j.appet.2012.09.006 · Cited by 66 · see citing works
Boesiger, P., Buchli, R., Meier, D., Steinmann, B. U., & GITZELMANN, R. (1994) · Pediatric Research · doi:10.1203/00006450-199410000-00004 · Cited by 62 · see citing works
High-fat diet: A trigger of non-alcoholic steatohepatitis? Preliminary findings in obese subjects
Vilar, L. K., de Oliveira, C. P. M. S., Faintuch, J., de Mello, E. S., Nogueira, M. A., dos Santos, T. E., Alves, V. A. F., & Carrilho, F. J. (2008) · Nutrition · doi:10.1016/j.nut.2008.05.017 · Cited by 61 · see citing works
Diacylglycerol/protein kinase C signalling: a mechanism for insulin resistance?
Shmueli, E., Alberti, K. G. M. M., & Record, C. O. (1993) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.1993.tb00761.x · Cited by 61 · see citing works
Preuss, H. G., Rao, C. V. S., Garris, R., Bramble, J. D., Ohia, S. E., Bagchi, M., & Bagchi, D. (2004) · PubMed · Cited by 54 · see citing works
The metabolic syndrome: a call to action
Gotto, A. M., Blackburn, G. L., DAILEY, G. E., Garber, A. J., Grundy, S. M., Sobel, B. E., & Weir, M. R. (2005) · Coronary Artery Disease · doi:10.1097/00019501-200602000-00013 · Cited by 44 · see citing works
High dietary fructose intake: Sweet or bitter life?
Collino, M. (2011) · World Journal of Diabetes · doi:10.4239/wjd.v2.i6.77 · Cited by 43 · see citing works
Softic, S., Kirby, M., Berger, N. G., Shroyer, N. F., Woods, S. C., & Kohli, R. (2012) · PLoS ONE · doi:10.1371/journal.pone.0038952 · Cited by 30 · see citing works
Self-citation
Flagged first, then by citations
1 of the 133 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Mechanisms of NAFLD development and therapeutic strategies
Friedman, S. L., Neuschwander-Tetri, B. A., Rinella, M., & Sanyal, A. J. (2018) · Nature Medicine · doi:10.1038/s41591-018-0104-9 · Cited by 4,354 · see citing works
The role of the gut microbiota in NAFLD
Leung, C., Rivera, L., Furness, J. B., & Angus, P. W. (2016) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2016.85 · Cited by 1,020 · see citing works
Fructose and sugar: A major mediator of non-alcoholic fatty liver disease
Jensen, T., Abdelmalek, M. F., Sullivan, S. A., Nadeau, K. J., Cree‐Green, M., Roncal, C., Nakagawa, T., Kuwabara, M., Sato, Y., Kang, D., et al. (2018) · Journal of Hepatology · doi:10.1016/j.jhep.2018.01.019 · Cited by 952 · see citing works
2019 Global NAFLD Prevalence: A Systematic Review and Meta-analysis
Le, M. H., Yeo, Y. H., Li, X., Li, J., Zou, B., Wu, Y., Ye, Q., Huang, D. Q., Zhao, C., Zhang, J., et al. (2022) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2021.12.002 · Cited by 711 · see citing works
Immune cell-mediated features of non-alcoholic steatohepatitis
Huby, T., & Gautier, E. L. (2022) · Nature Reviews Immunology · doi:10.1038/s41577-021-00639-3 · Cited by 573 · see citing works
Recent insights into the pathogenesis of nonalcoholic fatty liver disease
Arab, J. P., Arrese, M., & Trauner, M. (2018) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathol-020117-043617 · Cited by 573 · see citing works
Dietary fructose feeds hepatic lipogenesis via microbiota-derived acetate
Zhao, S., Jang, C., Liu, J., Uehara, K., Gilbert, M., Izzo, L., Zeng, X., Trefely, S., Fernandez, S., Carrer, A., et al. (2020) · Nature · doi:10.1038/s41586-020-2101-7 · Cited by 553 · see citing works
Pathophysiology of obesity and its associated diseases
Jin, X., Qiu, T., Li, L., Yu, R., Chen, X., Li, C., Proud, C. G., & Jiang, T. (2023) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2023.01.012 · Cited by 552 · see citing works
Impaired adipogenesis and dysfunctional adipose tissue in human hypertrophic obesity
Hammarstedt, A., Gogg, S., Hedjazifar, S., Nerstedt, A., & Smith, U. (2018) · Physiological Reviews · doi:10.1152/physrev.00034.2017 · Cited by 462 · see citing works
Dietary modifications for enhanced cancer therapy
Kanarek, N., Petrova, B., & Sabatini, D. M. (2020) · Nature · doi:10.1038/s41586-020-2124-0 · Cited by 414 · see citing works
The links between gut microbiota and obesity and obesity related diseases
Geng, J., Ni, Q., Sun, W., Li, L., & Feng, X. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.112678 · Cited by 410 · see citing works
Fructose Consumption, Lipogenesis, and Non-Alcoholic Fatty Liver Disease
ter Horst, K. W., & Serlie, M. J. M. (2017) · Nutrients · doi:10.3390/nu9090981 · Cited by 365 · see citing works
Divergent effects of glucose and fructose on hepatic lipogenesis and insulin signaling
Softic, S., Gupta, M. K., Wang, G.-X., Fujisaka, S., O'Neill, B. T., Rao, T. N., Willoughby, J. L. S., Harbison, C. E., Fitzgerald, K. J., Ilkayeva, O., et al. (2017) · Journal of Clinical Investigation · doi:10.1172/jci94585 · Cited by 349 · see citing works
Self-citationPathophysiology of Nonalcoholic Fatty Liver Disease/Nonalcoholic Steatohepatitis
Manne, V., Handa, P., & Kowdley, K. V. (2017) · Clinics in Liver Disease · doi:10.1016/j.cld.2017.08.007 · Cited by 341 · see citing works
Fructose stimulated de novo lipogenesis is promoted by inflammation
Todoric, J., Di Caro, G., Reibe, S., Henstridge, D. C., Green, C. R., Vrbanac, A., Ceteci, F., Conche, C., McNulty, R., Shalapour, S., et al. (2020) · Nature Metabolism · doi:10.1038/s42255-020-0261-2 · Cited by 328 · see citing works
PPAR-γ signaling in nonalcoholic fatty liver disease: Pathogenesis and therapeutic targets.
Chen, H., Tan, H.-B., Wan, J., Zeng, Y., Wang, J., Wang, H., & Lu, X. (2023) · Pharmacology and Therapeutics · doi:10.1016/j.pharmthera.2023.108391 · Cited by 292 · see citing works
Non-alcoholic fatty liver disease: an emerging driving force in chronic kidney disease
Targher, G., & Byrne, C. D. (2017) · Nature Reviews Nephrology · doi:10.1038/nrneph.2017.16 · Cited by 313 · see citing works
High fat diet-triggered non-alcoholic fatty liver disease: A review of proposed mechanisms
Lian, C.-Y., Zhai, Z., Li, Z., & Wang, L. (2020) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2020.109199 · Cited by 304 · see citing works
Dietary Fructose and the Metabolic Syndrome
Taskinen, M., Packard, C. J., & Borén, J. (2019) · Nutrients · doi:10.3390/nu11091987 · Cited by 298 · see citing works
Fructose and NAFLD: The Multifaceted Aspects of Fructose Metabolism
Jegatheesan, P., & Bandt, J. P. D. (2017) · Nutrients · doi:10.3390/nu9030230 · Cited by 280 · see citing works
Preclinical Models for Studying NASH-Driven HCC: How Useful Are They?
Febbraio, M. A., Reibe, S., Shalapour, S., Ooi, G., Watt, M. J., & Karin, M. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.10.012 · Cited by 250 · see citing works
Fructose and hepatic insulin resistance
Softic, S., Stanhope, K. L., Boucher, J., Divanovic, S., Lanaspa, M. A., Johnson, R. J., & Kahn, C. R. (2020) · Critical Reviews in Clinical Laboratory Sciences · doi:10.1080/10408363.2019.1711360 · Cited by 255 · see citing works
Self-citationMonounsaturated Fatty Acids in Obesity-Related Inflammation
Ravaut, G., Légiot, A., Bergeron, K., & Mounier, C. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms22010330 · Cited by 250 · see citing works
Softic, S., Meyer, J. G., Wang, G.-X., Gupta, M. K., Batista, T. M., Lauritzen, H. P. M. M., Fujisaka, S., Serra, D., Herrero, L., Willoughby, J., et al. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.09.003 · Cited by 227 · see citing works
Self-citationLinden, A. G., Li, S., Choi, H. Y., Fang, F., Fukasawa, M., Uyeda, K., Hammer, R. E., Horton, J. D., Engelking, L. J., & Liang, G. (2018) · Journal of Lipid Research · doi:10.1194/jlr.m081836 · Cited by 232 · see citing works
Disturbed Vitamin A Metabolism in Non-Alcoholic Fatty Liver Disease (NAFLD)
Saeed, A., Dullaart, R. P. F., Schreuder, T. C. M. A., Blokzijl, H., & Faber, K. N. (2017) · Nutrients · doi:10.3390/nu10010029 · Cited by 229 · see citing works
Nonalcoholic fatty liver disease in adults: current concepts in etiology, outcomes, and management
Marjot, T., Moolla, A., Cobbold, J. F., Hodson, L., & Tomlinson, J. W. (2020) · Endocrine Reviews · doi:10.1210/endrev/bnz009 · Cited by 228 · see citing works
Non-Alcoholic Steatohepatitis: A Review of Its Mechanism, Models and Medical Treatments
Peng, C. Y., Stewart, A. G., Woodman, O. L., Ritchie, R. H., & Qin, C. X. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.603926 · Cited by 225 · see citing works
Metabolic drivers of non-alcoholic fatty liver disease
Bence, K. K., & Birnbaum, M. J. (2020) · Molecular Metabolism · doi:10.1016/j.molmet.2020.101143 · Cited by 223 · see citing works
Tillman, E. J., & Rolph, T. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.601290 · Cited by 209 · see citing works
Insulin action at a molecular level – 100 years of progress
White, M. F., & Kahn, C. R. (2021) · Molecular Metabolism · doi:10.1016/j.molmet.2021.101304 · Cited by 214 · see citing works
Self-citationCD36 promotes de novo lipogenesis in hepatocytes through INSIG2-dependent SREBP1 processing
Zeng, H., Qin, H., Liao, M., Zheng, E., Luo, X., Xiao, A., Li, Y., Chen, L., Wei, L., Zhao, L., et al. (2022) · Molecular Metabolism · doi:10.1016/j.molmet.2021.101428 · Cited by 211 · see citing works
Qu, X., & Donnelly, R. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21218191 · Cited by 210 · see citing works
Inhibition of ATP-citrate lyase improves NASH, liver fibrosis, and dyslipidemia
Morrow, M. R., Batchuluun, B., Wu, J., Ahmadi, E., Leroux, J. M., Mohammadi-Shemirani, P., Desjardins, E. M., Wang, Z., Tsakiridis, E. E., Lavoie, D. C. T., et al. (2022) · Cell Metabolism · doi:10.1016/j.cmet.2022.05.004 · Cited by 199 · see citing works
Intestinal Absorption of Fructose
Ferraris, R. P., Choe, J.-Y., & Patel, C. R. (2018) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-082117-051707 · Cited by 180 · see citing works
Therapeutic landscape of metabolic dysfunction-associated steatohepatitis (MASH)
Do, A., Zahrawi, F. M., & Mehal, W. Z. (2024) · Nature Reviews Drug Discovery · doi:10.1038/s41573-024-01084-2 · Cited by 188 · see citing works
The small intestine shields the liver from fructose-induced steatosis
Jang, C., Wada, S., Yang, S. H., Gosis, B. S., Zeng, X., Zhang, Z., Shen, Y., Lee, G., Arany, Z. P., & Rabinowitz, J. D. (2020) · Nature Metabolism · doi:10.1038/s42255-020-0222-9 · Cited by 164 · see citing works
Scorletti, E., & Byrne, C. D. (2018) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2018.03.001 · Cited by 161 · see citing works
Mitochondria, oxidative stress and nonalcoholic fatty liver disease: A complex relationship
Karkucińska‐Więckowska, A., Simões, I. C. M., Kalinowski, P., Lebiedzińska, M., Zieniewicz, K., Milkiewicz, P., Górska‐Ponikowska, M., Pinton, P., Malik, A. N., Krawczyk, M. J., et al. (2021) · European Journal of Clinical Investigation · doi:10.1111/eci.13622 · Cited by 165 · see citing works
Metabolic liver disease in diabetes – From mechanisms to clinical trials
Dewidar, B., KAHL, S., Pafili, K., & Roden, M. (2020) · Metabolism · doi:10.1016/j.metabol.2020.154299 · Cited by 160 · see citing works
Muriel, P., López‐Sánchez, P., & Ramos‐Tovar, E. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22136969 · Cited by 159 · see citing works
Nonalcoholic Fatty Liver Disease in Children
Mann, J. P., Valenti, L. V. C., Scorletti, E., Byrne, C. D., & Nobili, V. (2018) · Seminars in Liver Disease · doi:10.1055/s-0038-1627456 · Cited by 161 · see citing works
Importance of Nutrients and Nutrient Metabolism on Human Health.
Chen, Y., Michalak, M., & Agellon, L. B. (2018) · Europe PMC (PubMed Central) · Cited by 153 · see citing works
Lipid Metabolism in Metabolic-Associated Steatotic Liver Disease (MASLD)
Syed‐Abdul, M. M. (2023) · Metabolites · doi:10.3390/metabo14010012 · Cited by 153 · see citing works
Fougerat, A., Montagner, A., Loiseau, N., Guillou, H., & Wahli, W. (2020) · Cells · doi:10.3390/cells9071638 · Cited by 147 · see citing works
Dietary Fructose and Fructose-Induced Pathologies
Jung, S., Bae, H., Song, W., & Jang, C. (2022) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-062220-025831 · Cited by 146 · see citing works
Portincasa, P., Khalil, M., Mahdi, L., Perniola, V., Idone, V., Graziani, A., Baffy, G., & Ciaula, A. D. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25115640 · Cited by 152 · see citing works
Yahoo, N., Dudek, M., Knolle, P. A., & Heikenwälder, M. F. (2023) · Journal of Hepatology · doi:10.1016/j.jhep.2023.02.033 · Cited by 145 · see citing works
Ultraprocessed Food: Addictive, Toxic, and Ready for Regulation
Lustig, R. H. (2020) · Nutrients · doi:10.3390/nu12113401 · Cited by 140 · see citing works
Intestinal Fructose and Glucose Metabolism in Health and Disease
Merino, B., Fernández-Díaz, C. M., Cózar‐Castellano, I., & Perdomo, G. (2019) · Nutrients · doi:10.3390/nu12010094 · Cited by 136 · see citing works
Influence of Dietary Macronutrients on Liver Fat Accumulation and Metabolism
Parry, S. A., & Hodson, L. (2017) · Journal of Investigative Medicine · doi:10.1136/jim-2017-000524 · Cited by 131 · see citing works
Corte, K. W. D., Perrar, I., Penczynski, K. J., Schwingshackl, L., Herder, C., & Buyken, A. E. (2018) · Nutrients · doi:10.3390/nu10050606 · Cited by 131 · see citing works
Evolving Role for Pharmacotherapy in NAFLD/NASH
Attia, S. L., Softic, S., & Mouzaki, M. (2020) · Clinical and Translational Science · doi:10.1111/cts.12839 · Cited by 130 · see citing works
Self-citationHerrera‐Balandrano, D. D., Chai, Z., Hutabarat, R. P., Trust Beta, Feng, J., Ma, K., Li, D., & Huang, W. (2021) · Redox Biology · doi:10.1016/j.redox.2021.102100 · Cited by 127 · see citing works
da Silva-Santi, L. G., Antunes, M. M., Caparroz‐Assef, S. M., Carbonera, F., Masi, L. N., Curi, R., Visentainer, J. V., & Bazotte, R. B. (2016) · Nutrients · doi:10.3390/nu8110682 · Cited by 121 · see citing works
Taskinen, M., Söderlund, S., Bogl, L. H., Hakkarainen, A., Matikainen, N., Pietiläinen, K. H., Räsänen, S., Lundbom, N. M. I., Björnson, E., Eliasson, B., et al. (2017) · Journal of Internal Medicine · doi:10.1111/joim.12632 · Cited by 118 · see citing works
Singh, A. K., Chaube, B., Zhang, X., Sun, J., Citrin, K. M., Canfrán-Duque, A., Aryal, B., Rotllan, N., Varela, L., Lee, R. G., et al. (2021) · Journal of Clinical Investigation · doi:10.1172/jci140989 · Cited by 115 · see citing works
Non-alcoholic fatty liver disease: An update with special focus on the role of gut microbiota
Doulberis, M., Kotronis, G., Gialamprinou, D., Kountouras, J., & Katsinelos, P. (2017) · Metabolism · doi:10.1016/j.metabol.2017.03.013 · Cited by 113 · see citing works
MicroRNA-27a regulates hepatic lipid metabolism and alleviates NAFLD via repressing FAS and SCD1
Zhang, M., Sun, W., Zhou, M., & Tang, Y. (2017) · Scientific Reports · doi:10.1038/s41598-017-15141-x · Cited by 113 · see citing works
Li, Y., Qiao, J., Wang, B., Bai, M., Shen, J.-D., & Cheng, Y. (2018) · Nutrients · doi:10.3390/nu10081024 · Cited by 111 · see citing works
Li, W., Yang, H., Zhao, Q., Wang, X., Zhang, J., & Zhao, X. (2019) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.9b02523 · Cited by 99 · see citing works
Emerging role of aging in the progression of NAFLD to HCC
He, Y., Su, Y., Duan, C., Wang, S., He, W. G., Zhang, Y., An, X., & He, M. (2022) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101833 · Cited by 98 · see citing works
Mouse models of nonalcoholic fatty liver disease (NAFLD): pathomechanisms and pharmacotherapies
Fang, T., Wang, H., Pan, X., Little, P. J., Xu, S., & Weng, J. (2022) · International Journal of Biological Sciences · doi:10.7150/ijbs.65044 · Cited by 96 · see citing works
Fructose metabolism, cardiometabolic risk, and the epidemic of coronary artery disease
Mirtschink, P., Jang, C., Arany, Z. P., & Krek, W. (2017) · European Heart Journal · doi:10.1093/eurheartj/ehx518 · Cited by 93 · see citing works
Rumanova, V. S., Okuliarová, M., & Zeman, M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21155478 · Cited by 93 · see citing works
Lau, L. H. S., & Wong, S. H. (2018) · Advances in experimental medicine and biology · doi:10.1007/978-981-10-8684-7_9 · Cited by 91 · see citing works
Longitudinal associations between ultra-processed foods and blood lipids in childhood
Leffa, P. D. S., Hoffman, D. J., Rauber, F., Sangalli, C. N., Valmórbida, J. L., & Vítolo, M. R. (2020) · British Journal Of Nutrition · doi:10.1017/s0007114520001233 · Cited by 92 · see citing works
Clinical assessment of hepatic de novo lipogenesis in non-alcoholic fatty liver disease
Paglialunga, S., & Dehn, C. A. (2016) · Lipids in Health and Disease · doi:10.1186/s12944-016-0321-5 · Cited by 90 · see citing works
Kim, J., Kang, J., Kang, Y.-L., Woo, J. J., Kim, Y., Huh, J., & Park, J. (2020) · Nature Communications · doi:10.1038/s41467-020-19263-1 · Cited by 90 · see citing works
The role of the gut microbiome and diet in the pathogenesis of non-alcoholic fatty liver disease
Jennison, E., & Byrne, C. D. (2020) · Clinical and Molecular Hepatology · doi:10.3350/cmh.2020.0129 · Cited by 89 · see citing works
Stanhope, K. L., Goran, M. I., Bosy‐Westphal, A., King, J. C., Schmidt, L. A., Schwarz, J., Stice, E. M., Sylvetsky, A. C., Turnbaugh, P. J., Bray, G. A., et al. (2018) · Obesity Reviews · doi:10.1111/obr.12699 · Cited by 87 · see citing works
The Role of SCAP/SREBP as Central Regulators of Lipid Metabolism in Hepatic Steatosis
Chandrasekaran, P., & Weiskirchen, R. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25021109 · Cited by 91 · see citing works
Kazierad, D. J., Chidsey, K., Somayaji, V. R., Bergman, A. J., Birnbaum, M. J., & Calle, R. A. (2021) · Med · doi:10.1016/j.medj.2021.04.007 · Cited by 86 · see citing works
Multifactorial Basis and Therapeutic Strategies in Metabolism-Related Diseases
Guerra, J. V. D. S., Dias, M. M. G., Brilhante, A. J. V. C., Terra, M. F., García‐Arévalo, M., & Figueira, A. C. M. (2021) · Nutrients · doi:10.3390/nu13082830 · Cited by 87 · see citing works
Cohen, C. C., Li, K. W., Alazraki, A. L., Beysen, C., Carrier, C., Cleeton, R. L., Dandan, M., Figueroa, J., Knight‐Scott, J., Knott, C. J., et al. (2021) · Journal of Clinical Investigation · doi:10.1172/jci150996 · Cited by 87 · see citing works
Fernandes‐da‐Silva, A., Miranda, C. S., Santana-Oliveira, D. A., Oliveira-Cordeiro, B., Rangel-Azevedo, C., Silva-Veiga, F. M., Martins, F. F., & Souza‐Mello, V. (2021) · European Journal of Nutrition · doi:10.1007/s00394-021-02542-y · Cited by 85 · see citing works
Rao, G., Peng, X., Li, X., An, K., He, H., Fu, X., Li, S., & An, Z. (2023) · Frontiers in Medicine · doi:10.3389/fmed.2023.1294267 · Cited by 85 · see citing works
Jayakumar, S., & Loomba, R. S. (2019) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.15314 · Cited by 88 · see citing works
Kord‐Varkaneh, H., Salehi‐Sahlabadi, A., Tinsley, G. M., Santos, H. O., & Hekmatdoost, A. (2022) · Nutrition · doi:10.1016/j.nut.2022.111847 · Cited by 84 · see citing works
Cheng, C., Li, Z., Zhao, X., Liao, C., Quan, J., Bode, A. M., Cao, Y., & Luo, X. (2020) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2020.172922 · Cited by 81 · see citing works
Truong, X. T., & Lee, D. H. (2025) · Diabetes & Metabolism Journal · doi:10.4093/dmj.2025.0644 · Cited by 84 · see citing works
“In addition, drugs targeting the DNL pathways, such as ci-trate-isocitrate carrier inhibitors [75], ACLY inhibitors [13,141], ACC inhibitors (alone or in combination with DGAT inhibitors) [105,142,143], FASN inhibitors [144], and adiponectin receptor 1/2 agonists have shown preclinical and/or…”
InfluentialLiu, S., Gao, Z., He, W., Wu, Y., Liu, J., Zhang, S., Yan, L., Mao, S., Shi, X., Fan, W., et al. (2022) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2022.10.270 · Cited by 80 · see citing works
Goss, A. M., Dowla, S. A., Pendergrass, M., Ashraf, A. P., Bolding, M., Morrison, S. A., Amerson, A., Soleymani, T., & Gower, B. A. (2020) · Pediatric Obesity · doi:10.1111/ijpo.12630 · Cited by 78 · see citing works
Tissue-Specific Fructose Metabolism in Obesity and Diabetes
Helsley, R. N., Moreau, F., Gupta, M. K., Radulescu, A., DeBosch, B. J., & Softic, S. (2020) · Current Diabetes Reports · doi:10.1007/s11892-020-01342-8 · Cited by 75 · see citing works
Self-citationLiverSex Computational Model: Sexual Aspects in Hepatic Metabolism and Abnormalities
Tomaš, T. C., Urlep, Ž., Moškon, M., Mraz, M., & Rozman, D. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00360 · Cited by 75 · see citing works
Fructose drives de novo lipogenesis affecting metabolic health
Geidl, B., & Gerber, P. A. (2023) · Journal of Endocrinology · doi:10.1530/joe-22-0270 · Cited by 83 · see citing works
Oral Diseases Associated with Nonalcoholic Fatty Liver Disease in the United States
Weintraub, J. A., Mitnik, G. L., & Dye, B. A. (2019) · Journal of Dental Research · doi:10.1177/0022034519866442 · Cited by 70 · see citing works
Park, E., Lee, Y., Kim, S. M., Park, G.-S., Lee, Y. H., Jeong, D. Y., Kang, J., & Lee, H. (2020) · Nutrients · doi:10.3390/nu12020542 · Cited by 70 · see citing works
Sun, S., Araki, Y., Hanzawa, F., Umeki, M., Kojima, T., Nishimura, N., Ikeda, S., Mochizuki, S., & Oda, H. (2021) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2021.108621 · Cited by 69 · see citing works
Bathish, B., Robertson, H., Dillon, J. F., Dinkova‐Kostova, A. T., & Hayes, J. D. (2022) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2022.06.226 · Cited by 68 · see citing works
Bergman, A. J., Carvajal‐Gonzalez, S., Tarabar, S., Saxena, A. R., Esler, W. P., & Amin, N. B. (2020) · Clinical Pharmacology in Drug Development · doi:10.1002/cpdd.782 · Cited by 67 · see citing works
Jeyapal, S., Kona, S. R., Mullapudi, S. V., Putcha, U. K., Gurumurthy, P., & Ibrahim, A. (2018) · Scientific Reports · doi:10.1038/s41598-018-29222-y · Cited by 65 · see citing works
Fatty liver and FGF21 physiology
Maratos–Flier, E. (2017) · Experimental Cell Research · doi:10.1016/j.yexcr.2017.05.006 · Cited by 64 · see citing works
Brandon, H., & Yan, L. (2019) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s198968 · Cited by 63 · see citing works
Fructose impairs fat oxidation: Implications for the mechanism of western diet-induced NAFLD
Inci, M. K., Park, S., Helsley, R. N., Attia, S. L., & Softic, S. (2022) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2022.109224 · Cited by 61 · see citing works
Self-citationNew Concepts on Pathogenesis and Diagnosis of Liver Fibrosis; A Review Article
Ebrahimi, H., Naderian, M., & Sohrabpour, A. A. (2016) · Middle East Journal of Digestive Diseases · doi:10.15171/mejdd.2016.29 · Cited by 61 · see citing works
Nutrition as Metabolic Treatment for Anxiety
Norwitz, N. G., & Naidoo, U. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.598119 · Cited by 63 · see citing works
Role of targeting TLR4 signaling axis in liver-related diseases
Tang, Y., Zhu, L., Tao, Y., Lu, W., & Cheng, H. S. (2023) · Pathology - Research and Practice · doi:10.1016/j.prp.2023.154410 · Cited by 59 · see citing works
Hepatic glucagon action: beyond glucose mobilization
Kajani, S., Laker, R. C., Ratkova, E. L., Will, S., & Rhodes, C. J. (2024) · Physiological Reviews · doi:10.1152/physrev.00028.2023 · Cited by 60 · see citing works
Wang, X., Rao, H., Liu, F., Wei, L., Li, H., & Wu, C. (2021) · Cells · doi:10.3390/cells10123300 · Cited by 60 · see citing works
- Authors
- Softic, S., Cohen, D. E., & Kahn, C. R.
- Affiliations
- Boston Children's Hospital (US)
- Brigham and Women's Hospital (US)
- Joslin Diabetes Center (US)
- Corresponding author
- Kahn, C. Ronald
- Venue
- Digestive Diseases and Sciences
- Published
- 2016-02-08
- Volume
- 61
- Issue
- 5
- Pages
- 1282-1293
- ISSN
- 0163-2116 (ISSN-L)
- 1573-2568
- PMC
- PMC4838515
- OpenAlex
- W2286797029
- Cited by
- 709
- References
- 133
- Citations by year
- 2026: 52 · 2025: 76 · 2024: 88 · 2023: 78 · 2022: 92 · 2021: 79 · 2020: 88 · 2019: 57 · 2018: 44 · 2017: 42 · 2016: 13
- FWCI
- 7.70
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Digestive Diseases and Sciences (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (R01 DK031036, R01 DK033201, K12 HD000850, R37 DK048873, R01 DK056626, R01 DK103046)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
- Health Sciences › Medicine › Epidemiology › Liver Disease Diagnosis and Treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Keywords
- non-alcoholic fatty liver disease, dietary fructose, hepatic de novo lipogenesis, high fructose corn syrup, high-fat diet, sugar-sweetened beverages, insulin resistance, SREBP-1c, endoplasmic reticulum stress, uric acid, mitochondrial fatty acid oxidation, reactive oxygen species, hepatic lipid metabolism, metabolic syndrome
- MeSH terms
- Diet, Fructose, Humans, Liver, Lipogenesis, Non-alcoholic Fatty Liver Disease, High Fructose Corn Syrup
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
