CoChat
Sign Up
Cited by 454Cell Adhesion Molecules ResearchGlycosylation and Glycoproteins ResearchCancer Cells and Metastasis

P-selectin deficiency attenuates tumor growth and metastasis

Open access
Kim, Young J., Borsig, Lubor, Varki, Nissi M., Varki, Ajit·1998·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.95.16.9325PMC PMC21337
Open this paper in CoChat — free account

Abstract

Selectins are adhesion receptors that normally recognize certain vascular mucin-type glycoproteins bearing the carbohydrate structure sialyl-Lewis x . The clinical prognosis and metastatic progression of many epithelial carcinomas has been correlated independently with production of tumor mucins and with enhanced expression of sialyl-Lewis x . Metastasis is thought to involve the formation of tumor-platelet-leukocyte emboli and their interactions with the endothelium of distant organs. We provide a link between these observations by showing that P-selectin, which normally binds leukocyte ligands, can promote tumor growth and facilitate the metastatic seeding of a mucin-producing carcinoma. P-selectin-deficient mice showed significantly slower growth of subcutaneously implanted human colon carcinoma cells and generated fewer lung metastases from intravenously injected cells. Three potential pathophysiological mechanisms are demonstrated: first, intravenously injected tumor cells home to the lungs of P-selectin deficient mice at a lower rate; second, P-selectin-deficient mouse platelets fail to adhere to tumor cell-surface mucins; and third, tumor cells lodged in lung vasculature after intravenous injection often are decorated with platelet clumps, and these are markedly diminished in P-selectin-deficient animals.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1073/pnas.95.16.9325

Cites

54 of 54 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Lung colonization by melanoma cells that express sialyl-Lewis X is significantly reduced in E/P-selectin-deficient mice.

    “Lung colonization by melanoma cells that express sialyl-Lewis X is significantly reduced in E/P-selectin-deficient mice52.”

    From Inflammation and cancer (2002) · cites this paper as [52]

  • Tumours are significantly smaller in mice treated with a receptor antagonist peptide.

    “and tumours are significantly smaller in mice treated with a receptor antagonist peptide.”

    From Inflammation and cancer (2002) · cites this paper as [52]

  • P-selectin deficiency attenuates tumour growth and metastasis.

    “P-selectin deficiency attenuates tumour growth and metastasis”

    From Inflammation and cancer (2002) · cites this paper as [52]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Research works printed but not linked: 15

  1. [2]Fidler I J. Cancer Res. 1990;50:6130–6138. [PubMed] [Google Scholar]
  2. [6]Toyoshima M, Nakajima M, Yamori T, Tsuruo T. Cancer Res. 1995;55:767–773. [PubMed] [Google Scholar]
  3. [9]Fukuda M. Cancer Res. 1996;56:2237–2244. [PubMed] [Google Scholar]
  4. [10]Hakomori S. Cancer Res. 1996;56:5309–5318. [PubMed] [Google Scholar]
  5. [15]Ogata S, Maimonis P J, Itzkowitz S H. Cancer Res. 1992;52:4741–4746. [PubMed] [Google Scholar]
  6. [16]Van de Wiel-van Kemenade E, Ligtenberg M J L, De Boer A J, Buijs F, Vos H L, Melief C J M, Hilkens J, Figdor C G. J Immunol. 1993;151:767–776. [PubMed] [Google Scholar]
  7. [18]Hoff S D, Matsushita Y, Ota D M, Cleary K R, Yamori T, Hakomori S, Irimura T. Cancer Res. 1989;49:6883–6888. [PubMed] [Google Scholar]
  8. [19]Matsushita Y, Cleary K R, Ota D M, Hoff S D, Irimura T. Lab Invest. 1990;63:780–791. [PubMed] [Google Scholar]
  9. [22]Nakamori S, Kameyama M, Imaoka S, Furukawa H, Ishikawa O, Sasaki Y, Kabuto T, Iwanaga T, Matsushita Y, Irimura T. Cancer Res. 1993;53:3632–3637. [PubMed] [Google Scholar]
  10. [30]Kansas G S. Blood. 1996;88:3259–3287. [PubMed] [Google Scholar]
  11. [35]Sawada R, Tsuboi S, Fukuda M. J Biol Chem. 1994;269:1425–1431. [PubMed] [Google Scholar]
  12. [37]Mannori G, Crottet P, Cecconi O, Hanasaki K, Aruffo A, Nelson R M, Varki A, Bevilacqua M P. Cancer Res. 1995;55:4425–4431. [PubMed] [Google Scholar]
  13. [44]McKenzie B A, Barrieux A, Varki N M. Cancer Commun. 1991;3:15–19. [PubMed] [Google Scholar]
  14. [49]Vlodavsky I, Mohsen M, Lider O, Svahn C M, Ekre H P, Vigoda M, Ishai-Michaeli R, Peretz T. Invasion Metastasis. 1994;14:290–302. [PubMed] [Google Scholar]
  15. [52]Sciumbata T, Caretto P, Pirovano P, Pozzi P, Cremonesi P, Galimberti G, Leoni F, Marcucci F. Invasion Metastasis. 1996;16:132–143. [PubMed] [Google Scholar]

Cited by

Sorted by citations

Related

Authors
Kim, Y. J., Borsig, L., Varki, N. M., & Varki, A.
Affiliations
University of California San Diego (US)
ORCID
Venue
Proceedings of the National Academy of Sciences
Publisher
National Academy of Sciences
Published
1998-08-04
Volume
95
Issue
16
Pages
9325-9330
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
DOI
10.1073/pnas.95.16.9325
PMC
PMC21337
OpenAlex
W2140336796
Cited by
454
References
54
Citations by year
2026: 6 · 2025: 14 · 2024: 15 · 2023: 9 · 2022: 14 · 2021: 17 · 2020: 15 · 2019: 18 · 2018: 21 · 2017: 21 · 2016: 22 · 2015: 25 · 2014: 19 · 2013: 17 · 2012: 17
FWCI
4.58
Type
journal article
Language
en
Open access
Locations
  • Proceedings of the National Academy of Sciences (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5p01ca058689-10)
  • National Cancer Institute (CA 58689, R01CA038701)
Topics
  • Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Glycosylation and Glycoproteins Research
  • Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
Keywords
P-selectin, metastasis, tumor growth, sialyl Lewis X, platelets, colon cancer, lung metastasis, platelet adhesion, tumor cell homing, cell adhesion receptors
MeSH terms
Animals, Base Sequence, Blood Platelets, Cell Division, Crosses, Genetic, Female, Humans, Lung Neoplasms, Male, Mucins, Neoplasm Metastasis, Neoplasm Transplantation, Rosette Formation, Colorectal Neoplasms, P-Selectin, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review