The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Pathogenesis of Staphylococcus aureus Bloodstream Infections
Open accessAbstract
Staphylococcus aureus, a Gram-positive bacterium colonizing nares, skin, and the gastrointestinal tract, frequently invades the skin, soft tissues, and bloodstreams of humans. Even with surgical and antibiotic therapy, bloodstream infections are associated with significant mortality. The secretion of coagulases, proteins that associate with and activate the host hemostatic factor prothrombin, and the bacterial surface display of agglutinins, proteins that bind polymerized fibrin, are key virulence strategies for the pathogenesis of S. aureus bloodstream infections, which culminate in the establishment of abscess lesions. Pathogen-controlled processes, involving a wide spectrum of secreted factors, are responsible for the recruitment and destruction of immune cells, transforming abscess lesions into purulent exudate, with which staphylococci disseminate to produce new infectious lesions or to infect new hosts. Research on S. aureus bloodstream infections is a frontier for the characterization of protective vaccine antigens and the development of immune therapeutics aiming to prevent disease or improve outcomes.
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1 retracted
Genetic requirements for Staphylococcus aureus abscess formation and persistence in host tissues
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Self-citationRetractedNeutrophil Extracellular Traps Kill Bacteria
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“aureus diseases requiring medical treatment includes more than one million skin and soft tissue infections (SSTIs) with and without deep-seated abscess lesions; 490,000 hospitalizations; 93,000 cases of bacteremia; and 35,000 cases of sepsis and/or endocarditis (11).”
David, M. Z., & Daum, R. S. (2010) · Clinical Microbiology Reviews · doi:10.1128/cmr.00081-09 · Cited by 1,972
Impaired TH17 cell differentiation in subjects with autosomal dominant hyper-IgE syndrome
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Health Care–Associated Invasive MRSA Infections, 2005-2008
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Cited by
Staphylococcus aureus bloodstream infections: pathogenesis and regulatory mechanisms
Kwiecinski, J. M., & Horswill, A. R. (2020) · Current Opinion in Microbiology · doi:10.1016/j.mib.2020.02.005 · Cited by 373
Metadata
- Authors
- Thomer, L., Schneewind, O., & Missiakas, D.
- Venue
- Annual Review of Pathology: Mechanisms of Disease
- Publisher
- Annual Reviews
- Published
- 2016-05-23
- Volume
- 11
- Issue
- 1
- Pages
- 343-364
- ISSN
- 1553-4006 (ISSN-L)
- 1553-4014
- OpenAlex
- W1716237860
- Cited by
- 292
- References
- 14
- FWCI
- 4.11
- Type
- journal article
- Language
- en
- Open access
- green
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- Thomer, L., Schneewind, O., & Missiakas, D. (2016). Pathogenesis of Staphylococcus aureus Bloodstream Infections. Annual Review of Pathology: Mechanisms of Disease. https://doi.org/10.1146/annurev-pathol-012615-044351
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
