Impaired TH17 cell differentiation in subjects with autosomal dominant hyper-IgE syndrome
Open accessAbstract
The autosomal dominant hyper-IgE syndrome (HIES, 'Job's syndrome') is characterized by recurrent and often severe pulmonary infections, pneumatoceles, eczema, staphylococcal abscesses, mucocutaneous candidiasis, and abnormalities of bone and connective tissue. Mutations presumed to underlie HIES have recently been identified in stat3, the gene encoding STAT3 (signal transducer and activator of transcription 3) (refs 3, 4). Although impaired production of interferon-gamma and tumour-necrosis factor by T cells, diminished memory T-cell populations, decreased delayed-type-hypersensitivity responses and decreased in vitro lymphoproliferation in response to specific antigens have variably been described, specific immunological abnormalities that can explain the unique susceptibility to particular infections seen in HIES have not yet been defined. Here we show that interleukin (IL)-17 production by T cells is absent in HIES individuals. We observed that ex vivo T cells from subjects with HIES failed to produce IL-17, but not IL-2, tumour-necrosis factor or interferon-gamma, on mitogenic stimulation with staphylococcal enterotoxin B or on antigenic stimulation with Candida albicans or streptokinase. Purified naive T cells were unable to differentiate into IL-17-producing (T(H)17) T helper cells in vitro and had lower expression of retinoid-related orphan receptor (ROR)-gammat, which is consistent with a crucial role for STAT3 signalling in the generation of T(H)17 cells. T(H)17 cells have emerged as an important subset of helper T cells that are believed to be critical in the clearance of fungal and extracellular bacterial infections. Thus, our data suggest that the inability to produce T(H)17 cells is a mechanism underlying the susceptibility to the recurrent infections commonly seen in HIES.
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STAT3 regulates both Th2 cell recruitment during allergic inflammation and the production of Th17 cells and the expansion and recruitment of neutrophils.
“STAT3 is known to regulate both Th2 cell recruitment during allergic inflammation and the production of Th17 cells and the expansion and recruitment of neutrophils (Chen et al., 2007; Ma et al., 2008; Milner et al., 2008).”
From Targeting Janus Kinases and Signal Transducer and Activator of Transcription 3 To Treat Inflammation, Fibrosis, and Cancer: Rationale, Progress, and Caution (2020) · cites this paper as Milner et al., 2008
The Abstract supports a crucial role for STAT3 signalling in TH17-cell generation and links loss of TH17 cells to impaired neutrophil recruitment, mobilization and influx. It does not establish that STAT3 regulates Th2-cell recruitment during allergic inflammation or neutrophil expansion. (LLM, conf=0.87)
Experimental — accuracy not yet measuredPatients with genetic mutations limiting the levels of IL-17A, such as Job's syndrome, suffer from recurring mucocutaneous infections and ulcers.
“Furthermore, patients with genetic mutations limiting the levels of IL-17A, such as Job's syndrome, suffer from recurring mucocutaneous infections and ulcers.78,79”
From The Innate Immune System in Acute and Chronic Wounds (2016) · cites this paper as [79]
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Development, cytokine profile and function of human interleukin 17-producing helper T cells
Wilson, N. J., Boniface, K., Chan, J. R., McKenzie, B. S., Blumenschein, W. M., Mattson, J. D., Basham, B., Smith, K., Chen, T., Morel, F., et al. (2007) · Nature Immunology · doi:10.1038/ni1497 · Cited by 2,035 · see citing works
Reciprocal T <sub>H</sub> 17 and Regulatory T Cell Differentiation Mediated by Retinoic Acid
Mucida, D., Park, Y., Kim, G., Turovskaya, O., Scott, I., Kronenberg, M., & Cheroutre, H. (2007) · Science · doi:10.1126/science.1145697 · Cited by 1,982 · see citing works
Acosta-Rodriguez, E. V., Napolitani, G., Lanzavecchia, A., & Sallusto, F. (2007) · Nature Immunology · doi:10.1038/ni1496 · Cited by 1,857 · see citing works
IL-21 initiates an alternative pathway to induce proinflammatory TH17 cells
Korn, T., Bettelli, E., Gao, W., Awasthi, A., Jäger, A., Strom, T. B., Oukka, M., & Kuchroo, V. K. (2007) · Nature · doi:10.1038/nature05970 · Cited by 1,841 · see citing works
Ye, P., Rodriguez, F. H., Kanaly, S. T., Stocking, K. L., Schurr, J. R., Schwarzenberger, P. O., Oliver, P., Huang, W., Zhang, P., Zhang, J., et al. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.194.4.519 · Cited by 1,522 · see citing works
Interleukin-2 Signaling via STAT5 Constrains T Helper 17 Cell Generation
Laurence, A., Tato, C. M., Davidson, T. S., Kanno, Y., Chen, Z., Yao, Z., Blank, R. B., Meylan, F., Siegel, R., Hennighausen, L., et al. (2007) · Immunity · doi:10.1016/j.immuni.2007.02.009 · Cited by 1,507 · see citing works
Self-citationSTAT3 Regulates Cytokine-mediated Generation of Inflammatory Helper T Cells
Yang, X. O., Panopoulos, A. D., Nurieva, R., Chang, S. H., Wang, D., Watowich, S. S., & Dong, C. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.c600321200 · Cited by 1,494 · see citing works
Essential autocrine regulation by IL-21 in the generation of inflammatory T cells
Nurieva, R., Yang, X. O., Martinez, G., Zhang, Y., Panopoulos, A. D., Ma, L., Schluns, K., Tian, Q., Watowich, S. S., Jetten, A. M., et al. (2007) · Nature · doi:10.1038/nature05969 · Cited by 1,466 · see citing works
Steinman, L. (2007) · Nature Medicine · doi:10.1038/nm1551 · Cited by 1,367 · see citing works
STAT3 Mutations in the Hyper-IgE Syndrome
Holland, S. M., DeLeo, F. R., Elloumi, H. Z., Hsu, A. P., Uzel, G., Brodsky, N. N., Freeman, A. F., Demidowich, A. P., Davis, J., Turner, M. L. C., et al. (2007) · New England Journal of Medicine · doi:10.1056/nejmoa073687 · Cited by 1,214 · see citing works
Self-citationDominant-negative mutations in the DNA-binding domain of STAT3 cause hyper-IgE syndrome
Minegishi, Y., Saito, M., Tsuchiya, S., Tsuge, I., Takada, H., Hara, T., Kawamura, N., Ariga, T., Pasic, S., Stojković, O., et al. (2007) · Nature · doi:10.1038/nature06096 · Cited by 987 · see citing works
A Critical Role for IL-21 in Regulating Immunoglobulin Production
Ozaki, K., Spolski, R., Feng, C. G., Qi, C.-F., Cheng, J., Sher, A., Morse, H. C., Liu, C., Schwartzberg, P. L., & Leonard, W. J. (2002) · Science · doi:10.1126/science.1077002 · Cited by 978 · see citing works
Requirement of Interleukin‐17A for Systemic Anti– <i>Candida albicans</i> Host Defense in Mice
Huang, W., Na, L., Fidel, P. L., & Schwarzenberger, P. (2004) · The Journal of Infectious Diseases · doi:10.1086/422329 · Cited by 859 · see citing works
Hyper-IgE Syndrome with Recurrent Infections — An Autosomal Dominant Multisystem Disorder
Grimbacher, B., Holland, S. M., Gallin, J. I., Greenberg, F., Hill, S. C., Malech, H. L., Miller, J., O’Connell, A. C., & Puck, J. M. (1999) · New England Journal of Medicine · doi:10.1056/nejm199903043400904 · Cited by 801 · see citing works
Self-citationPitcher, C. J., Quittner, C., Peterson, D. M., Connors, M., Koup, R. A., Maino, V. C., & Picker, L. J. (1999) · Nature Medicine · doi:10.1038/8400 · Cited by 746 · see citing works
Selective regulatory function of Socs3 in the formation of IL-17-secreting T cells
Chen, Z. J., Laurence, A. D. J., Kanno, Y., Pacher-Zavisin, M. C., Zhu, B., Tato, C. M., Yoshimura, A., Hennighausen, L. G., & O’Shea, J. J. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0600666103 · Cited by 652 · see citing works
Self-citationEXTREME HYPERIMMUNOGLOBULINEMIA E AND UNDUE SUSCEPTIBILITY TO INFECTION
Buckley, R. H., Wray, B. B., & Belmaker, E. Z. (1972) · PEDIATRICS · doi:10.1542/peds.49.1.59 · Cited by 610 · see citing works
Divergent roles of IL-23 and IL-12 in host defense against Klebsiella pneumoniae
Happel, K. I., Dubin, P. J., Zheng, M., Ghilardi, N., Lockhart, C., Quinton, L. J., Odden, A. R., Shellito, J. E., Bagby, G. J., Nelson, S., et al. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20050193 · Cited by 605 · see citing works
Interleukin-17 is a negative regulator of established allergic asthma
Schnyder‐Candrian, S., Togbe, D., Couillin, I., Mercier, I., Brombacher, F., Quesniaux, V. F. J., Fossiez, F., Ryffel, B., & Schnyder, B. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20061401 · Cited by 564 · see citing works
Stat3 and Stat4 Direct Development of IL-17-Secreting Th Cells
Mathur, A. N., Chang, H., Zisoulis, D. G., Stritesky, G. L., Yu, Q., O’Malley, J. T., Kapur, R., Levy, D. E., Kansas, G. S., & Kaplan, M. H. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.8.4901 · Cited by 548 · see citing works
Kao, C.-Y., Chen, Y., Thai, P., Wachi, S., Huang, F., Kim, C., Harper, R. W., & Wu, R. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.5.3482 · Cited by 424 · see citing works
Genetic Linkage of Hyper-IgE Syndrome to Chromosome 4
Grimbacher, B., Schäffer, A. A., Holland, S. M., et al. (1999) · The American Journal of Human Genetics · doi:10.1086/302547 · Cited by 406 · see citing works
Self-citationMiller, L. S., O’Connell, R. M., Gutiérrez, M. Á., Pietras, E. M., Shahangian, A., Gross, C. E., Thirumala, A., Cheung, A. L., Cheng, G., & Modlin, R. L. (2006) · Immunity · doi:10.1016/j.immuni.2005.11.011 · Cited by 348 · see citing works
The IL-21 receptor augments Th2 effector function and alternative macrophage activation
Pesce, J. T. (2006) · Journal of Clinical Investigation · doi:10.1172/jci27727 · Cited by 340 · see citing works
Kuchen, S., Robbins, R., Sims, G. P., Sheng, C., Phillips, T. M., Lipsky, P. E., & Ettinger, R. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.9.5886 · Cited by 326 · see citing works
Interleukin-22: A novel T- and NK-cell derived cytokine that regulates the biology of tissue cells
Wolk, K., & Sabat, R. (2006) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2006.09.001 · Cited by 303 · see citing works
Buckley, R. H. (2001) · Clinical Reviews in Allergy & Immunology · doi:10.1385/criai:20:1:139 · Cited by 137 · see citing works
Prete, G. D., Tiri, A., Maggi, E., et al. (1989) · Journal of Clinical Investigation · doi:10.1172/jci114368 · Cited by 121 · see citing works
King, C. L., Poindexter, R. W., Ragunathan, J., et al. (1991) · The Journal of Immunology · doi:10.4049/jimmunol.146.5.1478 · Cited by 74 · see citing works
Distinct gene expression patterns of peripheral blood cells in hyper–IgE syndrome
Tanaka, T., Takada, H., Nomura, A., Ohga, S., Shibata, R., & Hara, T. (2005) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2005.02805.x · Cited by 25 · see citing works
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Korn, T., Bettelli, E., Oukka, M., & Kuchroo, V. K. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132710 · Cited by 4,873 · see citing works
Hidden Killers: Human Fungal Infections
Brown, G. D., Denning, D. W., Gow, N. A. R., Levitz, S. M., Netea, M. G., & White, T. C. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3004404 · Cited by 4,284 · see citing works
STATs in cancer inflammation and immunity: a leading role for STAT3
Yu, H., Pardoll, D., & Jove, R. (2009) · Nature reviews. Cancer · doi:10.1038/nrc2734 · Cited by 4,383 · see citing works
Differentiation of Effector CD4 T Cell Populations
Zhu, J., Yamane, H., & Paul, W. E. (2010) · Annual Review of Immunology · doi:10.1146/annurev-immunol-030409-101212 · Cited by 3,452 · see citing works
Self-citationFollicular Helper CD4 T Cells (T <sub>FH</sub> )
Crotty, S. (2011) · Annual Review of Immunology · doi:10.1146/annurev-immunol-031210-101400 · Cited by 2,738 · see citing works
Romani, L. (2011) · Nature Reviews Immunology · doi:10.1038/nri2939 · Cited by 1,793 · see citing works
The IL-23-IL-17 immune axis: from mechanisms to therapeutic testing
Gaffen, S. L., Jain, R., Garg, A. V., & Cua, D. J. (2014) · Nature reviews. Immunology · doi:10.1038/nri3707 · Cited by 1,585 · see citing works
Structure and signalling in the IL-17 receptor family
Gaffen, S. L. (2009) · Nature reviews. Immunology · doi:10.1038/nri2586 · Cited by 1,475 · see citing works
IL-6 in inflammation, autoimmunity and cancer
Hirano, T. (2021) · International Immunology · doi:10.1093/intimm/dxaa078 · Cited by 1,453 · see citing works
“Of note is that both STAT3 LOF and STAT1 gain-of-function (GOF) mutations in patients show defects in T h 17 cell differentiation (179, 180).”
BackgroundInterleukin-17 and Type 17 Helper T Cells
Miossec, P., Korn, T., & Kuchroo, V. K. (2009) · New England Journal of Medicine · doi:10.1056/nejmra0707449 · Cited by 1,409 · see citing works
Fate mapping of IL-17-producing T cells in inflammatory responses
Hirota, K., Duarte, J. H., Veldhoen, M., Hornsby, E., Li, Y., Cua, D. J., Ahlfors, H., Wilhelm, C., Tolaini, M., Menzel, U., et al. (2011) · Nature Immunology · doi:10.1038/ni.1993 · Cited by 1,176 · see citing works
Chronic Mucocutaneous Candidiasis in Humans with Inborn Errors of Interleukin-17 Immunity
Puel, A., Cypowyj, S., Bustamante, J., Wright, J. F., Liu, L., Lim, H. K., Migaud, M., Israel, L., Chrabieh, M., Audry, M., et al. (2011) · Science · doi:10.1126/science.1200439 · Cited by 1,056 · see citing works
Conti, H. R., Shen, F., Nayyar, N., Stocum, E., Sun, J. N., Lindemann, M. J., Ho, A. W., Hai, J. H., Yu, J. J., Jung, J. W., et al. (2009) · Journal of Experimental Medicine · doi:10.1084/jem.20081463 · Cited by 1,024 · see citing works
Ishigame, H., Kakuta, S., Nagai, T., Kadoki, M., Nambu, A., Komiyama, Y., Fujikado, N., Tanahashi, Y., Akitsu, A., Kotaki, H., et al. (2009) · Immunity · doi:10.1016/j.immuni.2008.11.009 · Cited by 1,004 · see citing works
JAKs and STATs in immunity, immunodeficiency, and cancer
O'Shea, J. J., Holland, S. M., & Staudt, L. M. (2013) · New England Journal of Medicine · doi:10.1056/nejmra1202117 · Cited by 927 · see citing works
Self-citationPathogen-induced human TH17 cells produce IFN-γ or IL-10 and are regulated by IL-1β
Zielinski, C. E., Mele, F., Aschenbrenner, D., Jarrossay, D., Ronchi, F., Gattorno, M., Monticelli, S., Lanzavecchia, A., & Sallusto, F. (2012) · Nature · doi:10.1038/nature10957 · Cited by 919 · see citing works
Candida albicans morphogenesis and host defence: discriminating invasion from colonization
Gow, N. A. R., van de Veerdonk, F. L., Brown, A. J. P., & Netea, M. G. (2012) · Nature Reviews Microbiology · doi:10.1038/nrmicro2711 · Cited by 888 · see citing works
A Homozygous <i>CARD9</i> Mutation in a Family with Susceptibility to Fungal Infections
Glocker, E.-O., Hennigs, A., Nabavi, M., Schäffer, A. A., Woellner, C., Salzer, U., Pfeifer, D., Veelken, H., Warnatz, K., Tahami, F., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0810719 · Cited by 800 · see citing works
Candida albicans—The Virulence Factors and Clinical Manifestations of Infection
Talapko, J., Juzbašić, M., Matijević, T., Pustijanac, E., Bekić, S., Kotris, I., & Škrlec, I. (2021) · Journal of Fungi · doi:10.3390/jof7020079 · Cited by 794 · see citing works
“, IL-23, IL-21, IL-6) in the differentiation of IL-17 producing T helper cells [116].”
BackgroundHuman dectin-1 deficiency and mucocutaneous fungal infections
Ferwerda, B., Ferwerda, G., Plantinga, T. S., Willment, J. A., van Spriel, A. B., Venselaar, H., Elbers, C. C., Johnson, M. D., Cambi, A., Huysamen, C., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0901053 · Cited by 752 · see citing works
HIV and Tuberculosis: a Deadly Human Syndemic
Kwan, C. K., & Ernst, J. D. (2011) · Clinical Microbiology Reviews · doi:10.1128/cmr.00042-10 · Cited by 720 · see citing works
Immune defence against Candida fungal infections
Netea, M. G., Joosten, L. A. B., van der Meer, J. W. M., Kullberg, B.-J., & van de Veerdonk, F. L. (2015) · Nature Reviews Immunology · doi:10.1038/nri3897 · Cited by 642 · see citing works
IL-17 is essential for host defense against cutaneous Staphylococcus aureus infection in mice
Cho, J. S., Pietras, E. M., Garcia, N. C., Ramos, R. I., Farzam, D. M., Monroe, H. R., Magorien, J. E., Blauvelt, A., Kolls, J. K., Cheung, A. L., et al. (2010) · Journal of Clinical Investigation · doi:10.1172/jci40891 · Cited by 658 · see citing works
Deficiency of Th17 cells in hyper IgE syndrome due to mutations in <i>STAT3</i>
Ma, C. S., Chew, G. Y. J., Simpson, N., Priyadarshi, A., Wong, M., Grimbacher, B., Fulcher, D. A., Tangye, S. G., & Cook, M. C. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20080218 · Cited by 652 · see citing works
Yang, X.-P., Ghoreschi, K., Steward-Tharp, S. M., Rodriguez-Canales, J., Zhu, J., Grainger, J. R., Hirahara, K., Sun, H.-W., Wei, L., Vahedi, G., et al. (2011) · Nature Immunology · doi:10.1038/ni.1995 · Cited by 583 · see citing works
Self-citationSOCS3, a Major Regulator of Infection and Inflammation
Carow, B., & Rottenberg, M. E. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00058 · Cited by 555 · see citing works
Microbial Translocation Across the GI Tract
Brenchley, J. M., & Douek, D. C. (2012) · Annual Review of Immunology · doi:10.1146/annurev-immunol-020711-075001 · Cited by 496 · see citing works
Self-citationC-type lectin receptors orchestrate antifungal immunity
Hardison, S. E., & Brown, G. D. (2012) · Nature Immunology · doi:10.1038/ni.2369 · Cited by 460 · see citing works
The plasticity of human Treg and Th17 cells and its role in autoimmunity
Kleinewietfeld, M., & Hafler, D. A. (2013) · Seminars in Immunology · doi:10.1016/j.smim.2013.10.009 · Cited by 389 · see citing works
Dutzan, N., Kajikawa, T., Abusleme, L., Greenwell-Wild, T., Zuazo, C. E., Ikeuchi, T., Brenchley, L., Abe, T., Hurabielle, C., Martin, D., et al. (2018) · Science Translational Medicine · doi:10.1126/scitranslmed.aat0797 · Cited by 382 · see citing works
Self-citationTh17 cells in immunity to Candida albicans
Hernández-Santos, N., & Gaffen, S. L. (2012) · Cell Host & Microbe · doi:10.1016/j.chom.2012.04.008 · Cited by 361 · see citing works
Heterogeneity of CD4<sup>+</sup> memory T cells: Functional modules for tailored immunity
Sallusto, F., & Lanzavecchia, A. (2009) · European Journal of Immunology · doi:10.1002/eji.200939722 · Cited by 348 · see citing works
Influenza A inhibits Th17-mediated host defense against bacterial pneumonia in mice.
Kudva, A., Scheller, E. V., Robinson, K. M., Crowe, C. R., Choi, S. M., Slight, S. R., Khader, S. A., Dubin, P. J., Enelow, R. I., Kolls, J. K., et al. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1002194 · Cited by 346 · see citing works
Bharadwaj, U., Kasembeli, M. M., Robinson, P., & Tweardy, D. J. (2020) · Pharmacological Reviews · doi:10.1124/pr.119.018440 · Cited by 314 · see citing works
“STAT3 is known to regulate both Th2 cell recruitment during allergic inflammation and the production of Th17 cells and the expansion and recruitment of neutrophils (Chen et al., 2007; Ma et al., 2008; Milner et al., 2008).”
BackgroundGenomic views of STAT function in CD4+ T helper cell differentiation
O'Shea, J. J., Lahesmaa, R., Vahedi, G., Laurence, A., & Kanno, Y. (2011) · Nature Reviews Immunology · doi:10.1038/nri2958 · Cited by 295 · see citing works
Self-citationThe Innate Immune System in Acute and Chronic Wounds
MacLeod, A. S., & Mansbridge, J. N. (2016) · Advances in Wound Care · doi:10.1089/wound.2014.0608 · Cited by 289 · see citing works
IL-22 defines a novel immune pathway of antifungal resistance
De Luca, A., Zelante, T., D'Angelo, C., Zagarella, S., Fallarino, F., Spreca, A., Iannitti, R. G., Bonifazi, P., Renauld, J.-C., Bistoni, F., et al. (2010) · Mucosal Immunology · doi:10.1038/mi.2010.22 · Cited by 265 · see citing works
Interleukin-17 in chronic inflammatory neurological diseases
Milovanovic, J., Arsenijevic, A., Stojanovic, B., Kanjevac, T., Arsenijevic, D., Radosavljevic, G., Milovanovic, M., & Arsenijevic, N. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00947 · Cited by 250 · see citing works
Kagami, S., Rizzo, H. L., Kurtz, S. E., Miller, L. S., & Blauvelt, A. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1001153 · Cited by 216 · see citing works
Type 17 T helper cells-origins, features and possible roles in rheumatic disease.
Annunziato, F., Cosmi, L., Liotta, F., Maggi, E., & Romagnani, S. (2009) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2009.80 · Cited by 212 · see citing works
Host Control of Fungal Infections: Lessons from Basic Studies and Human Cohorts
Lionakis, M. S., & Levitz, S. M. (2018) · Annual Review of Immunology · doi:10.1146/annurev-immunol-042617-053318 · Cited by 209 · see citing works
Cheng, S.-C., van de Veerdonk, F. L., Lenardon, M., Stoffels, M., Plantinga, T., Smeekens, S., Rizzetto, L., Mukaremera, L., Preechasuth, K., Cavalieri, D., et al. (2011) · Journal of Leukocyte Biology · doi:10.1189/jlb.1210702 · Cited by 191 · see citing works
Leonard, W. J., & Wan, C.-K. (2016) · F1000Research · doi:10.12688/f1000research.7634.1 · Cited by 184 · see citing works
Hypomethylation of the IL17RC Promoter Associates with Age-Related Macular Degeneration
Wei, L., Liu, B., Tuo, J., Shen, D., Chen, P., Li, Z., Liu, X., Ni, J., Dagur, P., Sen, H. N., et al. (2012) · Cell Reports · doi:10.1016/j.celrep.2012.10.013 · Cited by 167 · see citing works
Dendritic epidermal T cells regulate skin antimicrobial barrier function
MacLeod, A. S., Hemmers, S., Garijo, O., Chabod, M., Mowen, K., Witherden, D. A., & Havran, W. L. (2013) · Journal of Clinical Investigation · doi:10.1172/jci70064 · Cited by 152 · see citing works
Berry, S. P. D.-G., Dossou, C., Kashif, A., Sharifinejad, N., Azizi, G., Hamedifar, H., Sabzvari, A., & Zian, Z. (2022) · International Immunopharmacology · doi:10.1016/j.intimp.2021.108402 · Cited by 124 · see citing works
Robinson, K. M., Choi, S. M., McHugh, K. J., Mandalapu, S., Enelow, R. I., Kolls, J. K., & Alcorn, J. F. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1301237 · Cited by 126 · see citing works
McNeely, T. B., Shah, N. A., Fridman, A., Joshi, A., Hartzel, J. S., Keshari, R. S., Lupu, F., & DiNubile, M. J. (2014) · Human Vaccines & Immunotherapeutics · doi:10.4161/hv.34407 · Cited by 99 · see citing works
A mouse model of HIES reveals pro- and anti-inflammatory functions of STAT3
Steward-Tharp, S. M., Laurence, A., Kanno, Y., Kotlyar, A., Villarino, A. V., Sciume, G., Kuchen, S., Resch, W., Wohlfert, E. A., Jiang, K., et al. (2014) · Blood · doi:10.1182/blood-2013-09-523167 · Cited by 87 · see citing works
Self-citationSignal transduction and Th17 cell differentiation
O'Shea, J. J., Steward-Tharp, S. M., Laurence, A., Watford, W. T., Wei, L., Adamson, A. S., & Fan, S. (2009) · Microbes and Infection · doi:10.1016/j.micinf.2009.04.007 · Cited by 73 · see citing works
Self-citationEvidence for anti‐inflammatory effects of C5a on the innate IL‐17A/IL‐23 axis
Bosmann, M., Sarma, J. V., Atefi, G., Zetoune, F. S., & Ward, P. A. (2012) · The FASEB Journal · doi:10.1096/fj.11-199216 · Cited by 67 · see citing works
IL-17C is required for lethal inflammation during systemic fungal infection
Huang, J., Meng, S., Hong, S., Lin, X., Jin, W., & Dong, C. (2016) · Cellular & Molecular Immunology · doi:10.1038/cmi.2015.56 · Cited by 61 · see citing works
van de Veerdonk, F. L., Kullberg, B. J., Verschueren, I. C., Hendriks, T., van der Meer, J. W. M., Joosten, L. A. B., & Netea, M. G. (2010) · Shock · doi:10.1097/shk.0b013e3181d67041 · Cited by 49 · see citing works
Li, Y., Ye, Z., Zhu, J., Fang, S., Meng, L., & Zhou, C. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.844335 · Cited by 45 · see citing works
Therapeutic potential of targeting IL‐17 and IL‐23 in sepsis
Bosmann, M., & Ward, P. A. (2012) · Clinical and Translational Medicine · doi:10.1186/2001-1326-1-4 · Cited by 42 · see citing works
Naglik, J. R. (2014) · New Journal of Science · doi:10.1155/2014/390241 · Cited by 29 · see citing works
Smeekens, S. P., Henriet, S. S. V., Gresnigt, M. S., Joosten, L. A. B., Hermans, P. W. M., Netea, M. G., Warris, A., & van de Veerdonk, F. L. (2012) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.2011.0046 · Cited by 20 · see citing works
- Authors
- Milner, J. D., Brenchley, J. M., Laurence, A., Freeman, A. F., Hill, B. J., Elias, K. M., Kanno, Y., Spalding, C., Elloumi, H. Z., Paulson, M. L., Davis, J., Hsu, A., Asher, A. I., O’Shea, J., Holland, S. M., Paul, W. E., & Douek, D. C.
- Affiliations
- National Institutes of Health (US)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (US)
- Vaccine Research Center (US)
- Vanderbilt University (US)
- Corresponding author
- Douek, Daniel C.
- ORCID
- Venue
- Nature
- Published
- 2008-03-12
- Volume
- 452
- Issue
- 7188
- Pages
- 773-776
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC2864108
- OpenAlex
- W2125573161
- Cited by
- 1,157
- References
- 30
- Citations by year
- 2026: 18 · 2025: 26 · 2024: 25 · 2023: 25 · 2022: 32 · 2021: 43 · 2020: 49 · 2019: 49 · 2018: 60 · 2017: 51 · 2016: 71 · 2015: 80 · 2014: 97 · 2013: 93 · 2012: 96
- FWCI
- 47.42
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Funders
- National Institutes of Health (Z99 AI999999)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immunodeficiency and Autoimmune Disorders
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Keywords
- autosomal dominant hyper-IgE syndrome, Job's syndrome, Th17 cell differentiation, IL-17, STAT3 signaling, RORγ, T helper cells, recurrent infections, fungal infection susceptibility, Candida albicans, staphylococcal enterotoxin B, naive T cells
- MeSH terms
- Adolescent, Adult, Candida albicans, Cell Differentiation, Child, Child, Preschool, Enterotoxins, Female, Genes, Dominant, T-Lymphocytes, Helper-Inducer, Humans, Interferon-gamma, Interleukin-2, Job Syndrome, Male, Middle Aged, Streptokinase, Tumor Necrosis Factor-alpha, Interleukin-17
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