The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Therapeutic Targeting of the Interleukin-6 Receptor
Abstract
Interleukin (IL)-6 is a typical cytokine featuring redundancy and pleiotropic activity. It contributes to host defense against pathogens, but dysregulation of IL-6 production plays a significant pathological role in various autoimmune and inflammatory diseases. Because IL-6 blockade was expected to constitute a novel strategy for the treatment of such diseases, tocilizumab, a humanized anti-IL-6 receptor antibody (anti-IL-6RAb), was developed. Clinical trials have demonstrated the efficacy of anti-IL-6RAb for patients with rheumatoid arthritis, Castleman's disease, and juvenile idiopathic arthritis, resulting in approval of this innovative biologic for the treatment of these diseases, and it can be expected to become a novel drug for various other autoimmune and inflammatory diseases. In murine models of autoimmune diseases, anti-IL-6RAb induces Treg and inhibits Th17 and/or Th1 differentiation, indicating that anti-IL-6RAb may be able to repair Th17/Treg imbalance in human diseases as well.
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Cites
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Cited by
IL‐6 in inflammation, immunity, and disease
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BackgroundA gp130–Src–YAP module links inflammation to epithelial regeneration
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Flavonoids as Cytokine Modulators: A Possible Therapy for Inflammation-Related Diseases
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Blockade of IL-6 Trans Signaling Attenuates Pulmonary Fibrosis
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Safety and efficacy of tocilizumab for the treatment of rheumatoid arthritis
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Self-citation
Metadata
- Authors
- Tanaka, T., Narazaki, M., & Kishimoto, T.
- Venue
- Annual Review of Pharmacology and Toxicology
- Publisher
- Annual Reviews
- Published
- 2012-02-10
- Volume
- 52
- Issue
- 1
- Pages
- 199-219
- ISSN
- 0362-1642 (ISSN-L)
- 1545-4304
- OpenAlex
- W2125396722
- Cited by
- 262
- References
- 12
- FWCI
- 2.83
- Type
- journal article
- Language
- en
- Open access
- closed
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