Repairing Mitochondrial Dysfunction in Disease

Harmonizing the Metabolic Syndrome: A Joint Interim Statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity

Alberti, K. G. M. M., Eckel, R. H., Grundy, S. M., Zimmet, P. Z., Cleeman, J. I., Donato, K. A., Fruchart, J.-C., James, W. P. T., Loria, C. M., & Smith, S. C. (2009) · Circulation · doi:10.1161/circulationaha.109.192644 · Cited by 14,860

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

Kim, J., Kundu, M., Viollet, B., & Guan, K.-L. (2011) · Nature Cell Biology · doi:10.1038/ncb2152 · Cited by 7,227

Mitochondrial Dysfunction and Oxidative Stress in Neurodegenerative Diseases

Lin, M. T., & Beal, M. F. (2006) · Nature · doi:10.1038/nature05292 · Cited by 6,455

Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

Kitada, T., Asakawa, S., Hattori, N., Matsumine, H., Yamamura, Y., Minoshima, S., Yokochi, M., Mizuno, Y., & Shimizu, N. (1998) · Nature · doi:10.1038/33416 · Cited by 5,227

A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis

Boström, P., Wu, J., Jedrychowski, M. P., Korde, A., Ye, L., Lo, J. C., Rasbach, K. A., Boström, E. A., Choi, J. H., Long, J. Z., et al. (2012) · Nature · doi:10.1038/nature10777 · Cited by 4,810

Dystrophin: the protein product of the Duchenne muscular dystrophy locus

Hoffman, E. P., Brown, R. H., & Kunkel, L. M. (1987) · Cell · doi:10.1016/0092-8674(87)90579-4 · Cited by 4,693

Resveratrol improves health and survival of mice on a high-calorie diet

Baur, J. A., Pearson, K. J., Price, N. L., Jamieson, H. A., Lerin, C., Kalra, A., Prabhu, V. V., Allard, J. S., Lopez-Lluch, G., Lewis, K., et al. (2006) · Nature · doi:10.1038/nature05354 · Cited by 4,290

Resveratrol Improves Mitochondrial Function and Protects against Metabolic Disease by Activating SIRT1 and PGC-1α

Lagouge, M., Argmann, C., Gerhart-Hines, Z., Meziane, H., Lerin, C., Daussin, F., Messadeq, N., Milne, J., Lambert, P., Elliott, P., et al. (2006) · Cell · doi:10.1016/j.cell.2006.11.013 · Cited by 4,057

Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

Narendra, D., Tanaka, A., Suen, D.-F., & Youle, R. J. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200809125 · Cited by 4,026

The role of CISD1 reduction in macrophages in promoting COPD development through M1 polarization and mitochondrial dysfunction

Gao, J., Dong, M., Tian, W., Xia, J., Qian, Y., Jiang, Z., Chen, Z., & Shen, Y. (2024) · European journal of medical research · doi:10.1186/s40001-024-02146-2 · Cited by 10

Regulatory Role of Bioactive Compounds from Natural Spices on Mitochondrial Function

Han, L., Ho, C., & Lu, M. (2025) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.4c12341 · Cited by 9

Functional foods and bioactive compounds: a comprehensive review on their role in mitigating drug-induced liver injury

Zhao, J.-W., Zhao, W., Zhao, M., & Lu, Y. (2025) · Frontiers in Nutrition · doi:10.3389/fnut.2024.1499697 · Cited by 10

Bone marrow mesenchymal stem cells protect against cerebral amyloid angiopathy by enhancing neutrophil mitocytosis

Hu, M., Yi, H., Wang, S., Kang, X., Liu, Y., Liu, Z., Huang, H., Qin, Q., Yuan, L., Cai, W., et al. (2025) · Neural Regeneration Research · doi:10.4103/nrr.nrr-d-24-01273 · Cited by 10

FTY720-P, a Biased S1PR Ligand, Increases Mitochondrial Function through STAT3 Activation in Cardiac Cells

Muñoz, J. P., Sànchez‐Fernàndez‐de‐Landa, P., Diarte‐Añazco, E. M. G., Antonio Zorzano, A., Blanco‐Vaca, F., & Julve, J. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24087374 · Cited by 7

PINK1 dominated mitochondria associated genes signature predicts abdominal aortic aneurysm with metabolic syndrome

Wang, K., Zhou, Z., Huang, L., Kan, Q., Wang, Z., Wu, W., & Yao, C. (2023) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2023.166919 · Cited by 8

A Small‐Molecule Drug for the Self‐Checking of Mitophagy

Gao, Y., Bai, Q., Ren, Y., Shao, X., Zhang, M., Wu, L., Lewis, S. E., James, T. D., Chen, X. S., & Chen, Q. (2025) · Angewandte Chemie International Edition · doi:10.1002/anie.202421269 · Cited by 8

Medication targeting to subcellular organelles: Emphasizing mitochondria as a therapeutic marvel—Current situation and future prospects

Alzhrani, R. F., Alhowyan, A., Taha, E. I., Attia, S. M., Salama, S. A., & Harisa, G. I. (2025) · Experimental Cell Research · doi:10.1016/j.yexcr.2025.114647 · Cited by 7

Macrophage Plasticity and Regulatory Networks During the Transition from Inflammation to Fibrosis in the Kidney

Moon, Y., Hong, J., Chung, J., & Baek, J.-H. (2025) · Life · doi:10.3390/life16010052 · Cited by 9

Fludioxonil induces cardiotoxicity via mitochondrial dysfunction and oxidative stress in two cardiomyocyte models

Seong, S., Go, R., Lee, H. K., & Choi, K. (2024) · Environmental Toxicology · doi:10.1002/tox.24176 · Cited by 7

Metabolic reprogramming of fibroblast-like synoviocytes with a supramolecular nano-drug for osteoarthritis therapy

Ma, Y., Dong, J., Zou, X., Jiang, X., Liu, L., Wang, B., Mao, X., Gong, L., Li, G., & Chen, C. (2025) · Advanced Composites and Hybrid Materials · doi:10.1007/s42114-025-01245-w · Cited by 8

Salidroside alleviates doxorubicin-induced hepatotoxicity via Sestrin2/AMPK-mediated pyroptotic inhibition

Wang, N., Gao, Z., Zhan, H., Lin, J., Meng, F., & Chen, M. (2025) · Food and Chemical Toxicology · doi:10.1016/j.fct.2025.115335 · Cited by 8

Restoration of NAD + homeostasis protects C2C12 myoblasts and mouse levator ani muscle from mechanical stress-induced damage

Huang, G., He, Y., Li, H., Zhou, M., Zuo, X., & Zhao, Z. (2022) · Animal Cells and Systems · doi:10.1080/19768354.2022.2106303 · Cited by 7

Hypoxia Affects Mitochondrial Stress and Facilitates Tumor Metastasis of Colorectal Cancer Through Slug SUMOylation

Wang, J., Ding, S., Liu, X.-S., Yu, T., Wu, Z., & Li, Y. (2023) · Current Molecular Medicine · doi:10.2174/0115665240271525231112121008 · Cited by 7

The Therapeutic Effects of Baicalein on the Hepatopulmonary Syndrome in the Rat Model of Chronic Common Bile Duct Ligation

Zeng, Z., Lei, Y., Yang, C., Wu, X., Zhang, L., Yang, Z., Chen, L., Wang, X., Belguise, K., Li, Y., et al. (2024) · Journal of Clinical and Translational Hepatology · doi:10.14218/jcth.2023.00513 · Cited by 7

Mitochondrial Biology and Medicine

Wallace, D. C., Lott, M. T., & Procaccio, V. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-812537-3.00010-x · Cited by 8

Mitochondrial dysfunction attenuates rapid regeneration in livers with toxin-induced fibrosis

Li, Z., Liang, Y., Ying, H., Chen, M., He, X., Wang, Y., Tong, Y., & Cai, X. (2021) · Annals of Translational Medicine · doi:10.21037/atm-20-4639 · Cited by 7

Molecular Mechanism of Action of Mitochondrial Therapeutic SS-31 (Elamipretide): Membrane Interactions and Effects on Surface ElectrostaticsPreprint

Mitchell, W., Ng, E. A., Tamucci, J. D., Boyd, K., Sathappa, M., Coscia, A., Pan, M., Han, X., Eddy, N. A., May, E. R., et al. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/735001 · Cited by 7

4- hydroxy-3,5-di-tret-butyl cinnamic acid restores the activity of the hippocampal mitochondria in rats under permanent focal cerebral ischemiaPreprint

Pozdnyakov, D. I. (2021) · doi:10.22541/au.161058198.82817521/v1 · Cited by 7

Targeting the Galectin‐7/ TRPM2 /Zn2+/ DRP ‐1 Signaling Pathway: A Potential Therapeutic Intervention in the Pathogenesis of SJS / TEN

Zhang, C., Pang, B., Luo, Y., Cao, Z., Qiao, P., Zhu, Z., Hui, F., Yang, J., Dang, E., Shen, S., et al. (2025) · Allergy · doi:10.1111/all.16510 · Cited by 6

Metformin-Induced Apoptosis Is Mediated Through Mitochondrial VDAC1

Shteinfer‐Kuzmine, A., Moyal, M. M., Nivedita, A. K., Trishna, S., Nadir, A., Tripathi, S., & Shoshan‐Barmatz, V. (2025) · Pharmaceuticals · doi:10.3390/ph18050757 · Cited by 7

Energy imbalance in oPOI ovarian granulosa cells is linked to reduced glucose bioavailability and metabolism

Marynowicz, W., Głód, P., Maduzia, D., Gogola-Mruk, J., & Ptak, A. (2025) · Reproductive Biology and Endocrinology · doi:10.1186/s12958-025-01426-8 · Cited by 6

Role of oxidative stress and endoplasmic reticulum stress in drug-induced liver injury

Wu, H., Bao, X., Gutierrez, A. H., Nevzorova, Y. A., & Cubero, F. J. (2023) · Exploration of Digestive Diseases · doi:10.37349/edd.2023.00020 · Cited by 8

Preferential Synaptic Type of GABA-A Receptor Ligands Enhancing Neuronal Survival and Facilitating Functional Recovery After Ischemic Stroke

Mordyl, B., Fajkis-Zajączkowska, N., Szafrańska, K., Siwek, A., Głuch‐Lutwin, M., Żmudzki, P., Jończyk, J., Karcz, T. P., Słoczyńska, K., Pękala, E., et al. (2024) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.4c01578 · Cited by 6

Diabetes mellitus and heart failure — a modern look at the mechanisms of development

Svarovskaya, A. V., & Анатольевна, Г. А. (2022) · Diabetes Mellitus · doi:10.14341/dm12648 · Cited by 6

Potential Diets to Improve Mitochondrial Activity in Amyotrophic Lateral Sclerosis

Yoshikawa, S., Taniguchi, K., Sawamura, H., Ikeda, Y., Tsuji, A., & Matsuda, S. (2022) · Diseases · doi:10.3390/diseases10040117 · Cited by 7

Toxicity mechanism of acrolein on energy metabolism disorder and apoptosis in human ovarian granulosa cells

Liu, X., Li, R., Xiu, Z., Tang, S., & Duan, Y. (2024) · Toxicology · doi:10.1016/j.tox.2024.153861 · Cited by 6

Oxidative stress, Chinese herbals and toxicity: A focused review with examples

Zhang, C., Wang, N., & Feng, Y. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-819092-0.00022-4 · Cited by 6

A study on the curative effect of nobiletin on paraquat induced toxicity in rat

Ijaz, M. U., Batool, M., Ashraf, A., Al‐Ghanim, K. A., Shahzadi, S., Samad, A. R., Al-Misned, F. A., Mruthinti, S. S., & Mahboob, S. (2021) · Journal of King Saud University - Science · doi:10.1016/j.jksus.2021.101673 · Cited by 6

Mitochondrial dysfunctions and neurodegenerative diseases: a mini-review

Kumari, R., Shekhar, N., Tyagi, S., & Thakur, A. K. (2021) · Journal of Analytical & Pharmaceutical Research · doi:10.15406/japlr.2021.10.00378 · Cited by 6

Recent advances in molecular mechanisms of anticancer natural products that target mitochondrial bioenergetics

Urra, F. A., Fuentes-Retamal, S., Palominos, C., & Araya‐Maturana, R. (2021) · Studies in natural products chemistry · doi:10.1016/b978-0-323-91095-8.00006-4 · Cited by 6

Anxa10 and neuropathic pain: Insights into dysregulation of endoplasmic reticulum-mitochondria contact tethering complex and therapeutic potential

Wu, F., Liu, B.-Z., Huang, Y.-Q., Zhu, C.-L., Xia, Y.-L., Zhang, K.-L., Li, S., Yang, Y., & Wang, Y. (2025) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2025.167856 · Cited by 5

Suppression of mPFC‐Amygdala Circuit Mitigates Sevoflurane‐Induced Cognitive Deficits in Aged Mice

Li, J., Wen, J., Zeng, M., Mei, J., Zeng, C., Liufu, N., & Li, Y. (2025) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.70443 · Cited by 5

TGF-β/JNK axis mediates mitochondrial damage and macrophage cGAS-STING activation in liver Mallory-Denk body pathogenesis

Shi, Y., Huang, M., Zhou, W., Zhao, Y., Zhao, J., Zhong, B., French, S. W., Tang, X., & Liu, H. (2025) · Journal of Translational Medicine · doi:10.1186/s12967-025-06618-9 · Cited by 5

Ablation of Steroidogenic Superoxide Dismutase 2 Increases Oxidative Stress and Diminishes Steroid Hormone Production

Shen, W., Huang, T., Cortez, Y., Zaidi, S. K., Arshad, S., Kraemer, F. B., & Azhar, S. (2025) · Endocrinology · doi:10.1210/endocr/bqaf120 · Cited by 5

Water-Soluble Tomato Concentrate, a Potential Antioxidant Supplement, Can Attenuate Platelet Apoptosis and Oxidative Stress in Healthy Middle-Aged and Elderly Adults: A Randomized, Double-Blinded, Crossover Clinical Trial

Tian, Z., Li, K., Fan, D., Gao, X., Ma, X., Zhao, Y., Zhao, D., Liang, Y. J., Ji, Q., Chen, Y.-T., et al. (2022) · Nutrients · doi:10.3390/nu14163374 · Cited by 5

Bioinformatics insights into mitochondrial and immune gene regulation in Alzheimer's disease

Tian, M., Zhang, Y., Yuan, Y., Li, H., & He, Y. (2025) · European journal of medical research · doi:10.1186/s40001-025-02297-w · Cited by 7

Phase separation in mitochondrial fate and mitochondrial diseases

Chen, Q., An, S., Wang, C., Zhou, Y., Liu, X., & Ren, W. (2025) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2422255122 · Cited by 6

Guanine quadruplexes mediate mitochondrial RNA polymerase pausing

Snyder, R. J., Shankar, U., Delker, D. A., Soerianto, W., Burdick, J. T., Cheung, V. G., & Watts, J. A. (2025) · BMC Biology · doi:10.1186/s12915-025-02229-4 · Cited by 5

Mitochondria-Targeting and ROS-Responsive Nanocarriers via Amphiphilic TPP-PEG-TK-Ce6 for Nanoenabled Photodynamic Therapy

Wang, Y., Zheng, J., Lin, J., Ye, K., & Wei, P. (2022) · Advances in Polymer Technology · doi:10.1155/2022/1178039 · Cited by 5

A water-soluble fluorescent probe for monitoring mitochondrial GSH fluctuations during oxidative stress

Wang, H., Zhang, L., Jin, X., Tian, P., Ding, X., & Chang, J. (2022) · RSC Advances · doi:10.1039/d2ra04732b · Cited by 5

Peptide Power: Mechanistic Insights into the Effect of Mitochondria-Targeted Tetrapeptides on Membrane Electrostatics from Molecular Simulations

Tamucci, J. D., Alder, N. N., & May, E. R. (2023) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.3c00480 · Cited by 5

The inhibition of MARCO by PolyG alleviates pulmonary fibrosis via regulating mitochondrial function in a silicotic rat model

Chang, M., Li, N., Zhou, Q., Yan, Y., Xu, W., Zhao, Y., & Yao, S. (2024) · Environmental Toxicology · doi:10.1002/tox.24241 · Cited by 5

High-resolution In-situ Structures of Mammalian Mitochondrial Respiratory Supercomplexes in Reaction within Native MitochondriaPreprint

Zheng, W., Chai, P., Zhu, J., & Zhang, K. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.04.02.587796 · Cited by 5

Mitochondrial metabolism: Critical mechanisms underpinning normal hematopoietic stem cell and acute myeloid leukemia stem cell function

Yu, H., & Yan, L. (2025) · Gene · doi:10.1016/j.gene.2025.149685 · Cited by 6

Unraveling the role of mitochondrial dysfunction in diabetic kidney disease: insights and interventions

Fan, Z., Luo, P., Gao, Y., Ma, H., Fan, J., Sanan, S., Zhang, P., Lu, K., & Xia, H. (2026) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1618418 · Cited by 4

Rotenone-Induced Optic Nerve Damage and Retinal Ganglion Cell Loss in Rats

Yamamoto, Y., Taniguchi, T., & Shimazaki, A. (2024) · Biomolecules · doi:10.3390/biom14091047 · Cited by 4

Leveraging the dual role of ROS in liver diseases with nanomaterials: clearing and amplifying for therapy

Liu, Z., Yao, Z., Yang, H., Wu, S., & Tang, Z. (2024) · Nanoscale · doi:10.1039/d4nr04469j · Cited by 4

Innovative strategies for mitochondrial dysfunction in myeloproliferative neoplasms a step toward precision medicine

Bosco, S., Beniwal, S. S., Munshi, S. S., Calderón, D. C., Jeong, Y., Cacas, A. C., Kumar, S., SANTOS, P. H. S. C. D., Syed, S., Dwivedi, A., et al. (2025) · Annals of Medicine and Surgery · doi:10.1097/ms9.0000000000003365 · Cited by 4

Cardiac Mitochondrial and Electrophysiological Changes in Transplanted Ovine Hearts Following Preservation by Hypothermic Oxygenated Perfusion

Hoe, L. E. S., Bouquet, M., Bartnikowski, N., Wells, M. A., Devaux, J. B. L., Hyslop, K., Passmore, M. R., Wilson, E., Reid, J. D., O'Neill, H., et al. (2025) · Transplantation · doi:10.1097/tp.0000000000005490 · Cited by 4

Cu–Mn Bimetallic Mesoporous Silica Nanosonosensitizers Enable Oxeiptosis-Mediated Sonodynamic Therapy for Ultra-Minimally Invasive Treatment of Benign Prostatic Hyperplasia

Chang, M., Lv, J., Sun, L., Chen, A., Zhang, F., Fan, G., Liu, Z., Li, J., Shen, H., Shi, M., et al. (2025) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.5c12846 · Cited by 5

Puerarin ameliorates high glucose-induced MIN6 cell injury by activating PINK1/Parkin-mediated mitochondrial autophagy

Zhu, H.-Y., Yu, Y., Li, Y., Chang, S., & Liu, Y. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e36176 · Cited by 4

Mitophagy Defects Exacerbate Inflammation and Aberrant Proliferation in Lymphocytic Thyroiditis

Lee, H. S., Lee, J., An, H., Sung, M. J., Heo, J. H., Lee, S., & Song, Y. S. (2024) · Thyroid · doi:10.1089/thy.2024.0125 · Cited by 4

Mitochondrial proteostasis and cellular health: insights from chaperones and autophagy

Jagtap, Y. A., Choudhary, A., Kinger, S., Kumar, P., Bhattacharyya, S., Jha, H. C., Dhiman, R., Sharma, V., Suresh, A. K., Poluri, K. M., et al. (2025) · The Journal of Physiology · doi:10.1113/jp287635 · Cited by 4

The role of mitochondria-related genes and immune infiltration in carotid atherosclerosis: identification of hub targets through bioinformatics and machine learning approaches

Liu, D., Guo, K., Liu, Y., Yu, X., Guan, X., & Guan, X. (2025) · Frontiers in Genetics · doi:10.3389/fgene.2025.1597445 · Cited by 4

Baccharis trimera phytochemicals and the mitochondria

Rabêlo, A. C. S. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-821562-3.00048-4 · Cited by 4

New Biocompatible β‐Phosphorylated Linear Nitrones Targeting Mitochondria: Protective Effect in Apoptotic Cells

Culcasi, M., Delehedde, C., Esgulian, M., Cassien, M., Chocry, M., Rockenbauer, A., Pietri, S., & Laurent, S. (2023) · ChemBioChem · doi:10.1002/cbic.202200749 · Cited by 4

Genetic Advance in Depressive Disorder

Zhang, C., & Rong, H. (2019) · Advances in experimental medicine and biology · doi:10.1007/978-981-32-9271-0_2 · Cited by 4

The genotype/phenotype conundrum of inherited mitochondrial disorders: Insights from a survey of mtDNA mutations associated with Leigh syndrome in complex I

Ahmadi, Z. A., & Brandt, U. (2025) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2025.167996 · Cited by 6

Benign prostatic hyperplasia nodules in patients treated with celecoxib and/or finasteride have reduced levels of NADH dehydrogenase [ubiquinone] iron‐sulfur protein 3, a mitochondrial protein essential for efficient function of the electron transport chain

Liu, T. T., Igarashi, T., El‐Khoury, N., Ihejirika, N., Paxton, K., Jaumotte, J. D., Dhir, R., Hudson, C. N., Nelson, J. B., DeFranco, D. B., et al. (2024) · The Prostate · doi:10.1002/pros.24766 · Cited by 3

The association between basal metabolic rate and ischemic stroke: a Mendelian randomization study

Chen, Y., Zhang, X., Liu, M., Zhang, Y., Song, L., Zhou, L., Yang, X., Chen, X., Yue, M., Qu, Q., et al. (2025) · Frontiers in Neurology · doi:10.3389/fneur.2025.1434740 · Cited by 3

How cytosolic compartments play safeguard functions against neuroinflammation and cell death in cerebral ischemia

Ryan, F., Khoshnam, S. E., Khodagholi, F., Ashabi, G., & Ahmadiani, A. (2021) · Metabolic Brain Disease · doi:10.1007/s11011-021-00770-z · Cited by 3

Tetramethylpyrazine protects mitochondrial function by up-regulation of TFAM and inhibition of neuronal apoptosis in a rat model of surgical brain injury.

Wang, C., Huang, Y., Gong, Y., Wu, M., Jiang, L., & Dang, B. (2024) · PubMed Central · doi:10.22038/ijbms.2023.72947.15862 · Cited by 3

Investigating the Modulatory Effect of Methanol Extract of Daniellia oliveri (ROLFE) Leaves on Mitochondrial Membrane Permeability Transition (MPT) Pore

Achem, J., Onyiba, C. I., Akinwole, M. T., Malgwi, J. M., Bolarin, O. L., & Olorunsogo, O. O. (2020) · International Journal of Biochemistry Research & Review · doi:10.9734/ijbcrr/2020/v29i930223 · Cited by 3

Modern research progress on extraction and purification, pharmacological activity, toxicology, pharmacokinetics and carrier new dosage forms of ophiopogonin

Wang, Q., Li, Y., Gao, P., & Dai, L. (2024) · Phytochemistry Reviews · doi:10.1007/s11101-024-09995-z · Cited by 2

A Small‐Molecule Drug for the Self‐Checking of Mitophagy

Gao, Y., Bai, Q., Ren, Y., Shao, X., Zhang, M., Wu, L., Lewis, S. E., James, T. D., Chen, X. S., & Chen, Q. (2025) · Angewandte Chemie · doi:10.1002/ange.202421269 · Cited by 2

PCSK9 Inhibitors: A Potential Priority Choice for Lipid Management in Patients with Diabetic Kidney Disease

Bao, L., Shi, X., & Shao, Y. (2025) · Drugs · doi:10.1007/s40265-025-02221-w · Cited by 3

Mitochondria targeted hydrogen sulfide donor AP39 attenuates allergic airway inflammation and airway hyperreactivity in mouse

Altiparmak, B., Karaman, Y., Kurtulan, O., Onder, S. C., & Bozkurt, T. E. (2025) · Respiratory Physiology & Neurobiology · doi:10.1016/j.resp.2025.104501 · Cited by 2

Mitochondrial Derived Peptides (MDPs) as Emerging Gero Protectors: Molecular Signaling, Systemic Effects, and Translational Perspectives

Sahu, P., Satapathy, A., Satapathy, A., & Satapathy, T. (2025) · International Journal of Peptide Research and Therapeutics · doi:10.1007/s10989-025-10797-w · Cited by 2

A big picture of the mitochondria-mediated signals: From mitochondria to organism

Acar, N. V., & Özgül, R. K. (2023) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2023.08.032 · Cited by 2

Mitochondrial toxicity of selected natural compounds: in vitro assessment and in silico molecular docking and dynamics simulation

Ergüç, A., Albayrak, G., Muhammed, M. T., Karakuş, F., & Arzuk, E. (2024) · Drug and Chemical Toxicology · doi:10.1080/01480545.2024.2412775 · Cited by 2

Oxidative Stress-Induced Mitochondrial Dysfunction and Asthma

Chakraborty, S., Khanna, K., & Agrawal, A. (2019) · Springer eBooks · doi:10.1007/978-981-32-9366-3_6 · Cited by 2

Autophagy and bioenergetics in aging

Zhang, J., Wang, H., & Fang, E. F. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-91617-2.00002-x · Cited by 2

Imbalanced Skeletal Muscle Mitochondrial Proteostasis Causes Bone LossPreprint

Jin, Z., Mao, Y., Guo, Q., Yin, Y., Kiram, A., Zhou, D., Yang, J., Zhou, Z., Xue, J., Feng, Z., et al. (2024) · SSRN Electronic Journal · doi:10.2139/ssrn.4782549 · Cited by 2

Exploring the Interconnections Between Mitochondrial Dysfunction and Polycystic Ovary Syndrome: A Comprehensive Integrated Analysis

Zhang, S., Zhu, M., & Chen, S. (2025) · Biochemical Genetics · doi:10.1007/s10528-025-11104-4 · Cited by 1

Decoding the diagnostic biomarkers of mitochondrial dysfunction related gene variants in pediatric T cell acute lymphoblastic leukemia

Lu, Y., Xi, Y., Liu, L., Sun, X., Li, X., Zhao, P., Guan, G., & Dai, Y. (2025) · Scientific Reports · doi:10.1038/s41598-025-08893-4 · Cited by 1

Evaluation of the Effects of cypermethrin Toxicity on Liver Mitochondria of Male Albino Rats

Poli, V., & Motireddy, S. R. (2025) · Journal of Pharmacological and Toxicological Methods · doi:10.1016/j.vascn.2025.108388 · Cited by 1

Amiodarone as a model compound for assessment of mitochondrial toxicity in hepatocytes

Park, J., Choi, M., Surh, Y., & Kang, K. W. (2025) · Toxicological Research · doi:10.1007/s43188-025-00310-2 · Cited by 1

Protective Effects of Luteolin in an In Vitro Model of Ethanol-Induced Gastric Epithelial Injury: Insights into ROS Modulation and Inflammatory Response

Zhu, X., Shao, Y., & Wang, J. P. (2025) · Molecular Biology · doi:10.1134/s0026893325700426 · Cited by 1

Protein Phosphatase 1 Regulatory Subunit 17 (PPP1R17) Regulates Cerebral Ischemia and Ischemia–Reperfusion Brain Injury by Suppressing YAP1-Mediated Mitophagy

Ma, M., Yang, J., Li, Z., Shi, X., & Xu, Z. (2025) · Molecular Neurobiology · doi:10.1007/s12035-025-05488-y · Cited by 1

Diagnostic and therapeutic innovations in myocardial infarction: a focus on mitochondrial dysfunction

Gao, X., Pan, Y., Liu, Q., & Wu, H. (2026) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2026.1748411 · Cited by 1

Mitoredox shifts in mitochondrial dysfunction

Moos, W. H., Faller, D. V., Glavas, I. P., Kanara, I., Kodukula, K., Pernokas, J., Pernokas, M., Pinkert, C. A., Powers, W. R., Sampani, K., et al. (2026) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2026.05.307 · Cited by 2

Targeting Mitochondria in Aging‐Related Diseases: Therapeutic Potential and Obstacles

Xiang, Z., Chen, Y., Liu, X., Lu, H., Yang, Y., Xing, L., Zhang, Y., Lang, C., Zhang, S., Zhao, S., et al. (2026) · MedComm · doi:10.1002/mco2.70790 · Cited by 2

Targeting mitochondrial ribosomal proteins: a functional and translational framework for neurodegenerative disease research

Giudice, L. D., Guida, M., Aletta, M., & Pontieri, P. (2026) · Frontiers in Neurology · doi:10.3389/fneur.2026.1882474 · Cited by 1

Nutrição celular: um padrão de cuidado

Giorelli, G., Machado, J. P., Addor, F., Sartoretto, B., & Toledo, D. O. (2021) · Braspen Journal · doi:10.37111/braspenj.2021.36.4.01 · Cited by 1

Editorial: Natural products in regulating mitochondrial dysfunction

Xie, C., Ma, L., Wang, X., & Xiong, X. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1233718 · Cited by 1

[Effects of nicotinamide mononucleotide adenylyl transferase 3 on mitochondrial function and anti-oxidative stress of rabbit bone marrow mesenchymal stem cells via regulating nicotinamide adenine dinucleotide levels].

Wang, T., Peng, W., Zhang, F., Zheng, Y., Wang, Z., & Yuan, D. (2020) · PubMed Central · doi:10.7507/1002-1892.201910037

Using the NIH symptom science model to understand fatigue and mitochondrial bioenergetics

Shen, Q., Mahoney, D. E., Peltzer, J. N., Rahman, F. K., Krueger, K. J., Hiebert, J. B., & Pierce, J. D. (2020) · Journal of Nursing · doi:10.7243/2056-9157-7-2

Plant-derived molecules for the prevention and treatment of mitochondria-related diseases

Asghari, M. H., Moloudizargari, M., & Abdollahi, M. R. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-821562-3.00002-2

Creation of cybrid cultures containing the mitochondrial genome mutation m.1555A>G (MT-RNR1 gene), which has a protective effect in atherosclerosis

Sazonova, M. A., Синёв, В. В., Ryzhkova, A. I., Sazonova, M. D., Дорощук, Н. А., Kirichenko, T. V., Орехов, А. Н., & Sobenin, I. A. (2021) · Zhurnal «Patologicheskaia fiziologiia i eksperimental`naia terapiia» · doi:10.25557/0031-2991.2021.04.121-127

Mitochondria-targeted drug delivery systems for the effective treatment of neurodegenerative disorders

Khare, V., Gupta, S., Bisht, P., & Garabadu, D. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-85544-0.00013-7

Differential mobility spectrometry-tandem mass spectrometry (DMS-MS/MS) uncovers the consequence of radiation exposure through the urinary acylcarnitine profile

Vera, N. B. (2019) · doi:10.17760/d20316345

Tetramethylpyrazine protects mitochondrial function by upregulating TFAM and alleviating nerve cell apoptosis in SBI ratsPreprint

Wang, C., Huang, Y., Gong, Y., Wu, M., Jiang, L., Xu, J., Dang, B., & Chen, G. (2022) · Research Square · doi:10.21203/rs.3.rs-2136730/v1

Caracterização dos efeitos de neuroproteção e neurodiferenciação de novos compostos inibidores de acetilcolinesterase em células PC12 diferenciadas em neurônios

Ono, R. M. D. S. (2022) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/d.17.2022.tde-10042023-084601

Gut microbiota modulation as an alternative in the management of non-alcoholic fatty liver disease and obesity

Juárez‐Fernández, M. (2023) · Buleria (Universidad de León) · doi:10.18002/10612/17419

An Insight into the Approach Taken to Appurtenances Disorders Linked to Mitochondria

Hmar, E. B. L., Paul, S., Islam, R., & Sharma, H. K. (2024) · Biology Bulletin · doi:10.1134/s1062359023604962

Neurovascular mitochondrial susceptibility impacts blood-brain barrier function and behaviorPreprint

Crockett, A. M., Kébir, H., Colόn, M. C. V., Iascone, D. M., Cielieski, B., Rossano, A. J., Sehgal, A., Anderson, S. A., & Alvarez, J. I. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.02.15.580544

THE USE OF CREATINE BEYOND ERGOGENIC POTENTIAL: A NARRATIVE REVIEW

Khouuri, L. M., & Oliveira, R. B. D. A. (2024) · International Journal of Health Science · doi:10.22533/at.ed.1594302422036

Cardiovascular diseases and mitochondrial transplantation

Borisov, A. B., McCusker, K., McIntyre, D., & Peduzzi-Nelson, J. D. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-18858-9.00016-0

Mitochondrial dynamics and quality control in alcohol-associated liver disease and liver tumorigenesis

Ma, X., Zhang, C., & Ding, W. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-15260-3.00016-8

Pharmacological approaches to restore mitochondrial function

Andreux, P. A., Houtkooper, R. H., & Auwerx, J. (2013) · Nature Reviews Drug Discovery · doi:10.1038/nrd4023 · Cited by 383

Mitochondria in health and disease: cellular powerhouses, signaling centers, and drivers of dysfunction

Akinkunmi, O. A., Araba, F. F., Adaeze, C. J., Adenle, V. A., Odeyemi, A. A., Akhigbe, T. M., & Akhigbe, R. E. (2026) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2026.1929130

An Insight into the Approach Taken to Appurtenances Disorders Linked to Mitochondria

Hmar, E. B. L., Paul, S., Islam, R., & Sharma, H. K. (2024) · Biology Bulletin · doi:10.1134/s1062359023604962

Mitochondrial Biogenesis as a Pharmacological Target: A New Approach to Acute and Chronic Diseases

Whitaker, R. M., Corum, D. G., Beeson, C., & Schnellmann, R. G. (2015) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-010715-103155 · Cited by 202

Mitochondria in health, disease, and aging

Harrington, J. S., Ryter, S. W., Plataki, M. E., Price, D. R., & Choi, A. M. K. (2023) · Physiological Reviews · doi:10.1152/physrev.00058.2021 · Cited by 641