Sorrentino, Vincenzo

Enhancing mitochondrial proteostasis reduces amyloid-β proteotoxicity

Sorrentino, V., Romani, M., Mouchiroud, L., Beck, J. S., Zhang, H., D’Amico, D., Moullan, N., Potenza, F., Schmid, A. W., Rietsch, S., et al. (2017) · Nature

Alzheimer's disease research and treatmentsMitochondrial Function and Pathology

Cited by 630

Repairing mitochondrial dysfunction in disease

Sorrentino, V., Menzies, K. J., & Auwerx, J. (2018) · Annual Review of Pharmacology and Toxicology

Mitochondrial Function and PathologyAutophagy in Disease and Therapy

Cited by 337

NAD + repletion improves muscle function in muscular dystrophy and counters global PARylation

Ryu, D., Zhang, H., Ropelle, E. R., Sorrentino, V., Mázala, D. A. G., Mouchiroud, L., Marshall, P. L., Campbell, M. D., Ali, A. S., Knowels, G. M., et al. (2016) · Science Translational Medicine

Sirtuins and Resveratrol in MedicineMuscle Physiology and Disorders

Cited by 256

PPARδ Promotes Running Endurance by Preserving Glucose

Fan, W., Waizenegger, W., Lin, C. S., Sorrentino, V., He, M.-X., Wall, C. E., Li, H., Liddle, C., Yu, R. T., Atkins, A. R., et al. (2017) · Cell Metabolism

Peroxisome Proliferator-Activated ReceptorsAdipose Tissue and Metabolism

Cited by 198

The RNA-Binding Protein PUM2 Impairs Mitochondrial Dynamics and Mitophagy During Aging

D’Amico, D., Mottis, A., Potenza, F., Sorrentino, V., Li, H., Romani, M., Lemos, V., Schoonjans, K., Zamboni, N., Knott, G., et al. (2019) · Molecular Cell

Genetics, Aging, and Longevity in Model OrganismsAutophagy in Disease and Therapy

Cited by 159

Trigonelline Is an NAD+ Precursor That Improves Muscle Function during Ageing and Is Reduced in Human Sarcopenia

Membrez, M., Migliavacca, E., Christen, S., Yaku, K., Trieu, J., Lee, A. K., Morandini, F., Giner, M. P., Stiner, J., Makarov, M. V., et al. (2024) · Nature Metabolism

Sirtuins and Resveratrol in MedicineNutrition and Health in Aging

Cited by 148

The E3 ubiquitin ligase IDOL induces the degradation of the low density lipoprotein receptor family members VLDLR and ApoER2

Hong, C., Duit, S., Jalonen, P., Out, R., Scheer, L., Sorrentino, V., Boyadjian, R., Rodenburg, K. W., Foley, E., Korhonen, L., et al. (2010) · Journal of Biological Chemistry

Cholesterol and Lipid MetabolismUbiquitin and proteasome pathways

Cited by 142

NAD+ boosting reduces age-associated amyloidosis and restores mitochondrial homeostasis in muscle

Romani, M., Sorrentino, V., Oh, C.-M., Li, H., de Lima, T. I., Zhang, H., Shong, M., & Auwerx, J. (2021) · Cell Reports

Sirtuins and Resveratrol in MedicineGenetics, Aging, and Longevity in Model Organisms

Cited by 92

The LXR-IDOL axis defines a clathrin-, caveolae-, and dynamin-independent endocytic route for LDLR internalization and lysosomal degradation

Sorrentino, V., Nelson, J. K., Maspero, E., Marques, A. R. A., Scheer, L., Polo, S., & Zelcer, N. (2013) · Journal of Lipid Research

Cholesterol and Lipid MetabolismCellular transport and secretion

Cited by 68

Distinct Functional Domains Contribute to Degradation of the Low Density Lipoprotein Receptor (LDLR) by the E3 Ubiquitin Ligase Inducible Degrader of the LDLR (IDOL)

Sorrentino, V., Scheer, L., Santos, A., Reits, E., Bleijlevens, B., & Zelcer, N. (2011) · Journal of Biological Chemistry

Cholesterol and Lipid MetabolismUbiquitin and proteasome pathways

Cited by 53

The Deubiquitylase USP2 Regulates the LDLR Pathway by Counteracting the E3-Ubiquitin Ligase IDOL

Nelson, J. K., Sorrentino, V., Avagliano Trezza, R., Heride, C., Urbe, S., Distel, B., & Zelcer, N. (2016) · Circulation Research

Ubiquitin and proteasome pathwaysCholesterol and Lipid Metabolism

Cited by 51

Identification of the (Pro)renin Receptor as a Novel Regulator of Low-Density Lipoprotein Metabolism

Lu, X., Meima, M. E., Nelson, J. K., Sorrentino, V., Loregger, A., Scheij, S., Dekkers, D. H. W., Mulder, M. T., Demmers, J. A. A., M-Dallinga-Thie, G., et al. (2016) · Circulation Research

Renin-Angiotensin System StudiesCholesterol and Lipid Metabolism

Cited by 48