The DOI matches its Crossref record; 99 of the 99 references it cites were found in a registry or an index.
Cardiac Sarcoplasmic Reticulum Calcium Leak: Basis and Roles in Cardiac Dysfunction
Abstract
Synchronized SR calcium (Ca) release is critical to normal cardiac myocyte excitation-contraction coupling, and ideally this release shuts off completely between heartbeats. However, other SR Ca release events are referred to collectively as SR Ca leak (which includes Ca sparks and waves as well as smaller events not detectable as Ca sparks). Much, but not all, of the SR Ca leak occurs via ryanodine receptors and can be exacerbated in pathological states such as heart failure. The extent of SR Ca leak is important because it can (a) reduce SR Ca available for release, causing systolic dysfunction; (b) elevate diastolic [Ca]i, contributing to diastolic dysfunction; (c) cause triggered arrhythmias; and (d) be energetically costly because of extra ATP used to repump Ca. This review addresses quantitative aspects and manifestations of SR Ca leak and its measurement, and how leak is modulated by Ca, associated proteins, and posttranslational modifications in health and disease.
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Cites
Cardiac excitation–contraction coupling
Bers, D. M. (2002) · Nature · doi:10.1038/415198a · Cited by 4,744
Self-citationPKA Phosphorylation Dissociates FKBP12.6 from the Calcium Release Channel (Ryanodine Receptor)
Marx, S. O., Reiken, S., Hisamatsu, Y., Jayaraman, T., Burkhoff, D., Rosemblit, N., & Marks, A. R. (2000) · Cell · doi:10.1016/s0092-8674(00)80847-8 · Cited by 1,978
Calcium Sparks: Elementary Events Underlying Excitation-Contraction Coupling in Heart Muscle
Cheng, H., Lederer, W. J., & Cannell, M. B. (1993) · Science · doi:10.1126/science.8235594 · Cited by 1,935
Excitation-Contraction Coupling and Cardiac Contractile Force
Bers, D. M. (2001) · Developments in Cardiovascular Medicine · doi:10.1007/978-94-010-0658-3 · Cited by 1,548
Self-citationA Dynamic Pathway for Calcium-Independent Activation of CaMKII by Methionine Oxidation
Erickson, J. R., Joiner, M.-L. A., Guan, X., Kutschke, W., Yang, J., Oddis, C. V., Bartlett, R. K., Lowe, J. S., O'Donnell, S. E., Aykin-Burns, N., et al. (2008) · Cell · doi:10.1016/j.cell.2008.02.048 · Cited by 1,122
Ryanodine Receptor/Ca2+ Release Channels and Their Regulation by Endogenous Effectors
Meissner, G. (1994) · Annual Review of Physiology · doi:10.1146/annurev.ph.56.030194.002413 · Cited by 928
Excitation-Contraction Coupling and Cardiac Contractile Force
Bers, D. M. (1993) · Developments in Cardiovascular Medicine · doi:10.1007/978-94-017-1512-6 · Cited by 772
Self-citationPogwizd, S. M., Schlotthauer, K., Li, L., Yuan, W., & Bers, D. M. (2001) · Circulation Research · doi:10.1161/hh1101.091193 · Cited by 758
Self-citationAi, X., Curran, J. W., Shannon, T. R., Bers, D. M., & Pogwizd, S. M. (2005) · Circulation Research · doi:10.1161/01.res.0000194329.41863.89 · Cited by 697
Self-citationRelaxation in rabbit and rat cardiac cells: species-dependent differences in cellular mechanisms
Bassani, J. W., Bassani, R. A., & Bers, D. M. (1994) · The Journal of Physiology · doi:10.1113/jphysiol.1994.sp020130 · Cited by 662
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Cited by
Calcium and Excitation-Contraction Coupling in the Heart
Eisner, D. A., Caldwell, J. L., Kistamás, K., & Trafford, A. W. (2017) · Circulation Research · doi:10.1161/circresaha.117.310230 · Cited by 866
Tham, Y. K., Bernardo, B. C., Ooi, J. Y. Y., Weeks, K. L., & McMullen, J. R. (2015) · Archives of Toxicology · doi:10.1007/s00204-015-1477-x · Cited by 708
Brundel, B. J. J. M., Ai, X., Hills, M. T., Kuipers, M. F., Lip, G. Y. H., & de Groot, N. M. S. (2022) · Nature Reviews Disease Primers · doi:10.1038/s41572-022-00347-9 · Cited by 499
The mechanosensitive Piezo1 channel mediates heart mechano-chemo transduction
Jiang, F., Yin, K., Wu, K., Zhang, M., Wang, S., Cheng, H., Zhou, Z., & Xiao, B. (2021) · Nature Communications · doi:10.1038/s41467-021-21178-4 · Cited by 283
Activation of PDGF pathway links LMNA mutation to dilated cardiomyopathy
Lee, J., Termglinchan, V., Diecke, S., Itzhaki, I., Lam, C. K., Garg, P., Lau, E., Greenhaw, M., Seeger, T., Wu, H., et al. (2019) · Nature · doi:10.1038/s41586-019-1406-x · Cited by 222
Metadata
- Authors
- Bers, D. M.
- Venue
- Annual Review of Physiology
- Publisher
- Annual Reviews
- Published
- 2014-02-10
- Volume
- 76
- Issue
- 1
- Pages
- 107-127
- ISSN
- 0066-4278 (ISSN-L)
- 1545-1585
- OpenAlex
- W2145563296
- Cited by
- 329
- References
- 99
- FWCI
- 0.97
- Type
- journal article
- Language
- en
- Open access
- closed
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- Bers, D. M. (2014). Cardiac Sarcoplasmic Reticulum Calcium Leak: Basis and Roles in Cardiac Dysfunction. Annual Review of Physiology. https://doi.org/10.1146/annurev-physiol-020911-153308
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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