The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Cilia Dysfunction in Lung Disease
Open accessAbstract
A characteristic feature of the human airway epithelium is the presence of ciliated cells bearing motile cilia, specialized cell surface projections containing axonemes composed of microtubules and dynein arms, which provide ATP-driven motility. In the airways, cilia function in concert with airway mucus to mediate the critical function of mucociliary clearance, cleansing the airways of inhaled particles and pathogens. The prototypical disorder of respiratory cilia is primary ciliary dyskinesia, an inherited disorder that leads to impaired mucociliary clearance, to repeated chest infections, and to the progressive destruction of lung architecture. Numerous acquired lung diseases are also marked by abnormalities in both cilia structure and function. In this review we summarize current knowledge regarding airway ciliated cells and cilia, how they function to maintain a healthy epithelium, and how disorders of cilia structure and function contribute to inherited and acquired lung disease.
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Cites
Identification of the Cystic Fibrosis Gene: Cloning and Characterization of Complementary DNA
Riordan, J. R., Rommens, J. M., Kerem, B.-S., Alon, N., Rozmahel, R., Grzelczak, Z., Zielenski, J., Lok, S., Plavsic, N., Chou, J.-L., et al. (1989) · Science · doi:10.1126/science.2475911 · Cited by 7,418
A CFTR Potentiator in Patients with Cystic Fibrosis and the G551D Mutation
Ramsey, B. W., Davies, J., McElvaney, N. G., Tullis, E., Bell, S. C., Dřevínek, P., Griese, M., McKone, E. F., Wainwright, C. E., Konstan, M. W., et al. (2011) · New England Journal of Medicine · doi:10.1056/nejmoa1105185 · Cited by 2,195
Mucus clearance as a primary innate defense mechanism for mammalian airways
Knowles, M. R., & Boucher, R. C. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0215217 · Cited by 1,054
Functional interaction between autophagy and ciliogenesis
Pampliega, O., Orhon, I., Patel, B., Sridhar, S., Díaz-Carretero, A., Beau, I., Codogno, P., Satir, B. H., Satir, P., & Cuervo, A. M. (2013) · Nature · doi:10.1038/nature12639 · Cited by 424
HO, J. C., CHAN, K. N., HU, W. H., LAM, W. K., ZHENG, L., TIPOE, G. L., SUN, J., LEUNG, R., & TSANG, K. W. (2001) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.163.4.9909121 · Cited by 324
Histone deacetylase 6–mediated selective autophagy regulates COPD-associated cilia dysfunction
Lam, H. C., Cloonan, S. M., Bhashyam, A. R., Haspel, J. A., Singh, A., Sathirapongsasuti, J. F., Cervo, M., Yao, H., Chung, A. L., Mizumura, K., et al. (2013) · Journal of Clinical Investigation · doi:10.1172/jci69636 · Cited by 307
Long-term clearance from small airways decreases with age
Svartengren, M., Falk, R., & Philipson, K. (2005) · European Respiratory Journal · doi:10.1183/09031936.05.00002105 · Cited by 144
Cited by
The complexity of the cilium: spatiotemporal diversity of an ancient organelle
Heydeck, W., Fievet, L., Davis, E. E., & Katsanis, N. (2018) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2018.08.001 · Cited by 25
Morphologically intact airways in lung fibrosis have an abnormal proteome
Herrera, J. A., Dingle, L. A., Monetero, M. A., Venkateswaran, R. V., Blaikley, J. F., Granato, F., Pearson, S., Lawless, C., & Thornton, D. J. (2023) · Respiratory Research · doi:10.1186/s12931-023-02400-x · Cited by 12
Metadata
- Authors
- Tilley, A. E., Walters, M. S., Shaykhiev, R., & Crystal, R. G.
- Venue
- Annual Review of Physiology
- Publisher
- Annual Reviews
- Published
- 2015-02-10
- Volume
- 77
- Issue
- 1
- Pages
- 379-406
- ISSN
- 0066-4278 (ISSN-L)
- 1545-1585
- OpenAlex
- W2128807576
- Cited by
- 436
- References
- 7
- FWCI
- 2.71
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Tilley, A. E., Walters, M. S., Shaykhiev, R., & Crystal, R. G. (2015). Cilia Dysfunction in Lung Disease. Annual Review of Physiology. https://doi.org/10.1146/annurev-physiol-021014-071931
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
