Cited by 352Circadian rhythm and melatoninNuclear Receptors and SignalingPeroxisome Proliferator-Activated Receptors

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Mammalian Per-Arnt-Sim Proteins in Environmental Adaptation

McIntosh, Brian E., Hogenesch, John B., Bradfield, Christopher A.·2010·Annual Review of Physiology

DOI 10.1146/annurev-physiol-021909-135922

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Abstract

The Per-Arnt-Sim (PAS) domain is conserved across the kingdoms of life and found in an ever-growing list of proteins. This domain can bind to and sense endogenous or xenobiotic small molecules such as molecular oxygen, cellular metabolites, or polyaromatic hydrocarbons. Members of this family are often found in pathways that regulate responses to environmental change; in mammals these include the hypoxia, circadian, and dioxin response pathways. These pathways function in development and throughout life to regulate cellular, organ, and whole-organism adaptive responses. Remarkably, in the case of the clock, this adaptation includes anticipation of environmental change. In this review, we summarize the roles of PAS domain-containing proteins in mammals. We provide structural evidence that functionally classifies both known and unknown biological roles. Finally, we discuss the role of PAS proteins in anticipation of and adaptation to environmental change.

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“Notably, ARNT is now known to dimerize with HIFs, and through these interactions are essential in biological processes including the hypoxia response, glucose metabolism, blood cell development, and angiogenesis (Gradin et al. 1996; McIntosh et al. 2010).”
BackgroundSelf-citation

Authors: McIntosh, B. E., Hogenesch, J. B., & Bradfield, C. A.
Affiliations: University of Wisconsin–Madison (US)
University of Pennsylvania (US)
ORCID: McIntosh, Brian E.
Hogenesch, John B.
Bradfield, Christopher A.
Venue: Annual Review of Physiology
Publisher: Annual Reviews
Published: 2010-03-17
Volume: 72
Issue: 1
Pages: 625-645
ISSN: 0066-4278 (ISSN-L)
1545-1585
DOI: 10.1146/annurev-physiol-021909-135922
OpenAlex: W2143654291
Cited by: 352
References: 233
Citations by year: 2026: 4 · 2025: 13 · 2024: 24 · 2023: 21 · 2022: 26 · 2021: 30 · 2020: 18 · 2019: 14 · 2018: 15 · 2017: 14 · 2016: 28 · 2015: 18 · 2014: 25 · 2013: 36 · 2012: 32
FWCI: 3.23
Type: journal article
Language: en
Open access: closed
Locations: Annual Review of Physiology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Environmental Health Sciences (R37ES005703)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Receptors and Signaling
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
Keywords: environmental adaptation, hypoxia response, circadian clock, metabolite sensing, polycyclic aromatic hydrocarbons, protein structure, mammalian physiology
MeSH terms: Adaptation, Physiological, Amino Acid Sequence, Animals, Hypoxia, Circadian Rhythm, Dioxins, Environment, Humans, Mammals, Terminology as Topic, Polycyclic Aromatic Hydrocarbons, Signal Transduction, Aryl Hydrocarbon Receptor Nuclear Translocator, Basic Helix-Loop-Helix Proteins, Basic Helix-Loop-Helix Transcription Factors, Period Circadian Proteins

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Mammalian Per-Arnt-Sim Proteins in Environmental Adaptation

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