The DOI matches its Crossref record; 147 of the 147 references it cites were found in a registry or an index.
The ABCs of Sterol Transport
Abstract
Cholesterol homeostasis and trafficking are critical to the maintenance of the asymmetric plasma membrane of eukaryotic cells. Disruption or dysfunction of cholesterol trafficking leads to numerous human diseases. ATP-binding cassette (ABC) transporters play several critical roles in this process, and mutations in these sterol transporters lead to disorders such as Tangier disease and sitosterolemia. Biochemical and structural information on ABC sterol transporters is beginning to emerge, with published structures of ABCA1 and ABCG5/G8; these two proteins function in the reverse cholesterol transport pathway and mediate the efflux of cholesterol and xenosterols to high-density lipoprotein and bile salt micelles, respectively. Although both of these transporters belong to the ABC family and mediate the efflux of a sterol substrate, they have many distinct differences. Here, we summarize the current understanding of sterol transport driven by ABC transporters, with an emphasis on these two extensively characterized transporters.
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“ABCA1 is instrumental in this process, as it mediates the efflux of cholesterol and phospholipids to apolipoprotein A-I (ApoA-I) and apolipoprotein E (ApoE), culminating in the formation of nascent high-density lipoprotein (HDL) [21, 22].”
From miR-223 accelerates lipid droplets clearance in microglia following spinal cord injury by upregulating ABCA1 (2024) · cites this paper as [22]
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Cites
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The Enzymes, Regulation, and Genetics of Bile Acid Synthesis
Russell, D. W. (2003) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.72.121801.161712 · Cited by 2,069
Understanding the diversity of membrane lipid composition
Harayama, T., & Riezman, H. (2018) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2017.138 · Cited by 2,046
Mechanisms and regulation of cholesterol homeostasis
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Model Systems, Lipid Rafts, and Cell Membranes
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Cited by
Pathways and Mechanisms of Cellular Cholesterol Efflux—Insight From Imaging
Juhl, A. D., & Wüstner, D. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.834408 · Cited by 57
Ou, Z., Cheng, Y., Ma, H., Chen, K., Lin, Q., Chen, J., Guo, R., Huang, Z., Cheng, Q., Alaeiilkhchi, N., et al. (2024) · Journal of Translational Medicine · doi:10.1186/s12967-024-05480-5 · Cited by 23
Chen, Q., Wang, S., Bao, R., Wang, D., Wu, Y., Zhang, Y., Liu, M., & Wang, T. (2024) · Chinese Medicine · doi:10.1186/s13020-023-00876-9 · Cited by 16
Metadata
- Authors
- Plummer, A. M., Culbertson, A. T., & Liao, M.
- Affiliations
- Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA;
- Venue
- Annual Review of Physiology
- Publisher
- Annual Reviews
- Published
- 2021-02-10
- Volume
- 83
- Issue
- 1
- Pages
- 153-181
- ISSN
- 0066-4278
- 1545-1585
- Cited by
- 60
- References
- 147
- Language
- en
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- Plummer, A. M., Culbertson, A. T., & Liao, M. (2021). The ABCs of Sterol Transport. Annual Review of Physiology. https://doi.org/10.1146/annurev-physiol-031620-094944
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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