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The ABCs of Sterol Transport

Plummer, Ashlee M., Culbertson, Alan T., Liao, Maofu·2021·Annual Review of Physiology

DOI 10.1146/annurev-physiol-031620-094944

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Abstract

Cholesterol homeostasis and trafficking are critical to the maintenance of the asymmetric plasma membrane of eukaryotic cells. Disruption or dysfunction of cholesterol trafficking leads to numerous human diseases. ATP-binding cassette (ABC) transporters play several critical roles in this process, and mutations in these sterol transporters lead to disorders such as Tangier disease and sitosterolemia. Biochemical and structural information on ABC sterol transporters is beginning to emerge, with published structures of ABCA1 and ABCG5/G8; these two proteins function in the reverse cholesterol transport pathway and mediate the efflux of cholesterol and xenosterols to high-density lipoprotein and bile salt micelles, respectively. Although both of these transporters belong to the ABC family and mediate the efflux of a sterol substrate, they have many distinct differences. Here, we summarize the current understanding of sterol transport driven by ABC transporters, with an emphasis on these two extensively characterized transporters.

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See all 60

Authors: Plummer, A. M., Culbertson, A. T., & Liao, M.
Affiliations: Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA;
Venue: Annual Review of Physiology
Publisher: Annual Reviews
Published: 2021-02-10
Volume: 83
Issue: 1
Pages: 153-181
ISSN: 0066-4278
1545-1585
DOI: 10.1146/annurev-physiol-031620-094944
Cited by: 60
References: 147
Language: en

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The ABCs of Sterol Transport

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