The DOI matches its Crossref record; 53 of the 53 references it cites were found in a registry or an index.
Early Intervention to Reduce the Global Health and Economic Burden of Major Depression in Older Adults
Open accessAbstract
Randomized trials for selective and indicated prevention of depression in both mixed-aged and older adult samples, conducted in high-income countries (HICs), show that rates of incident depression can be reduced by 20–25% over 1–2 years through the use of psychoeducational and psychological interventions designed to increase protective factors. Recurrence of major depression can also be substantially reduced through both psychological and psychopharmacological strategies. Additional research is needed, however, to address the specific issues of depression prevention in older adults in low- and middle-income countries (LMICs). The growing number of older adults globally, as well as workforce issues and the expense of interventions, makes it important to develop rational, targeted, and cost-effective risk-reduction strategies. In our opinion, one strategy to address these issues entails the use of lay health counselors (LHCs), a form of task shifting already shown to be effective in the treatment of common mental disorders in LMICs. We suggest in this review that the time is right for research into the translation of depression-prevention strategies for use in LMICs.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“The lifetime suicide rate is 25 times greater in major depression than in the general population, with highest rates amongst older adults196, 197, 198.”
From Mental health care for older adults: recent advances and new directions in clinical practice and research (2022) · cites this paper as [196]
In the citing paper
“This condition presents increasing public health challenges to both high‐income and low‐ and middle‐income countries, reflecting demographic shifts to older populations and scarcity of treatment resources195, 196.”
From Mental health care for older adults: recent advances and new directions in clinical practice and research (2022) · cites this paper as [196]
In the citing paper
“In essence, the global public health and clinical burden of depression in old age has three dimensions: it is a mirror of brain aging, a mediator of bad outcomes, and a murderer that leads to dementia and to suicide. It is also an unwanted co‐traveler with the ills of aging: cancer, cardiovascular disease, and neurodegenerative disorders195, 196, 197.”
From Mental health care for older adults: recent advances and new directions in clinical practice and research (2022) · cites this paper as [196]
In the citing paper
“Major depression can be prevented across the life cycle196, 208.”
From Mental health care for older adults: recent advances and new directions in clinical practice and research (2022) · cites this paper as [196]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Developing and evaluating complex interventions: the new Medical Research Council guidance
Craig, P., Dieppe, P., Macintyre, S., Michie, S., Nazareth, I., & Petticrew, M. (2008) · BMJ · doi:10.1136/bmj.a1655 · Cited by 10,995
Depression, chronic diseases, and decrements in health: results from the World Health Surveys
Moussavi, S., Chatterji, S., Verdes, E., Tandon, A., Patel, V., & Ustun, B. (2007) · The Lancet · doi:10.1016/s0140-6736(07)61415-9 · Cited by 4,070
Self-citationEpidemiologic study of sleep disturbances and psychiatric disorders. An opportunity for prevention?
Ford, D. E. (1989) · JAMA · doi:10.1001/jama.262.11.1479 · Cited by 2,440
Epidemiologic Study of Sleep Disturbances and Psychiatric Disorders: An Opportunity for Prevention?
Ford, D. E. (1989) · JAMA · doi:10.1001/jama.1989.03430110069030 · Cited by 2,252
Reducing Risks for Mental Disorders: Frontiers for Preventive Intervention Research
(1994) · doi:10.17226/2139 · Cited by 2,073
(2009) · Cited by 2,013
Antidepressant Drug Effects and Depression Severity: A Patient-Level Meta-analysis
Fournier, J. C., DeRubeis, R. J., Hollon, S. D., Dimidjian, S., Amsterdam, J. D., Shelton, R. C., & Fawcett, J. (2010) · JAMA · doi:10.1001/jama.2009.1943 · Cited by 2,009
Reducing Risks for Mental Disorders: Frontiers for Preventive Intervention Research
Novins, D. K. (1995) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-199503000-00028 · Cited by 1,085
Bruce, M. L., Ten Have, T. R., Reynolds III, C. F., Katz, I. I., Schulberg, H. C., Mulsant, B. H., Brown, G. K., McAvay, G. J., Pearson, J. L., & Alexopoulos, G. S. (2004) · JAMA · doi:10.1001/jama.291.9.1081 · Cited by 963
Meta‐Analysis of Psychosocial Interventions for Caregivers of People with Dementia
Brodaty, H., Green, A., & Koschera, A. (2003) · Journal of the American Geriatrics Society · doi:10.1034/j.1600-0579.2003.00210.x · Cited by 952
Research works printed but not linked: 1
- Natl. Inst. Ment. Health, 2008, National Institute of Mental Health Strategic Plan, 15
Cited by
Sorted by citations
Diniz, B. S., Butters, M. A., Albert, S. M., Dew, M. A., & Reynolds, C. F. (2013) · British Journal of Psychiatry · doi:10.1192/bjp.bp.112.118307 · Cited by 1,290
Self-citationReynolds, C. F., Jeste, D. V., Sachdev, P. S., & Blazer, D. G. (2022) · World Psychiatry · doi:10.1002/wps.20996 · Cited by 465
Self-citationDepression Among Older Adults: A 20-Year Update on Five Common Myths and Misconceptions
Haigh, E. A. P., Bogucki, O. E., Sigmon, S. T., & Blazer, D. G. (2017) · American Journal of Geriatric Psychiatry · doi:10.1016/j.jagp.2017.06.011 · Cited by 345
Okereke, O. I., Reynolds, C. F., Mischoulon, D., Chang, G., Vyas, C. M., Cook, N. R., Weinberg, A., Bubes, V., Copeland, T., Friedenberg, G., et al. (2020) · JAMA · doi:10.1001/jama.2020.10224 · Cited by 171
Self-citationDepression and associated factors in older adults in South Africa
Peltzer, K., & Phaswana-Mafuya, N. R. (2013) · Global Health Action · doi:10.3402/gha.v6i0.18871 · Cited by 169
Metadata
- Authors
- Reynolds, C. F., Cuijpers, P., Patel, V., Cohen, A., Dias, A., Chowdhary, N., Okereke, O. I., Amanda Dew, M., Anderson, S. J., Mazumdar, S., Lotrich, F., & Albert, S. M.
- Affiliations
- University of Pittsburgh (US)
- Vrije Universiteit Amsterdam (NL)
- London School of Hygiene & Tropical Medicine (GB)
- Goa Medical College (IN)
- Brigham and Women's Hospital (US)
- School of Medicine,
- ORCID
- Venue
- Annual Review of Public Health
- Publisher
- Annual Reviews
- Published
- 2012-04-21
- Volume
- 33
- Issue
- 1
- Pages
- 123-135
- ISSN
- 0163-7525 (ISSN-L)
- 1545-2093
- PMC
- PMC3356692
- OpenAlex
- W2171413723
- Cited by
- 163
- References
- 53
- Citations by year
- 2026: 9 · 2025: 17 · 2024: 11 · 2023: 9 · 2022: 16 · 2021: 13 · 2020: 10 · 2019: 9 · 2018: 13 · 2017: 8 · 2016: 12 · 2015: 12 · 2014: 10 · 2013: 13 · 2012: 1
- FWCI
- 1.63
- Type
- journal article
- Language
- en
- Open access
- green
- research.vu.nl
- Licence
- other-oa
- Locations
- Annual Review of Public Health (publishedVersion)
- PubMed (publishedVersion)
- VU Research Portal (publishedVersion, other-oa)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Digital Academic REpository of VU University Amsterdam (Vrije Universiteit Amsterdam) (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
- Funders
- University of Pittsburgh (P30 MH090333)
- Wellcome Trust (091834)
- National Institutes of Health (UL1TR000005, MH091448)
- Medical Center, University of Pittsburgh
- National Institute on Aging (P30AG024827)
- National Institute of Mental Health (P30MH090333, R01MH091448, R01MH083660)
- National Center for Research Resources (UL1RR024153)
- National Center for Advancing Translational Sciences
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Mental Health Treatment and Access
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Aging, Health, and Disability
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Keywords
- major depressive disorder, older adults, depression prevention, early intervention, task shifting, low- and middle-income countries, protective factors, recurrence prevention, psychopharmacological treatment, cost-effectiveness, global health burden, economic burden
- MeSH terms
- Aged, Antidepressive Agents, Community Health Workers, Major Depressive Disorder, Developing Countries, Humans, Mental Health Services, Preventive Health Services, Primary Prevention, Public Health, Global Health, Cost of Illness, Risk Assessment, Developed Countries, Early Medical Intervention
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
