Cited by 163Mental Health Treatment and AccessAging, Health, and DisabilityAnxiety, Depression, Psychometrics, Treatment, Cognitive Processes

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Early Intervention to Reduce the Global Health and Economic Burden of Major Depression in Older Adults

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Reynolds, Charles F., Cuijpers, Pim, Patel, Vikram, Cohen, Alex, Dias, Amit, Chowdhary, Neerja, Okereke, Olivia I., Amanda Dew, Mary, Anderson, Stewart J., Mazumdar, Sati, Lotrich, Frank, Albert, Steven M.·2012·Annual Review of Public Health

DOI 10.1146/annurev-publhealth-031811-124544PMC PMC3356692

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Abstract

Randomized trials for selective and indicated prevention of depression in both mixed-aged and older adult samples, conducted in high-income countries (HICs), show that rates of incident depression can be reduced by 20–25% over 1–2 years through the use of psychoeducational and psychological interventions designed to increase protective factors. Recurrence of major depression can also be substantially reduced through both psychological and psychopharmacological strategies. Additional research is needed, however, to address the specific issues of depression prevention in older adults in low- and middle-income countries (LMICs). The growing number of older adults globally, as well as workforce issues and the expense of interventions, makes it important to develop rational, targeted, and cost-effective risk-reduction strategies. In our opinion, one strategy to address these issues entails the use of lay health counselors (LHCs), a form of task shifting already shown to be effective in the treatment of common mental disorders in LMICs. We suggest in this review that the time is right for research into the translation of depression-prevention strategies for use in LMICs.

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Self-citation

Authors: Reynolds, C. F., Cuijpers, P., Patel, V., Cohen, A., Dias, A., Chowdhary, N., Okereke, O. I., Amanda Dew, M., Anderson, S. J., Mazumdar, S., Lotrich, F., & Albert, S. M.
Affiliations: University of Pittsburgh (US)
Vrije Universiteit Amsterdam (NL)
London School of Hygiene & Tropical Medicine (GB)
Goa Medical College (IN)
Brigham and Women's Hospital (US)
School of Medicine,
ORCID: Reynolds, Charles F.
Cuijpers, Pim
Patel, Vikram
Cohen, Alex
Dias, Amit
Chowdhary, Neerja
Okereke, Olivia I.
Anderson, Stewart J.
Albert, Steven M.
Venue: Annual Review of Public Health
Publisher: Annual Reviews
Published: 2012-04-21
Volume: 33
Issue: 1
Pages: 123-135
ISSN: 0163-7525 (ISSN-L)
1545-2093
DOI: 10.1146/annurev-publhealth-031811-124544
PMC: PMC3356692
OpenAlex: W2171413723
Cited by: 163
References: 53
Citations by year: 2026: 9 · 2025: 17 · 2024: 11 · 2023: 9 · 2022: 16 · 2021: 13 · 2020: 10 · 2019: 9 · 2018: 13 · 2017: 8 · 2016: 12 · 2015: 12 · 2014: 10 · 2013: 13 · 2012: 1
FWCI: 1.63
Type: journal article
Language: en
Open access: green
research.vu.nl
Licence: other-oa
Locations: Annual Review of Public Health (publishedVersion)
PubMed (publishedVersion)
VU Research Portal (publishedVersion, other-oa)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Digital Academic REpository of VU University Amsterdam (Vrije Universiteit Amsterdam) (submittedVersion)
Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
Funders: University of Pittsburgh (P30 MH090333)
Wellcome Trust (091834)
National Institutes of Health (UL1TR000005, MH091448)
Medical Center, University of Pittsburgh
National Institute on Aging (P30AG024827)
National Institute of Mental Health (P30MH090333, R01MH091448, R01MH083660)
National Center for Research Resources (UL1RR024153)
National Center for Advancing Translational Sciences
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Mental Health Treatment and Access
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Aging, Health, and Disability
Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Keywords: major depressive disorder, older adults, depression prevention, early intervention, task shifting, low- and middle-income countries, protective factors, recurrence prevention, psychopharmacological treatment, cost-effectiveness, global health burden, economic burden
MeSH terms: Aged, Antidepressive Agents, Community Health Workers, Major Depressive Disorder, Developing Countries, Humans, Mental Health Services, Preventive Health Services, Primary Prevention, Public Health, Global Health, Cost of Illness, Risk Assessment, Developed Countries, Early Medical Intervention

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Early Intervention to Reduce the Global Health and Economic Burden of Major Depression in Older Adults

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