Late-life depression and risk of vascular dementia and Alzheimer's disease: systematic review and meta-analysis of community-based cohort studies
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Background: Late-life depression may increase the risk of incident dementia, in particular of Alzheimer's disease and vascular dementia. Aims: To conduct a systematic review and meta-analysis to evaluate the risk of incident all-cause dementia, Alzheimer's disease and vascular dementia in individuals with late-life depression in population-based prospective studies. Method: A total of 23 studies were included in the meta-analysis. We used the generic inverse variance method with a random-effects model to calculate the pooled risk of dementia, Alzheimer's disease and vascular dementia in older adults with late-life depression. Results: Late-life depression was associated with a significant risk of all-cause dementia (1.85, 95% CI 1.67-2.04, P< 0.001), Alzheimer's disease (1.65, 95% CI 1.42-1.92, P<0.001) and vascular dementia (2.52, 95% CI 1.77-3.59, P<0.001). Subgroup analysis, based on five studies, showed that the risk of vascular dementia was significantly higher than for Alzheimer's disease (P=0.03). Conclusions: Late-life depression is associated with an increased risk for all-cause dementia, vascular dementia and Alzheimer's disease. The present results suggest that it will be valuable to design clinical trials to investigate the effect of late-life depression prevention on risk of dementia, in particular vascular dementia and Alzheimer's disease.
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Insomnia may partially mediate depression risk for Alzheimer's and related dementias via beta-amyloid accumulation, tau protein aggregation, inflammation and blood-brain-barrier disruption.
“Insomnia may partially mediate depression risk for Alzheimer's and related dementias via beta‐amyloid accumulation, tau protein aggregation, inflammation and blood‐brain‐barrier disruption204, 205, 206.”
From Mental health care for older adults: recent advances and new directions in clinical practice and research (2022) · cites this paper as [205]
Data-driven proteomic analyses have revealed several biological pathways and molecular functions associated with cognitive impairment in late-life major depression, related to neuro-inflammatory control, neurotrophic support, cell survival/apoptosis, endothelial function, and lipid/protein metabolism.
“Data‐driven proteomic analyses have revealed several biological pathways and molecular functions associated with cognitive impairment in late‐life major depression, related to neuro‐inflammatory control, neurotrophic support, cell survival/apoptosis, endothelial function, and lipid/protein metabolism204, 205, 206.”
From Mental health care for older adults: recent advances and new directions in clinical practice and research (2022) · cites this paper as [205]
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- Authors
- Diniz, B. S., Butters, M. A., Albert, S. M., Dew, M. A., & Reynolds, C. F.
- Affiliations
- Universidade Federal de Minas Gerais (BR)
- University of Pittsburgh (US)
- Corresponding author
- Butters, Meryl A.
- Venue
- British Journal of Psychiatry
- Publisher
- Royal College of Psychiatrists
- Published
- 2013-05
- Volume
- 202
- Issue
- 5
- Pages
- 329-335
- ISSN
- 0007-1250 (ISSN-L)
- 1472-1465
- PMC
- PMC3640214
- OpenAlex
- W2142827889
- Cited by
- 1,290
- References
- 39
- Citations by year
- 2026: 80 · 2025: 93 · 2024: 108 · 2023: 115 · 2022: 123 · 2021: 125 · 2020: 132 · 2019: 101 · 2018: 82 · 2017: 102 · 2016: 90 · 2015: 74 · 2014: 55 · 2013: 7 · 2012: 1
- FWCI
- 10.02
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The British Journal of Psychiatry (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- John A. Hartford Foundation
- Hartford Foundation for Public Giving
- American Foundation for Suicide Prevention
- National Institutes of Health (UL1TR000005)
- National Institute on Aging (RR024153, P30AG024827)
- National Heart, Lung, and Blood Institute
- National Institute of Mental Health (R01MH072947, P30MH090333, MH 072947, R01MH080240, MH080240, MH090333)
- National Center for Research Resources (UL1RR024153)
- National Center for Advancing Translational Sciences
- National Institute on Minority Health and Health Disparities
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Social Sciences › Psychology › Social Psychology › Mental Health Treatment and Access
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Aging, Health, and Disability
- Keywords
- geriatric depression, vascular dementia, Alzheimer's disease, dementia risk, all-cause dementia, older adults, depression prevention
- MeSH terms
- Adolescent, Adult, Aged, Aged, 80 and over, Alzheimer Disease, Child, Depressive Disorder, Female, Humans, Male, Middle Aged, Risk Factors, Dementia, Vascular, Young Adult
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