THE BIOCHEMISTRY OF P-GLYCOPROTEIN-MEDIATED MULTIDRUG RESISTANCE
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The Hippo pathway was initially discovered in Drosophila melanogaster as a key regulator of tissue growth. It is an evolutionarily conserved signaling cascade regulating numerous biological processes, including cell growth and fate decision, organ size ...Read More
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P-glycoprotein efflux pumps can transport drugs back into the blood by ATP-dependent efflux.
“In addition, due to the presence of P-glycoprotein (referred to as multidrug resistance associated membrane protein), drugs could be transported back into the blood by ATP-dependent efflux pumps.8,9”
From The blood–brain barrier: Structure, regulation and drug delivery (2023) · cites this paper as [9]
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The blood–brain barrier: Structure, regulation and drug delivery
Wu, D., Chen, Q., Chen, X., Han, F., Chen, Z., & Wang, Y. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01481-w · Cited by 1,906 · see citing works
“8,9 Thus, it is urging to address the issue of brain-targeted therapeutics by developing effective and safe delivery strategies.”
BackgroundDeeley, R. G., Westlake, C., & Cole, S. P. C. (2006) · Physiological Reviews · doi:10.1152/physrev.00035.2005 · Cited by 761 · see citing works
Emran, T. B., Shahriar, A., Mahmud, A. R., Rahman, T., Abir, M. H., Siddiquee, M. F. R., Ahmed, H., Rahman, N., Nainu, F., Wahyudin, E., et al. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.891652 · Cited by 606 · see citing works
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Chen, W., Miao, Y.-Q., Fan, D.-J., Yang, S.-S., Lin, X., Meng, L.-K., & Tang, X. (2011) · AAPS PharmSciTech · doi:10.1208/s12249-011-9632-z · Cited by 363 · see citing works
Sahoo, S. K., & Labhasetwar, V. (2005) · Molecular Pharmaceutics · doi:10.1021/mp050032z · Cited by 340 · see citing works
Cytokine Signaling Modulates Blood-Brain Barrier Function
Pan, W., P. Stone, K., Hsuchou, H., K. Manda, V., Zhang, Y., & J. Kastin, A. (2011) · Current Pharmaceutical Design · doi:10.2174/138161211798220918 · Cited by 241 · see citing works
CNS Drug Delivery Systems: Novel Approaches
Pathan, S., Iqbal, Z., Zaidi, S., Talegaonkar, S., Vohra, D., Jain, G., Azeem, A., Jain, N., Lalani, J., Khar, R., et al. (2009) · Recent Patents on Drug Delivery & Formulation · doi:10.2174/187221109787158355 · Cited by 193 · see citing works
Chen, J., Feng, Y., Lu, L., Wang, H., Dai, L., Li, Y., & Zhang, P. (2012) · Immunobiology · doi:10.1016/j.imbio.2011.10.016 · Cited by 164 · see citing works
The effects of cannabinoids on P-glycoprotein transport and expression in multidrug resistant cells
Holland, M. L., Panetta, J. A., Hoskins, J. M., Bebawy, M., Roufogalis, B. D., Allen, J. D., & Arnold, J. C. (2006) · Biochemical Pharmacology · doi:10.1016/j.bcp.2005.12.033 · Cited by 157 · see citing works
Reed, K., Hembruff, S. L., Sprowl, J. A., & Parissenti, A. M. (2010) · The Pharmacogenomics Journal · doi:10.1038/tpj.2010.1 · Cited by 56 · see citing works
- Authors
- Endicott, J. A., & Ling, V.
- Affiliations
- Princess Margaret Cancer Centre (CA)
- Venue
- Annual Review of Biochemistry
- Publisher
- Annual Reviews
- Published
- 1989-06
- Volume
- 58
- Issue
- 1
- Pages
- 137-171
- ISSN
- 0066-4154 (ISSN-L)
- 1545-4509
- OpenAlex
- W2097878215
- Cited by
- 2,071
- References
- 0
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 10 · 2023: 15 · 2022: 14 · 2021: 8 · 2020: 10 · 2019: 12 · 2018: 6 · 2017: 12 · 2016: 18 · 2015: 19 · 2014: 19 · 2013: 22 · 2012: 26
- FWCI
- 55.12
- Type
- journal article
- Language
- en
- Open access
- green
- doi.org
- Locations
- Annual Review of Biochemistry (publishedVersion)
- PubMed (publishedVersion)
- Newcastle University ePrints (Newcastle Univesity)
- Funders
- National Cancer Institute (CA 37130)
- Topics
- Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Antibiotic Resistance in Bacteria
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
- Keywords
- multidrug resistance, P-glycoprotein, ABC transporters, drug efflux, cancer chemotherapy resistance, efflux pumps
- MeSH terms
- Animals, Bacteria, Cell Line, Drug Resistance, Fungi, Multigene Family, Humans, Membrane Glycoproteins, Neoplasms, Protein Binding, ATP Binding Cassette Transporter, Subfamily B, Member 1
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