Global analyses of mRNA translational control during early Drosophila embryogenesis
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Background: In many animals, the first few hours of life proceed with little or no transcription, and developmental regulation at these early stages is dependent on maternal cytoplasm rather than the zygotic nucleus. Translational control is critical for early Drosophila embryogenesis and is exerted mainly at the gene level. To understand post-transcriptional regulation during Drosophila early embryonic development, we used sucrose polysomal gradient analyses and GeneChip analysis to illustrate the translation profile of individual mRNAs. Results: We determined ribosomal density and ribosomal occupancy of over 10,000 transcripts during the first ten hours after egg laying. Conclusion: We report the extent and general nature of gene regulation at the translational level during early Drosophila embryogenesis on a genome-wide basis. The diversity of the translation profiles indicates multiple mechanisms modulating transcript-specific translation. Cluster analyses suggest that the genes involved in some biological processes are co-regulated at the translational level at certain developmental stages.
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In early Drosophila embryo data sets measuring translation, stability, and localization, the authors obtained dozens of significant associations between the presence of motif matches and specific regulatory outcomes.
“we have examined data sets measuring translation40, stability41 and localization42 of transcripts in the early Drosophila embryo, obtaining dozens of significant associations between the presence of motif matches and specific regulatory outcomes”
From A compendium of RNA-binding motifs for decoding gene regulation (2013) · cites this paper as [40]
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- Authors
- Qin, X., Ahn, S., Speed, T. P., & Rubin, G. M.
- Affiliations
- Howard Hughes Medical Institute (US)
- University of California, Berkeley (US)
- Corresponding author
- Qin, Xiaoli
- Venue
- Genome Biology
- Published
- 2007-04-22
- Volume
- 8
- Issue
- 4
- Pages
- R63-R63
- ISSN
- 1465-6906 (ISSN-L)
- 1474-760X
- PMC
- PMC1896012
- OpenAlex
- W2168679249
- Cited by
- 86
- References
- 35
- Citations by year
- 2025: 4 · 2022: 3 · 2021: 4 · 2020: 3 · 2019: 4 · 2018: 4 · 2017: 3 · 2016: 8 · 2015: 4 · 2014: 7 · 2013: 7 · 2012: 8
- FWCI
- 2.92
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Genome biology (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Minerva Access (University of Melbourne) (submittedVersion, cc-by)
- Funders
- Howard Hughes Medical Institute
- National Institutes of Health
- U.S. National Library of Medicine (LM07609, R01LM007609)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- translational regulation, mRNA translation, Drosophila embryogenesis, post-transcriptional regulation, ribosome profiling, zygotic gene expression, early embryonic development
- MeSH terms
- Animals, Drosophila, Embryo, Nonmammalian, Polyribosomes, Ribosomes, RNA, Messenger, Protein Biosynthesis, Cluster Analysis, Gene Expression Regulation, Developmental, RNA 5' Terminal Oligopyrimidine Sequence, Embryonic Development
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