The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Conus Peptides Targeted to Specific Nicotinic Acetylcholine Receptor Subtypes
Abstract
▪ Abstract The venoms of predatory cone snails represent a rich combinatorial-like library of evolutionarily selected, neuropharmacologically active peptides. A major fraction of the venom components are conotoxins—small, disulfide-rich peptides that potently and specifically target components of the neuromuscular system, particularly ligand- and voltage-gated ion channels. This review focuses on Conus peptides, which act at nicotinic acetylcholine receptors. These nicotinic antagonist peptides from Conus are broadly divided into two groups: those that act at the neuromuscular junction and those that act at subtypes of neuronal nicotinic acetylcholine receptors. The latter include peptides specific for the α7, α3β2, and α3β4 nicotinic receptor subtypes. The degree of specificity exhibited by these peptides is remarkable, particularly given their relatively small size. As a group the nicotinic acetylcholine receptor-targeted Conus peptides represent an increasingly well-defined set of tools for probing the structure, function, and physiological role of nicotinic acetylcholine receptors.
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Citations
Cites
Presynaptic nicotinic ACh receptors
Wonnacott, S. (1997) · Trends in Neurosciences · doi:10.1016/s0166-2236(96)10073-4 · Cited by 1,308
Competition in Retinogeniculate Patterning Driven by Spontaneous Activity
Penn, A. A., Riquelme, P. A., Feller, M. B., & Shatz, C. J. (1998) · Science · doi:10.1126/science.279.5359.2108 · Cited by 514
Cited by
Mammalian nicotinic acetylcholine receptors: from structure to function
Albuquerque, E. X., Pereira, E. F. R., Alkondon, M., & Rogers, S. W. (2009) · Physiological Reviews · doi:10.1152/physrev.00015.2008 · Cited by 1,724
Discovery, Synthesis, and Structure–Activity Relationships of Conotoxins
Akondi, K. B., Muttenthaler, M., Dutertre, S., Kaas, Q., Craik, D. J., Lewis, R. J., & Alewood, P. F. (2014) · Chemical Reviews · doi:10.1021/cr400401e · Cited by 323
A rational nomenclature for naming peptide toxins from spiders and other venomous animals
King, G. F., Gentz, M. C., Escoubas, P., & Nicholson, G. M. (2008) · Toxicon · doi:10.1016/j.toxicon.2008.05.020 · Cited by 313
Celie, P. H. N., Kasheverov, I. E., Mordvintsev, D. Y., Hogg, R. C., van Nierop, P., van Elk, R., van Rossum-Fikkert, S. E., Zhmak, M. N., Bertrand, D., Tsetlin, V., et al. (2005) · Nature Structural & Molecular Biology · doi:10.1038/nsmb951 · Cited by 310
Neuronal nicotinic receptors: A perspective on two decades of drug discovery research
Arneric, S. P., Holladay, M., & Williams, M. (2007) · Biochemical Pharmacology · doi:10.1016/j.bcp.2007.06.033 · Cited by 208
Metadata
- Authors
- McIntosh, J. M., Santos, A. D., & Olivera, B. M.
- Venue
- Annual Review of Biochemistry
- Publisher
- Annual Reviews
- Published
- 1999-06
- Volume
- 68
- Issue
- 1
- Pages
- 59-88
- ISSN
- 0066-4154 (ISSN-L)
- 1545-4509
- OpenAlex
- W2139437087
- Cited by
- 295
- References
- 2
- FWCI
- 1.04
- Type
- journal article
- Language
- en
- Open access
- closed
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- McIntosh, J. M., Santos, A. D., & Olivera, B. M. (1999). Conus Peptides Targeted to Specific Nicotinic Acetylcholine Receptor Subtypes. Annual Review of Biochemistry. https://doi.org/10.1146/annurev.biochem.68.1.59
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