The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Fidelity of Aminoacyl-tRNA Selection on the Ribosome: Kinetic and Structural Mechanisms
Abstract
▪ Abstract The ribosome discriminates between correct and incorrect aminoacyl-tRNAs (aa-tRNAs), or their complexes with elongation factor Tu (EF-Tu) and GTP, according to the match between anticodon and mRNA codon in the A site. Selection takes place at two stages, prior to GTP hydrolysis (initial selection) and after GTP hydrolysis but before peptide bond formation (proofreading). In part, discrimination results from different rejection rates that are due to different stabilities of the respective codon-anticodon complexes. An important additional contribution is provided by induced fit, in that only correct codon recognition leads to acceleration of rate-limiting rearrangements that precede chemical steps. Recent elucidation of ribosome structures and mutational analyses suggest which residues of the decoding center may be involved in signaling formation of the correct codon-anticodon duplex to the functional centers of the ribosome. In utilizing induced fit for substrate discrimination, the ribosome resembles other nucleic acid–programmed polymerases.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Structure of the 30S ribosomal subunit
Wimberly, B. T., Brodersen, D. E., Clemons, W. M., Morgan-Warren, R. J., Carter, A. P., Vonrhein, C., Hartsch, T., & Ramakrishnan, V. (2000) · Nature · doi:10.1038/35030006 · Cited by 2,035
CONFORMATIONAL COUPLING IN DNA POLYMERASE FIDELITY
Johnson, K. A. (1993) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.62.070193.003345 · Cited by 560
The frequency of errors in protein biosynthesis
Loftfield, R. B., & Vanderjagt, D. (1972) · Biochemical Journal · doi:10.1042/bj1281353 · Cited by 399
A Single Adenosine with a Neutral p K a in the Ribosomal Peptidyl Transferase Center
Muth, G. W., Ortoleva-Donnelly, L., & Strobel, S. A. (2000) · Science · doi:10.1126/science.289.5481.947 · Cited by 242
Cited by
What recent ribosome structures have revealed about the mechanism of translation
Schmeing, T. M., & Ramakrishnan, V. (2009) · Nature · doi:10.1038/nature08403 · Cited by 699
Selection of tRNA by the Ribosome Requires a Transition from an Open to a Closed Form
Ogle, J. M., Murphy, F. V., Tarry, M. J., & Ramakrishnan, V. (2002) · Cell · doi:10.1016/s0092-8674(02)01086-3 · Cited by 663
tRNA’s Wobble Decoding of the Genome: 40 Years of Modification
Agris, P. F., Vendeix, F. A. P., & Graham, W. D. (2007) · Journal of Molecular Biology · doi:10.1016/j.jmb.2006.11.046 · Cited by 543
The Molecular Mechanics of Eukaryotic Translation
Kapp, L. D., & Lorsch, J. R. (2004) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.73.030403.080419 · Cited by 538
Determinants of translation efficiency and accuracy
Gingold, H., & Pilpel, Y. (2011) · Molecular Systems Biology · doi:10.1038/msb.2011.14 · Cited by 489
Metadata
- Authors
- Rodnina, M. V., & Wintermeyer, W.
- Venue
- Annual Review of Biochemistry
- Publisher
- Annual Reviews
- Published
- 2001-06
- Volume
- 70
- Issue
- 1
- Pages
- 415-435
- ISSN
- 0066-4154 (ISSN-L)
- 1545-4509
- OpenAlex
- W2169284526
- Cited by
- 336
- References
- 4
- FWCI
- 0.92
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Fidelity of Aminoacyl-tRNA Selection on the Ribosome: Kinetic and Structural Mechanisms. https://app.cochat.ai/papers/10.1146/annurev.biochem.70.1.415
- The paper
- Rodnina, M. V., & Wintermeyer, W. (2001). Fidelity of Aminoacyl-tRNA Selection on the Ribosome: Kinetic and Structural Mechanisms. Annual Review of Biochemistry. https://doi.org/10.1146/annurev.biochem.70.1.415
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
