Cited by 1,438Metalloenzymes and iron-sulfur proteinsEnzyme Structure and FunctionInorganic Chemistry and Materials

The DOI matches its Crossref record; 209 of the 209 references it cites were found in a registry or an index.

STRUCTURE, FUNCTION, AND FORMATION OF BIOLOGICAL IRON-SULFUR CLUSTERS

Johnson, Deborah C., Dean, Dennis R., Smith, Archer D., Johnson, Michael K.·2005·Annual Review of Biochemistry

DOI 10.1146/annurev.biochem.74.082803.133518

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Abstract

Iron-sulfur [Fe-S] clusters are ubiquitous and evolutionary ancient prosthetic groups that are required to sustain fundamental life processes. Owing to their remarkable structural plasticity and versatile chemical/electronic features [Fe-S] clusters participate in electron transfer, substrate binding/activation, iron/sulfur storage, regulation of gene expression, and enzyme activity. Formation of intracellular [Fe-S] clusters does not occur spontaneously but requires a complex biosynthetic machinery. Three different types of [Fe-S] cluster biosynthetic systems have been discovered, and all of them are mechanistically unified by the requirement for a cysteine desulfurase and the participation of an [Fe-S] cluster scaffolding protein. Important mechanistic questions related to [Fe-S] cluster biosynthesis involve the molecular details of how [Fe-S] clusters are assembled on scaffold proteins, how [Fe-S] clusters are transferred from scaffolds to target proteins, how various accessory proteins participate in [Fe-S] protein maturation, and how the biosynthetic process is regulated.

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10.1074/jbc.275.12.8283 · DOI
10.1074/jbc.M104067200 · DOI

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Metal Chelation Dynamically Regulates the Mechanical Properties of Engineered Protein Hydrogels
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Metabolomic analysis reveals dose-dependent alteration of maize (Zea mays L.) metabolites and mineral nutrient profiles upon exposure to zerovalent iron nanoparticles
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Identification and characterization of genes differentially expressed in X and Y sperm using suppression subtractive hybridization and cDNA microarray
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“Iron-sulfur clusters are ubiquitous and functionally versatile prosthetic groups, aremajor components of the respiratory chain, define electron transport pathways in numerous membrane-bound and redox enzymes, and constitute the redox-active centers of ferredoxins (Johnson et al., 2005; Lill and Muhlenhoff, 2008).”
Background
Ancestral roles of eukaryotic frataxin: mitochondrial frataxin function and heterologous expression of hydrogenosomal Trichomonas homologues in trypanosomes
Long, S., Jirků, M., Mach, J., Ginger, M. L., Šuťák, R., Richardson, D. R., Tachezy, J., & Lukeš, J. (2008) · Molecular Microbiology · doi:10.1111/j.1365-2958.2008.06260.x · Cited by 42
“However, bacteria often operate multiple functionally distinct systems for Fe–S cluster assembly, and some component proteins even appear to be required only for the maturation of dedicated targets (Takahashi and Tokumoto, 2002; Nachin et al., 2003; Johnson et al., 2005; Loiseau et al., 2007).”
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Molecular chaperones involved in mitochondrial iron–sulfur protein biogenesis
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A Redox Role for the [4Fe4S] Cluster of Yeast DNA Polymerase δ
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The CRISPR-associated Cas4 protein Pcal_0546 from Pyrobaculum calidifontis contains a [2Fe-2S] cluster: crystal structure and nuclease activity
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“coli is known to contain the biosynthetic pathways for both cluster types (37).”
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Protein Splicing of SufB Is Crucial for the Functionality of the Mycobacterium tuberculosis SUF Machinery
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“understood (2, 8), several studies brought to light its major role”
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Iron–sulfur proteins as initiators of radical chemistry
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There Is Treasure Everywhere: Reductive Plastid Evolution in Apicomplexa in Light of Their Close Relatives
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The Janus-Faced Role of Lipid Droplets in Aging: Insights from the Cellular Perspective
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IBA57 mutations abrogate iron-sulfur cluster assembly leading to cavitating leukoencephalopathy
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Accessory Proteins of the Nitrogenase Assembly, NifW, NifX/NafY, and NifZ, Are Essential for Diazotrophic Growth in the Nonheterocystous Cyanobacterium Leptolyngbya boryana
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“In the first stage, a sulfur atom is released from Cys by Cys desulfurase (NifS), and a precursor cluster is assembled on NifU (Johnson et al., 2005).”
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Iron–Sulfur Cluster Biogenesis and Iron Homeostasis in Cyanobacteria
Gao, F. (2020) · Frontiers in Microbiology · doi:10.3389/fmicb.2020.00165 · Cited by 43
Highly chemoselective turn-on fluorescent probe for ferrous (Fe2+) ion detection in cosmetics and live cells
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Turning Saccharomyces cerevisiae into a Frataxin-Independent Organism
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“Iron-sulfur cluster intermediates contain iron and sulfur bound to the Isu1 scaffold in a [Fe2S2] configuration [8].”
Background
Iron Insertion at the Assembly Site of the ISCU Scaffold Protein Is a Conserved Process Initiating Fe–S Cluster Biosynthesis
Srour, B., Gervason, S., Hoock, M. H., Monfort, B., Want, K., Larkem, D., Trabelsi, N., Landrot, G., Zitolo, A., Fonda, E., et al. (2022) · Journal of the American Chemical Society · doi:10.1021/jacs.2c06338 · Cited by 40
Methods for Studying Iron Metabolism in Yeast Mitochondria
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Genome-wide transcriptional response of an avian pathogenic Escherichia coli (APEC) pst mutant
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“Iron-sulfur cluster complexes play several important roles in cellular processes, such as iron storage, electron transfer and regulation of enzyme activity and gene expression [49].”
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Iron–sulfur repair YtfE protein from Escherichia coli: structural characterization of the di-iron center
Todorović, S., Justino, M. C., Wellenreuther, G., Hildebrandt, P., Murgida, D. H., Meyer‐Klaucke, W., & Saraiva, L. M. (2008) · JBIC Journal of Biological Inorganic Chemistry · doi:10.1007/s00775-008-0362-y · Cited by 40
Siderophore-controlled Iron Assimilation in the Enterobacterium Erwinia chrysanthemi
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Tryptophan-to-heme electron transfer in ferrous myoglobins
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“E transfer plays a fundamental role in many biological systems (1–3) ranging from photosynthetic proteins (4) to iron–sulfur (5), copper (6), and heme (7, 8) proteins.”
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Regulation of theHelicobacter pyloriFe-S Cluster Synthesis Protein NifS by Iron, Oxidative Stress Conditions, and Fur
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“NifS belongs to the crucial IscS family of proteins, which is involved in Fe-S cluster formation (12).”
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Critical Role of Dispensable Genes inMycoplasma agalactiaeInteraction with Mammalian Cells
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Escherichia coli FtnA acts as an iron buffer for re-assembly of iron–sulfur clusters in response to hydrogen peroxide stress
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“…which are highly conserved from bacteria J. P. Bitoun G. Wu H. Ding (&) Department of Biological Sciences, Louisiana State University, 202 Life Sciences Building, Baton Rouge, LA 70803, USA e-mail: hding@lsu.edu to humans (Johnson et al. 2005; Rouault and Tong 2005; Lill and Muhlenhoff 2006).”
Spectroscopic and Functional Characterization of Iron-Bound Forms of Azotobacter vinelandiiNifIscA
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“The bacterial homologue of frataxin, CyaY, is evolutionarily rather divergent from it; moreover, CyaY is not essential, because prokaryotes operate several functionally distinct Fe-S cluster assembly pathways (8, 9).”
Background
Stage‐specific requirement for Isa1 and Isa2 proteins in the mitochondrion of Trypanosoma brucei and heterologous rescue by human and Blastocystis orthologues
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“…underestimate because numerous other Fe-S clusterdependent functions are continuously being elucidated and more proteins than previously appreciated have been shown to possess the evolutionarily ancient Fe-S cofactors (Johnson et al., 2005; Lill and Mühlenhoff, 2005; Fontecave, 2006; Lill, 2009).”
Background
Identification of homocysteine-suppressive mitochondrial ETC complex genes and tissue expression profile – Novel hypothesis establishment
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A ratiometric near-infrared naphthalimide-based fluorescent probe with high sensitivity for detecting Fe2+ in vivo
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Rational Design of a Miniature Photocatalytic CO2-Reducing Enzyme
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Iron–Sulphur Clusters, Their Biosynthesis, and Biological Functions in Protozoan Parasites
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Structures of the Rare-Cutting Restriction Endonuclease NotI Reveal a Unique Metal Binding Fold Involved in DNA Binding
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“Such iron centers have been shown to be one-electron carriers, and Fe/S clusters are often found in components of electron transport chains, such as those found in photosynthesis and aerobic respiration ( Johnson et al., 2005 ).”
Background
Transcriptional response of Desulfovibrio vulgaris Hildenborough to oxidative stress mimicking environmental conditions
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“The observed up-regulation of the nifU and nifS genes, which are involved in the biosynthesis and repair of iron–sulfur clusters (Johnson et al. 2005) serves to counter this eVect.”
Background
A Novel Variant in CMAH Is Associated with Blood Type AB in Ragdoll Cats
Gandolfi, B., Grahn, R. A., Gustafson, N. A., Proverbio, D., Spada, E., Adhikari, B., Cheng, J., Andrews, G. A., Lyons, L. A., & Helps, C. R. (2016) · PLoS ONE · doi:10.1371/journal.pone.0154973 · Cited by 38
Sulfur Administration in Fe–S Cluster Homeostasis
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“The primary task of iron ions results from their ability to change their oxidation state from Fe2+ to Fe3+, contrary to sulfur that is also a part of clusters and is always present in S2− oxidation state [15,16].”
Background

Authors: Johnson, D. C., Dean, D. R., Smith, A. D., & Johnson, M. K.
Affiliations: Virginia Tech (US)
University of Georgia (US)
ORCID: Dean, Dennis R.
Venue: Annual Review of Biochemistry
Publisher: Annual Reviews
Published: 2005-06-01
Volume: 74
Issue: 1
Pages: 247-281
ISSN: 0066-4154 (ISSN-L)
1545-4509
DOI: 10.1146/annurev.biochem.74.082803.133518
OpenAlex: W2116472408
Cited by: 1,438
References: 209
Citations by year: 2026: 48 · 2025: 68 · 2024: 57 · 2023: 62 · 2022: 75 · 2021: 94 · 2020: 64 · 2019: 67 · 2018: 65 · 2017: 72 · 2016: 64 · 2015: 63 · 2014: 73 · 2013: 69 · 2012: 74
FWCI: 7.17
Type: journal article
Language: en
Open access: closed
Locations: Annual Review of Biochemistry (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of General Medical Sciences (GM62524)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Metalloenzymes and iron-sulfur proteins
Life Sciences › Biochemistry, Genetics and Molecular Biology › Structural Biology › Enzyme Structure and Function
Physical Sciences › Chemistry › Inorganic Chemistry › Inorganic Chemistry and Materials
Keywords: iron-sulfur clusters, Fe-S cluster biosynthesis, cysteine desulfurase, cluster assembly, protein maturation, electron transfer, prosthetic groups, gene expression regulation, enzyme activity
MeSH terms: Amino Acid Sequence, Bacterial Proteins, Carrier Proteins, Escherichia coli, Genes, Bacterial, Iron-Sulfur Proteins, Molecular Sequence Data, Nitrogenase, Protein Processing, Post-Translational, Sequence Homology, Amino Acid, Escherichia coli Proteins

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STRUCTURE, FUNCTION, AND FORMATION OF BIOLOGICAL IRON-SULFUR CLUSTERS

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