Antibacterial Action of Nitric Oxide-Releasing Chitosan Oligosaccharides against Pseudomonas aeruginosa under Aerobic and Anaerobic Conditions
Open accessAbstract
Chitosan oligosaccharides were modified with N -diazeniumdiolates to yield biocompatible nitric oxide (NO) donor scaffolds. The minimum bactericidal concentrations and MICs of the NO donors against Pseudomonas aeruginosa were compared under aerobic and anaerobic conditions. Differential antibacterial activities were primarily the result of NO scavenging by oxygen under aerobic environments and not changes in bacterial physiology. Bacterial killing was also tested against nonmucoid and mucoid biofilms and compared to that of tobramycin. Smaller NO payloads were required to eradicate P. aeruginosa biofilms under anaerobic versus aerobic conditions. Under oxygen-free environments, the NO treatment was 10-fold more effective at killing biofilms than tobramycin. These results demonstrate the potential utility of NO-releasing chitosan oligosaccharides under both aerobic and anaerobic environments.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Biodegradable polymers such as citrate-based or saccharide-based polymers (dextran, chitosan) are attractive scaffolds for NO delivery because of natural occurrence, biodegradability, tolerability to mammalian cells, and accessibility for NO donor functionalization.
“Lastly, several biodegradable polymers, such as citrate-based225 or saccharide-based polymers (e.g., dextran227,244 and chitosan86,87,220) provide very attractive scaffolds for NO delivery because of their natural occurrence, biodegradability, tolerability to mammalian cells and accessibility for NO donor functionalization reactions.220,244,245”
From Recent advances in thromboresistant and antimicrobial polymers for biomedical applications: just say yes to nitric oxide (NO) (2016) · cites this paper as [86]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Correspondence - Tranexamic acid for traumatic brain injury
(2005) · London School of Economics and Political Science Theses Online (London School of Economics and Political Science) · doi:10.1016/s0140-6736 · Cited by 11,894 · see citing works
Antibiotic resistance of bacteria in biofilms
Stewart, P. S., & Costerton, J. W. (2001) · The Lancet · doi:10.1016/s0140-6736(01)05321-1 · Cited by 4,596 · see citing works
Biodegradation, biodistribution and toxicity of chitosan
Kean, T., & Thanou, M. (2010) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2009.09.004 · Cited by 1,837 · see citing works
Structure, function, and formation of biological iron-sulfur clusters
Johnson, D. C., Dean, D. R., Smith, A. D., & Johnson, M. K. (2005) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.74.082803.133518 · Cited by 1,438 · cited 1× · see citing works
“As these proteins are linked to nearly every cellular process, including metabolism, respiration, RNA modification, and DNA repair and replication, their alteration greatly influences bacterial viability (23).”
BackgroundChitosan and Its Use as a Pharmaceutical Excipient
Ilium, L. (1998) · Pharmaceutical Research · doi:10.1023/a:1011929016601 · Cited by 1,400 · see citing works
Mechanisms of antibiotic resistance in bacterial biofilms
Stewart, P. S. (2002) · International Journal of Medical Microbiology · doi:10.1078/1438-4221-00196 · Cited by 1,388 · see citing works
Establishment of infection: lessons from a versatile opportunist
Lyczak, J. B., Cannon, C. L., & Pier, G. B. (2000) · Microbes and Infection · doi:10.1016/s1286-4579(00)01259-4 · Cited by 1,343 · see citing works
Pseudomonas aeruginosa: all roads lead to resistance
Breidenstein, E. B. M., de la Fuente‐Núñez, C., & Hancock, R. E. W. (2011) · Trends in Microbiology · doi:10.1016/j.tim.2011.04.005 · Cited by 1,338 · see citing works
Fang, F. C. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119473 · Cited by 1,139 · see citing works
Worlitzsch, D., Tarran, R., Ulrich, M., Schwab, U. E., Cekici, A., Meyer, K. C., Birrer, P., Bellon, G., Berger, J., Weiß, T., et al. (2002) · Journal of Clinical Investigation · doi:10.1172/jci13870 · Cited by 1,133 · see citing works
Nitric oxide release: part III. Measurement and reporting.
Coneski, P. N., & Schoenfisch, M. (2012) · Chemical Society Reviews · doi:10.1039/c2cs15271a · Cited by 1,023 · see citing works
Self-citationNitric oxide release: Part II. Therapeutic applications
Carpenter, A. W., & Schoenfisch, M. H. (2012) · Chemical Society Reviews · doi:10.1039/c2cs15273h · Cited by 964 · see citing works
Self-citationPseudomonas Aeruginosa: Resistance to the Max
Poole, K. (2011) · Frontiers in Microbiology · doi:10.3389/fmicb.2011.00065 · Cited by 950 · see citing works
Worlitzsch, D., Tarran, R., Ulrich, M., Schwab, U., Cekici, A., Meyer, K. C., Birrer, P., Bellon, G., Berger, J., Weiss, T., et al. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0213870 · Cited by 932 · see citing works
Involvement of Nitric Oxide in Biofilm Dispersal of Pseudomonas aeruginosa
Barraud, N., Hassett, D. J., Hwang, S.-H., Rice, S. A., Kjelleberg, S. J., & Webb, J. S. (2006) · Journal of Bacteriology · doi:10.1128/jb.00779-06 · Cited by 785 · see citing works
Adaptation of Pseudomonas aeruginosa to the cystic fibrosis airway: an evolutionary perspective
Folkesson, A., Jelsbak, L., Yang, L., Johansen, H. K., Ciofu, O., Høiby, N., & Molin, S. (2012) · Nature Reviews Microbiology · doi:10.1038/nrmicro2907 · Cited by 699 · see citing works
Alginate Overproduction Affects Pseudomonas aeruginosa Biofilm Structure and Function
Hentzer, M., Teitzel, G. M., Balzer, G. J., Heydorn, A., Molin, S., Givskov, M., & Parsek, M. R. (2001) · Journal of Bacteriology · doi:10.1128/jb.183.18.5395-5401.2001 · Cited by 697 · see citing works
Pseudomonas Aeruginosa Biofilms in Cystic fibrosis
Høiby, N., Ciofu, O., & Bjarnsholt, T. (2010) · Future Microbiology · doi:10.2217/fmb.10.125 · Cited by 687 · see citing works
Nitric oxide and its role in the cardiovascular system
Loscalzo, J., & Welch, G. N. (1995) · Progress in Cardiovascular Diseases · doi:10.1016/s0033-0620(05)80001-5 · Cited by 599 · see citing works
Pseudomonas aeruginosa Anaerobic Respiration in Biofilms
Yoon, S. S., Hennigan, R. F., Hilliard, G. M., Ochsner, U. A., Parvatiyar, K., Kamani, M. C., Allen, H. L., Dekievit, T., Gardner, P. R., Schwab, U. E., et al. (2002) · Developmental Cell · doi:10.1016/s1534-5807(02)00295-2 · Cited by 587 · see citing works
Pseudomonas aeruginosa: resistance and therapeutic options at the turn of the new millennium
Mesaros, N. E., Nordmann, P., Plésiat, P., Roussel‐Delvallez, M., Eldere, J. V., Glupczynski, Y., Laethem, Y. V., Jacobs, F., Lebecque, P., Malfroot, A., et al. (2007) · Clinical Microbiology and Infection · doi:10.1111/j.1469-0691.2007.01681.x · Cited by 585 · see citing works
Xu, K. D., Stewart, P. S., Xia, F., Huang, C., & McFeters, G. A. (1998) · Applied and Environmental Microbiology · doi:10.1128/aem.64.10.4035-4039.1998 · Cited by 501 · see citing works
Oxygen Limitation Contributes to Antibiotic Tolerance of Pseudomonas aeruginosa in Biofilms
Borriello, G., Werner, E., Roe, F., Kim, A. M., Ehrlich, G. D., & Stewart, P. S. (2004) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.48.7.2659-2664.2004 · Cited by 480 · see citing works
Nitric oxide release: Part I. Macromolecular scaffolds
Riccio, D. A., & Schoenfisch, M. H. (2012) · Chemical Society Reviews · doi:10.1039/c2cs15272j · Cited by 475 · see citing works
Self-citationMechanisms of nitric oxide-related antimicrobial activity
Fang, F. C. (1997) · Journal of Clinical Investigation · Cited by 446 · see citing works
Anti-biofilm efficacy of nitric oxide-releasing silica nanoparticles
Hetrick, E. M., Shin, J. H., Paul, H. S., & Schoenfisch, M. H. (2009) · Biomaterials · doi:10.1016/j.biomaterials.2009.01.052 · Cited by 408 · see citing works
Self-citationHassett, D. J., Cuppoletti, J., Trapnell, B. C., Lymar, S. V., Rowe, J. J., Yoon, S. S., Hilliard, G. M., Parvatiyar, K., Kamani, M. C., Wozniak, D. J., et al. (2002) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(02)00152-7 · Cited by 306 · see citing works
Barraud, N., Storey, M. V., Moore, Z. P., Webb, J. S., Rice, S. A., & Kjelleberg, S. (2009) · Microbial Biotechnology · doi:10.1111/j.1751-7915.2009.00098.x · Cited by 289 · see citing works
The Comparative Toxicity of Nitric Oxide and Peroxynitrite to Escherichia coli
Brunelli, L., Crow, J. P., & Beckman, J. S. (1995) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1995.1044 · Cited by 284 · see citing works
Synthesis of Nitric Oxide-Releasing Silica Nanoparticles
Shin, J. H., O’Neal, S., & Schoenfisch, M. H. (2007) · Journal of the American Chemical Society · doi:10.1021/ja0674338 · Cited by 250 · see citing works
Self-citationSamama, C. M., Diaby, M., Fellahi, J.-L., Mdhafar, A., Eyraud, D., Arock, M., Guillosson, J., Coriat, P., & Rouby, J. (1995) · Anesthesiology · doi:10.1097/00000542-199507000-00007 · Cited by 215 · see citing works
Hill, D., Rose, B. R., Pajkos, A., Robinson, M., Bye, P. T. P., Bell, S. C., Elkins, M. R., Thompson, B., MacLeod, C., Aaron, S. D., et al. (2005) · Journal of Clinical Microbiology · doi:10.1128/jcm.43.10.5085-5090.2005 · Cited by 213 · see citing works
Role of Size and Shape on Biofilm Eradication for Nitric Oxide-Releasing Silica Nanoparticles
Slomberg, D. L., Lu, Y., Broadnax, A. D., Hunter, R. A., Carpenter, A. W., & Schoenfisch, M. H. (2013) · ACS Applied Materials & Interfaces · doi:10.1021/am402618w · Cited by 209 · see citing works
Self-citationRegulators of bacterial responses to nitric oxide
Spiro, S. (2007) · FEMS Microbiology Reviews · doi:10.1111/j.1574-6976.2006.00061.x · Cited by 208 · see citing works
Outer Membranes and Efflux: The Path to Multidrug Resistance in Gram- Negative Bacteria
Poole, K. (2002) · Current Pharmaceutical Biotechnology · doi:10.2174/1389201023378454 · Cited by 198 · see citing works
Jones, M. L., Ganopolsky, J. G., Labbé, A., Wahl, C., & Prakash, S. (2010) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-010-2733-x · Cited by 196 · see citing works
Harrison-Balestra, C., Cazzaniga, A. L., Davis, S. C., & Mertz, P. M. (2003) · Dermatologic Surgery · doi:10.1046/j.1524-4725.2003.29146.x · Cited by 195 · see citing works
Cole, S. J., Records, A. R., Orr, M. W., Linden, S. B., & Lee, V. T. (2014) · Infection and Immunity · doi:10.1128/iai.01652-14 · Cited by 187 · see citing works
Burns, biofilm and a new appraisal of burn wound sepsis
Kennedy, P. J., Brammah, S., & Wills, E. J. (2009) · Burns · doi:10.1016/j.burns.2009.02.017 · Cited by 172 · see citing works
THE NUMBER OF COLONIES ALLOWABLE ON SATISFACTORY AGAR PLATES
Breed, R. S., & Dotterrer, W. D. (1916) · Journal of Bacteriology · doi:10.1128/jb.1.3.321-331.1916 · Cited by 165 · see citing works
Dendrimers as a Scaffold for Nitric Oxide Release
Stasko, N. A., & Schoenfisch, M. H. (2006) · Journal of the American Chemical Society · doi:10.1021/ja060875z · Cited by 157 · see citing works
Self-citationSeabra, A. B., Justo, G. Z., & Haddad, P. S. (2015) · Biotechnology Advances · doi:10.1016/j.biotechadv.2015.01.005 · Cited by 151 · see citing works
Nitric oxide-releasing chitosan oligosaccharides as antibacterial agents
Lu, Y., Slomberg, D. L., & Schoenfisch, M. H. (2014) · Biomaterials · doi:10.1016/j.biomaterials.2013.11.015 · Cited by 149 · see citing works
Self-citationAaron, S. D., Ferris, W., Ramotar, K., Vandemheen, K. L., Chan, F., & Saginur, R. (2002) · Journal of Clinical Microbiology · doi:10.1128/jcm.40.11.4172-4179.2002 · Cited by 145 · see citing works
Influence of Scaffold Size on Bactericidal Activity of Nitric Oxide-Releasing Silica Nanoparticles
Carpenter, A. W., Slomberg, D. L., Rao, K. S., & Schoenfisch, M. H. (2011) · ACS Nano · doi:10.1021/nn202054f · Cited by 134 · see citing works
Self-citationCarpenter, A. W., Worley, B. V., Slomberg, D. L., & Schoenfisch, M. H. (2012) · Biomacromolecules · doi:10.1021/bm301108x · Cited by 132 · see citing works
Self-citationBiofilms on Central Venous Catheters: Is Eradication Possible?
Donlan, R. M. (2008) · Current topics in microbiology and immunology · doi:10.1007/978-3-540-75418-3_7 · Cited by 131 · see citing works
Inaccuracies of Nitric Oxide Measurement Methods in Biological Media
Hunter, R. A., Storm, W. L., Coneski, P. N., & Schoenfisch, M. H. (2013) · Analytical Chemistry · doi:10.1021/ac303787p · Cited by 130 · see citing works
Self-citationNitric Oxide-Releasing Dendrimers as Antibacterial Agents
Sun, B., Slomberg, D. L., Chudasama, S. L., Lu, Y., & Schoenfisch, M. H. (2012) · Biomacromolecules · doi:10.1021/bm301109c · Cited by 126 · see citing works
Self-citationNitric Oxide-Releasing Amphiphilic Poly(amidoamine) (PAMAM) Dendrimers as Antibacterial Agents
Lu, Y., Slomberg, D. L., Shah, A., & Schoenfisch, M. H. (2013) · Biomacromolecules · doi:10.1021/bm400961r · Cited by 123 · see citing works
Self-citationAcceleration of nitric oxide autoxidation and nitrosation by membranes
Möller, M. N., Li, Q., Lancaster, J. R., & Denicola, A. (2007) · IUBMB Life · doi:10.1080/15216540701311147 · Cited by 122 · see citing works
Nitric Oxide-Releasing Silica Nanoparticle Inhibition of Ovarian Cancer Cell Growth
Stevens, E. V., Carpenter, A. W., Shin, J. H., Liu, J., Der, C. J., & Schoenfisch, M. H. (2010) · Molecular Pharmaceutics · doi:10.1021/mp9002865 · Cited by 105 · see citing works
Self-citationFailure of aminoglycoside antibiotics to kill anaerobic, low-pH, and resistant cultures
Schlessinger, D. (1988) · Clinical Microbiology Reviews · doi:10.1128/cmr.1.1.54 · Cited by 87 · see citing works
Worley, B. V., Slomberg, D. L., & Schoenfisch, M. H. (2014) · Bioconjugate Chemistry · doi:10.1021/bc5000719 · Cited by 87 · see citing works
Self-citationNitric oxide‐induced bacteriostasis and modification of iron‐sulphur proteins in Escherichia coli
Ren, B., Zhang, N., Yang, J., & Ding, H. (2008) · Molecular Microbiology · doi:10.1111/j.1365-2958.2008.06464.x · Cited by 80 · see citing works
The potential of chitosan for pulmonary drug delivery
Grenha, A., Al‐Qadi, S., Seijo, B., & Remuñán‐López, C. (2010) · Journal of Drug Delivery Science and Technology · doi:10.1016/s1773-2247(10)50004-2 · Cited by 70 · see citing works
Field, T. R., White, A. P., Elborn, J. S., & Tunney, M. M. (2005) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-005-0031-9 · Cited by 67 · see citing works
Structurally Diverse Nitric Oxide-Releasing Poly(propylene imine) Dendrimers
Lu, Y., Sun, B., Li, C., & Schoenfisch, M. H. (2011) · Chemistry of Materials · doi:10.1021/cm201628z · Cited by 63 · see citing works
Self-citationEffects of inhaled nitric oxide in a rat model of Pseudomonas aeruginosa pneumonia
Webert, K. E., Vanderzwan, J., Duggan, M., Scott, J. A., McCormack, D. G., Lewis, J. F., & Mehta, S. (2000) · Critical Care Medicine · doi:10.1097/00003246-200007000-00035 · Cited by 63 · see citing works
Miller, C. C., Hergott, C. A., Rohan, M., Arsenault-Mehta, K., Döring, G., & Mehta, S. (2013) · Journal of Cystic Fibrosis · doi:10.1016/j.jcf.2013.01.008 · Cited by 54 · see citing works
Wyckoff, T. J. O., Thomas, B., Hassett, D. J., & Wozniak, D. J. (2002) · Microbiology · doi:10.1099/00221287-148-11-3423 · Cited by 50 · see citing works
Kim, J., Jung, H., An, Y., Hun, J., Suh, P., Lee, H., Lee, S., & Cha, S. (2006) · Open Access System for Information Sharing (Pohang University of Science and Technology) · doi:10.1111/j.1365-2958 · Cited by 46 · see citing works
Nitric oxide, health and disease
Ferrari, C. K. B., França, E. L., & Honório‐França, A. C. (2009) · Journal of Applied Biomedicine · doi:10.32725/jab.2009.019 · Cited by 37 · see citing works
Carpenter, A. W., Reighard, K. P., Saavedra, J. E., & Schoenfisch, M. H. (2013) · Biomaterials Science · doi:10.1039/c3bm00153a · Cited by 36 · see citing works
Self-citationHarrison-Balestra, C., Cazzaniga, A. L., Davis, S. C., et al. (2003) · Dermatologic Surgery · doi:10.1097/00042728-200306000-00016 · Cited by 29 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Wo, Y., Brisbois, E. J., Bartlett, R. H., & Meyerhoff, M. E. (2016) · Biomaterials Science · doi:10.1039/c6bm00271d · Cited by 251 · see citing works
Chitosan and their derivatives: Antibiofilm drugs against pathogenic bacteria
Khan, F., Pham, D. T. N., Oloketuyi, S. F., Manivasagan, P., Oh, J., & Kim, Y. (2019) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2019.110627 · Cited by 247 · see citing works
Approaches for the inhibition and elimination of microbial biofilms using macromolecular agents
Blackman, L. D., Qu, Y., Cass, P., & Locock, K. E. S. (2021) · Chemical Society Reviews · doi:10.1039/d0cs00986e · Cited by 161 · see citing works
Antibacterial gas therapy: Strategies, advances, and prospects
Wang, T., Zhu, X., & Wu, F. (2022) · Bioactive Materials · doi:10.1016/j.bioactmat.2022.10.008 · Cited by 155 · see citing works
Recent advances in nitric oxide delivery for antimicrobial applications using polymer-based systems
Sadrearhami, Z., Nguyen, T., Namivandi‐Zangeneh, R., Jung, K., Wong, E. H. H., & Boyer, C. A. (2018) · Journal of Materials Chemistry B · doi:10.1039/c8tb00299a · Cited by 136 · see citing works
Poh, W. H., & Rice, S. A. (2022) · Molecules · doi:10.3390/molecules27030674 · Cited by 112 · see citing works
A tale of two sites: how inflammation can reshape the microbiomes of the gut and lungs
Scales, B. S., Dickson, R. P., & Huffnagle, G. B. (2016) · Journal of Leukocyte Biology · doi:10.1189/jlb.3mr0316-106r · Cited by 109 · see citing works
Chen, X., Thomsen, T. R., Winkler, H., & Xu, Y. (2020) · BMC Microbiology · doi:10.1186/s12866-020-01947-9 · Cited by 104 · see citing works
Zang, S., Mu, R., Chen, F., Wei, X., Zhu, L., Han, B., Yu, H.-C., Bi, B., Chen, B., Wang, Q., et al. (2019) · Materials Science and Engineering C · doi:10.1016/j.msec.2019.02.024 · Cited by 102 · see citing works
Exogenous Nitric Oxide Improves Antibiotic Susceptibility in Resistant Bacteria
Rouillard, K. R., Novák, O., Pistiolis, A. M., Yang, L., Ahonen, M. J. R., McDonald, R. A., & Schoenfisch, M. H. (2020) · ACS Infectious Diseases · doi:10.1021/acsinfecdis.0c00337 · Cited by 94 · see citing works
Self-citationWo, Y., Brisbois, E. J., Wu, J., Li, Z., Major, T. C., Mohammed, A., Wang, X., Colletta, A., Bull, J. L., Matzger, A. J., et al. (2017) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.6b00622 · Cited by 78 · see citing works
Mode of Nitric Oxide Delivery Affects Antibacterial Action
Hall, J. R., Rouillard, K. R., Suchyta, D. J., Brown, M. D., Ahonen, M. J. R., & Schoenfisch, M. H. (2019) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.9b01384 · Cited by 75 · see citing works
Self-citationDual Action Nitric Oxide and Fluoride Ion-Releasing Hydrogels for Combating Dental Caries
Bright, L. M. E., Garren, M. R. S., Ashcraft, M. M., Kumar, A., Husain, H., Brisbois, E. J., & Handa, H. (2022) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.2c02301 · Cited by 53 · see citing works
Reighard, K. P., Hill, D. B., Dixon, G. A., Worley, B. V., & Schoenfisch, M. H. (2015) · Biofouling · doi:10.1080/08927014.2015.1107548 · Cited by 53 · see citing works
Self-citationWo, Y., Li, Z., Colletta, A., Wu, J., Xi, C., Matzger, A. J., Brisbois, E. J., Bartlett, R. H., & Meyerhoff, M. E. (2017) · Composites Part B Engineering · doi:10.1016/j.compositesb.2017.03.027 · Cited by 48 · see citing works
Antimicrobial Nitric Oxide Releasing Contact Lens Gels for the Treatment of Microbial Keratitis
Aveyard, J., Deller, R. C., Lace, R., Williams, R., Kaye, S. B., Kolegraff, K. N., Curran, J. M., & D’Sa, R. A. (2019) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.9b13958 · Cited by 46 · see citing works
Dose controlled nitric oxide-based strategies for antibacterial property in biomedical devices
Mendhi, J., Asgari, M. S., Ratheesh, G., Prasadam, I., Yang, Y., & Xiao, Y. (2020) · Applied Materials Today · doi:10.1016/j.apmt.2020.100562 · Cited by 42 · see citing works
Pulling the Brakes on Fast and Furious Multiple Drug-Resistant (MDR) Bacteria
Khan, A. A., Manzoor, K. N., Sultan, A., Saeed, M., Rafique, M., Noushad, S., Talib, A., Rentschler, S., & Deigner, H. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22020859 · Cited by 41 · see citing works
Antibiofilm Efficacy of Nitric Oxide-Releasing Alginates against Cystic Fibrosis Bacterial Pathogens
Ahonen, M. J. R., Dorrier, J. M., & Schoenfisch, M. H. (2019) · ACS Infectious Diseases · doi:10.1021/acsinfecdis.9b00016 · Cited by 39 · see citing works
Self-citationHibbard, H. A. J., & Reynolds, M. M. (2019) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2019.103318 · Cited by 37 · see citing works
Therapeutic Delivery of Nitric Oxide Utilizing Saccharide-Based Materials
Qian, Y., Kumar, R. U., Chug, M. K., Massoumi, H., & Brisbois, E. J. (2021) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.1c10964 · Cited by 38 · see citing works
Yang, L., Teles, F., Gong, W., Dua, S. A., Martin, L., & Schoenfisch, M. H. (2020) · Dental Materials · doi:10.1016/j.dental.2020.03.012 · Cited by 30 · see citing works
Self-citationRole of Nitric Oxide-Releasing Chitosan Oligosaccharides on Mucus Viscoelasticity
Reighard, K. P., Ehré, C., Rushton, Z. L., Ahonen, M. J. R., Hill, D. B., & Schoenfisch, M. H. (2017) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.7b00039 · Cited by 27 · see citing works
Self-citationMapping of the Denitrification Pathway in Burkholderia thailandensis by Genome-Wide Mutant Profiling
Vitale, A., Paszti, S., Takahashi, K., Toyofuku, M., Pessi, G., & Eberl, L. (2020) · Journal of Bacteriology · doi:10.1128/jb.00304-20 · Cited by 25 · see citing works
Nitric Oxide, an Old Molecule With Noble Functions in Pseudomonas aeruginosa Biology
Toyofuku, M., & Yoon, S. S. (2018) · Advances in microbial physiology/Advances in Microbial Physiology · doi:10.1016/bs.ampbs.2018.01.005 · Cited by 23 · see citing works
Kumar, A., Mondal, A., Douglass, M. E., Francis, D. J., Garren, M. R. S., Bright, L. M. E., Ghalei, S., Xie, J., Brisbois, E. J., & Handa, H. (2023) · Journal of Colloid and Interface Science · doi:10.1016/j.jcis.2023.02.083 · Cited by 23 · see citing works
Antimicrobial Synergism Toward Pseudomonas aeruginosa by Gallium(III) and Inorganic Nitrite
Zemke, A. C., Madison, C. J., Kasturiarachi, N. S., Pearce, L. L., & Peterson, J. (2020) · Frontiers in Microbiology · doi:10.3389/fmicb.2020.02113 · Cited by 22 · see citing works
Molecular Mechanisms of Biofilm Formation in Helicobacter pylori
Fauzia, K. A., Effendi, W. I., Alfaray, R. I., Malaty, H. M., Yamaoka, Y., & Miftahussurur, M. (2024) · Antibiotics · doi:10.3390/antibiotics13100976 · Cited by 20 · see citing works
Yi, Z., Luo, X., & Zhao, L. (2019) · Current Medicinal Chemistry · doi:10.2174/0929867326666190712180147 · Cited by 20 · see citing works
Rouillard, K. R., Markovetz, M. R., Kissner, W. J., Boone, W., Plott, L. M., & Hill, D. B. (2023) · Biofilm · doi:10.1016/j.bioflm.2023.100104 · Cited by 19 · see citing works
Nitric Oxide-Releasing Alginates as Mucolytic Agents
Ahonen, M. J. R., Hill, D. B., & Schoenfisch, M. H. (2019) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.9b00482 · Cited by 17 · see citing works
Self-citationCationic polymer–based antibacterial smart coatings
Ghosh, S., & Haldar, J. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-849870-5.00011-2 · Cited by 16 · see citing works
Grayton, Q. E., Nguyen, H. K., Broberg, C. A., Ocampo, J., Nagy, S. G., & Schoenfisch, M. H. (2023) · ACS Infectious Diseases · doi:10.1021/acsinfecdis.3c00198 · Cited by 15 · see citing works
Self-citationMaury, G. L., Morris, H. J., Heykers, A., Lanckacker, E. A., Cappoen, D., Delputte, P., Berghe, W. V., Salgueiro, Z., & Cos, P. (2021) · Journal of Fungi · doi:10.3390/jof7030206 · Cited by 15 · see citing works
Electrospun Bioabsorbable Fibers Containing S-Nitrosoglutathione for Tissue Engineering Applications
Hopkins, S. P., Pant, J., Goudie, M. J., Nguyen, D. T., & Handa, H. (2020) · ACS Applied Bio Materials · doi:10.1021/acsabm.0c00862 · Cited by 12 · see citing works
Wood vinegar and chitosan compound preservative affects on fish balls stability
Wang, J., Потороко, И. Ю., & Цирульниченко, Л. А. (2021) · Food Bioscience · doi:10.1016/j.fbio.2021.101102 · Cited by 12 · see citing works
Allison, C. L., Lutzke, A., & Reynolds, M. M. (2018) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2018.09.052 · Cited by 11 · see citing works
Impact of Nitric Oxide-Release Kinetics on Antifungal Activity
Grayton, Q. E., Conlon, I. L., Broberg, C. A., & Schoenfisch, M. H. (2024) · Journal of Fungi · doi:10.3390/jof10050308 · Cited by 7 · see citing works
Self-citationNitric oxide diffusion through cystic fibrosis-relevant media and lung tissue
Hall, J. R., Maloney, S. E., Jin, H., Taylor, J. B., & Schoenfisch, M. H. (2019) · RSC Advances · doi:10.1039/c9ra07367a · Cited by 7 · see citing works
Self-citationJensen, J., Packert, D., Miller, C., Packert, G., Hanft, J. R., & Jensen, S. (2020) · Clinics in Podiatric Medicine and Surgery · doi:10.1016/j.cpm.2019.11.001 · Cited by 4 · see citing works
Delivery of Biomolecules Using Chitosan Wound Dressings
Guebitz, G. M., Pellis, A., & Nyanhongo, G. S. (2021) · Advances in polymer science · doi:10.1007/12_2021_95 · Cited by 3 · see citing works
Efficacy of a Topical Nitric Oxide-Releasing Gel on Polymicrobial Wound Infections
Davis, S. C., Gil, J., Solis, M., Strong, R., & Cassagnol, R. (2024) · Military Medicine · doi:10.1093/milmed/usae551 · Cited by 2 · see citing works
Improving the hemocompatibility of catheters via NO release/generation
Wo, Y., Brisbois, E. J., Bartlett, R. H., & Meyerhoff, M. E. (2017) · Elsevier eBooks · doi:10.1016/b978-0-08-100497-5.00013-6 · Cited by 2 · see citing works
Hyperbaric Oxygen Treatment May Advance the Outcome of Antibiotic Treatment of Biofilm Infections
Jensen, P. Ø., Møller, S. A., Stjernekilde, S., Olsen, P., Moser, C. E., Schwartz, F. A., Lerche, C. J., Høiby, N., Hyldegaard, O., Faurholt‐Jepsen, D., et al. (2022) · Springer series on biofilms · doi:10.1007/978-3-031-10992-8_9 · Cited by 2 · see citing works
Andamios de quitosano con L-Arginina para su aplicación en salud dental
Herrera-Guardiola, S., & Zapata, M. E. V. (2021) · Revista Nacional de Odontología · doi:10.16925/2357-4607.2021.02.07 · Cited by 1 · see citing works
Kumar, A. S., Thomas, N. G., Dalvi, Y. B., Letha, S. S., Sreelekshmi, S., & Rosemary, M. J. (2024) · Materials Today Communications · doi:10.1016/j.mtcomm.2024.109647 · Cited by 1 · see citing works
Antimicrobial Properties and Applications of Pyrrolidone and Caprolactam‐Based Materials
Winkowski, K., & Turovskiy, Y. (2021) · doi:10.1002/9781119468769.hpcbm025
Biofilm Formation and Its Contribution to Antibiotic Resistance
Anushiya, M., Saranraj, P., Nancy, J., Vithiya, G., Prakathi, P., & Manigandan, M. (2026) · IGI Global eBooks · doi:10.4018/979-8-3373-3825-5.ch005
Attard, S. T., Aquib, M., Gmedhin, H., Boyer, C. A., Thordarson, P., Black, D. S., & Kumar, N. (2026) · RSC Advances · doi:10.1039/d6ra04633a
- Authors
- Reighard, K. P., & Schoenfisch, M. H.
- Affiliations
- University of North Carolina at Chapel Hill (US)
- ORCID
- Schoenfisch, Mark H.
- Venue
- Antimicrobial Agents and Chemotherapy
- Publisher
- American Society for Microbiology
- Published
- 2015-10
- Volume
- 59
- Issue
- 10
- Pages
- 6506-6513
- ISSN
- 0066-4804 (ISSN-L)
- 1098-6596
- PMC
- PMC4576085
- OpenAlex
- W1959736416
- Cited by
- 49
- References
- 62
- Citations by year
- 2026: 2 · 2024: 4 · 2023: 3 · 2022: 4 · 2021: 8 · 2020: 8 · 2019: 10 · 2018: 3 · 2017: 4 · 2016: 2 · 2015: 1
- FWCI
- 1.45
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Antimicrobial Agents and Chemotherapy (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Carolina Digital Repository (University of North Carolina at Chapel Hill) (submittedVersion)
- UNC Libraries
- Funders
- National Institutes of Health
- University of North Carolina at Chapel Hill
- National Institute of Allergy and Infectious Diseases (R21AI112029, AI 112029)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bacterial biofilms and quorum sensing
- Physical Sciences › Chemistry › Organic Chemistry › Antimicrobial agents and applications
- Physical Sciences › Materials Science › Biomaterials › Nanocomposite Films for Food Packaging
- Keywords
- nitric oxide donors, chitooligosaccharides, N-diazeniumdiolates, Pseudomonas aeruginosa, antibacterial activity, biofilm, mucoid biofilm, aerobic and anaerobic conditions, oxygen scavenging, tobramycin, minimum bactericidal concentration
- MeSH terms
- Aerobiosis, Anaerobiosis, Anti-Bacterial Agents, Azo Compounds, Glycosaminoglycans, Microbial Sensitivity Tests, Nitric Oxide, Oxygen, Pseudomonas aeruginosa, Tobramycin, Biofilms, Nitric Oxide Donors, Chitosan
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review