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Cited by 990

The DOI matches its Crossref record; 111 of the 111 references it cites were found in a registry or an index.

Biosynthesis and Assembly of Capsular Polysaccharides in Escherichia coli

Whitfield, Chris·2006·Annual Review of Biochemistry

Abstract

Capsules are protective structures on the surfaces of many bacteria. The remarkable structural diversity in capsular polysaccharides is illustrated by almost 80 capsular serotypes in Escherichia coli. Despite this variation, the range of strategies used for capsule biosynthesis and assembly is limited, and E. coli isolates provide critical prototypes for other bacterial species. Related pathways are also used for synthesis and export of other bacterial glycoconjugates and some enzymes/processes have counterparts in eukaryotes. In gram-negative bacteria, it is proposed that biosynthesis and translocation of capsular polysaccharides to the cell surface are temporally and spatially coupled by multiprotein complexes that span the cell envelope. These systems have an impact on both a general understanding of membrane trafficking in bacteria and on bacterial pathogenesis.

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Crossref · 10.1146/annurev.biochem.75.103004.142545

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Metadata

Authors
Whitfield, C.
Venue
Annual Review of Biochemistry
Published
2006-06-01
Volume
75
Issue
1
Pages
39-68
ISSN
  • 0066-4154 (ISSN-L)
  • 1545-4509
OpenAlex
W2117319600
Cited by
990
References
111
FWCI
2.66
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Biosynthesis and Assembly of Capsular Polysaccharides in Escherichia coli. https://app.cochat.ai/papers/10.1146/annurev.biochem.75.103004.142545
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Whitfield, C. (2006). Biosynthesis and Assembly of Capsular Polysaccharides in Escherichia coli. Annual Review of Biochemistry. https://doi.org/10.1146/annurev.biochem.75.103004.142545

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.