The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
Axonal Transport and Alzheimer's Disease
Abstract
In contrast to most eukaryotic cells, neurons possess long, highly branched processes called axons and dendrites. In large mammals, such as humans, some axons reach lengths of over 1 m. These lengths pose a major challenge to the movement of proteins, vesicles, and organelles between presynaptic sites and cell bodies. To overcome this challenge axons and dendrites rely upon specialized transport machinery consisting of cytoskeletal motor proteins generating directed movements along cytoskeletal tracks. Not only are these transport systems crucial to maintain neuronal viability and differentiation, but considerable experimental evidence suggests that failure of axonal transport may play a role in the development or progression of neurological diseases such as Alzheimer's disease.
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Citations
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Cited by
Myelination and the trophic support of long axons
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Alzheimer's Disease: From Pathology to Therapeutic Approaches
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The preclinical phase of the pathological process underlying sporadic Alzheimer’s disease
Braak, H., & Del Tredici, K. (2015) · Brain · doi:10.1093/brain/awv236 · Cited by 540
Deciphering the mechanism underlying late-onset Alzheimer disease
Krstic, D., & Knuesel, I. (2013) · Nature Reviews Neurology · doi:10.1038/nrneurol.2012.236 · Cited by 457
Metadata
- Authors
- Stokin, G. B., & Goldstein, L. S. B.
- Venue
- Annual Review of Biochemistry
- Publisher
- Annual Reviews
- Published
- 2006-06-01
- Volume
- 75
- Issue
- 1
- Pages
- 607-627
- ISSN
- 0066-4154 (ISSN-L)
- 1545-4509
- OpenAlex
- W2125635130
- Cited by
- 293
- References
- 26
- FWCI
- 2.24
- Type
- journal article
- Language
- en
- Open access
- closed
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- Stokin, G. B., & Goldstein, L. S. B. (2006). Axonal Transport and Alzheimer's Disease. Annual Review of Biochemistry. https://doi.org/10.1146/annurev.biochem.75.103004.142637
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
