Alzheimer's Disease: From Pathology to Therapeutic Approaches

Neuropathological stageing of Alzheimer-related changes.

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Alzheimer's disease: the amyloid cascade hypothesis

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Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid β-peptide

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Inflammation and Alzheimer’s disease

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Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound‐B

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Alzheimer's Disease Is a Synaptic Failure

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Naturally secreted oligomers of amyloid β protein potently inhibit hippocampal long-term potentiation in vivo

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Mild cognitive impairment

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β-Secretase Cleavage of Alzheimer's Amyloid Precursor Protein by the Transmembrane Aspartic Protease BACE

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Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

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Phases of Aβ-deposition in the human brain and its relevance for the development of AD

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Immunization with amyloid-β attenuates Alzheimer-disease-like pathology in the PDAPP mouse

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The molecular pathology of Alzheimer's disease

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Curcumin Inhibits Formation of Amyloid β Oligomers and Fibrils, Binds Plaques, and Reduces Amyloid in Vivo

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Tau-mediated neurodegeneration in Alzheimer’s disease and related disorders

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Copper, iron and zinc in Alzheimer's disease senile plaques

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Peripherally administered antibodies against amyloid β-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease

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3D structure of Alzheimer's amyloid-β(1–42) fibrils

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Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and γ-secretase activity

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Twenty years of the Alzheimer's disease amyloid hypothesis: a genetic perspective

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Purification and cloning of amyloid precursor protein β-secretase from human brain

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Extensive Involvement of Autophagy in Alzheimer Disease: An Immuno-Electron Microscopy Study

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Regulation of NMDA receptor trafficking by amyloid-β

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Soluble Amyloid β Peptide Concentration as a Predictor of Synaptic Change in Alzheimer's Disease

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Aβ peptide vaccination prevents memory loss in an animal model of Alzheimer's disease

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An english translation of alzheimer’s 1907 paper, “über eine eigenartige erkankung der hirnrinde”

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Treatment with a Copper-Zinc Chelator Markedly and Rapidly Inhibits β-Amyloid Accumulation in Alzheimer's Disease Transgenic Mice

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Membrane-anchored aspartyl protease with Alzheimer's disease β-secretase activity

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Aβ peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease

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Mitochondrial abnormalities in Alzheimer's disease

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Alzheimer’s disease β-amyloid peptides are released in association with exosomes

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The metallobiology of Alzheimer's disease

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ABAD Directly Links Aß to Mitochondrial Toxicity in Alzheimer's Disease

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Peripheral anti-Aβ antibody alters CNS and plasma Aβ clearance and decreases brain Aβ burden in a mouse model of Alzheimer's disease

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Amyloid β-protein (Aβ) assembly: Aβ40 and Aβ42 oligomerize through distinct pathways

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Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid β-protein in both transfected cells and transgenic mice

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Correlation Between Elevated Levels of Amyloid β-Peptide in the Brain and Cognitive Decline

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Recovery of learning and memory is associated with chromatin remodelling

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Axonopathy and Transport Deficits Early in the Pathogenesis of Alzheimer’s Disease

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Deciphering the Molecular Basis of Memory Failure in Alzheimer's Disease

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Tangle and neuron numbers, but not amyloid load, predict cognitive status in Alzheimer’s disease

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Evidence of oxidative damage in Alzheimer's disease brain: central role for amyloid β-peptide

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Imaging β-amyloid burden in aging and dementia

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Identification of a Novel Aspartic Protease (Asp 2) as β-Secretase

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Alzheimer's disease-affected brain: Presence of oligomeric Aβ ligands (ADDLs) suggests a molecular basis for reversible memory loss

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Calcium Dysregulation and Membrane Disruption as a Ubiquitous Neurotoxic Mechanism of Soluble Amyloid Oligomers*♦

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Dramatic Aggregation of Alzheimer Aβ by Cu(II) Is Induced by Conditions Representing Physiological Acidosis

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Potential therapeutic applications of autophagy

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Targeting small Aβ oligomers: the solution to an Alzheimer's disease conundrum?

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Metal-Protein Attenuation With Iodochlorhydroxyquin (Clioquinol) Targeting Aβ Amyloid Deposition and Toxicity in Alzheimer Disease: A Pilot Phase 2 Clinical Trial

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Macroautophagy—a novel β-amyloid peptide-generating pathway activated in Alzheimer's disease

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Evidence That Tumor Necrosis Factor α Converting Enzyme Is Involved in Regulated α-Secretase Cleavage of the Alzheimer Amyloid Protein Precursor

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Metabolic Regulation of Brain Aβ by Neprilysin

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Tau blocks traffic of organelles, neurofilaments, and APP vesicles in neurons and enhances oxidative stress

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Environmental Enrichment Reduces Aβ Levels and Amyloid Deposition in Transgenic Mice

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Reconstitution of γ-secretase activity

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Functional gamma‐secretase inhibitors reduce beta‐amyloid peptide levels in brain

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Immunization reverses memory deficits without reducing brain Aβ burden in Alzheimer's disease model

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Staging of Alzheimer-Related Cortical Destruction

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Microglia and cytokines in neurological disease, with special reference to AIDS and Alzheimer's disease

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-amyloid imaging and memory in non-demented individuals: evidence for preclinical Alzheimer's disease

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Antibodies against β-Amyloid Slow Cognitive Decline in Alzheimer's Disease

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Human aspartic protease memapsin 2 cleaves the β-secretase site of β-amyloid precursor protein

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Cu(II) Potentiation of Alzheimer Aβ Neurotoxicity

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Roles of amyloid precursor protein and its fragments in regulating neural activity, plasticity and memory

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Cell Biology of the Amyloid beta-Protein Precursor and the Mechanism of Alzheimer's Disease

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Chronic Treatment with the γ-Secretase Inhibitor LY-411,575 Inhibits β-Amyloid Peptide Production and Alters Lymphopoiesis and Intestinal Cell Differentiation

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Green tea Epigallocatechin-3-Gallate (EGCG) Modulates Amyloid Precursor Protein Cleavage and Reduces Cerebral Amyloidosis in Alzheimer Transgenic Mice

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Enhanced Proteolysis of β-Amyloid in APP Transgenic Mice Prevents Plaque Formation, Secondary Pathology, and Premature Death

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Control of Peripheral Nerve Myelination by the ß-Secretase BACE1

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Apolipoprotein E and Alzheimer disease.

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Efficacy of rosiglitazone in a genetically defined population with mild-to-moderate Alzheimer’s disease

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The genetic epidemiology of neurodegenerative disease

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P-glycoprotein deficiency at the blood-brain barrier increases amyloid- deposition in an Alzheimer disease mouse model

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Alzheimer's Disease Amyloid-β Binds Copper and Zinc to Generate an Allosterically Ordered Membrane-penetrating Structure Containing Superoxide Dismutase-like Subunits

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Characterization of Copper Interactions with Alzheimer Amyloid β Peptides: Identification of an Attomolar‐Affinity Copper Binding Site on Amyloid β1‐42

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NSAIDs and enantiomers of flurbiprofen target γ-secretase and lower Aβ42 in vivo

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A quantitative morphometric analysis of the neuronal and synaptic content of the frontal and temporal cortex in patients with Alzheimer's disease

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Human amyloid-β synthesis and clearance rates as measured in cerebrospinal fluid in vivo

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Kinesin-mediated axonal transport of a membrane compartment containing β-secretase and presenilin-1 requires APP

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Copper-Targeting Approaches in Alzheimer’s Disease: How To Improve the Fallouts Obtained from in Vitro Studies

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