The DOI matches its Crossref record; 165 of the 165 references it cites were found in a registry or an index.
Why Do We Still Have a Maternally Inherited Mitochondrial DNA? Insights from Evolutionary Medicine
Abstract
The human cell is a symbiosis of two life forms, the nucleus-cytosol and the mitochondrion. The nucleus-cytosol emphasizes structure and its genes are Mendelian, whereas the mitochondrion specializes in energy and its mitochondrial DNA (mtDNA) genes are maternal. Mitochondria oxidize calories via oxidative phosphorylation (OXPHOS) to generate a mitochondrial inner membrane proton gradient (ΔP). ΔP then acts as a source of potential energy to produce ATP, generate heat, regulate reactive oxygen species (ROS), and control apoptosis, etc. Interspecific comparisons of mtDNAs have revealed that the mtDNA retains a core set of electron and proton carrier genes for the proton-translocating OXPHOS complexes I, III, IV, and V. Human mtDNA analysis has revealed these genes frequently contain region-specific adaptive polymorphisms. Therefore, the mtDNA with its energy controlling genes may have been retained to permit rapid adaptation to new environments.
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Cites
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Self-citationMitochondrial DNA and human evolution
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Cited by
Wallace, D. C. (2012) · Nature Reviews Cancer · doi:10.1038/nrc3365 · Cited by 2,404
Self-citationMitochondrial fragmentation in neurodegeneration.
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A mouse model of mitochondrial disease reveals germline selection against severe mtDNA mutations
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Self-citationSignaling the mitochondrial unfolded protein response
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Metadata
- Authors
- Wallace, D. C.
- Venue
- Annual Review of Biochemistry
- Publisher
- Annual Reviews
- Published
- 2007-06-07
- Volume
- 76
- Issue
- 1
- Pages
- 781-821
- ISSN
- 0066-4154 (ISSN-L)
- 1545-4509
- OpenAlex
- W2170946953
- Cited by
- 363
- References
- 165
- FWCI
- 1.25
- Type
- journal article
- Language
- en
- Open access
- closed
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- Wallace, D. C. (2007). Why Do We Still Have a Maternally Inherited Mitochondrial DNA? Insights from Evolutionary Medicine. Annual Review of Biochemistry. https://doi.org/10.1146/annurev.biochem.76.081205.150955
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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