The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
PLECKSTRIN HOMOLOGY DOMAINS: A Common Fold with Diverse Functions
Abstract
Pleckstrin homology (PH) motifs are approximately 100 amino-acid residues long and have been identified in nearly 100 different eukaryotic proteins, many of which participate in cell signaling and cytoskeletal regulation. Despite minimal sequence homology, the three-dimensional structures are remarkably conserved. This review gives an overview of the PH domain architecture and examines the best-studied examples in an attempt to understand their function.
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Cites
The relation between the divergence of sequence and structure in proteins.
Chothia, C., & Lesk, A. M. (1986) · The EMBO Journal · doi:10.1002/j.1460-2075.1986.tb04288.x · Cited by 2,458
Specific and high-affinity binding of inositol phosphates to an isolated pleckstrin homology domain
Lemmon, M. A., Ferguson, K. M., O'Brien, R., Sigler, P. B., & Schlessinger, J. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.23.10472 · Cited by 566
Cited by
Synthesis and Function of 3-Phosphorylated Inositol Lipids
Vanhaesebroeck, B., Leevers, S. J., Ahmadi, K., Timms, J., Katso, R., Driscoll, P. C., Woscholski, R., Parker, P. J., & Waterfield, M. D. (2001) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.70.1.535 · Cited by 1,535
Guanine nucleotide exchange factors for Rho GTPases: turning on the switch
Schmidt, A., & Hall, A. (2002) · Genes & Development · doi:10.1101/gad.1003302 · Cited by 1,241
PLCζ: a sperm-specific trigger of Ca2+ oscillations in eggs and embryo development
Saunders, C. M., Larman, M. G., Parrington, J., Cox, L. J., Royse, J., Blayney, L. M., Swann, K., & Lai, F. A. (2002) · Development · doi:10.1242/dev.129.15.3533 · Cited by 1,010
Spectrin and Ankyrin-Based Pathways: Metazoan Inventions for Integrating Cells Into Tissues
Bennett, V., & Baines, A. J. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.3.1353 · Cited by 930
Chan, T. O., Rittenhouse, S. E., & Tsichlis, P. N. (1999) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.68.1.965 · Cited by 737
Metadata
- Authors
- Rebecchi, M. J., & Scarlata, S.
- Venue
- Annual Review of Biophysics and Biomolecular Structure
- Publisher
- Annual Reviews
- Published
- 1998-06
- Volume
- 27
- Issue
- 1
- Pages
- 503-528
- ISSN
- 1056-8700 (ISSN-L)
- 1545-4266
- OpenAlex
- W2102436071
- Cited by
- 291
- References
- 2
- FWCI
- 9.57
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: PLECKSTRIN HOMOLOGY DOMAINS: A Common Fold with Diverse Functions. https://app.cochat.ai/papers/10.1146/annurev.biophys.27.1.503
- The paper
- Rebecchi, M. J., & Scarlata, S. (1998). PLECKSTRIN HOMOLOGY DOMAINS: A Common Fold with Diverse Functions. Annual Review of Biophysics and Biomolecular Structure. https://doi.org/10.1146/annurev.biophys.27.1.503
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
