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SIGNALING COMPLEXES:Biophysical Constraints on Intracellular Communication
Abstract
This review surveys the kinds of protein complex that participate in cell communication and identifies, where possible, general principles by which they form and act. It also advances the notion that biophysical constraints imposed by macromolecular crowding and diffusion have had a controlling influence on the evolution of cell signaling pathways. Complexes associated with the bacterial aspartate receptor, with eucaryotic tyrosine kinase receptors, with T-cell receptors, and with focal contacts are examined together with proteins that serve as adaptors, anchors, and scaffolds for signaling complexes. The importance of diffusion in controlling the numbers and locations of signaling complexes is discussed, as is the special role played by membranes in signaling pathways.
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Cites
Functional rafts in cell membranes
Simons, K., & Ikonen, E. (1997) · Nature · doi:10.1038/42408 · Cited by 9,757
Cited by
Cell-signalling dynamics in time and space
Kholodenko, B. N. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1838 · Cited by 1,347
The pathobiology of the septin gene family
Hall, P. A., & Russell, S. H. (2004) · The Journal of Pathology · doi:10.1002/path.1654 · Cited by 323
Sheng, R., Chen, Y., Yung Gee, H., Stec, E., Melowic, H. R., Blatner, N. R., Tun, M. P., Kim, Y., Källberg, M., Fujiwara, T. K., et al. (2012) · Nature Communications · doi:10.1038/ncomms2221 · Cited by 179
From Water and Ions to Crowded Biomacromolecules: In Vivo Structuring of a Prokaryotic Cell
Spitzer, J. (2011) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00010-11 · Cited by 77
Santamaria, F., Gonzalez, J., Augustine, G. J., & Raghavachari, S. (2010) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1000780 · Cited by 53
Metadata
- Authors
- Bray, D.
- Venue
- Annual Review of Biophysics and Biomolecular Structure
- Publisher
- Annual Reviews
- Published
- 1998-06
- Volume
- 27
- Issue
- 1
- Pages
- 59-75
- ISSN
- 1056-8700 (ISSN-L)
- 1545-4266
- OpenAlex
- W2112175922
- Cited by
- 169
- References
- 1
- FWCI
- 3.15
- Type
- journal article
- Language
- en
- Open access
- closed
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- Bray, D. (1998). SIGNALING COMPLEXES:Biophysical Constraints on Intracellular Communication. Annual Review of Biophysics and Biomolecular Structure. https://doi.org/10.1146/annurev.biophys.27.1.59
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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