The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Unnatural Ligands for Engineered Proteins: New Tools for Chemical Genetics
Abstract
▪ Abstract Small molecules that modulate the activity of biological signaling molecules can be powerful probes of signal transduction pathways. Highly specific molecules with high affinity are difficult to identify because of the conserved nature of many protein active sites. A newly developed approach to discovery of such small molecules that relies on protein engineering and chemical synthesis has yielded powerful tools for the study of a wide variety of proteins involved in signal transduction (G-proteins, protein kinases, 7-transmembrane receptors, nuclear hormone receptors, and others). Such chemical genetic tools combine the advantages of traditional genetics and the unparalleled temporal control over protein function afforded by small molecule inhibitors/activators that act at diffusion controlled rates with targets.
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Cites
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Cited by
Armbruster, B. N., Li, X., Pausch, M. H., Herlitze, S., & Roth, B. L. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0700293104 · Cited by 2,046
Rapid blue-light–mediated induction of protein interactions in living cells
Kennedy, M. J., Hughes, R. M., Peteya, L. A., Schwartz, J. W., Ehlers, M. D., & Tucker, C. L. (2010) · Nature Methods · doi:10.1038/nmeth.1524 · Cited by 1,120
Structure–function of the multifunctional Ca2+/calmodulin-dependent protein kinase II
HUDMON, A., & SCHULMAN, H. (2002) · Biochemical Journal · doi:10.1042/bj20020228 · Cited by 615
Zhang, Y., Larraufie, M.-H., Musavi, L., Akkiraju, H., Brown, L. M., & Stockwell, B. R. (2018) · Biochemistry · doi:10.1021/acs.biochem.7b01113 · Cited by 16
Metadata
- Authors
- Bishop, A., Buzko, O., Heyeck-Dumas, S., Jung, I., Kraybill, B., Liu, Y., Shah, K., Ulrich, S., Witucki, L., Yang, F., Zhang, C., & Shokat, K. M.
- Venue
- Annual Review of Biophysics and Biomolecular Structure
- Publisher
- Annual Reviews
- Published
- 2000-06
- Volume
- 29
- Issue
- 1
- Pages
- 577-606
- ISSN
- 1056-8700 (ISSN-L)
- 1545-4266
- OpenAlex
- W2099405888
- Cited by
- 158
- References
- 4
- FWCI
- 4.06
- Type
- journal article
- Language
- en
- Open access
- closed
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- Bishop, A., Buzko, O., Heyeck-Dumas, S., Jung, I., Kraybill, B., Liu, Y., Shah, K., Ulrich, S., Witucki, L., Yang, F., Zhang, C., & Shokat, K. M. (2000). Unnatural Ligands for Engineered Proteins: New Tools for Chemical Genetics. Annual Review of Biophysics and Biomolecular Structure. https://doi.org/10.1146/annurev.biophys.29.1.577
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