The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
FUSION PORES AND FUSION MACHINES IN CA2+-TRIGGERED EXOCYTOSIS
Abstract
Exocytosis is initiated within a highly localized region of contact between two biological membranes. Small areas of these membranes draw close, molecules on the two surfaces interact, and structural transformations take place. Membrane fusion requires the action of proteins specialized for this task, and these proteins act as a fusion machine. At a critical point in this process, a fusion pore forms within the membrane contact site and then expands as the spherical vesicle merges with the flat target membrane. Hence, the operation of a fusion machine must be realized through the formation and expansion of a fusion pore. Delineating the relation between the fusion machine and the fusion pore thus emerges as a central goal in elucidating the mechanisms of membrane fusion. We summarize present knowledge of fusion machines and fusion pores studied in vitro, in neurons, and in neuroendocrine cells, and synthesize this knowledge into some specific and detailed hypotheses for exocytosis.
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Cites
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Cited by
Chernomordik, L. V., & Kozlov, M. M. (2008) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1455 · Cited by 1,037
Mechanisms of membrane fusion: disparate players and common principles
Martens, S., & McMahon, H. T. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2417 · Cited by 710
Selective Activation of Cognate SNAREpins by Sec1/Munc18 Proteins
Shen, J., Tareste, D. C., Paumet, F., Rothman, J. E., & Melia, T. J. (2007) · Cell · doi:10.1016/j.cell.2006.12.016 · Cited by 484
Helical extension of the neuronal SNARE complex into the membrane
Stein, A., Weber, G., Wahl, M. C., & Jahn, R. (2009) · Nature · doi:10.1038/nature08156 · Cited by 437
The Dynamic Control of Kiss-And-Run and Vesicular Reuse Probed with Single Nanoparticles
Zhang, Q., Li, Y., & Tsien, R. W. (2009) · Science · doi:10.1126/science.1167373 · Cited by 366
Metadata
- Authors
- Jackson, M. B., & Chapman, E. R.
- Venue
- Annual Review of Biophysics and Biomolecular Structure
- Publisher
- Annual Reviews
- Published
- 2006-06
- Volume
- 35
- Issue
- 1
- Pages
- 135-160
- ISSN
- 1056-8700 (ISSN-L)
- 1545-4266
- OpenAlex
- W2118260534
- Cited by
- 180
- References
- 6
- FWCI
- 11.73
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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