The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
EXPANDING THE GENETIC CODE
Abstract
Recently, a general method was developed that makes it possible to genetically encode unnatural amino acids with diverse physical, chemical, or biological properties in Escherichia coli, yeast, and mammalian cells. More than 30 unnatural amino acids have been incorporated into proteins with high fidelity and efficiency by means of a unique codon and corresponding tRNA/aminoacyl-tRNA synthetase pair. These include fluorescent, glycosylated, metal-ion-binding, and redox-active amino acids, as well as amino acids with unique chemical and photochemical reactivity. This methodology provides a powerful tool both for exploring protein structure and function in vitro and in vivo and for generating proteins with new or enhanced properties.
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Citations
Cites
A General Method for Site-specific Incorporation of Unnatural Amino Acids into Proteins
Noren, C. J., Anthony-Cahill, S. J., Griffith, M. C., & Schultz, P. G. (1989) · Science · doi:10.1126/science.2649980 · Cited by 1,019 · cited 1×
“A general in vitro biosynthetic method for incorporating unnatural amino acids into proteins uses nonsense or frameshift suppressor tRNAs that are chemically misacylated with the amino acid (6, 40, 62).”
Self-citationBiosynthetic site-specific incorporation of a non-natural amino acid into a polypeptide
Bain, J. D., Diala, E. S., Glabe, C. G., Dix, T. A., & Chamberlin, A. R. (1989) · Journal of the American Chemical Society · doi:10.1021/ja00202a052 · Cited by 250
Cited by
The return of metabolism: biochemistry and physiology of the pentose phosphate pathway
Stincone, A., Prigione, A., Cramer, T., Wamelink, M. M. C., Campbell, K., Cheung, E., Olin‐Sandoval, V., Grüning, N., Krüger, A., Tauqeer Alam, M., et al. (2015) · Biological Reviews · doi:10.1111/brv.12140 · Cited by 1,576
Dill, K. A., Ozkan, S. B., Shell, M. S., & Weikl, T. R. (2008) · Annual Review of Biophysics · doi:10.1146/annurev.biophys.37.092707.153558 · Cited by 1,163
Super-resolution microscopy with DNA-PAINT
Schnitzbauer, J., Strauss, M. T., Schlichthaerle, T., Schueder, F., & Jungmann, R. (2017) · Nature Protocols · doi:10.1038/nprot.2017.024 · Cited by 1,047
Origin and evolution of the genetic code: The universal enigma
Koonin, E. V., & Novozhilov, A. S. (2009) · IUBMB Life · doi:10.1002/iub.146 · Cited by 392
Natural expansion of the genetic code
Ambrogelly, A., Palioura, S., & Söll, D. (2007) · Nature Chemical Biology · doi:10.1038/nchembio847 · Cited by 361
Metadata
- Authors
- Wang, L., Xie, J., & Schultz, P. G.
- Venue
- Annual Review of Biophysics and Biomolecular Structure
- Publisher
- Annual Reviews
- Published
- 2006-06
- Volume
- 35
- Issue
- 1
- Pages
- 225-249
- ISSN
- 1056-8700 (ISSN-L)
- 1545-4266
- OpenAlex
- W2616139473
- Cited by
- 582
- References
- 2
- FWCI
- 18.66
- Type
- journal article
- Language
- en
- Open access
- closed
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- Wang, L., Xie, J., & Schultz, P. G. (2006). EXPANDING THE GENETIC CODE. Annual Review of Biophysics and Biomolecular Structure. https://doi.org/10.1146/annurev.biophys.35.101105.121507
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
