The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Bilayer Thickness and Membrane Protein Function: An Energetic Perspective
Abstract
The lipid bilayer component of biological membranes is important for the distribution, organization, and function of bilayer-spanning proteins. This regulation is due to both specific lipid-protein interactions and general bilayer-protein interactions, which modulate the energetics and kinetics of protein conformational transitions, as well as the protein distribution between different membrane compartments. The bilayer regulation of membrane protein function arises from the hydrophobic coupling between the protein's hydrophobic domains and the bilayer hydrophobic core, which causes protein conformational changes that involve the protein/bilayer boundary to perturb the adjacent bilayer. Such bilayer perturbations, or deformations, incur an energetic cost, which for a given conformational change varies as a function of the bilayer material properties (bilayer thickness, intrinsic lipid curvature, and the elastic compression and bending moduli). Protein function therefore is regulated by changes in bilayer material properties, which determine the free-energy changes caused by the protein-induced bilayer deformation. The lipid bilayer thus becomes an allosteric regulator of membrane function.
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Cites
Lipid–protein interactions in biological membranes: A structural perspective
Lee, A. G. (2003) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/s0005-2736(03)00056-7 · Cited by 886 · cited 2×
“In fact, when lipid molecules can be discerned and identified in membrane protein structures, they usually are resolved only in part (59, 60)—even at cryogenic temperatures— suggesting limited chemical specificity, significant disorder/mobility, or both.”
BackgroundPermeability of small nonelectrolytes through lipid bilayer membranes
Walter, A., & Gutknecht, J. (1986) · The Journal of Membrane Biology · doi:10.1007/bf01870127 · Cited by 502
Cited by
Membrane lipids: where they are and how they behave
van Meer, G., Voelker, D. R., & Feigenson, G. W. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2330 · Cited by 7,157
Emerging Diversity in Lipid–Protein Interactions
Corradi, V., Sejdiu, B. I., Mesa-Galloso, H., Abdizadeh, H., Noskov, S. Y., Marrink, S. J., & Tieleman, D. P. (2019) · Chemical Reviews · doi:10.1021/acs.chemrev.8b00451 · Cited by 459
Optically monitoring voltage in neurons by photo-induced electron transfer through molecular wires
Miller, E. W., Lin, J. Y., Frady, E. P., Steinbach, P. A., Kristan, W. B., & Tsien, R. Y. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1120694109 · Cited by 323
Coon, B. G., Baeyens, N., Han, J., Budatha, M., Ross, T. D., Fang, J. S., Yun, S., Thomas, J.-L., & Schwartz, M. A. (2015) · Journal of Cell Biology · doi:10.1083/jcb.201408103 · Cited by 299
Torres, M. J., Kew, K. A., Ryan, T. E., Pennington, E. R., Lin, C.-T., Buddo, K. A., Fix, A. M., Smith, C. A., Gilliam, L. A., Karvinen, S., et al. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2017.10.003 · Cited by 170
Metadata
- Authors
- Andersen, O. S., & Koeppe, R. E.
- Venue
- Annual Review of Biophysics and Biomolecular Structure
- Publisher
- Annual Reviews
- Published
- 2007-06-01
- Volume
- 36
- Issue
- 1
- Pages
- 107-130
- ISSN
- 1056-8700 (ISSN-L)
- 1545-4266
- OpenAlex
- W2101934167
- Cited by
- 866
- References
- 2
- FWCI
- 12.69
- Type
- journal article
- Language
- en
- Open access
- closed
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- Andersen, O. S., & Koeppe, R. E. (2007). Bilayer Thickness and Membrane Protein Function: An Energetic Perspective. Annual Review of Biophysics and Biomolecular Structure. https://doi.org/10.1146/annurev.biophys.36.040306.132643
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