17β-estradiol directly lowers mitochondrial membrane microviscosity and improves bioenergetic function in skeletal muscle
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Menopause results in a progressive decline in 17β-estradiol (E2) levels, increased adiposity, decreased insulin sensitivity, and a higher risk for type 2 diabetes. Estrogen therapies can help reverse these effects, but the mechanism(s) by which E2 modulates susceptibility to metabolic disease is not well understood. In young C57BL/6N mice, short-term ovariectomy decreased-whereas E2 therapy restored-mitochondrial respiratory function, cellular redox state (GSH/GSSG), and insulin sensitivity in skeletal muscle. E2 was detected by liquid chromatography-mass spectrometry in mitochondrial membranes and varied according to whole-body E2 status independently of ERα. Loss of E2 increased mitochondrial membrane microviscosity and H 2 O 2 emitting potential, whereas E2 administration in vivo and in vitro restored membrane E2 content, microviscosity, complex I and I + III activities, H 2 O 2 emitting potential, and submaximal OXPHOS responsiveness. These findings demonstrate that E2 directly modulates membrane biophysical properties and bioenergetic function in mitochondria, offering a direct mechanism by which E2 status broadly influences energy homeostasis.
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17β-estradiol can directly reduce the microviscosity of mitochondrial membrane and bioenergetic function in skeletal muscle without dependence on its receptor.
“A recent study also showed that 17β-estradiol could directly reduce the microviscosity of mitochondrial membrane and bioenergetic function in skeletal muscle without dependence on its receptor (135).”
From From mitochondria to sarcopenia: role of 17β-estradiol and testosterone (2023) · cites this paper as [135]
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Iñigo, M. R., Amorese, A. J., Tarpey, M. D., Balestrieri, N. P., Jones, K. G., Patteson, D. J., Jackson, K. C., Torres, M. J., Lin, C.-T., Smith, C. D., et al. (2020) · Molecular Metabolism · doi:10.1016/j.molmet.2019.12.010 · Cited by 29 · see citing works
Self-citation
- Authors
- Torres, M. J., Kew, K. A., Ryan, T. E., Pennington, E. R., Lin, C.-T., Buddo, K. A., Fix, A. M., Smith, C. A., Gilliam, L. A., Karvinen, S., Lowe, D. A., Spangenburg, E. E., Zeczycki, T. N., Shaikh, S. R., & Neufer, P. D.
- Affiliations
- East Carolina University (US)
- University of Minnesota (US)
- Corresponding author
- Neufer, P. Darrell
- ORCID
- Venue
- Cell Metabolism
- Publisher
- Elsevier BV
- Published
- 2018-01
- Volume
- 27
- Issue
- 1
- Pages
- 167-179.e7
- ISSN
- 1550-4131 (ISSN-L)
- PMC
- PMC5762397
- OpenAlex
- W2766307829
- Cited by
- 170
- References
- 91
- Citations by year
- 2026: 15 · 2025: 20 · 2024: 24 · 2023: 14 · 2022: 23 · 2021: 22 · 2020: 19 · 2019: 16 · 2018: 17
- FWCI
- 5.81
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- The Scholarship East Carolina University's Institutional Repository (East Carolina University) (submittedVersion)
- Funders
- U.S. Public Health Services (R01 HL123647, R01 AT008375)
- ADA (R01 AG031743, R01 DK096907, R01 DK110656)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
- Keywords
- estradiol, skeletal muscle bioenergetics, menopause, ovariectomy, estrogen therapy, mitochondrial respiration, oxidative phosphorylation, hydrogen peroxide emission, redox state, glutathione, insulin sensitivity, type 2 diabetes, energy homeostasis
- MeSH terms
- Animals, Diabetes Mellitus, Experimental, Electron Transport, Energy Metabolism, Estradiol, Female, Glucose, Homeostasis, Mice, Inbred C57BL, Mitochondria, Obesity, Ovary, Oxidation-Reduction, Viscosity, Muscle, Skeletal, Cell Respiration, Electron Transport Complex I, Adiposity, Mitochondrial Membranes, Cellular Microenvironment
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