The Cell Biology of Infection by Intracellular Bacterial Pathogens
Abstract
Listeria monocytogenes and Shigella flexneri are unrelated bacterial pathogens that have independently evolved similar strategies of survival within an infected host animal. Bacteria coming into contact with the surface of an epithelial cell induce cytoskeletal rearrangements resulting in phagocytosis. They then secrete enzymes that degrade the phagosomal membrane, releasing the bacteria into the host cytoplasm. Intracytoplasmic bacteria move rapidly, in association with a "comet tail" made up of host cell actin filaments. When moving bacteria reach the cell margin, they push out long protrusions with the bacteria at the tips that are then taken up by neighboring cells, allowing the infection to spread from cell to cell. This review summarizes what is currently known about the interactions between the bacteria and the host at each stage of the infection and discusses what mammalian cell biologists can learn by studying bacterial pathogens.
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If ingested bacteria have no intracellular survival mechanisms, the bacteria-containing phagosomes fuse with the lysosomal compartment, and bacteria are digested within 15-30 min.
“If the ingested bacteria have no intracellular survival mechanisms, the bacteria-containing phagosomes fuse with the lysosomal compartment, and bacteria are digested within 15–30 min.”
From Strategies of intracellular pathogens for obtaining iron from the environment (2015) · cites this paper as [7]
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Strategies of intracellular pathogens for obtaining iron from the environment
Leon-Sicairos, N., Reyes-Cortes, R., Guadrón-Llanos, A. M., Madueña-Molina, J., Leon-Sicairos, C., & Canizalez-Román, A. (2015) · BioMed Research International · doi:10.1155/2015/476534 · Cited by 51 · see citing works
“For this reason, the majority of intracellular bacteria and other parasites must keep host cells alive as long as possible while they are reproducing and growing [7, 9].”
Background
- Authors
- Theriot, J. A.
- Affiliations
- Whitehead Institute for Biomedical Research (US)
- Corresponding author
- Theriot, Julie A.
- ORCID
- Theriot, Julie A.
- Venue
- Annual Review of Cell and Developmental Biology
- Publisher
- Annual Reviews
- Published
- 1995-11
- Volume
- 11
- Issue
- 1
- Pages
- 213-239
- ISSN
- 1081-0706 (ISSN-L)
- 1530-8995
- OpenAlex
- W2124758037
- Cited by
- 122
- References
- 87
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 1 · 2021: 3 · 2018: 2 · 2017: 1 · 2015: 2 · 2014: 4 · 2013: 2 · 2012: 1
- FWCI
- 12.68
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annual Review of Cell and Developmental Biology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Allergy and Infectious Diseases (R37AI036929)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Escherichia coli research studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Listeria monocytogenes in Food Safety
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
- Keywords
- intracellular bacterial pathogens, Listeria monocytogenes, Shigella flexneri, phagocytosis, actin comet tails, cytoskeletal rearrangement, cell-to-cell transmission, host-bacteria interactions, epithelial cells
- MeSH terms
- Animals, Bacterial Adhesion, Cell Movement, Cytoplasm, Cytoskeleton, Dysentery, Bacillary, Epithelium, Humans, Listeriosis, Listeria monocytogenes, Phagocytosis, Shigella flexneri
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