The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Trafficking to the Ciliary Membrane: How to Get Across the Periciliary Diffusion Barrier?
Open accessAbstract
The primary cilium organizes numerous signal transduction cascades, and an understanding of signaling receptor trafficking to cilia is now emerging. A defining feature of cilia is the periciliary diffusion barrier that separates the ciliary and plasma membranes. Although lateral transport through this barrier may take place, polarized exocytosis to the base of the cilium has been the prevailing model for delivering membrane proteins to cilia. Key players for this polarized exocytosis model include the GTPases Rab8 and Rab11, the exocyst, and possibly the intraflagellar tranport machinery. In turn, the sorting of membrane proteins to cilia critically relies on the recognition of ciliary targeting signals by sorting machines such as the BBSome coat complex or the GTPase Arf4. Finally, some proteins need to exit from cilia, and ubiquitination may regulate this step. The stage is now set to dissect the interplay between signaling and regulated trafficking to and from cilia.
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Cites
Phosphoinositides in cell regulation and membrane dynamics
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Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells
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Vertebrate Smoothened functions at the primary cilium
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Patched1 Regulates Hedgehog Signaling at the Primary Cilium
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Nachury, M. V., Loktev, A. V., Zhang, Q., Westlake, C. J., Peränen, J., Merdes, A., Slusarski, D. C., Scheller, R. H., Bazan, J. F., Sheffield, V. C., et al. (2007) · Cell · doi:10.1016/j.cell.2007.03.053 · Cited by 1,384
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Self-citationOverview of Structure and Function of Mammalian Cilia
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Establishing and regulating the composition of cilia for signal transduction
Nachury, M. V., & Mick, D. U. (2019) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-019-0116-4 · Cited by 397
Self-citationOpen Sesame: How Transition Fibers and the Transition Zone Control Ciliary Composition
Garcia-Gonzalo, F. R., & Reiter, J. F. (2017) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a028134 · Cited by 290
BBSome trains remove activated GPCRs from cilia by enabling passage through the transition zone
Ye, F., Nager, A. R., & Nachury, M. V. (2018) · Journal of Cell Biology · doi:10.1083/jcb.201709041 · Cited by 256
Self-citationIntraflagellar transport: mechanisms of motor action, cooperation, and cargo delivery
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Metadata
- Authors
- Nachury, M. V., Seeley, E. S., & Jin, H.
- Venue
- Annual Review of Cell and Developmental Biology
- Publisher
- Annual Reviews
- Published
- 2010-11-10
- Volume
- 26
- Issue
- 1
- Pages
- 59-87
- ISSN
- 1081-0706 (ISSN-L)
- 1530-8995
- OpenAlex
- W2159434269
- Cited by
- 426
- References
- 12
- FWCI
- 3.78
- Type
- journal article
- Language
- en
- Open access
- green
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- Nachury, M. V., Seeley, E. S., & Jin, H. (2010). Trafficking to the Ciliary Membrane: How to Get Across the Periciliary Diffusion Barrier? Annual Review of Cell and Developmental Biology. https://doi.org/10.1146/annurev.cellbio.042308.113337
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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