Intraflagellar transport: mechanisms of motor action, cooperation, and cargo delivery

Prevo, Bram; Scholey, Jonathan M.; Peterman, Erwin J. G.

doi:10.1111/febs.14068

Cited by 203Genetic and Kidney Cyst DiseasesCystic Fibrosis Research AdvancesMicrotubule and mitosis dynamics

Intraflagellar transport: mechanisms of motor action, cooperation, and cargo delivery

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Prevo, Bram, Scholey, Jonathan M., Peterman, Erwin J. G.·2017·The FEBS Journal

DOI 10.1111/febs.14068PMC PMC5603355

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Abstract

Intraflagellar transport (IFT) is a form of motor‐dependent cargo transport that is essential for the assembly, maintenance, and length control of cilia, which play critical roles in motility, sensory reception, and signal transduction in virtually all eukaryotic cells. During IFT, anterograde kinesin‐2 and retrograde IFT dynein motors drive the bidirectional transport of IFT trains that deliver cargo, for example, axoneme precursors such as tubulins as well as molecules of the signal transduction machinery, to their site of assembly within the cilium. Following its discovery in Chlamydomonas, IFT has emerged as a powerful model system for studying general principles of motor‐dependent cargo transport and we now appreciate the diversity that exists in the mechanism of IFT within cilia of different cell types. The absence of heterotrimeric kinesin‐2 function, for example, causes a complete loss of both IFT and cilia in Chlamydomonas, but following its loss in Caenorhabditis elegans, where its primary function is loading the IFT machinery into cilia, homodimeric kinesin‐2‐driven IFT persists and assembles a full‐length cilium. Generally, heterotrimeric kinesin‐2 and IFT dynein motors are thought to play widespread roles as core IFT motors, whereas homodimeric kinesin‐2 motors are accessory motors that mediate different functions in a broad range of cilia, in some cases contributing to axoneme assembly or the delivery of signaling molecules but in many other cases their ciliary functions, if any, remain unknown. In this review, we focus on mechanisms of motor action, motor cooperation, and motor‐dependent cargo delivery during IFT.

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Subsequent work in protists and metazoans, including Tetrahymena, Trypanosoma, C. elegans, sea urchin, zebrafish, mouse and human, substantiated the evolutionary conservation of IFT and provided insight into its molecular workings and physiological roles.
“Subsequent work in a range of additional organisms, including protists such as Tetrahymena thermophila and Trypanosoma brucei and metazoans like C. elegans, sea urchin, zebrafish, mouse, and human, have substantiated this view, and provided remarkable insight into the molecular workings and physiological roles of IFT 25, 30, 31, 46.”
From Cellular signalling by primary cilia in development, organ function and disease (2019) · cites this paper as [31]
Section 7 (IFT in different Model Systems; page unavailable) describes IFT studies across protists, C. elegans, sea urchins, zebrafish, and mice, and says direct assays in several systems have yielded mechanistic insight. Its Protists subsection covers Trypanosoma, and its references identify an IFT assay in Tetrahymena. The passages support the broad cross-eukaryote point, but do not document human work as part of the claimed subsequent studies. (LLM, conf=0.82)
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These IFT polypeptides can be subdivided into IFT-A, IFT-B1 and IFT-B2 sub-complexes containing 6, 10 and 6 different IFT particle proteins, respectively.
“We now know these polypeptides can be subdivided into IFT-A, IFT-B1 and IFT-B2 sub-complexes that contain 6, 10 and 6 different IFT particle proteins, respectively 25, 30, 31, 46, 47.”
From Cellular signalling by primary cilia in development, organ function and disease (2019) · cites this paper as [31]

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The Molecular Motor Toolbox for Intracellular Transport
Vale, R. D. (2003) · Cell · doi:10.1016/s0092-8674(03)00111-9 · Cited by 1,982 · see citing works
Kinesin superfamily motor proteins and intracellular transport
Hirokawa, N., Noda, Y., Tanaka, Y., & Niwa, S. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2774 · Cited by 1,859 · cited 1× · see citing works
“It is important to realize that, in contrast to many other intracellular transport mechanisms [205, 206], IFT cargoes are not contained in membranous vesicles, but in most cases comprise proteins that directly attach to the IFT machinery.”
Background
The primary cilium: a signalling centre during vertebrate development
Goetz, S. C., & Anderson, K. V. (2010) · Nature Reviews Genetics · doi:10.1038/nrg2774 · Cited by 1,824 · see citing works
Randomization of Left–Right Asymmetry due to Loss of Nodal Cilia Generating Leftward Flow of Extraembryonic Fluid in Mice Lacking KIF3B Motor Protein
Nonaka, S., Tanaka, Y., Okada, Y., Takeda, S., Harada, A., Kanai, Y., Kido, M. A., & Hirokawa, N. (1998) · Cell · doi:10.1016/s0092-8674(00)81705-5 · Cited by 1,619 · see citing works
Intraflagellar transport
Rosenbaum, J. L., & Witman, G. B. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm952 · Cited by 1,423 · see citing works
A Core Complex of BBS Proteins Cooperates with the GTPase Rab8 to Promote Ciliary Membrane Biogenesis
Nachury, M. V., Loktev, A. V., Zhang, Q., Westlake, C. J., Peränen, J., Merdes, A., Slusarski, D. C., Scheller, R. H., Bazan, J. F., Sheffield, V. C., et al. (2007) · Cell · doi:10.1016/j.cell.2007.03.053 · Cited by 1,384 · see citing works
Overview of Structure and Function of Mammalian Cilia
Satir, P., & Christensen, S. T. (2007) · Annual Review of Physiology · doi:10.1146/annurev.physiol.69.040705.141236 · Cited by 1,142 · cited 1× · see citing works
“In motile cilia, 9 symmetrically arranged doublet MTs often surround a pair of single MTs, in a so-called 9 + 2 configuration [58].”
Background
Single kinesin molecules studied with a molecular force clamp
Visscher, K., Schnitzer, M. J., & Block, S. M. (1999) · Nature · doi:10.1038/22146 · Cited by 1,027 · see citing works
A motility in the eukaryotic flagellum unrelated to flagellar beating.
Kozminski, K. G., Johnson, K. A., Forscher, P., & Rosenbaum, J. L. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.12.5519 · Cited by 1,007 · see citing works
The phagotrophic origin of eukaryotes and phylogenetic classification of Protozoa.
Cavalier‐Smith, T. (2002) · INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY · doi:10.1099/00207713-52-2-297 · Cited by 995 · see citing works
Ciliogenesis: building the cell's antenna
Ishikawa, H., & Marshall, W. F. (2011) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3085 · Cited by 956 · see citing works
Mutant sensory cilia in the nematode Caenorhabditis elegans
Perkins, L. A., Hedgecock, E. M., Thomson, J. N., & Culotti, J. G. (1986) · Developmental Biology · doi:10.1016/0012-1606(86)90314-3 · Cited by 907 · see citing works
Chlamydomonas Kinesin-II–dependent Intraflagellar Transport (IFT): IFT Particles Contain Proteins Required for Ciliary Assembly in Caenorhabditis elegans Sensory Neurons
Cole, D. G., Diener, D. R., Himelblau, A. L., Beech, P. L., Fuster, J. C., & Rosenbaum, J. L. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.141.4.993 · Cited by 898 · see citing works
The Molecular Architecture of Axonemes Revealed by Cryoelectron Tomography
Nicastro, D., Schwartz, C. L., Pierson, J., Gaudette, R., Porter, M. E., & McIntosh, J. R. (2006) · Science · doi:10.1126/science.1128618 · Cited by 881 · see citing works
Post-translational regulation of the microtubule cytoskeleton: mechanisms and functions
Janke, C., & Bulinski, J. C. (2011) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3227 · Cited by 838 · see citing works
Kinesin superfamily motor protein KIF17 and mLin-10 in NMDA receptor-containing vesicle transport.
Setou, M., Nakagawa, T., Seog, D., & Hirokawa, N. (2000) · Science · doi:10.1126/science.288.5472.1796 · Cited by 744 · see citing works
CENTRIOLES AND THE FORMATION OF RUDIMENTARY CILIA BY FIBROBLASTS AND SMOOTH MUSCLE CELLS
Sorokin, S. (1962) · The Journal of Cell Biology · doi:10.1083/jcb.15.2.363 · Cited by 732 · see citing works
Single-molecule analysis of dynein processivity and stepping behavior.
Reck-Peterson, S., Yildiz, A., Carter, A., Gennerich, A., Zhang, N., & Vale, R. (2006) · Cell · doi:10.1016/j.cell.2006.05.046 · Cited by 649 · see citing works
Regulation of microtubule motors by tubulin isotypes and post-translational modifications
Sirajuddin, M., Rice, L. M., & Vale, R. D. (2014) · Nature Cell Biology · doi:10.1038/ncb2920 · Cited by 604 · see citing works
The Conserved Bardet-Biedl Syndrome Proteins Assemble a Coat that Traffics Membrane Proteins to Cilia
Jin, H., White, S. R., Shida, T., Schulz, S., Aguiar, M., Gygi, S. P., Bazán, J. F., & Nachury, M. V. (2010) · Cell · doi:10.1016/j.cell.2010.05.015 · Cited by 594 · see citing works
The Chlamydomonas kinesin-like protein FLA10 is involved in motility associated with the flagellar membrane.
Kozminski, K. G., Beech, P. L., & Rosenbaum, J. L. (1995) · The Journal of cell biology · doi:10.1083/jcb.131.6.1517 · Cited by 586 · see citing works
Activation of cytoplasmic dynein motility by dynactin-cargo adapter complexes
McKenney, R. J., Huynh, W., Tanenbaum, M. E., Bhabha, G., & Vale, R. D. (2014) · Science · doi:10.1126/science.1254198 · Cited by 571 · see citing works
The Tubulin Code
Verhey, K. J., & Gaertig, J. (2007) · Cell Cycle · doi:10.4161/cc.6.17.4633 · Cited by 558 · see citing works
Traffic control: regulation of kinesin motors
Verhey, K. J., & Hammond, J. W. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2782 · Cited by 546 · see citing works
Chapter Two Intraflagellar Transport (IFT)
Pedersen, L. B., & Rosenbaum, J. L. (2008) · Current Topics in Developmental Biology · doi:10.1016/s0070-2153(08)00802-8 · Cited by 521 · see citing works
Flagellar motility is required for the viability of the bloodstream trypanosome
Broadhead, R., Dawe, H. R., Farr, H., Griffiths, S. J., Hart, S. R., Portman, N., Shaw, M. K., Ginger, M. L., Gaskell, S. J., McKean, P. G., et al. (2006) · Nature · doi:10.1038/nature04541 · Cited by 488 · see citing works
THE CILIARY NECKLACE
Gilula, N. B., & Satir, P. (1972) · The Journal of Cell Biology · doi:10.1083/jcb.53.2.494 · Cited by 484 · see citing works
The base of the cilium: roles for transition fibres and the transition zone in ciliary formation, maintenance and compartmentalization
Reiter, J. F., Blacque, O. E., & Leroux, M. R. (2012) · EMBO Reports · doi:10.1038/embor.2012.73 · Cited by 476 · see citing works
The DHC1b (DHC2) Isoform of Cytoplasmic Dynein Is Required for Flagellar Assembly
Pazour, G. J., Dickert, B. L., & Witman, G. B. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.144.3.473 · Cited by 471 · see citing works
MKS and NPHP modules cooperate to establish basal body/transition zone membrane associations and ciliary gate function during ciliogenesis
Williams, C. L., Li, C., Kida, K., Inglis, P. N., Mohan, S., Semenec, L., Bialas, N. J., Stupay, R. M., Chen, N., Blacque, O. E., et al. (2011) · The Journal of Cell Biology · doi:10.1083/jcb.201012116 · Cited by 453 · see citing works
Intraflagellar transport balances continuous turnover of outer doublet microtubules
Marshall, W. F., & Rosenbaum, J. L. (2001) · The Journal of Cell Biology · doi:10.1083/jcb.200106141 · Cited by 436 · see citing works
TULP3 bridges the IFT-A complex and membrane phosphoinositides to promote trafficking of G protein-coupled receptors into primary cilia
Mukhopadhyay, S., Wen, X., Chih, B., Nelson, C. D., Lane, W. S., Scales, S. J., & Jackson, P. K. (2010) · Genes & Development · doi:10.1101/gad.1966210 · Cited by 435 · see citing works
Tug-of-War in Motor Protein Ensembles Revealed with a Programmable DNA Origami Scaffold
Derr, N. D., Goodman, B. S., Jungmann, R., Leschziner, A. E., Shih, W. M., & Reck‐Peterson, S. L. (2012) · Science · doi:10.1126/science.1226734 · Cited by 434 · see citing works
A Dynein Light Chain Is Essential for the Retrograde Particle Movement of Intraflagellar Transport (IFT)
Pazour, G. J., Wilkerson, C. G., & Witman, G. B. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.141.4.979 · Cited by 425 · see citing works
Motor coordination via a tug-of-war mechanism drives bidirectional vesicle transport
Hendricks, A. G., Perlson, E., Ross, J. L., Schroeder, H. W., Tokito, M., & Holzbaur, E. L. F. (2010) · Current Biology · doi:10.1016/j.cub.2010.02.058 · Cited by 423 · see citing works
Trafficking to the Ciliary Membrane: How to Get Across the Periciliary Diffusion Barrier?
Nachury, M. V., Seeley, E. S., & Jin, H. (2010) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.042308.113337 · Cited by 423 · see citing works
Functional coordination of intraflagellar transport motors
Ou, G., E. Blacque, O., Snow, J. J., Leroux, M. R., & Scholey, J. M. (2005) · Nature · doi:10.1038/nature03818 · Cited by 411 · see citing works
Self-citation
Genetic Evidence for Selective Transport of Opsin and Arrestin by Kinesin-II in Mammalian Photoreceptors
Marszalek, J. R., Liu, X., Roberts, E. A., Chui, D., Marth, J. D., Williams, D. S., & Goldstein, L. S. B. (2000) · Cell · doi:10.1016/s0092-8674(00)00023-4 · Cited by 405 · see citing works
Tracing the origins of centrioles, cilia, and flagella
Carvalho-Santos, Z., Azimzadeh, J., Pereira‐Leal, J. B., & Bettencourt‐Dias, M. (2011) · The Journal of Cell Biology · doi:10.1083/jcb.201011152 · Cited by 405 · see citing works
Two anterograde intraflagellar transport motors cooperate to build sensory cilia on C. elegans neurons
Snow, J. J., Ou, G., Gunnarson, A. L., Walker, M. R. S., Zhou, H. M., Brust-Mascher, I., & Scholey, J. M. (2004) · Nature Cell Biology · doi:10.1038/ncb1186 · Cited by 404 · see citing works
Self-citation
Cooperative cargo transport by several molecular motors
Klumpp, S., & Lipowsky, R. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0507363102 · Cited by 397 · see citing works
Localization of intraflagellar transport protein IFT52 identifies basal body transitional fibers as the docking site for IFT particles
Deane, J. A., Cole, D. G., Seeley, E. S., Diener, D. R., & Rosenbaum, J. L. (2001) · Current Biology · doi:10.1016/s0960-9822(01)00484-5 · Cited by 391 · see citing works
Intraflagellar Transport
Scholey, J. M. (2003) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.19.111401.091318 · Cited by 378 · see citing works
Self-citation
In vitro reconstitution of a highly processive recombinant human dynein complex
Schlager, M. A., Hoang, H. T., Urnavicius, L., Bullock, S. L., & Carter, A. P. (2014) · The EMBO Journal · doi:10.15252/embj.201488792 · Cited by 351 · see citing works
The Intraflagellar Transport Machinery
Taschner, M., & Lorentzen, E. (2016) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a028092 · Cited by 349 · see citing works
The Chlamydomonas reinhardtii BBSome is an IFT cargo required for export of specific signaling proteins from flagella
Lechtreck, K.-F., Johnson, E. C., Sakai, T., Cochran, D., Ballif, B. A., Rush, J., Pazour, G. J., Ikebe, M., & Witman, G. B. (2009) · Journal of Cell Biology · doi:10.1083/jcb.200909183 · Cited by 347 · see citing works
Loss of C. elegans BBS-7 and BBS-8 protein function results in cilia defects and compromised intraflagellar transportPreprint
Blacque, O. E., Reardon, M. J., Li, C., McCarthy, J., Mahjoub, M. R., Ansley, S. J., Badano, J. L., Mah, A. K., Beales, P. L., Davidson, W. S., et al. (2004) · Genes & Development · doi:10.1101/gad.1194004 · Cited by 347 · see citing works
THM1 negatively modulates mouse sonic hedgehog signal transduction and affects retrograde intraflagellar transport in cilia
Tran, P. V., Haycraft, C. J., Besschetnova, T. Y., Turbé-Doan, A., Stottmann, R. W., Herron, B. J., Chesebro, A. L., Qiu, H., Scherz, P., Shah, J. V., et al. (2008) · Nature Genetics · doi:10.1038/ng.105 · Cited by 337 · see citing works
OLFACTORY CILIA IN THE FROG
Reese, T. S. (1965) · The Journal of Cell Biology · doi:10.1083/jcb.25.2.209 · Cited by 334 · see citing works
Cytoplasmic Dynein Heavy Chain 1b Is Required for Flagellar Assembly inChlamydomonas
Porter, M. E., Bower, R., Knott, J. A., Byrd, P., & Dentler, W. (1999) · Molecular Biology of the Cell · doi:10.1091/mbc.10.3.693 · Cited by 333 · see citing works
Molecular Basis of Tubulin Transport Within the Cilium by IFT74 and IFT81
Bhogaraju, S., Cajanek, L., Fort, C., Blisnick, T., Weber, K., Taschner, M., Mizuno, N., Lamla, S., Bastin, P., Nigg, E. A., et al. (2013) · Science · doi:10.1126/science.1240985 · Cited by 317 · see citing works
IFT–Cargo Interactions and Protein Transport in Cilia
Lechtreck, K. F. (2015) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2015.09.003 · Cited by 316 · see citing works
A size-exclusion permeability barrier and nucleoporins characterize a ciliary pore complex that regulates transport into cilia
Kee, H. L., Dishinger, J. F., Blasius, T. L., Liu, C., Margolis, B. L., & Verhey, K. J. (2012) · Nature Cell Biology · doi:10.1038/ncb2450 · Cited by 311 · see citing works
The kinesin-4 protein Kif7 regulates mammalian Hedgehog signalling by organizing the cilium tip compartment
He, M., Subramanian, R., Bangs, F., Omelchenko, T., Liem Jr, K. F., Kapoor, T. M., & Anderson, K. V. (2014) · Nature Cell Biology · doi:10.1038/ncb2988 · Cited by 302 · cited 1× · see citing works
“tip of the cilium to regulate transcription factors involved in Hedgehog signaling [160].”
Background
Role of a Class Dhc1b Dynein in Retrograde Transport of Ift Motors and Ift Raft Particles along Cilia, but Not Dendrites, in Chemosensory Neurons of Living Caenorhabditis elegans
Signor, D., Wedaman, K. P., Orozco, J. T., Dwyer, N. D., Bargmann, C. I., Rose, L. S., & Scholey, J. M. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.147.3.519 · Cited by 301 · see citing works
Self-citation
Early steps in primary cilium assembly require EHD1/EHD3-dependent ciliary vesicle formation
Lü, Q., Insinna, C., Ott, C. M., Stauffer, J. K., Pintado, P. A., Rahajeng, J., Baxa, U., Walia, V., Cuenca, A. A., Hwang, Y.-S., et al. (2015) · Nature Cell Biology · doi:10.1038/ncb3109 · Cited by 299 · see citing works
Ciliary entry of the kinesin-2 motor KIF17 is regulated by importin-β2 and RanGTP
Dishinger, J. F., Kee, H. L., Jenkins, P. M., Fan, S., Hurd, T. W., Hammond, J. W., Truong, Y. N., Margolis, B. L., Martens, J. R., & Verhey, K. J. (2010) · Nature Cell Biology · doi:10.1038/ncb2073 · Cited by 285 · see citing works
Transport of a novel complex in the cytoplasmic matrix of Chlamydomonas flagella
Piperno, G., & Mead, K. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.9.4457 · Cited by 275 · see citing works
Novel heterotrimeric kinesin-related protein purified from sea urchin eggs
Cole, D. G., Chinn, S. W., Wedaman, K. P., Hall, K., Vuong, T., & Scholey, J. M. (1993) · Nature · doi:10.1038/366268a0 · Cited by 269 · see citing works
Self-citation
Axoneme Structure from Motile CiliaPreprint
Ishikawa, T. (2016) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a028076 · Cited by 257 · see citing works
Polarity of flagellar assembly in Chlamydomonas.
Johnson, K. A., & Rosenbaum, J. L. (1992) · The Journal of Cell Biology · doi:10.1083/jcb.119.6.1605 · Cited by 255 · see citing works
Microtubule doublets are double-track railways for intraflagellar transport trains
S̆tĕpánek, L., & Pigino, G. (2016) · Science · doi:10.1126/science.aaf4594 · Cited by 252 · see citing works
Mechanism and Regulation of Cytoplasmic Dynein
Cianfrocco, M. A., DeSantis, M. E., Leschziner, A. E., & Reck‐Peterson, S. L. (2015) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-100814-125438 · Cited by 245 · see citing works
Protein Particles inChlamydomonasFlagella Undergo a Transport Cycle Consisting of Four Phases
Iomini, C., Babaev-Khaimov, V., Sassaroli, M., & Piperno, G. (2001) · The Journal of Cell Biology · doi:10.1083/jcb.153.1.13 · Cited by 241 · see citing works
Flagellar Length Control System: Testing a Simple Model Based on Intraflagellar Transport and Turnover
Marshall, W. F., Qin, H., Rodrigo-Brenni, M. C., & Rosenbaum, J. L. (2004) · Molecular Biology of the Cell · doi:10.1091/mbc.e04-07-0586 · Cited by 241 · see citing works
Measuring collective transport by defined numbers of processive and nonprocessive kinesin motors
Furuta, K., Furuta, A., Toyoshima, Y. Y., Amino, M., Oiwa, K., & Kojima, H. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1201390110 · Cited by 238 · see citing works
Stages of ciliogenesis and regulation of ciliary length
Avasthi, P., & Marshall, W. F. (2012) · Differentiation · doi:10.1016/j.diff.2011.11.015 · Cited by 234 · see citing works
The Intraflagellar Transport Machinery of Chlamydomonas reinhardtii
Cole, D. G. (2003) · Traffic · doi:10.1034/j.1600-0854.2003.t01-1-00103.x · Cited by 232 · see citing works
Cilium-generated signaling and cilia-related disorders
Pan, J., Wang, Q., & Snell, W. J. (2005) · Laboratory Investigation · doi:10.1038/labinvest.3700253 · Cited by 226 · see citing works
The Chlamydomonas FLA10 gene encodes a novel kinesin-homologous protein.
Walther, Z., Vashishtha, M., & Hall, J. L. (1994) · The Journal of cell biology · doi:10.1083/jcb.126.1.175 · Cited by 226 · see citing works
Functional analysis of an individual IFT protein: IFT46 is required for transport of outer dynein arms into flagella
Hou, Y., Qin, H., Follit, J. A., Pazour, G. J., Rosenbaum, J. L., & Witman, G. B. (2007) · The Journal of Cell Biology · doi:10.1083/jcb.200608041 · Cited by 226 · see citing works
Ciliary Targeting of Olfactory CNG Channels Requires the CNGB1b Subunit and the Kinesin-2 Motor Protein, KIF17
Jenkins, P. M., Hurd, T. W., Zhang, L., McEwen, D. P., Brown, R. L., Margolis, B. L., Verhey, K. J., & Martens, J. R. (2006) · Current Biology · doi:10.1016/j.cub.2006.04.034 · Cited by 221 · see citing works
Evolution of intraflagellar transport from coated vesicles and autogenous origin of the eukaryotic cilium
Jékely, G., & Arendt, D. (2006) · BioEssays · doi:10.1002/bies.20369 · Cited by 221 · see citing works
Centriolar Kinesin Kif24 Interacts with CP110 to Remodel Microtubules and Regulate Ciliogenesis
Kobayashi, T., Tsang, W. Y., Li, J., Lane, W. S., & Dynlacht, B. D. (2011) · Cell · doi:10.1016/j.cell.2011.04.028 · Cited by 220 · see citing works
The BBSome controls IFT assembly and turnaround in cilia
Wei, Q., Zhang, Y., Li, Y., Zhang, Q., Ling, K., & Hu, J. (2012) · Nature Cell Biology · doi:10.1038/ncb2560 · Cited by 208 · see citing works
Intraflagellar Transport Is Required for the Vectorial Movement of TRPV Channels in the Ciliary Membrane
Qin, H., Burnette, D. T., Bae, Y.-K., Forscher, P., Barr, M. M., & Rosenbaum, J. L. (2005) · Current Biology · doi:10.1016/j.cub.2005.08.047 · Cited by 206 · see citing works
Electron-tomographic analysis of intraflagellar transport particle trains in situ
Pigino, G., Geimer, S., Lanzavecchia, S., Paccagnini, E., Cantele, F., Diener, D. R., Rosenbaum, J. L., & Lupetti, P. (2009) · The Journal of Cell Biology · doi:10.1083/jcb.200905103 · Cited by 204 · see citing works
Intraflagellar transport particle size scales inversely with flagellar length: revisiting the balance-point length control model
Engel, B. D., Ludington, W. B., & Marshall, W. F. (2009) · The Journal of Cell Biology · doi:10.1083/jcb.200812084 · Cited by 203 · see citing works
The ZebrafishfleerGene Encodes an Essential Regulator of Cilia Tubulin Polyglutamylation
Pathak, N. H., Obara, T., Mangos, S., Liu, Y., & Drummond, I. A. S. (2007) · Molecular Biology of the Cell · doi:10.1091/mbc.e07-06-0537 · Cited by 203 · see citing works
Dynactin Is Required for Transport Initiation from the Distal Axon
Moughamian, A. J., & Holzbaur, E. L. F. (2012) · Neuron · doi:10.1016/j.neuron.2012.02.025 · Cited by 198 · see citing works
Cloning and characterization of KAP3: a novel kinesin superfamily-associated protein of KIF3A/3B.
Yamazaki, H., Nakata, T., Okada, Y., & Hirokawa, N. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.16.8443 · Cited by 197 · see citing works
Cilia and Diseases
Brown, J., & Witman, G. B. (2014) · BioScience · doi:10.1093/biosci/biu174 · Cited by 197 · see citing works
Tubulin transport by IFT is upregulated during ciliary growth by a cilium-autonomous mechanism
Weghe, J. C. V. D., Harris, J. A., Hyman, S., Kner, P., & Lechtreck, K. F. (2015) · The Journal of Cell Biology · doi:10.1083/jcb.201409036 · Cited by 197 · see citing works
A high-resolution morphological and ultrastructural map of anterior sensory cilia and glia in Caenorhabditis elegans
Doroquez, D. B., Berciu, C., Anderson, J. R., Sengupta, P., & Nicastro, D. (2014) · eLife · doi:10.7554/elife.01948 · Cited by 196 · see citing works
Function and dynamics of PKD2 in Chlamydomonas reinhardtii flagella
Huang, K., Diener, D. R., Mitchell, A. P., Pazour, G. J., Witman, G. B., & Rosenbaum, J. L. (2007) · The Journal of Cell Biology · doi:10.1083/jcb.200704069 · Cited by 192 · see citing works
Mechanism of transport of IFT particles in C. elegans cilia by the concerted action of kinesin-II and OSM-3 motors
Pan, X., Ou, G., Civelekoglu‐Scholey, G., Blacque, O. E., Endres, N., Li, T., Mogilner, A., Leroux, M. R., Vale, R. D., & Scholey, J. M. (2006) · The Journal of Cell Biology · doi:10.1083/jcb.200606003 · Cited by 192 · see citing works
Self-citation
Intraflagellar transport delivers tubulin isotypes to sensory cilium middle and distal segments
Hao, L., Thein, M. C., Brust‐Mascher, I., Civelekoglu‐Scholey, G., Lu, Y., Açar, Ş., Prevo, B., Shaham, S., & Scholey, J. M. (2011) · Nature Cell Biology · doi:10.1038/ncb2268 · Cited by 188 · see citing works
Self-citation
Intraflagellar transport proteins 172, 80, 57, 54, 38, and 20 form a stable tubulin‐binding IFT‐B2 complex
Taschner, M. J., Weber, K., Mourão, A., Vetter, M., Awasthi, M., Stiegler, M., Bhogaraju, S., & Lorentzen, E. (2016) · The EMBO Journal · doi:10.15252/embj.201593164 · Cited by 186 · see citing works
Characterization of the Intraflagellar Transport Complex B Core
Lucker, B. F., Behal, R. H., Qin, H., Siron, L. C., Taggart, W. D., Rosenbaum, J. L., & Cole, D. G. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m505062200 · Cited by 184 · see citing works
Heterotrimeric Kinesin-II Is Required for the Assembly of Motile 9+2 Ciliary Axonemes on Sea Urchin Embryos
Morris, R. L., & Scholey, J. M. (1997) · The Journal of Cell Biology · doi:10.1083/jcb.138.5.1009 · Cited by 184 · see citing works
Self-citation
Molecular basis for photoreceptor outer segment architecture
Goldberg, A. F. X., Moritz, O. L., & Williams, D. S. (2016) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2016.05.003 · Cited by 180 · see citing works
Ultrastructure of cilia and flagella - back to the future!
Fisch, C., & Dupuis‐Williams, P. (2011) · Biology of the Cell · doi:10.1042/bc20100139 · Cited by 179 · see citing works
Intraflagellar Transport: The Eyes Have It
Rosenbaum, J. L., Cole, D. G., & Diener, D. R. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.144.3.385 · Cited by 178 · see citing works
Dissecting the Molecular Mechanisms of Intraflagellar Transport in Chlamydomonas
Pedersen, L. B., Geimer, S., & Rosenbaum, J. L. (2006) · Current Biology · doi:10.1016/j.cub.2006.02.020 · Cited by 174 · see citing works
The ciliary membrane
Rohatgi, R., & Snell, W. J. (2010) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2010.03.010 · Cited by 173 · see citing works
Direct evidence for BBSome-associated intraflagellar transport reveals distinct properties of native mammalian cilia
Williams, C. L., McIntyre, J. C., Norris, S. R., Jenkins, P. M., Zhang, L., Pei, Q., Verhey, K. J., & Martens, J. R. (2014) · Nature Communications · doi:10.1038/ncomms6813 · Cited by 171 · see citing works
Phylogeny and expression of axonemal and cytoplasmic dynein genes in sea urchins.
Gibbons, B. H., Asai, D. J., Tang, W., Hays, T. S., & Gibbons, I. R. (1994) · Molecular Biology of the Cell · doi:10.1091/mbc.5.1.57 · Cited by 169 · see citing works
Movement of motor and cargo along cilia
Orozco, J. T., Wedaman, K. P., Signor, D., Brown, H. M., Rose, L. S., & Scholey, J. M. (1999) · Nature · doi:10.1038/19448 · Cited by 167 · see citing works
Self-citation
Structure of human cytoplasmic dynein-2 primed for its power stroke
Schmidt, H., Zalyte, R., Urnavicius, L., & Carter, A. P. (2014) · Nature · doi:10.1038/nature14023 · Cited by 165 · see citing works
A Differential Cargo-Loading Model of Ciliary Length Regulation by IFT
Wren, K. N., Weghe, J. C. V. D., Tritschler, D., Schauer, A., Patel, D. K., Smith, E. F., Porter, M. E., Kner, P., & Lechtreck, K. F. (2013) · Current Biology · doi:10.1016/j.cub.2013.10.044 · Cited by 164 · see citing works
Functional differentiation of cooperating kinesin-2 motors orchestrates cargo import and transport in C. elegans cilia
Prevo, B., Mangeol, P., Oswald, F., Scholey, J. M., & Peterman, E. J. G. (2015) · Nature Cell Biology · doi:10.1038/ncb3263 · Cited by 163 · see citing works
Self-citation
Intraflagellar transport and the generation of dynamic, structurally and functionally diverse cilia
Silverman, M. A., & Leroux, M. R. (2009) · Trends in Cell Biology · doi:10.1016/j.tcb.2009.04.002 · Cited by 161 · see citing works
Molecular architecture of axonemal microtubule doublets revealed by cryo-electron tomography
Sui, H., & Downing, K. H. (2006) · Nature · doi:10.1038/nature04816 · Cited by 158 · see citing works
1001 model organisms to study cilia and flagella
Vincensini, L., Blisnick, T., & Bastin, P. (2011) · Biology of the Cell · doi:10.1042/bc20100104 · Cited by 153 · see citing works
The ciliopathy-associated CPLANE proteins direct basal body recruitment of intraflagellar transport machinery
Toriyama, M., Lee, C., Taylor, S. P., Durán, I., Cohn, D. H., Bruel, A., Tabler, J. M., Drew, K., Kelly, M. R., Kim, S., et al. (2016) · Nature Genetics · doi:10.1038/ng.3558 · Cited by 153 · see citing works
Evolution of modular intraflagellar transport from a coatomer-like progenitor
van Dam, T. J. P., Townsend, M. J., Turk, M., Schlessinger, A., Šali, A., Field, M. C., & Huynen, M. A. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1221011110 · Cited by 152 · see citing works
Kinesin-2: A Family of Heterotrimeric and Homodimeric Motors with Diverse Intracellular Transport Functions
Scholey, J. M. (2013) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-101512-122335 · Cited by 151 · see citing works
Self-citation
Two Heteromeric Kinesin Complexes in Chemosensory Neurons and Sensory Cilia ofCaenorhabditis elegans
Signor, D., Wedaman, K. P., Rose, L. S., & Scholey, J. M. (1999) · Molecular Biology of the Cell · doi:10.1091/mbc.10.2.345 · Cited by 149 · see citing works
Self-citation
Axonemal Dynein ArmsPreprint
King, S. M. (2016) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a028100 · Cited by 149 · see citing works
Cryo-electron tomography reveals conserved features of doublet microtubules in flagella
Nicastro, D., Fu, X., Heuser, T., Tso, A., Porter, M. E., & Linck, R. W. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1106178108 · Cited by 147 · see citing works
Kinesin-13 Regulates Flagellar, Interphase, and Mitotic Microtubule Dynamics in Giardia intestinalis
Dawson, S. C., Sagolla, M. S., Mancuso, J. J., Woessner, D. J., House, S. A., Fritz‐Laylin, L. K., & Cande, W. Z. (2007) · Eukaryotic Cell · doi:10.1128/ec.00128-07 · Cited by 146 · see citing works
Chapter 5 Targeting Proteins to the Ciliary Membrane
Pazour, G. J., & Bloodgood, R. A. (2008) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/s0070-2153(08)00805-3 · Cited by 145 · see citing works
Motility occurring in association with the surface of the Chlamydomonas flagellum.
Bloodgood, R. A. (1977) · The Journal of Cell Biology · doi:10.1083/jcb.75.3.983 · Cited by 144 · see citing works
Sequence and submolecular localization of the 115-kD accessory subunit of the heterotrimeric kinesin-II (KRP85/95) complex.
Wedaman, K. P., Meyer, D. W., Rashid, D. J., Cole, D. G., & Scholey, J. M. (1996) · The Journal of Cell Biology · doi:10.1083/jcb.132.3.371 · Cited by 143 · see citing works
Self-citation
The KLP-6 Kinesin Is Required for Male Mating Behaviors and Polycystin Localization in Caenorhabditis elegans
Peden, E. M., & Barr, M. M. (2005) · Current Biology · doi:10.1016/j.cub.2004.12.073 · Cited by 143 · see citing works
Sensory Ciliogenesis inCaenorhabditis elegans: Assignment of IFT Components into Distinct Modules Based on Transport and Phenotypic Profiles
Ou, G., Koga, M., Blacque, O. E., Murayama, T., Ohshima, Y., Schafer, J. C., Li, C., Yoder, B. K., Leroux, M. R., & Scholey, J. M. (2007) · Molecular Biology of the Cell · doi:10.1091/mbc.e06-09-0805 · Cited by 143 · see citing works
Self-citation
Cycling of the signaling protein phospholipase D through cilia requires the BBSome only for the export phase
Lechtreck, K. F., Brown, J. M., Sampaio, J. L., Craft, J. M., Shevchenko, A., Evans, J. E., & Witman, G. B. (2013) · Journal of Cell Biology · doi:10.1083/jcb.201207139 · Cited by 140 · see citing works
Single molecule imaging reveals a major role for diffusion in the exploration of ciliary space by signaling receptors
Ye, F., Breslow, D. K., Koslover, E. F., Spakowitz, A. J., Nelson, W. J., & Nachury, M. V. (2013) · eLife · doi:10.7554/elife.00654 · Cited by 138 · see citing works
XBX-1 Encodes a Dynein Light Intermediate Chain Required for Retrograde Intraflagellar Transport and Cilia Assembly inCaenorhabditis elegans
Schafer, J. C., Haycraft, C. J., Thomas, J. H., Yoder, B. K., & Swoboda, P. (2003) · Molecular Biology of the Cell · doi:10.1091/mbc.e02-10-0677 · Cited by 137 · see citing works
The FLA3 KAP Subunit Is Required for Localization of Kinesin-2 to the Site of Flagellar Assembly and Processive Anterograde Intraflagellar Transport
Mueller, J. M., Perrone, C. A., Bower, R., Cole, D. G., & Porter, M. E. (2004) · Molecular Biology of the Cell · doi:10.1091/mbc.e04-10-0931 · Cited by 134 · see citing works
Functional modulation of IFT kinesins extends the sensory repertoire of ciliated neurons in Caenorhabditis elegans
Evans, J. E., Snow, J. J., Gunnarson, A. L., Ou, G., Stahlberg, H., McDonald, K. L., & Scholey, J. M. (2006) · The Journal of Cell Biology · doi:10.1083/jcb.200509115 · Cited by 133 · see citing works
Self-citation
Inner dynein arms but not outer dynein arms require the activity of kinesin homologue protein KHP1(FLA10) to reach the distal part of flagella in Chlamydomonas.
Piperno, G., Mead, K., & Henderson, S. C. (1996) · The Journal of Cell Biology · doi:10.1083/jcb.133.2.371 · Cited by 131 · see citing works
A Novel Dynein Light Intermediate Chain Colocalizes with the Retrograde Motor for Intraflagellar Transport at Sites of Axoneme Assembly inChlamydomonasand Mammalian Cells
Perrone, C. A., Tritschler, D., Taulman, P. D., Bower, R., Yoder, B. K., & Porter, M. E. (2003) · Molecular Biology of the Cell · doi:10.1091/mbc.e02-10-0682 · Cited by 130 · see citing works
Mutation of the MAP kinase DYF-5 affects docking and undocking of kinesin-2 motors and reduces their speed in the cilia of Caenorhabditis elegans
Burghoorn, J., Dekkers, M. P. J., Rademakers, S., de Jong, T., Willemsen, R., & Jansen, G. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0606974104 · Cited by 129 · see citing works
A microtubule depolymerizing kinesin functions during both flagellar disassembly and flagellar assembly in Chlamydomonas
Piao, T., Luo, M., Wang, L., Guo, Y., Li, D., Li, P., Snell, W. J., & Pan, J. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0808671106 · Cited by 129 · see citing works
Neck Linker Length Determines the Degree of Processivity in Kinesin-1 and Kinesin-2 Motors
Shastry, S., & Hancock, W. O. (2010) · Current Biology · doi:10.1016/j.cub.2010.03.065 · Cited by 129 · see citing works
Two Kinesins Transport Cargo Primarily via the Action of One Motor: Implications for Intracellular Transport
Jamison, D. K., Driver, J. W., Rogers, A. R., Constantinou, P. E., & Diehl, M. R. (2010) · Biophysical Journal · doi:10.1016/j.bpj.2010.08.025 · Cited by 128 · see citing works
Coordination of molecular motors: from in vitro assays to intracellular dynamics
Holzbaur, E. L. F., & Goldman, Y. E. (2010) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2009.12.014 · Cited by 128 · see citing works
Uni-directional ciliary membrane protein trafficking by a cytoplasmic retrograde IFT motor and ciliary ectosome shedding
Cao, M., Ning, J., Hernandez-Lara, C. I., Belzile, O., Wang, Q., Dutcher, S. K., Liu, Y., & Snell, W. J. (2015) · eLife · doi:10.7554/elife.05242 · Cited by 127 · see citing works
The Microtubule Plus End-Tracking Protein EB1 Is Localized to the Flagellar Tip and Basal Bodies in Chlamydomonas reinhardtii
Pedersen, L. B., Geimer, S., Sloboda, R. D., & Rosenbaum, J. L. (2003) · Current Biology · doi:10.1016/j.cub.2003.10.058 · Cited by 126 · see citing works
Basal bodies platforms for building cilia.
Marshall, W. F. (2008) · PubMed · doi:10.1016/s0070-2153(08)00801-6 · Cited by 125 · see citing works
The Tubulin Deglutamylase CCPP-1 Regulates the Function and Stability of Sensory Cilia in C. elegans
O’Hagan, R., Piasecki, B. P., Silva, M., Phirke, P., Nguyen, K. C. Q., Hall, D. H., Swoboda, P., & Barr, M. M. (2011) · Current Biology · doi:10.1016/j.cub.2011.08.049 · Cited by 125 · see citing works
Autoinhibition of the kinesin-2 motor KIF17 via dual intramolecular mechanisms
Hammond, J. W., Blasius, T. L., Soppina, V., Cai, D., & Verhey, K. J. (2010) · The Journal of Cell Biology · doi:10.1083/jcb.201001057 · Cited by 124 · see citing works
Chapter 3 How Did the Cilium Evolve?
Satir, P., Mitchell, D. R., & Jékely, G. (2008) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/s0070-2153(08)00803-x · Cited by 123 · see citing works
Crystal structures of IFT70/52 and IFT52/46 provide insight into intraflagellar transport B core complex assembly
Taschner, M. J., Kotsis, F., Bräuer, P., Kuehn, E. W., & Lorentzen, E. (2014) · The Journal of Cell Biology · doi:10.1083/jcb.201408002 · Cited by 120 · see citing works
Isolation of a sea urchin egg kinesin-related protein using peptide antibodies
Cole, D. G., Cande, W. Z., Baskin, R. J., Skoufias, D. A., Hogan, C. J., & Scholey, J. M. (1992) · Journal of Cell Science · doi:10.1242/jcs.101.2.291 · Cited by 119 · see citing works
Self-citation
Autoinhibition regulates the motility of the C. elegans intraflagellar transport motor OSM-3
Imanishi, M., Endres, N., Gennerich, A., & Vale, R. D. (2006) · The Journal of Cell Biology · doi:10.1083/jcb.200605179 · Cited by 119 · see citing works
Erratum: Corrigendum: The ciliopathy-associated CPLANE proteins direct basal body recruitment of intraflagellar transport machinery
Toriyama, M., Lee, C., Taylor, S. P., Durán, I., Cohn, D. H., Bruel, A., Tabler, J. M., Drew, K., Kelly, M. R., Kim, S., et al. (2016) · Nature Genetics · doi:10.1038/ng0816-970b · Cited by 118 · see citing works
FLA8/KIF3B Phosphorylation Regulates Kinesin-II Interaction with IFT-B to Control IFT Entry and Turnaround
Liang, Y., Pang, Y., Wu, Q., Hu, Z., Han, X., Xu, Y., Deng, H., & Pan, J. (2014) · Developmental Cell · doi:10.1016/j.devcel.2014.07.019 · Cited by 116 · see citing works
Review: Structure and mechanism of the dynein motor ATPase
Schmidt, H., & Carter, A. P. (2016) · Biopolymers · doi:10.1002/bip.22856 · Cited by 116 · see citing works
Avalanche-like behavior in ciliary import
Ludington, W. B., Wemmer, K. A., Lechtreck, K. F., Witman, G. B., & Marshall, W. F. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1217354110 · Cited by 115 · see citing works
Intraflagellar transport proteins cycle between the flagellum and its base
Buisson, J., Chenouard, N., Lagache, T., Blisnick, T., Olivo‐Marín, J., & Bastin, P. (2012) · Journal of Cell Science · doi:10.1242/jcs.117069 · Cited by 113 · see citing works
The role of retrograde intraflagellar transport in flagellar assembly, maintenance, and function
Engel, B. D., Ishikawa, H., Wemmer, K. A., Geimer, S., Wakabayashi, K., Hirono, M., Craige, B., Pazour, G. J., Witman, G. B., Kamiya, R., et al. (2012) · The Journal of Cell Biology · doi:10.1083/jcb.201206068 · Cited by 111 · see citing works
Collective Dynamics of Interacting Molecular Motors
Campàs, O., Kafri, Y., Zeldovich, K. B., Casademunt, J., & Joanny, J. (2006) · Physical Review Letters · doi:10.1103/physrevlett.97.038101 · Cited by 111 · see citing works
Intraflagellar transport drives flagellar surface motility
Shih, S. M., Engel, B. D., Kocabaş, F., Bilyard, T., Gennerich, A., Marshall, W. F., & Yıldız, A. (2013) · eLife · doi:10.7554/elife.00744 · Cited by 109 · see citing works
Speculations on the evolution of 9+2 organelles and the role of central pair microtubules
Mitchell, D. R. (2004) · Biology of the Cell · doi:10.1016/j.biolcel.2004.07.004 · Cited by 107 · see citing works
Endocytic Control of Cellular Signaling at the Primary Cilium
Pedersen, L. B., Mogensen, J. B., & Christensen, S. T. (2016) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2016.06.002 · Cited by 105 · see citing works
The WD Repeat-containing Protein IFTA-1 Is Required for Retrograde Intraflagellar Transport
Blacque, O. E., Li, C., Inglis, P. N., Esmail, M. A., Ou, G., Mah, A. K., Baillie, D. L., Scholey, J. M., & Leroux, M. R. (2006) · Molecular Biology of the Cell · doi:10.1091/mbc.e06-06-0571 · Cited by 103 · see citing works
Self-citation
Subunit composition of the human cytoplasmic dynein-2 complex
Asante, D., Stevenson, N. L., & Stephens, D. J. (2014) · Journal of Cell Science · doi:10.1242/jcs.159038 · Cited by 103 · see citing works
Together, the IFT81 and IFT74 N-termini form the main module for intraflagellar transport of tubulin
Kubo, T., Brown, J., Bellve, K. D., Craige, B., Weghe, J. C. V. D., Fogarty, K. E., Lechtreck, K. F., & Witman, G. B. (2016) · Journal of Cell Science · doi:10.1242/jcs.187120 · Cited by 103 · see citing works
Regulation of Cilium Length and Intraflagellar Transport by the RCK-Kinases ICK and MOK in Renal Epithelial Cells
Broekhuis, J. R., Verhey, K. J., & Jansen, G. (2014) · PLoS ONE · doi:10.1371/journal.pone.0108470 · Cited by 97 · see citing works
Cellular Mechanisms of Ciliary Length Control
Keeling, J., Tsiokas, L., & Maskey, D. (2016) · Cells · doi:10.3390/cells5010006 · Cited by 97 · see citing works
Evolution of CiliaPreprint
Mitchell, D. R. (2016) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a028290 · Cited by 94 · see citing works
Biophysical Challenges to Axonal Transport: Motor-Cargo Deficiencies and Neurodegeneration
Encalada, S. E., & Goldstein, L. S. B. (2014) · Annual Review of Biophysics · doi:10.1146/annurev-biophys-051013-022746 · Cited by 93 · see citing works
Intraflagellar transport: from molecular characterisation to mechanism
Blacque, O. E. (2007) · Frontiers in bioscience · doi:10.2741/2871 · Cited by 92 · see citing works
Kinesin-2 family in vertebrate ciliogenesis
Zhao, C., Omori, Y., Brodowska, K., Kovach, P., & Malicki, J. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1116035109 · Cited by 91 · see citing works
Interhead tension determines processivity across diverse N-terminal kinesins
Shastry, S., & Hancock, W. O. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1102628108 · Cited by 89 · see citing works
Cilium transition zone proteome reveals compartmentalization and differential dynamics of ciliopathy complexes
Dean, S., Moreira-Leite, F. F., Varga, V., & Keith Gull, B. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1604258113 · Cited by 89 · see citing works
Single-molecule imaging of Hedgehog pathway protein Smoothened in primary cilia reveals binding events regulated by Patched1
Milenković, L., Weiss, L. E., Yoon, J., Roth, T. L., Su, Y. S., Sahl, S. J., Scott, M. P., & Moerner, W. E. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1510094112 · Cited by 86 · see citing works
The Mechanochemical Cycle of Mammalian Kinesin-2 KIF3A/B under Load
Andreasson, J. O. L., Shastry, S., Hancock, W. O., & Block, S. M. (2015) · Current Biology · doi:10.1016/j.cub.2015.03.013 · Cited by 86 · see citing works
Role for the IFT-A Complex in Selective Transport to the Primary Cilium
Fu, W., Wang, L., Kim, S., Li, J., & Dynlacht, B. D. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.10.018 · Cited by 86 · see citing works
Dopamine receptors reveal an essential role of IFT-B, KIF17, and Rab23 in delivering specific receptors to primary cilia
Leaf, A., & von Zastrow, M. (2015) · eLife · doi:10.7554/elife.06996 · Cited by 85 · see citing works
Biochemical Mapping of Interactions within the Intraflagellar Transport (IFT) B Core Complex
Taschner, M. J., Bhogaraju, S., Vetter, M., Morawetz, M., & Lorentzen, E. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.254920 · Cited by 84 · see citing works
Direct Interactions of Intraflagellar Transport Complex B Proteins IFT88, IFT52, and IFT46
Lucker, B. F., Miller, M. S., Dziedzic, S. A., Blackmarr, P. T., & Cole, D. G. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.106997 · Cited by 83 · see citing works
The intraflagellar transport machinery in ciliary signaling
Mourão, A., Christensen, S. T., & Lorentzen, E. (2016) · Current Opinion in Structural Biology · doi:10.1016/j.sbi.2016.06.009 · Cited by 83 · see citing works
Force-Dependent Detachment of Kinesin-2 Biases Track Switching at Cytoskeletal Filament Intersections
Schroeder, H. W., Hendricks, A. G., Ikeda, K., Shuman, H., Rodionov, V., Ikebe, M., Goldman, Y. E., & Holzbaur, E. L. F. (2012) · Biophysical Journal · doi:10.1016/j.bpj.2012.05.037 · Cited by 82 · see citing works
Chapter 4 Ciliary Tubulin and Its Post-Translational Modifications
Gaertig, J., & Włoga, D. (2008) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/s0070-2153(08)00804-1 · Cited by 79 · see citing works
Kinesin-3 KLP-6 Regulates Intraflagellar Transport in Male-Specific Cilia of Caenorhabditis elegans
Morsci, N. S., & Barr, M. M. (2011) · Current Biology · doi:10.1016/j.cub.2011.06.027 · Cited by 79 · see citing works
Ciliary diffusion barrier: The gatekeeper for the primary cilium compartment
Hu, Q., & Nelson, W. J. (2011) · Cytoskeleton · doi:10.1002/cm.20514 · Cited by 79 · see citing works
Kinesin motors and primary cilia
Verhey, K. J., Dishinger, J., & Kee, H. L. (2011) · Biochemical Society Transactions · doi:10.1042/bst0391120 · Cited by 79 · see citing works
The axonemal microtubules of the chlamydomonas flagellum differ in tubulin isoform content
Johnson, K. A. (1998) · Journal of Cell Science · doi:10.1242/jcs.111.3.313 · Cited by 77 · see citing works
Axonemal radial spokes
Pigino, G., & Ishikawa, T. (2012) · BioArchitecture · doi:10.4161/bioa.20394 · Cited by 76 · see citing works
Kinesin’s Neck-Linker Determines its Ability to Navigate Obstacles on the Microtubule Surface
Hoeprich, G. J., Thompson, A. R., McVicker, D. P., Hancock, W. O., & Berger, C. L. (2014) · Biophysical Journal · doi:10.1016/j.bpj.2014.02.034 · Cited by 76 · see citing works
Cooperative Responses of Multiple Kinesins to Variable and Constant Loads
Jamison, D. K., Driver, J. W., & Diehl, M. R. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.296582 · Cited by 72 · see citing works
TTC26/DYF13 is an intraflagellar transport protein required for transport of motility-related proteins into flagella
Ishikawa, H., Ide, T., Yagi, T., Jiang, X., Hirono, M., Sasaki, H., Yanagisawa, H., Wemmer, K. A., Stainier, D. Y. R., Qin, H., et al. (2014) · eLife · doi:10.7554/elife.01566 · Cited by 71 · see citing works
The GTPase IFT27 is involved in both anterograde and retrograde intraflagellar transport
Huet, D., Blisnick, T., Perrot, S., & Bastin, P. (2014) · eLife · doi:10.7554/elife.02419 · Cited by 71 · see citing works
Dynein and intraflagellar transport
Hou, Y., & Witman, G. B. (2015) · Experimental Cell Research · doi:10.1016/j.yexcr.2015.02.017 · Cited by 70 · see citing works
Live-Cell Imaging Evidence for the Ciliary Transport of Rod Photoreceptor Opsin by Heterotrimeric Kinesin-2
Trivedi, D., Colin, E., Louie, C. M., & Williams, D. S. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.0015-12.2012 · Cited by 70 · see citing works
Microtubule Motors Drive Hedgehog Signaling in Primary Cilia
He, M., Agbu, S. O., & Anderson, K. V. (2016) · Trends in Cell Biology · doi:10.1016/j.tcb.2016.09.010 · Cited by 69 · see citing works
Compartmentalized Calcium Signaling in Cilia Regulates Intraflagellar Transport
Collingridge, P. W., Brownlee, C., & Wheeler, G. L. (2013) · Current Biology · doi:10.1016/j.cub.2013.09.059 · Cited by 68 · see citing works
Myosin Va and myosin VI coordinate their steps while engaged in an in vitro tug of war during cargo transport
Ali, M. Y., Kennedy, G. G., Safer, D., Trybus, K. M., Sweeney, H. L., & Warshaw, D. M. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1104298108 · Cited by 67 · see citing works
Control of vertebrate intraflagellar transport by the planar cell polarity effector Fuz
Brooks, E., & Wallingford, J. B. (2012) · The Journal of Cell Biology · doi:10.1083/jcb.201204072 · Cited by 65 · see citing works
The reciprocal coordination and mechanics of molecular motors in living cells
Laib, J. A., Marin, J. A., Bloodgood, R. A., & Guilford, W. H. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0809849106 · Cited by 64 · see citing works
The essential roles of transition fibers in the context of cilia
Wei, Q., Ling, K., & Hu, J. (2015) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2015.04.015 · Cited by 64 · see citing works
Regulation of Cilium Length and Intraflagellar Transport
(2013) · International Review of Cell and Molecular Biology · doi:10.1016/b978-0-12-407697-6.00003-9 · Cited by 63 · see citing works
Regulation of a heterodimeric kinesin-2 through an unprocessive motor domain that is turned processive by its partner
Brunnbauer, M., Mueller‐Planitz, F., Kösem, S., Ho, T. H., Dombi, R., Gebhardt, J. C. M., Rief, M., & Ökten, Z. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1005177107 · Cited by 63 · see citing works
The Ciliary Cytoskeleton
Pedersen, L. B., Schrøder, J. M., Satir, P., & Christensen, S. T. (2012) · Comprehensive physiology · doi:10.1002/cphy.c110043 · Cited by 62 · see citing works
The Processivity of Kinesin-2 Motors Suggests Diminished Front-Head Gating
Muthukrishnan, G., Zhang, Y., Shastry, S., & Hancock, W. O. (2009) · Current Biology · doi:10.1016/j.cub.2009.01.058 · Cited by 61 · see citing works
Ciliary entry of KIF17 is dependent on its binding to the IFT-B complex via IFT46–IFT56 as well as on its nuclear localization signal
Funabashi, T., Katoh, Y., Michisaka, S., Terada, M., Sugawa, M., & Nakayama, K. (2017) · Molecular Biology of the Cell · doi:10.1091/mbc.e16-09-0648 · Cited by 61 · see citing works
Single-particle imaging reveals intraflagellar transport–independent transport and accumulation of EB1 inChlamydomonasflagella
Harris, J. A., Liu, Y., Yang, P., Kner, P., & Lechtreck, K. F. (2015) · Molecular Biology of the Cell · doi:10.1091/mbc.e15-08-0608 · Cited by 60 · see citing works
Life with eight flagella: flagellar assembly and division in Giardia
Dawson, S. C., & House, S. A. (2010) · Current Opinion in Microbiology · doi:10.1016/j.mib.2010.05.014 · Cited by 59 · see citing works
Heterotrimeric Kinesin-2 (KIF3) Mediates Transition Zone and Axoneme Formation of Mouse Photoreceptors
Jiang, L., Wei, Y., Ronquillo, C. C., Marc, R. E., Yoder, B. K., Frederick, J. M., & Baehr, W. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.638437 · Cited by 59 · see citing works
Collective dynamics of processive cytoskeletal motors
McLaughlin, R. T., Diehl, M. R., & Kolomeisky, A. B. (2015) · Soft Matter · doi:10.1039/c5sm01609f · Cited by 57 · see citing works
WD60/FAP163 is a dynein intermediate chain required for retrograde intraflagellar transport in cilia
Patel, R., Gilberti, R. M., Hom, E. F. Y., & King, S. M. (2013) · Molecular Biology of the Cell · doi:10.1091/mbc.e13-05-0266 · Cited by 57 · see citing works
Basal body structure and cell cycle-dependent biogenesis in Trypanosoma brucei
Vaughan, S., & Gull, K. (2015) · Cilia · doi:10.1186/s13630-016-0023-7 · Cited by 56 · see citing works
A Systematic Comparison of Mathematical Models for Inherent Measurement of Ciliary Length: How a Cell Can Measure Length and Volume
Ludington, W. B., Ishikawa, H., Serebrenik, Y. V., Ritter, A., Hernández-López, R. A., Gunzenhäuser, J., Kannegaard, E. S., & Marshall, W. F. (2015) · Biophysical Journal · doi:10.1016/j.bpj.2014.12.051 · Cited by 55 · see citing works
Somatic CRISPR–Cas9-induced mutations reveal roles of embryonically essential dynein chains in Caenorhabditis elegans cilia
Li, W., Yi, P., & Ou, G. (2015) · The Journal of Cell Biology · doi:10.1083/jcb.201411041 · Cited by 54 · see citing works
Intraflagellar transport is required for the maintenance of the trypanosome flagellum composition but not its length
Fort, C., Bonnefoy, S., Kohl, L., & Bastin, P. (2016) · Journal of Cell Science · doi:10.1242/jcs.188227 · Cited by 53 · see citing works
Kinesin-related proteins in eukaryotic flagella
Fox, L. A., Sawin, K. E., & Sale, W. S. (1994) · Journal of Cell Science · doi:10.1242/jcs.107.6.1545 · Cited by 51 · see citing works
Kinesin family 17 (osmotic avoidance abnormal‐3) is dispensable for photoreceptor morphology and function
Jiang, L., Tam, B. M., Ying, G., Wu, S., Hauswirth, W. W., Frederick, J. M., Moritz, O. L., & Baehr, W. (2015) · The FASEB Journal · doi:10.1096/fj.15-275677 · Cited by 50 · see citing works

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Cellular signalling by primary cilia in development, organ function and disease
Anvarian, Z., Mykytyn, K., Mukhopadhyay, S., Pedersen, L. B., & Christensen, S. T. (2019) · Nature Reviews Nephrology · doi:10.1038/s41581-019-0116-9 · Cited by 845 · see citing works
Primary cilia as dynamic and diverse signalling hubs in development and disease
Mill, P., Christensen, S. T., & Pedersen, L. B. (2023) · Nature Reviews Genetics · doi:10.1038/s41576-023-00587-9 · Cited by 417 · see citing works
From molecular manipulation of domesticated Chlamydomonas reinhardtii to survival in nature
Sasso, S., Stibor, H., Mittag, M., & Grossman, A. R. (2018) · eLife · doi:10.7554/elife.39233 · Cited by 202 · see citing works
Cilium structure, assembly, and disassembly regulated by the cytoskeleton
Mirvis, M., Stearns, T., & Nelson, W. J. (2018) · Biochemical Journal · doi:10.1042/bcj20170453 · Cited by 191 · see citing works
Trafficking of ciliary membrane proteins by the intraflagellar transport/BBSome machinery
Wingfield, J. L., Lechtreck, K.-F., & Lorentzen, E. (2018) · Essays in Biochemistry · doi:10.1042/ebc20180030 · Cited by 157 · see citing works
Dynamics of the IFT machinery at the ciliary tip
Chien, A. J., Shih, S. M., Bower, R., Tritschler, D., Porter, M. E., & Yıldız, A. (2017) · eLife · doi:10.7554/elife.28606 · Cited by 153 · see citing works
Cellular Logistics: Unraveling the Interplay Between Microtubule Organization and Intracellular Transport
Burute, M., & Kapitein, L. C. (2019) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-100818-125149 · Cited by 101 · see citing works
Assembly, Functions and Evolution of Archaella, Flagella and Cilia
Khan, S., & Scholey, J. M. (2018) · Current Biology · doi:10.1016/j.cub.2018.01.085 · Cited by 96 · see citing works
Self-citation
Primary cilia proteins: ciliary and extraciliary sites and functions
Hua, K., & Ferland, R. J. (2018) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-017-2740-5 · Cited by 91 · see citing works
Architecture of the IFT ciliary trafficking machinery and interplay between its components
Nakayama, K., & Katoh, Y. (2020) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.1080/10409238.2020.1768206 · Cited by 79 · see citing works
Emerging principles of primary cilia dynamics in controlling tissue organization and function
Gopalakrishnan, J., Feistel, K., Friedrich, B. M., Grapin‐Botton, A., Jurisch‐Yaksi, N., Mass, E., Mick, D. U., Müller, R., May‐Simera, H., Schermer, B., et al. (2023) · The EMBO Journal · doi:10.15252/embj.2023113891 · Cited by 79 · see citing works
Intraflagellar transporter protein (IFT27), an IFT25 binding partner, is essential for male fertility and spermiogenesis in mice
Zhang, Y., Liu, H., Li, W., Zhang, Z., Shang, X., Zhang, D. K. Y., Li, Y., Zhang, S., Liu, J., Hess, R. A., et al. (2017) · Developmental Biology · doi:10.1016/j.ydbio.2017.09.023 · Cited by 81 · see citing works
Haploid male germ cells—the Grand Central Station of protein transport
Pleuger, C., Lehti, M. S., Dunleavy, J. E. M., Fietz, D., & O’Bryan, M. K. (2020) · Human Reproduction Update · doi:10.1093/humupd/dmaa004 · Cited by 72 · see citing works
Acute Inhibition of Heterotrimeric Kinesin-2 Function Reveals Mechanisms of Intraflagellar Transport in Mammalian Cilia
Engelke, M. F., Waas, B., Kearns, S. E., Suber, A., Boss, A. P., Allen, B. L., & Verhey, K. J. (2019) · Current Biology · doi:10.1016/j.cub.2019.02.043 · Cited by 69 · see citing works
Interaction of WDR60 intermediate chain with TCTEX1D2 light chain of the dynein-2 complex is crucial for ciliary protein trafficking
Hamada, Y., Tsurumi, Y., Nozaki, S., Katoh, Y., & Nakayama, K. (2018) · Molecular Biology of the Cell · doi:10.1091/mbc.e18-03-0173 · Cited by 69 · see citing works
Intraflagellar transport trains and motors: Insights from structure
Webb, S., Mukhopadhyay, A. G., & Roberts, A. J. (2020) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2020.05.021 · Cited by 66 · see citing works
Interaction of heterotrimeric kinesin-II with IFT-B–connecting tetramer is crucial for ciliogenesis
Funabashi, T., Katoh, Y., Okazaki, M., Sugawa, M., & Nakayama, K. (2018) · Journal of Cell Biology · doi:10.1083/jcb.201801039 · Cited by 65 · see citing works
Emerging mechanisms of dynein transport in the cytoplasm versus the cilium
Roberts, A. J. (2018) · Biochemical Society Transactions · doi:10.1042/bst20170568 · Cited by 62 · see citing works
Intraflagellar transporter protein 140 (IFT140), a component of IFT‐A complex, is essential for male fertility and spermiogenesis in mice
Zhang, Y., Liu, H., Li, W., Zhang, Z., Zhang, S., Teves, M. E., Stevens, C. M., Foster, J. A., Campbell, G. E., Windle, J. J., et al. (2017) · Cytoskeleton · doi:10.1002/cm.21427 · Cited by 61 · see citing works
Vertebrate Dynein-f depends on Wdr78 for axonemal localization and is essential for ciliary beat
Zhang, Y., Chen, Y., Zheng, J., Wang, J., Duan, S., Zhang, W., Yan, X., & Zhu, X. (2018) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjy043 · Cited by 61 · see citing works
Maintaining centrosomes and cilia
Werner, S., Pimenta-Marques, A., & Bettencourt‐Dias, M. (2017) · Journal of Cell Science · doi:10.1242/jcs.203505 · Cited by 59 · see citing works
The developmental biology of kinesins
Konjikusic, M. J., Gray, R. S., & Wallingford, J. B. (2020) · Developmental Biology · doi:10.1016/j.ydbio.2020.09.009 · Cited by 57 · see citing works
Motile cilia genetics and cell biology: big results from little mice
Lee, L., & Ostrowski, L. E. (2020) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-020-03633-5 · Cited by 58 · see citing works
Bidirectional intraflagellar transport is restricted to two sets of microtubule doublets in the trypanosome flagellum
Bertiaux, E., Mallet, A., Fort, C., Blisnick, T., Bonnefoy, S., Jung, J., Lemos, M., Marco, S., Vaughan, S., Trépout, S., et al. (2018) · The Journal of Cell Biology · doi:10.1083/jcb.201805030 · Cited by 52 · see citing works
Regulation of ciliary membrane protein trafficking and signalling by kinesin motor proteins
Morthorst, S. K., Christensen, S. T., & Pedersen, L. B. (2018) · The FEBS Journal · doi:10.1111/febs.14583 · Cited by 49 · see citing works
Biallelic Mutations in Tetratricopeptide Repeat Domain 26 (Intraflagellar Transport 56) Cause Severe Biliary Ciliopathy in Humans
Shaheen, R., Alsahli, S., Ewida, N., Alzahrani, F., Shamseldin, H. E., Patel, N., Qahtani, A. A., Alhebbi, H., Alhashem, A. M., Al‐Sheddi, T., et al. (2019) · Hepatology · doi:10.1002/hep.30982 · Cited by 49 · see citing works
Balancing the length of the distal tip by septins is key for stability and signalling function of primary cilia
Kanamaru, T., Neuner, A., Kurtulmus, B., & Pereira, G. (2021) · The EMBO Journal · doi:10.15252/embj.2021108843 · Cited by 43 · see citing works
Transmission at rod and cone ribbon synapses in the retina
Thoreson, W. B. (2021) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-021-02548-9 · Cited by 48 · see citing works
Primary cilia: biosensors of the male reproductive tract
Girardet, L., Augière, C., Asselin, M., & Belleannée, C. (2019) · Andrology · doi:10.1111/andr.12650 · Cited by 45 · see citing works
Compartmentalization of Photoreceptor Sensory Cilia
Barnes, C. L., Malhotra, H., & Calvert, P. D. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.636737 · Cited by 44 · see citing works
Robust interaction of IFT70 with IFT52–IFT88 in the IFT-B complex is required for ciliogenesis
Takei, R., Katoh, Y., & Nakayama, K. (2018) · Biology Open · doi:10.1242/bio.033241 · Cited by 44 · see citing works
Ciliary Proteins: Filling the Gaps. Recent Advances in Deciphering the Protein Composition of Motile Ciliary Complexes
Osinka, A., Poprzeczko, M., Zielińska, M., Fabczak, H., Joachimiak, E., & Włoga, D. (2019) · Cells · doi:10.3390/cells8070730 · Cited by 41 · see citing works
Ciliary Dyneins and Dynein Related Ciliopathies
Antony, D., Brunner, H. G., & Schmidts, M. (2021) · Cells · doi:10.3390/cells10081885 · Cited by 41 · see citing works
ARF family GTPases with links to cilia
Fisher, S. I., Kuna, D., Caspary, T., Kahn, R., & Sztul, E. S. (2020) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00188.2020 · Cited by 38 · see citing works
Basic Biology of Trypanosoma cruzi
Zuma, A. A., Barrias, E., & de Souza, W. (2020) · Current Pharmaceutical Design · doi:10.2174/1381612826999201203213527 · Cited by 49 · see citing works
Reconstitution reveals motor activation for intraflagellar transport
Mohamed, M. A. A., Stepp, W. L., & Ökten, Z. (2018) · Nature · doi:10.1038/s41586-018-0105-3 · Cited by 38 · see citing works
A Grow-and-Lock Model for the Control of Flagellum Length in Trypanosomes
Bertiaux, E., Morga, B., Blisnick, T., Rotureau, B., & Bastin, P. (2018) · Current Biology · doi:10.1016/j.cub.2018.10.031 · Cited by 38 · see citing works
Anterograde trafficking of ciliary MAP kinase–like ICK/CILK1 by the intraflagellar transport machinery is required for intraciliary retrograde protein trafficking
Nakamura, K., Noguchi, T., Takahara, M., Omori, Y., Furukawa, T., Katoh, Y., & Nakayama, K. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.ra120.014142 · Cited by 37 · see citing works
Motor Cooperation During Mitosis and Ciliogenesis
Ou, G., & Scholey, J. M. (2022) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-121420-100107 · Cited by 35 · see citing works
Self-citation
The intraflagellar transport protein IFT20 controls lysosome biogenesis by regulating the post-Golgi transport of acid hydrolases
Finetti, F., Cassioli, C., Cianfanelli, V., Onnis, A., Paccagnini, E., Kabanova, A., & Baldari, C. T. (2019) · Cell Death and Differentiation · doi:10.1038/s41418-019-0357-y · Cited by 35 · see citing works
Length regulation of multiple flagella that self-assemble from a shared pool of components
Fai, T. G., Mohapatra, L., Kar, P., Kondev, J., & Amir, A. (2019) · eLife · doi:10.7554/elife.42599 · Cited by 35 · see citing works
The Emerging Roles of Axonemal Glutamylation in Regulation of Cilia Architecture and Functions
Yang, W., Hong, S., He, K., Ling, K., Shaiv, K., Hu, J., & Lin, Y. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.622302 · Cited by 37 · see citing works
WDR60-mediated dynein-2 loading into cilia powers retrograde IFT and transition zone crossing
De-Castro, A. R. G., Rodrigues, D. R. M., De-Castro, M. J. G., Vieira, N., Vieira, C., Carvalho, A. X., Gassmann, R., Abreu, C. M. C., & Dantas, T. J. (2021) · The Journal of Cell Biology · doi:10.1083/jcb.202010178 · Cited by 35 · see citing works
Chemical structure-guided design of dynapyrazoles, cell-permeable dynein inhibitors with a unique mode of action
Steinman, J. B., Santarossa, C., Miller, R. M., Yu, L. S., Serpinskaya, A. S., Furukawa, H., Morimoto, S., Tanaka, Y., Nishitani, M., Asano, M., et al. (2017) · eLife · doi:10.7554/elife.25174 · Cited by 35 · see citing works
Structures and functions of cilia during vertebrate embryo development
Amack, J. D. (2022) · Molecular Reproduction and Development · doi:10.1002/mrd.23650 · Cited by 30 · see citing works
Kinesin-2 motors: Kinetics and biophysics
Gilbert, S. P., Guzik-Lendrum, S., & Rayment, I. (2018) · Journal of Biological Chemistry · doi:10.1074/jbc.r117.001324 · Cited by 31 · see citing works
Interplay between the Kinesin and Tubulin Mechanochemical Cycles Underlies Microtubule Tip Tracking by the Non-motile Ciliary Kinesin Kif7
Jiang, S., Mani, N., Kubalek, E. W., Ku, P.-I., Milligan, R. A., & Subramanian, R. (2019) · Developmental Cell · doi:10.1016/j.devcel.2019.04.001 · Cited by 31 · see citing works
Genetic compensation for cilia defects in cep290 mutants by upregulation of cilia-associated small GTPases
Cárdenas-Rodríguez, M., Austin-Tse, C. A., Bergboer, J. G. M., Molinari, E., Sugano, Y., Bachmann‐Gagescu, R., Sayer, J. A., & Drummond, I. A. S. (2021) · Journal of Cell Science · doi:10.1242/jcs.258568 · Cited by 30 · see citing works
Motor guidance by long-range communication on the microtubule highway
Wijeratne, S. S., Fiorenza, S. A., Neary, A. E., Subramanian, R., & Betterton, M. D. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2120193119 · Cited by 35 · see citing works
Murine germ cell-specific disruption of Ift172 causes defects in spermiogenesis and male fertility
Zhang, S., Liu, Y., Huang, Q., Yuan, S., Liu, H., Shi, L., Yap, Y. T., Li, W., Zhen, J., Zhang, L., et al. (2020) · Reproduction · doi:10.1530/rep-17-0789 · Cited by 29 · see citing works
Mechanisms of Regulation in Intraflagellar Transport
Mul, W., Mitra, A., & Peterman, E. J. G. (2022) · Cells · doi:10.3390/cells11172737 · Cited by 27 · see citing works
Self-citation
On the Wrong Track: Alterations of Ciliary Transport in Inherited Retinal Dystrophies
Sánchez-Bellver, L., Toulis, V., & Marfany, G. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.623734 · Cited by 25 · see citing works
DYF-5/MAK–dependent phosphorylation promotes ciliary tubulin unloading
Jiang, X., Shao, W., Chai, Y., Huang, J., Mohamed, M. A. A., Ökten, Z., Li, W., Zhu, Z., & Ou, G. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2207134119 · Cited by 23 · see citing works
The route of the visual receptor rhodopsin along the cilium
Chadha, A., Volland, S., Baliaouri, N. V., Tran, E., & Williams, D. S. (2019) · Journal of Cell Science · doi:10.1242/jcs.229526 · Cited by 25 · see citing works
Regulation of hyperoxia-induced social behaviour in Pristionchus pacificus nematodes requires a novel cilia-mediated environmental input
Moreno, E., Sieriebriennikov, B., Witte, H., Rödelsperger, C., Lightfoot, J. W., & Sommer, R. J. (2017) · Scientific Reports · doi:10.1038/s41598-017-18019-0 · Cited by 25 · see citing works
Cilia drive developmental plasticity and are essential for efficient prey detection in predatory nematodes
Moreno, E., Lightfoot, J. W., Lenuzzi, M., & Sommer, R. J. (2019) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.2019.1089 · Cited by 24 · see citing works
The Intraflagellar Transport Protein IFT20 Recruits ATG16L1 to Early Endosomes to Promote Autophagosome Formation in T Cells
Finetti, F., Cassioli, C., Cianfanelli, V., Zevolini, F., Onnis, A., Gesualdo, M., Brunetti, J., Cecconi, F., & Baldari, C. T. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.634003 · Cited by 24 · see citing works
Microtubule‐associated proteins and emerging links to primary cilium structure, assembly, maintenance, and disassembly
Conkar, D., & Firat‐Karalar, E. N. (2020) · FEBS Journal · doi:10.1111/febs.15473 · Cited by 24 · see citing works
The Role of Centrosome Distal Appendage Proteins (DAPs) in Nephronophthisis and Ciliogenesis
Mansour, F., Boivin, F. J., Shaheed, I. B., Schueler, M., & Schmidt-Ott, K. M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222212253 · Cited by 20 · see citing works
The multifaceted roles of microtubule-associated proteins in the primary cilium and ciliopathies
Deretic, J., Odabasi, E., & Firat‐Karalar, E. N. (2023) · Journal of Cell Science · doi:10.1242/jcs.261148 · Cited by 22 · see citing works
Direct imaging of intraflagellar-transport turnarounds reveals that motors detach, diffuse, and reattach to opposite-direction trains
Zhang, Z., Danné, N., Meddens, B., Heller, I., & Peterman, E. J. G. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2115089118 · Cited by 22 · see citing works
Self-citation
Hedgehog-induced ciliary trafficking of kinesin-4 motor KIF7 requires intraflagellar transport but not KIF7’s microtubule binding
Yue, Y., Engelke, M. F., Blasius, T. L., & Verhey, K. J. (2021) · Molecular Biology of the Cell · doi:10.1091/mbc.e21-04-0215 · Cited by 21 · see citing works
CCDC66 regulates primary cilium length and signaling via interactions with transition zone and axonemal proteins
Odabasi, E., Conkar, D., Deretic, J., Batman, U., Frikstad, K.-A. M., Patzke, S., & Firat‐Karalar, E. N. (2023) · Journal of Cell Science · doi:10.1242/jcs.260327 · Cited by 20 · see citing works
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Li, Y., Zhu, D., Yang, T., Cheng, L., Sun, J., & Tan, L. (2020) · Journal of Cellular Physiology · doi:10.1002/jcp.30198 · Cited by 20 · see citing works
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Moye, A. R., Singh, R. K., Kimler, V. A., Dilan, T. L., Munezero, D., Saravanan, T., Goldberg, A. F. X., & Ramamurthy, V. (2018) · Molecular Biology of the Cell · doi:10.1091/mbc.e18-01-0040 · Cited by 20 · see citing works
DNALI1 interacts with the MEIG1/PACRG complex within the manchette and is required for proper sperm flagellum assembly in mice
Yap, Y. T., Li, W., Huang, Q., Zhou, Q., Zhang, D., Sheng, Y., Mladenovic-Lucas, L., Yee, S., Orwig, K. E., Granneman, J. G., et al. (2023) · eLife · doi:10.7554/elife.79620 · Cited by 19 · see citing works
Dlec1 is required for spermatogenesis and male fertility in mice
Okitsu, Y., Nagano, M., Yamagata, T., Ito, C., Toshimori, K., Dohra, H., Fujii, W., & Yogo, K. (2020) · Scientific Reports · doi:10.1038/s41598-020-75957-y · Cited by 19 · see citing works
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Tiberio, F., Parolini, O., & Lattanzi, W. (2021) · Genes · doi:10.3390/genes12071073 · Cited by 19 · see citing works
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Clupper, M., Gill, R., Elsayyid, M. W., Touroutine, D., Caplan, J. L., & Tanis, J. E. (2022) · iScience · doi:10.1016/j.isci.2022.105262 · Cited by 17 · see citing works
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Chen, Z., Li, M., Zhu, H., & Ou, G. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2303955120 · Cited by 18 · see citing works
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Antagonistic regulation of trafficking to Caenorhabditis elegans sensory cilia by a Retinal Degeneration 3 homolog and retromer
Martinez-Velazquez, L., & Ringstad, N. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1712302115 · Cited by 13 · see citing works
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Physiological and Pathophysiological Aspects of Primary Cilia—A Literature Review with View on Functional and Structural Relationships in Cartilage
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Non-ciliary Roles of IFT Proteins in Cell Division and Polycystic Kidney Diseases
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Neofunctionalization of ciliary BBS proteins to nuclear roles is likely a frequent innovation across eukaryotes
Ewerling, A., Maissl, V., Wickstead, B., & May‐Simera, H. (2023) · iScience · doi:10.1016/j.isci.2023.106410 · Cited by 13 · see citing works
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Rao, L., & Gennerich, A. (2024) · Cells · doi:10.3390/cells13040330 · Cited by 13 · see citing works
Cilium Length and Intraflagellar Transport Regulation by Kinases PKG-1 and GCK-2 in Caenorhabditis elegans Sensory Neurons
Shanmugam, M. M., Bhan, P., Huang, H., Hsieh, J., Hua, T.-E., Wu, G., Punjabi, H., Aplícano, V. D. L., Chen, C., & Wagner, O. I. (2018) · Molecular and Cellular Biology · doi:10.1128/mcb.00612-17 · Cited by 13 · see citing works
CCRK/CDK20 regulates ciliary retrograde protein trafficking via interacting with BROMI/TBC1D32
Noguchi, T., Nakamura, K., Satoda, Y., Katoh, Y., & Nakayama, K. (2021) · PLoS ONE · doi:10.1371/journal.pone.0258497 · Cited by 12 · see citing works
Expression and potential functions of KIF3A/3B to promote nuclear reshaping and tail formation during Larimichthys polyactis spermiogenesis
Wang, J., Gao, X., Zheng, X., Hou, C.-C., Xie, Q., Lou, B., & Zhu, J. (2019) · Development Genes and Evolution · doi:10.1007/s00427-019-00637-5 · Cited by 12 · see citing works
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van Krugten, J., Danné, N., & Peterman, E. J. G. (2022) · Communications Biology · doi:10.1038/s42003-022-03683-4 · Cited by 11 · see citing works
Self-citation
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Binó, L., & Čajánek, L. (2023) · Scientific Reports · doi:10.1038/s41598-023-39887-9 · Cited by 12 · see citing works
Novel functions of the primary cilium in bone disease and cancer
Shi, W., Ma, Z., Zhang, G., Wang, C., & Jiao, Z. (2019) · Cytoskeleton · doi:10.1002/cm.21529 · Cited by 12 · see citing works
Photoreceptor Compartment-Specific TULP1 Interactomes
Ebke, L. A., Sinha, S., Pauer, G. J. T., & Hagstrom, S. A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22158066 · Cited by 10 · see citing works
WDR31 displays functional redundancy with GTPase-activating proteins (GAPs) ELMOD and RP2 in regulating IFT complex and recruiting the BBSome to cilium
Cevik, S., Peng, X., Beyer, T., Pir, M. S., Yenisert, F., Woerz, F., Hoffmann, F., Altunkaynak, B., Pir, B., Boldt, K., et al. (2023) · Life Science Alliance · doi:10.26508/lsa.202201844 · Cited by 14 · see citing works
Pleiotropic effects of mutant huntingtin on retinopathy in two mouse models of Huntington's disease
Xu, H., Ajayan, A., Langen, R., & Chen, J. (2024) · Neurobiology of Disease · doi:10.1016/j.nbd.2024.106780 · Cited by 11 · see citing works

Authors: Prevo, B., Scholey, J. M., & Peterman, E. J. G.
Affiliations: University of California San Diego (US)
University of California, Davis (US)
Vrije Universiteit Amsterdam (NL)
Corresponding author: Peterman, Erwin J. G.
ORCID: Prevo, Bram
Peterman, Erwin J. G.
Venue: The FEBS Journal
Publisher: Wiley
Published: 2017-04-18
Volume: 284
Issue: 18
Pages: 2905-2931
ISSN: 1742-464X (ISSN-L)
1742-4658
DOI: 10.1111/febs.14068
PMC: PMC5603355
OpenAlex: W2598068367
Cited by: 203
References: 240
Citations by year: 2026: 7 · 2025: 13 · 2024: 19 · 2023: 20 · 2022: 30 · 2021: 24 · 2020: 27 · 2019: 24 · 2018: 28 · 2017: 10
FWCI: 3.12
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
Locations: FEBS Journal (publishedVersion, cc-by)
PubMed (publishedVersion)
VU Research Portal (publishedVersion, other-oa)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
eScholarship (California Digital Library) (submittedVersion, cc-by)
Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
Funders: Nederlandse Organisatie voor Wetenschappelijk Onderzoek (ALW Open, Vici)
Stichting voor Fundamenteel Onderzoek der Materie
National Institutes of Health (GM50718)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and Kidney Cyst Diseases
Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cystic Fibrosis Research Advances
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Microtubule and mitosis dynamics
Keywords: intraflagellar transport, cilia, kinesin-2, axoneme assembly, Chlamydomonas, Caenorhabditis elegans, signal transduction
MeSH terms: Animals, Biological Transport, Chlamydomonas, Cilia, Dyneins, Flagella, Gene Expression Regulation, Tubulin, Signal Transduction, Kinesins, Caenorhabditis elegans, Axoneme, Protein Multimerization, Basal Bodies

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Intraflagellar transport: mechanisms of motor action, cooperation, and cargo delivery

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