The DOI matches its Crossref record; 140 of the 140 references it cites were found in a registry or an index.
AH RECEPTOR SIGNALING PATHWAYS
Abstract
▪ Abstract The aryl hydrocarbon (Ah) receptor has occupied the attention of toxicologists for over two decades. Interest arose from the early observation that this soluble protein played key roles in the adaptive metabolic response to polycyclic aromatic hydrocarbons and in the toxic mechanism of halogenated dioxins and dibenzofurans. More recent investigations have provided a fairly clear picture of the primary adaptive signaling pathway, from agonist binding to the transcriptional activation of genes involved in the metabolism of xenobiotics. Structure-activity studies have provided an understanding of the pharmacology of this receptor; recombinant DNA approaches have identified the enhancer sequences through which this factor regulates gene expression; and functional analysis of cloned cDNAs has allowed the characterization of the major signaling components in this pathway. Our objective is to review the Ah receptor's role in regulation of xenobiotic metabolism and use this model as a framework for understanding the less well-characterized mechanism of dioxin toxicity. In addition, it is hoped that this information can serve as a model for future efforts to understand an emerging superfamily of related signaling pathways that control biological responses to an array of environmental stimuli.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Among the various domains of the AhR that exhibit distinct functional activities (1,13-15), we have primarily focused our attention on that of PAS B, one of the two structural repeats (PAS A and PAS B) within the PAS domain, that is involved in both ligand and hsp90 binding.”
From Structural and Functional Characterization of the Aryl Hydrocarbon Receptor Ligand Binding Domain by Homology Modeling and Mutational Analysis (2007) · cites this paper as [1]
In the citing paper
“The aryl hydrocarbon receptor (AhR) 1 is a basic helix-loop-helix (bHLH), PAS- (Per-ArntSim-) containing transcription factor which is present in numerous species and tissues and activates gene expression in a ligand-dependent manner (1-3).”
From Structural and Functional Characterization of the Aryl Hydrocarbon Receptor Ligand Binding Domain by Homology Modeling and Mutational Analysis (2007) · cites this paper as [1]
Citations
Cites
The nuclear receptor superfamily: the second decade
Mangelsdorf, D. J., Thummel, C., Beato, M., Herrlich, P., Schütz, G., Umesono, K., Blumberg, B., Kastner, P., Mark, M., Chambon, P., et al. (1995) · Cell · doi:10.1016/0092-8674(95)90199-x · Cited by 6,964
Wang, G. L., Jiang, B. H., Rue, E. A., & Semenza, G. L. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.12.5510 · Cited by 6,212
The Leucine Zipper: A Hypothetical Structure Common to a New Class of DNA Binding Proteins
Landschulz, W. H., Johnson, P. F., & McKnight, S. L. (1988) · Science · doi:10.1126/science.3289117 · Cited by 3,443
Murre, C., Page-McCaw, P., & Baltimore, D. (1989) · Cell · doi:10.1016/0092-8674(89)90682-x · Cited by 2,713
Semenza, G. L., & Wang, G. L. (1992) · Molecular and Cellular Biology · doi:10.1128/mcb.12.12.5447 · Cited by 2,617
Poland, A., & Knutson, J. C. (1982) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pa.22.040182.002505 · Cited by 2,515
The protein Id: A negative regulator of helix-loop-helix DNA binding proteins
Benezra, R., Davis, R. L., Lockshon, D., Turner, D. L., & Weintraub, H. M. (1990) · Cell · doi:10.1016/0092-8674(90)90214-y · Cited by 2,202
Purification and Characterization of Hypoxia-inducible Factor 1
Wang, G. L., & Semenza, G. L. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.3.1230 · Cited by 2,094
Murre, C., Page-McCaw, P., Vaessin, H., Caudy, M. A., Jan, L. Y., Jan, Y. N., Cabrera, C. V., Buskin, J. N., Hauschka, S. D., Lassar, A. B., et al. (1989) · Cell · doi:10.1016/0092-8674(89)90434-0 · Cited by 1,815
The myoD Gene Family: Nodal Point During Specification of the Muscle Cell Lineage
Weintraub, H. M., Davis, R. L., Tapscott, S. J., Thayer, M., Krause, M., Benezra, R., Blackwell, T. K., Turner, D. L., Rupp, R. A. W., Hollenberg, S. M., et al. (1991) · Science · doi:10.1126/science.1846704 · Cited by 1,581
Research works printed but not linked: 19
- Bacsi SG, 1995, Mol. Pharmacol., 47, 432
- Bradfield CA, 1988, Mol. Pharmacol., 34, 229
- Brooks B, 1989, Am. J. Hum. Genet., 45, A132
- Conney AH, 1956, Cancer Res., 16, 450
- Dolwick KM, 1993, Mol. Pharmacol., 44, 911
- Eppig JT, 1993, Mouse Genome, 91, 8
- Kadesch T, 1993, Cell Growth Diff., 4, 49
- Okey AB, 1989, Mol. Pharmacol., 35, 823
- Pitot HC, 1980, Cancer Res., 40, 3616
- Pohjanvirta R, 1994, Pharmacol. Rev., 46, 483
- Poland A, 1975, Mol. Pharmacol., 11, 389
- Poland A, 1979, Cancer Res., 39, 3341
- Poland A, 1980, Mol. Pharmacol., 17, 86
- Poland A, 1990, Mol. Pharmacol., 38, 306
- Poland A, 1987, Mol. Pharmacol., 32, 471
- Poland A, 1994, Mol. Pharmacol., 46, 915
- Pollenz RS, 1994, Mol. Pharmacol., 45, 428
- Tucker AN, 1986, Mol. Pharmacol., 29, 372
- Vanden Heuvel JP, 1994, Cancer Res., 54, 62
Cited by
Sorted by citations
Ankley, G. T., Bennett, R. S., Erickson, R. J., Hoff, D. J., Hornung, M. W., Johnson, R. D., Mount, D. R., Nichols, J. W., Russom, C. L., Schmieder, P. K., et al. (2009) · Environmental Toxicology and Chemistry · doi:10.1002/etc.34 · Cited by 2,734
Denison, M. S., & Nagy, S. R. (2003) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.43.100901.135828 · Cited by 1,895
The aryl hydrocarbon receptor links TH17-cell-mediated autoimmunity to environmental toxins
Veldhoen, M., Hirota, K., Westendorf, A. M., Buer, J., Dumoutier, L., Renauld, J.-C., & Stockinger, B. (2008) · Nature · doi:10.1038/nature06881 · Cited by 1,634
Zebrafish as a Model Vertebrate for Investigating Chemical Toxicity
Hill, A. J., Teraoka, H., Heideman, W., & Peterson, R. E. (2005) · Toxicological Sciences · doi:10.1093/toxsci/kfi110 · Cited by 1,380
Tian, H., McKnight, S. L., & Russell, D. W. (1997) · Genes & Development · doi:10.1101/gad.11.1.72 · Cited by 1,351
Metadata
- Authors
- Schmidt, J. V., & Bradfield, C. A.
- Affiliations
- Northwestern University (US)
- University of Wisconsin–Madison (US)
- Venue
- Annual Review of Cell and Developmental Biology
- Publisher
- Annual Reviews
- Published
- 1996-11
- Volume
- 12
- Issue
- 1
- Pages
- 55-89
- ISSN
- 1081-0706 (ISSN-L)
- 1530-8995
- OpenAlex
- W2133972226
- Cited by
- 899
- References
- 140
- Citations by year
- 2026: 3 · 2025: 9 · 2024: 3 · 2023: 16 · 2022: 10 · 2021: 20 · 2020: 16 · 2019: 17 · 2018: 28 · 2017: 29 · 2016: 16 · 2015: 19 · 2014: 28 · 2013: 27 · 2012: 26
- FWCI
- 11.14
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annual Review of Cell and Developmental Biology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Cancer Institute (CA09560, T32CA009560)
- National Institute of Environmental Health Sciences (ES06883, R01ES006883)
- Topics
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Toxic Organic Pollutants Impact
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics, phytochemicals, and oxidative stress
- Keywords
- aryl hydrocarbon receptor, dioxin toxicity, dibenzofuran, polycyclic aromatic hydrocarbons, xenobiotic metabolism, transcriptional activation, gene expression regulation, enhancers, structure-activity relationship, signaling pathways, ecotoxicology
- MeSH terms
- Amino Acid Sequence, Animals, Binding Sites, Dioxins, Humans, Molecular Sequence Data, Peptide Mapping, Signal Transduction, Receptors, Aryl Hydrocarbon, Mice, Knockout, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
