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AH RECEPTOR SIGNALING PATHWAYS

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DNA sequence determinants for binding of transformed Ah receptor to a dioxin-responsive enhancer

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Protein-DNA interactions at a dioxin-responsive enhancer. Mutational analysis of the DNA-binding site for the liganded Ah receptor.

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Carbaryl, a Carbamate Insecticide, Is a Ligand for the Hepatic Ah (Dioxin) Receptor

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Rapid vertical tube rotor gradient assay for binding of 2,3,7,8-tetrachIorodibenzo-p-dioxin to the Ah receptor

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Characterization of the interaction of transformed rat hepatic cytosolic Ah receptor with a dioxin responsive transcriptional enhancer

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Identification of a Novel Cis-acting Negative Regulatory Element Affecting Expression of the CYP1A1 Gene in Rat Epidermal Cells

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DNA binding properties of dioxin receptors in wild-type and mutant mouse hepatoma cells

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Expression of the Arylhydrocarbon Receptor and the Arylhydrocarbon Receptor Nuclear Translocator during Early Gestation in the Rabbit Uterus

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Protamine sulfate precipitation: A new assay for the Ah receptor

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Nuclear Ah receptor from mouse hepatoma cells: Effect of partial proteolysis on relative molecular mass and DNA-binding properties

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CH223191 Is a Ligand-Selective Antagonist of the Ah (Dioxin) Receptor

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Rewiring the altered tryptophan metabolism as a novel therapeutic strategy in inflammatory bowel diseases

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Gut Microbial Catabolites of Tryptophan Are Ligands and Agonists of the Aryl Hydrocarbon Receptor: A Detailed Characterization

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Structural and Functional Characterization of the Aryl Hydrocarbon Receptor Ligand Binding Domain by Homology Modeling and Mutational Analysis

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Butyrate acts through HDAC inhibition to enhance aryl hydrocarbon receptor activation by gut microbiota-derived ligands

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Effects of Cigarette Smoking on Metabolism and Effectiveness of Systemic Therapy for Lung Cancer

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Detection of the TCDD Binding-Fingerprint within the Ah Receptor Ligand Binding Domain by Structurally Driven Mutagenesis and Functional Analysis

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Aryl Hydrocarbon Receptor and Its Diverse Ligands and Functions: An Exposome Receptor

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Activation of the aryl hydrocarbon receptor is essential for mediating the anti-inflammatory effects of a novel low-molecular-weight compound

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The aryl hydrocarbon receptor mediates raloxifene-induced apoptosis in estrogen receptor-negative hepatoma and breast cancer cells

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Role of the Per/Arnt/Sim Domains in Ligand-dependent Transformation of the Aryl Hydrocarbon Receptor

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Analysis of Ah receptor pathway activation by brominated flame retardants

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Changing the Face of Kynurenines and Neurotoxicity: Therapeutic Considerations

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The Aryl Hydrocarbon Receptor Mediates Leflunomide-Induced Growth Inhibition of Melanoma Cells

O’Donnell, E. F., Kopparapu, P., Koch, D. C., Jang, H. S., Phillips, J. L., Tanguay, R. L., Kerkvliet, N. I., & Kolluri, S. K. (2012) · PLoS ONE · doi:10.1371/journal.pone.0040926 · Cited by 81 · see citing works

New Aryl Hydrocarbon Receptor Homology Model Targeted To Improve Docking Reliability

Motto, I., Bordogna, A., Soshilov, A. A., Denison, M. S., & Bonati, L. (2011) · Journal of Chemical Information and Modeling · doi:10.1021/ci2001617 · Cited by 80 · see citing works

Persistent Binding of Ligands to the Aryl Hydrocarbon Receptor

Bohonowych, J. E. S., & Denison, M. S. (2007) · Toxicological Sciences · doi:10.1093/toxsci/kfm085 · Cited by 75 · see citing works

Indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors activate the aryl hydrocarbon receptor

Moyer, B. J., Rojas, I. Y., Murray, I. A., Lee, S., Hazlett, H. F., Perdew, G. H., & Tomlinson, C. R. (2017) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2017.03.012 · Cited by 64 · see citing works

The aryl hydrocarbon receptor links integrin signaling to the TGF-β pathway

Silginer, M., Burghardt, I., Gramatzki, D., Bunse, L., Leske, H., Rushing, E. J., Hao, N., Platten, M., Weller, M., & Roth, P. (2015) · Oncogene · doi:10.1038/onc.2015.387 · Cited by 60 · see citing works

A novel prenylflavone restricts breast cancer cell growth through AhR-mediated destabilization of ERα protein

Tiong, C. T., Chen, C., Zhang, S. J., Li, J., Soshilov, A. A., Denison, M. S., Lee, L., Tam, V. H., Wong, S. P., Xu, H. E., et al. (2012) · Carcinogenesis · doi:10.1093/carcin/bgs110 · Cited by 54 · see citing works

Pelargonidin activates the AhR and induces CYP1A1 in primary human hepatocytes and human cancer cell lines HepG2 and LS174T

Kamenickova, A., Anzenbacherová, E., Pávek, P., Soshilov, A. A., Denison, M. S., Anzenbacher, P., & Dvořák, Z. (2013) · Toxicology Letters · doi:10.1016/j.toxlet.2013.01.020 · Cited by 50 · see citing works

Aryl Hydrocarbon Receptor Activation Suppresses EBF1 and PAX5 and Impairs Human B Lymphopoiesis

Li, J., Bhattacharya, S., Zhou, J., Phadnis-Moghe, A. S., Crawford, R. B., & Kaminski, N. E. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1700289 · Cited by 49 · see citing works

The Aryl Hydrocarbon Receptor in Immunity: Tools and Potential

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Identification of benzothiazole derivatives and polycyclic aromatic hydrocarbons as aryl hydrocarbon receptor agonists present in tire extracts

He, G., Zhao, B., & Denison, M. S. (2011) · Environmental Toxicology and Chemistry · doi:10.1002/etc.581 · Cited by 45 · see citing works

Monoterpenoid aryl hydrocarbon receptor allosteric antagonists protect against ultraviolet skin damage in female mice

Poulíková, K., Bartoňková, I., Vyhlídalová, B., Krasulová, K., Miková, E., Vrzal, R., Nádvorník, P., Nepal, B., Kortagere, S., Kopečná, M., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-38478-6 · Cited by 44 · see citing works

Newspapers and Newspaper Ink Contain Agonists for the Ah Receptor

Bohonowych, J. E. S., Zhao, B., Timme‐Laragy, A. R., Jung, D., Giulio, R. T. D., & Denison, M. S. (2008) · Toxicological Sciences · doi:10.1093/toxsci/kfn011 · Cited by 44 · see citing works

Considerations for potency equivalent calculations in the Ah receptor-based CALUX bioassay: Normalization of superinduction results for improved sample potency estimation

Baston, D. S., & Denison, M. S. (2010) · Talanta · doi:10.1016/j.talanta.2010.11.035 · Cited by 39 · see citing works

Transitional States in Ligand-Dependent Transformation of the Aryl Hydrocarbon Receptor into Its DNA-Binding Form

Soshilov, A. A., Motta, S., Bonati, L., & Denison, M. S. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21072474 · Cited by 36 · see citing works

Vemurafenib acts as an aryl hydrocarbon receptor antagonist: Implications for inflammatory cutaneous adverse events

Hawerkamp, H. C., Kislat, A., Gerber, P. A., Pollet, M., Rolfes, K. M., Soshilov, A. A., Denison, M. S., Momin, A. A., Arold, S. T., Datsi, A., et al. (2019) · Allergy · doi:10.1111/all.13972 · Cited by 34 · see citing works

Effects of anthocyanins on the AhR–CYP1A1 signaling pathway in human hepatocytes and human cancer cell lines

Kamenickova, A., Anzenbacherová, E., Pávek, P., Soshilov, A. A., Denison, M. S., Zapletalova, M. K., Anzenbacher, P., & Dvořák, Z. (2013) · Toxicology Letters · doi:10.1016/j.toxlet.2013.05.007 · Cited by 32 · see citing works

Enantiospecific Effects of Ketoconazole on Aryl Hydrocarbon Receptor

Novotná, A., Korhoňová, M., Bartoňková, I., Soshilov, A. A., Denison, M. S., Bogdanová, K., Kolář, M., Bednář, P., & Dvořák, Z. (2014) · PLoS ONE · doi:10.1371/journal.pone.0101832 · Cited by 29 · see citing works

Interaction of diuron and related substituted phenylureas with the Ah receptor pathway

Zhao, B., Baston, D. S., Hammock, B. D., & Denison, M. S. (2006) · Journal of Biochemical and Molecular Toxicology · doi:10.1002/jbt.20126 · Cited by 28 · see citing works

Naturally Occurring Marine Brominated Indoles Are Aryl Hydrocarbon Receptor Ligands/Agonists

DeGroot, D. E., Franks, D. G., Higa, T., Tanaka, J., Hahn, M. E., & Denison, M. S. (2015) · Chemical Research in Toxicology · doi:10.1021/acs.chemrestox.5b00003 · Cited by 27 · see citing works

Common Commercial and Consumer Products Contain Activators of the Aryl Hydrocarbon (Dioxin) Receptor

Zhao, B., Bohonowych, J. E. S., Timme‐Laragy, A. R., Jung, D., Affatato, A. A., Rice, R. H., Giulio, R. T. D., & Denison, M. S. (2013) · PLoS ONE · doi:10.1371/journal.pone.0056860 · Cited by 26 · see citing works

β-Naphthoflavone and 3′-methoxy-4′-nitroflavone exert ambiguous effects on Ah receptor-dependent cell proliferation and gene expression in rat liver ‘stem-like’ cells

Procházková, J., Sindlerova, L. S., Kozubı́k, A., Krčmář, P., Machala, M., & Vondráček, J. (2007) · Biochemical Pharmacology · doi:10.1016/j.bcp.2007.01.032 · Cited by 26 · see citing works

Discovery and Mechanistic Characterization of a Select Modulator of AhR-regulated Transcription (SMAhRT) with Anti-cancer Effects

O’Donnell, E. F., Jang, H. S., Liefwalker, D. F., Kerkvliet, N. I., & Kolluri, S. K. (2021) · APOPTOSIS · doi:10.1007/s10495-021-01666-0 · Cited by 24 · see citing works

Ginsenosides Are Novel Naturally-Occurring Aryl Hydrocarbon Receptor Ligands

Hu, Q., He, G., Zhao, J., Soshilov, A. A., Denison, M. S., Zhang, A., Yin, H.-J., Fraccalvieri, D., Bonati, L., Xie, H. Q., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0066258 · Cited by 24 · see citing works

Targeting the Aryl Hydrocarbon Receptor with Microbial Metabolite Mimics Alleviates Experimental Colitis in Mice

Grycová, A., Joo, H., Maier, V., Illéš, P., Vyhlídalová, B., Poulíková, K., Sládeková, L., Nádvorník, P., Vrzal, R., Zemánková, L., et al. (2022) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.2c00208 · Cited by 23 · see citing works

Rosmarinus officinalis L. Leaf Extracts and Their Metabolites Inhibit the Aryl Hydrocarbon Receptor (AhR) Activation In Vitro and in Human Keratinocytes: Potential Impact on Inflammatory Skin Diseases and Skin Cancer

Kallimanis, P., Chinou, İ., Panagiotopoulou, A., Soshilov, A. A., He, G., Denison, M. S., & Magiatis, P. (2022) · Molecules · doi:10.3390/molecules27082499 · Cited by 23 · see citing works

Toxicogenomic Evaluation of Long-term Hepatic Effects of TCDD in Immature, Ovariectomized C57BL/6 Mice

Kopec, A. K., Boverhof, D. R., Nault, R., Harkema, J. R., Tashiro, C. H. M., Potter, D., Sharratt, B., Chittim, B. G., & Zacharewski, T. R. (2013) · Toxicological Sciences · doi:10.1093/toxsci/kft156 · Cited by 23 · see citing works

Nucleotide Specificity of DNA Binding of the Aryl Hydrocarbon Receptor:ARNT Complex Is Unaffected by Ligand Structure

DeGroot, D. E., & Denison, M. S. (2013) · Toxicological Sciences · doi:10.1093/toxsci/kft234 · Cited by 18 · see citing works

Induction of quinone oxidoreductase 1 enzyme by Rhazya stricta through Nrf2-dependent mechanism

Gendy, M. A. M. E., Ali, B. H., Michail, K., Siraki, A. G., & El‐Kadi, A. O. S. (2012) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2012.09.032 · Cited by 15 · see citing works

Aryl hydrocarbon receptor‐based bioassays for dioxin detection: Thinking outside the box

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Chronic Cardiovascular Disease-Associated Gene Network Analysis in Human Umbilical Vein Endothelial Cells Exposed to 2,3,7,8-Tetrachlorodibenzo-p-dioxin

Yu, Y., Qin, J., Chen, D., Wang, H., Wang, J., & Yu, Y. (2014) · Cardiovascular Toxicology · doi:10.1007/s12012-014-9279-6 · Cited by 11 · see citing works

SHP-1 is directly activated by the aryl hydrocarbon receptor and regulates BCL-6 in the presence of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)

Phadnis-Moghe, A. S., Li, J., Crawford, R. B., & Kaminski, N. E. (2016) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2016.08.014 · Cited by 11 · see citing works

Lack of ligand-selective binding of the aryl hydrocarbon receptor to putative DNA binding sites regulating expression of Bax and paraoxonase 1 genes

DeGroot, D. E., Hayashi, A., & Denison, M. S. (2013) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2013.10.021 · Cited by 9 · see citing works

Auto-induction mechanism of aryl hydrocarbon receptor 2 (AHR2) gene by TCDD-activated AHR1 and AHR2 in the red seabream (Pagrus major)

Bak, S.-M., Iida, M., Soshilov, A. A., Denison, M. S., Iwata, H., & Kim, E. (2016) · Archives of Toxicology · doi:10.1007/s00204-016-1732-9 · Cited by 7 · see citing works

Modulation of aryl hydrocarbon receptor activity by halogenated indoles

Vrzalová, A., Vrzal, R., Nádvorník, P., Šebela, M., & Dvořák, Z. (2024) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2024.117964 · Cited by 5 · see citing works

Inhibition of Aryl hydrocarbon receptor Interleukin-22 signaling and worsening of intestinal inflammation by Sutterella species

Dupraz, L., Orianne, G., da Costa, G., Gauthier, R., Blondeau, A., Boinet, M., Farfar, A., Creusot, L., Magniez, A., Dubois, L., et al. (2026) · Gut microbes · doi:10.1080/19490976.2026.2690688 · Cited by 2 · see citing works

Development of a novel recombinant cell line for detection and characterization of Ah receptor nuclear translocation in intact cells

Hayashi, A., & Denison, M. S. (2020) · Toxicology in Vitro · doi:10.1016/j.tiv.2020.104873 · Cited by 3 · see citing works

Development and Application of a CAFLUX HepG2 Reporter Cell Line for Real-Time Monitoring of AhR-Mediated CYP1A1 Gene Expression in Response to Environmental Toxicants and Bioactive Modulators

La, H. T., Hoang, H., Le, P. M. T., Linh, N. T., Nguyen, D. T., Nguyen, V. H., Ha, T. M. T., Nguyen, L. H., & Nguyen, D. T. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms262010029 · Cited by 1 · see citing works

Assessment of receptor-mediated activity (AhR and ERα), mutagenicity, and teratogenicity of metal shredder wastes in Wallonia, Belgium

Matranxhi, B., Mertens, B., Anthonissen, R., Maes, J., Ny, A., de Witte, P. A. M., Brouhon, J.-M., Bast, B. D., & Elskens, M. T. (2024) · Environmental Science and Pollution Research · doi:10.1007/s11356-024-34820-7 · Cited by 1 · see citing works

Responses of paraoxonase 1 to dioxin-like pcb 126 ( 3,3',4,4',5-pentachlorobiphenyl)

Shen, H. (2011) · doi:10.17077/etd.3dqb6nvc · Cited by 1 · see citing works

Interactions de la fumée de cigarette et ses composés avec les transporteurs membranaires dans des modèles hépatiques et non-hépatiques

Sayyed, K. (2018) · doi:10.70675/7e400b17ze758z46cazb379z5fa6d3d667e8

Dialogue entre le microbiote intestinal et l'hôte via le métabolisme du L-tryptophane

Modoux, M. (2022) · theses.fr (ABES) · doi:10.70675/e7e50c6bz7d58z452fzb065z884298a05c4a

BindingDB Entry 50017805: Targeting the Aryl Hydrocarbon Receptor with Microbial Metabolite Mimics Alleviates Experimental Colitis in Mice.

BindingDB (2023) · UC San Diego · doi:10.7270/q27d3076

BindingDB Entry 50022758: Modulation of aryl hydrocarbon receptor activity by halogenated indoles.

BindingDB (2026) · UC San Diego · doi:10.7270/q2sq9565

AH RECEPTOR SIGNALING PATHWAYS

Schmidt, J. V., & Bradfield, C. A. (1996) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.12.1.55 · Cited by 899 · see citing works

A Human Aryl Hydrocarbon Receptor Signaling Pathway Constructed in Yeast Displays Additive Responses to Ligand Mixtures

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Aryl Hydrocarbon Receptor-Mediated Signal Transduction

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