Cited by 2,344Ion channel regulation and functionCardiac electrophysiology and arrhythmiasIon Channels and Receptors

The DOI matches its Crossref record; 225 of the 226 references it cites were found in a registry or an index.

Structure and Regulation of Voltage-Gated Ca 2+ Channels

Catterall, William A.·2000·Annual Review of Cell and Developmental Biology

Open this paper in CoChat — free account

Abstract

▪ Abstract Voltage-gated Ca 2+ channels mediate Ca 2+ entry into cells in response to membrane depolarization. Electrophysiological studies reveal different Ca 2+ currents designated L-, N-, P-, Q-, R-, and T-type. The high-voltage-activated Ca 2+ channels that have been characterized biochemically are complexes of a pore-forming α 1 subunit of ∼190–250 kDa; a transmembrane, disulfide-linked complex of α 2 and δ subunits; an intracellular β subunit; and in some cases a transmembrane γ subunit. Ten α 1 subunits, four α 2 δ complexes, four β subunits, and two γ subunits are known. The Ca v 1 family of α 1 subunits conduct L-type Ca 2+ currents, which initiate muscle contraction, endocrine secretion, and gene transcription, and are regulated primarily by second messenger-activated protein phosphorylation pathways. The Ca v 2 family of α 1 subunits conduct N-type, P/Q-type, and R-type Ca 2+ currents, which initiate rapid synaptic transmission and are regulated primarily by direct interaction with G proteins and SNARE proteins and secondarily by protein phosphorylation. The Ca v 3 family of α 1 subunits conduct T-type Ca 2+ currents, which are activated and inactivated more rapidly and at more negative membrane potentials than other Ca 2+ current types. The distinct structures and patterns of regulation of these three families of Ca 2+ channels provide a flexible array of Ca 2+ entry pathways in response to changes in membrane potential and a range of possibilities for regulation of Ca 2+ entry by second messenger pathways and interacting proteins.

Integrity signals

Registry

Crossref · 10.1146/annurev.cellbio.16.1.521

Cites

225 of 225 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

1 retracted

Calmodulin kinase determines calcium-dependent facilitation of L-type calcium channels
Dzhura, I., Wu, Y., Colbran, R. J., Balser, J. R., & Anderson, M. E. (2000) · Nature Cell Biology · doi:10.1038/35004052 · Cited by 339
Retracted
Three types of neuronal calcium channel with different calcium agonist sensitivity
Nowycky, M. C., Fox, A. P., & Tsien, R. W. (1985) · Nature · doi:10.1038/316440a0 · Cited by 2,203
The synaptic vesicle cycle: a cascade of protein–protein interactions
Südhof, T. C. (1995) · Nature · doi:10.1038/375645a0 · Cited by 1,991
Nomenclature of Voltage-Gated Sodium Channels
Goldin, A. L., Barchi, R. L., Caldwell, J. H., Hofmann, F. B., Howe, J. R., Hunter, J. C., Kallen, R. G., Mandel, G., Meisler, M. H., Berwald‐Netter, Y., et al. (2000) · Neuron · doi:10.1016/s0896-6273(00)00116-1 · Cited by 1,484
Self-citation
Multiple types of neuronal calcium channels and their selective modulation
Tsien, R. W., Lipscombe, D., Madison, D. V., Bley, K. R., & Fox, A. P. (1988) · Trends in Neurosciences · doi:10.1016/0166-2236(88)90194-4 · Cited by 1,381
Primary structure of the receptor for calcium channel blockers from skeletal muscle
Tanabe, T., Takeshima, H., Mikami, A., Flockerzi, V., Takahashi, H., Kangawa, K., Kojima, M., Matsuo, H., Hirose, T., & Numa, S. (1987) · Nature · doi:10.1038/328313a0 · Cited by 1,370
Different modes of Ca channel gating behaviour favoured by dihydropyridine Ca agonists and antagonists
Hess, P., Lansman, J. B., & Tsien, R. W. (1984) · Nature · doi:10.1038/311538a0 · Cited by 1,270
Calcium channel modulation by neurotransmitters, enzymes and drugs
REUTER, H. (1983) · Nature · doi:10.1038/301569a0 · Cited by 1,266
Classes Of Calcium Channels In Vertebrate Cells
Bean, B. P. (1989) · Annual Review of Physiology · doi:10.1146/annurev.ph.51.030189.002055 · Cited by 1,085
Regulation and modulation of calcium channels in cardiac, skeletal, and smooth muscle cells
McDonald, T. F., Pelzer, S., Trautwein, W., & Pelzer, D. J. (1994) · Physiological Reviews · doi:10.1152/physrev.1994.74.2.365 · Cited by 995

Show all 226 references

Research works printed but not linked: 8

Bean BP. 1994. β-adrenergic modulation of cardiac calcium channel gating. In Ion Channels in the Cardiovacular System; Function and Dysfunction , ed. PM Spooner, AM Brown, WA Catterall, GJ Kaczorowski, HC Strauss, pp. 237–52. New York: Futura. 580 pp.
Fleming NW, 1993, J. Pharmacol. Exp. Ther., 265, 1199
Kernell D, 1983, Exp. Brain Res., 50, 220
Kwan YW, 1997, Can. J. Cardiol., 13, 1202
Nilius B, 1986, Biomed. Biochem. Acta, 45, 795
Oz M, 1991, J. Pharmacol. Exp. Ther., 257, 575
Rubin CS, 1994, Biochim. Biophys. Acta, 1224, 467
Tobi D, 1999, Recept. Channels, 6, 89

Sorted by citations

Items 201–300 of 1,004

Differential targeting of the L‐type Ca 2+ channel α 1C (Ca V 1.2) to synaptic and extrasynaptic compartments in hippocampal neurons
Obermair, G. J., Szabó, Z. M., Bourinet, E., & Flucher, B. E. (2004) · European Journal of Neuroscience · doi:10.1111/j.0953-816x.2004.03272.x · Cited by 149
L-type calcium channel targeting and local signalling in cardiac myocytes.
Shaw, R., & Colecraft, H. M. (2013) · Cardiovascular Research · doi:10.1093/cvr/cvt021 · Cited by 150
Association of Ca V 1.3 L-Type Calcium Channels with Shank
Zhang, H., Maximov, A., Fu, Y., Xu, F., Tang, T.-S., Tkatch, T., Surmeier, D. J., & Борисович, Б. И. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.4554-04.2005 · Cited by 148
Molecular mechanisms of active zone function
Rosenmund, C., Rettig, J., & Brose, N. (2003) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2003.09.011 · Cited by 144
Targeting Ca channels to treat pain: T-type versus N-type
Altier, C., & Zamponi, G. W. (2004) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2004.07.004 · Cited by 148
The Two-pore Domain K+ Channel, TRESK, Is Activated by the Cytoplasmic Calcium Signal through Calcineurin
Czirják, G., Tóth, Z., & Enyedi, P. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m312229200 · Cited by 147
The α 2 δ Ligand Gabapentin Inhibits the Rab11-Dependent Recycling of the Calcium Channel Subunit α 2 δ-2
Tran-Van-Minh, A., & DOLPHIN, A. C. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.2700-10.2010 · Cited by 153
Calcium Dependence of Polycystin-2 Channel Activity Is Modulated by Phosphorylation at Ser812
Cai, Y., Anyatonwu, G. I., Okuhara, D. Y., Lee, K., Yu, Z., Onoe, T., Mei, C.-L., Qian, Q., Geng, L., Wiztgall, R., et al. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m312031200 · Cited by 149
Voltage-activated calcium channel expression profiles in mouse brain and cultured hippocampal neurons
Schlick, B., Flucher, B. E., & Obermair, G. J. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.02.037 · Cited by 144
C-termini of P/Q-type Ca 2+ channel α1A subunits translocate to nuclei and promote polyglutamine-mediated toxicity
Kordasiewicz, H. B., Thompson, R. M., Clark, H. B., & Gomez, C. M. (2006) · Human Molecular Genetics · doi:10.1093/hmg/ddl080 · Cited by 144
Neuronal P/Q-type calcium channel dysfunction in inherited disorders of the CNS
Rajakulendran, S., Kaski, D. N., & Hanna, M. G. (2012) · Nature Reviews Neurology · doi:10.1038/nrneurol.2011.228 · Cited by 143
Interactions between presynaptic Ca2+ channels, cytoplasmic messengers and proteins of the synaptic vesicle release complex
Jarvis, S. E., & Zamponi, G. W. (2001) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(00)01800-9 · Cited by 143
A voltage-driven switch for ion-independent signaling by ether-à-go-go K + channels
Hegle, A. P., Marble, D. D., & Wilson, G. F. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0505909103 · Cited by 142
Ca2+-calmodulin-dependent phosphodiesterase (PDE1): Current perspectives
Goraya, T. A., & Cooper, D. M. F. (2005) · Cellular Signalling · doi:10.1016/j.cellsig.2004.12.017 · Cited by 139
Homeostatic plasticity at the Drosophila neuromuscular junction
Frank, C. A. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.06.015 · Cited by 140
Identification of a Novel A-kinase Anchoring Protein 18 Isoform and Evidence for Its Role in the Vasopressin-induced Aquaporin-2 Shuttle in Renal Principal Cells
Henn, V., Edemir, B., Stefan, E., Wiesner, B., Lorenz, D., Theilig, F., Schmitt, R., Vossebein, L., Tamma, G., Beyermann, M., et al. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m312835200 · Cited by 140
Role of Lipid Microdomains in P/Q-type Calcium Channel (Cav2.1) Clustering and Function in Presynaptic Membranes
Taverna, E., Saba, E., Rowe, J., Francolini, M., Clementi, F., & Rosa, P. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m308798200 · Cited by 139
Signaling complexes of voltage-gated sodium and calcium channels
Catterall, W. A. (2010) · Neuroscience Letters · doi:10.1016/j.neulet.2010.08.085 · Cited by 135
Self-citation
Functional role of voltage gated Ca2+ channels in heart automaticity
Mesirca, P., Torrente, A. G., & Mangoni, M. E. (2015) · Frontiers in Physiology · doi:10.3389/fphys.2015.00019 · Cited by 138
Plasticity of dendritic excitability
Frick, A., & Johnston, D. (2005) · Journal of Neurobiology · doi:10.1002/neu.20148 · Cited by 146
Complete heart block and sudden death in mice overexpressing calreticulin
Nakamura, K., Robertson, M. A., Liu, G., Dickie, P., Nakamura, K. M., Guo, J. Q., Duff, H. J., Opas, M., Kavanagh, K. M., & Michalak, M. (2001) · Journal of Clinical Investigation · doi:10.1172/jci12412 · Cited by 138
L-Type Calcium Channels
Triggle, D. J. (2006) · Current Pharmaceutical Design · doi:10.2174/138161206775474503 · Cited by 137
T-Type Ca2+Channels in Normal and Abnormal Brain Functions
Cheong, E., & Shin, H. (2013) · Physiological Reviews · doi:10.1152/physrev.00010.2012 · Cited by 139
Unchanged β-Adrenergic Stimulation of Cardiac L-type Calcium Channels in Cav1.2 Phosphorylation Site S1928A Mutant Mice
Lemke, T., Welling, A., Christel, C. J., Blaich, A., Bernhard, D., Lenhardt, P., Hofmann, F. B., & Moosmang, S. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m804981200 · Cited by 136
L‐type calcium channels and psychiatric disorders: A brief review
Casamassima, F., Hay, A. C., Benedetti, A., Lattanzi, L., Cassano, G. B., & Perlis, R. H. (2010) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.31122 · Cited by 139
Critical Role of cAMP-Dependent Protein Kinase Anchoring to the L-Type Calcium Channel Cav1.2 via A-Kinase Anchor Protein 150 in Neurons
Hall, D. D., Davare, M. A., Shi, M., Allen, M. L., Weisenhaus, M., McKnight, G. S., & Hell, J. W. (2007) · Biochemistry · doi:10.1021/bi062217x · Cited by 139
Ion channel networks in the control of cerebral blood flow
Longden, T. A., Hill-Eubanks, D. C., & Nelson, M. T. (2016) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x15616138 · Cited by 137
Intracellular Calcium, Endothelial Cells and Angiogenesis
Munaron, L. (2006) · Recent Patents on Anti-Cancer Drug Discovery · doi:10.2174/157489206775246502 · Cited by 136
Pokes, sunburn, and hot sauce: Drosophila as an emerging model for the biology of nociception
Im, S. H., & Galko, M. J. (2011) · Developmental Dynamics · doi:10.1002/dvdy.22737 · Cited by 135
Auxiliary subunit regulation of high‐voltage activated calcium channels expressed in mammalian cells
Yasuda, T., Chen, L., Barr, W., McRory, J. E., Lewis, R. J., Adams, D. J., & Zamponi, G. W. (2004) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03434.x · Cited by 133
Calcium channels, transporters and exchangers in placenta: a review
Belkacemi, L., Bédard, I., Simoneau, L., & Lafond, J. (2004) · Cell Calcium · doi:10.1016/j.ceca.2004.06.010 · Cited by 133
High Blood Pressure Upregulates Arterial L-Type Ca 2+ Channels
Pesic, A., Madden, J. A., Pesic, M., & Rusch, N. J. (2004) · Circulation Research · doi:10.1161/01.res.0000131495.93500.3c · Cited by 133
A CACNA1F mutation identified in an X-linked retinal disorder shifts the voltage dependence of Ca v 1.4 channel activation
Hemara‐Wahanui, A., Berjukow, S., Hope, C., Dearden, P. K., Wu, S., Wilson-Wheeler, J. C., Sharp, D. M., Lundon-Treweek, P., Clover, G. M., Hoda, J., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0501907102 · Cited by 132
Electrophysiology of Islet Cells
Drews, G., Krippeit-Drews, P., & Düfer, M. (2010) · Advances in Experimental Medicine and Biology · doi:10.1007/978-90-481-3271-3_7 · Cited by 152
A Putative Cation Channel, NCA-1, and a Novel Protein, UNC-80, Transmit Neuronal Activity in C. elegans
Yeh, E., Ng, S., Zhang, M., Bouhours, M., Wang, Y., Wang, M., Hung, W., Aoyagi, K., Melnik-Martínez, K. V., Li, M., et al. (2008) · PLoS Biology · doi:10.1371/journal.pbio.0060055 · Cited by 131
Ca V 1.2 β-subunit coordinates CaMKII-triggered cardiomyocyte death and afterdepolarizations
Koval, O. M., Guan, X., Wu, Y., Joiner, M.-L. A., Gao, Z., Chen, B., Grumbach, I. M., Luczak, E. D., Colbran, R. J., Song, L., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0913760107 · Cited by 138
Structural and Functional Abnormalities of Retinal Ribbon Synapses due to Cacna2d4 Mutation
Wycisk, K. A., Budde, B. S., Feil, S., Skosyrski, S., Buzzi, F., Neidhardt, J., Glaus, E., Nu¨rnberg, P., Rüether, K., & Berger, W. (2006) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.06-0271 · Cited by 130
Electro-magnetic field promotes osteogenic differentiation of BM-hMSCs through a selective action on Ca2+-related mechanisms
Petecchia, L., Sbrana, F., Utzeri, R., Vercellino, M., Usai, C., Visai, L., Vassalli, M., & Gavazzo, P. (2015) · Scientific Reports · doi:10.1038/srep13856 · Cited by 130
Potassium, sodium, calcium and glutamate‐gated channels: pore architecture and ligand action
Zhorov, B. S., & Tikhonov, D. B. (2004) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02261.x · Cited by 129
Review: Is levetiracetam different from other antiepileptic drugs? Levetiracetam and its cellular mechanism of action in epilepsy revisited
Surges, R., Volynski, K. E., & Walker, M. C. (2008) · Therapeutic Advances in Neurological Disorders · doi:10.1177/1756285608094212 · Cited by 129
Differential Expression of Intrinsic Membrane Currents in Defined Cell Types of the Anterolateral Bed Nucleus of the Stria Terminalis
Hammack, S. E., Mania, I., & Rainnie, D. G. (2007) · Journal of Neurophysiology · doi:10.1152/jn.00382.2007 · Cited by 128
Age-related working memory impairment is correlated with increases in the L-type calcium channel protein α1D (Cav1.3) in area CA1 of the hippocampus and both are ameliorated by chronic nimodipine treatment
Veng, L., Mesches, M. H., & Browning, M. D. (2003) · Molecular Brain Research · doi:10.1016/s0169-328x(02)00643-5 · Cited by 128
Trafficking of L-type Calcium Channels Mediated by the Postsynaptic Scaffolding Protein AKAP79
Altier, C., Dubel, S. J., Barr�re, C., Jarvis, S. E., Stotz, S. C., Spaetgens, R. L., Scott, J. D., Cornet, V., WAARD, M. M. D., Zamponi, G. W., et al. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m202476200 · Cited by 128
Regulation of Cardiac L-Type Ca 2+ Channel Ca V 1.2 Via the β-Adrenergic-cAMP-Protein Kinase A Pathway
Weiss, S., Oz, S., Benmocha, A., & Dascal, N. (2013) · Circulation Research · doi:10.1161/circresaha.113.301781 · Cited by 132
From Gene to Behavior: L-Type Calcium Channel Mechanisms Underlying Neuropsychiatric Symptoms
Kabir, Z. D., Martínez-Rivera, A., & Rajadhyaksha, A. M. (2017) · Neurotherapeutics · doi:10.1007/s13311-017-0532-0 · Cited by 128
Calcium signalling in human spermatozoa: a specialized ‘toolkit’ of channels, transporters and stores
Jiménez-González, C., Michelangeli, F., Harper, C. V., Barratt, C. L. R., & Publicover, S. J. (2005) · Human Reproduction Update · doi:10.1093/humupd/dmi050 · Cited by 126
Role of exercise in maintaining the integrity of the neuromuscular junction
Nishimune, H., Stanford, J. A., & Mori, Y. (2013) · Muscle and Nerve · doi:10.1002/mus.24095 · Cited by 119
Modulation of CaV2.1 channels by Ca2+/calmodulin-dependent protein kinase II bound to the C-terminal domain
Jiang, X., Lautermilch, N., Watari, H., Westenbroek, R., Scheuer, T., & Catterall, W. (2008) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.0710213105 · Cited by 106
Self-citation
Zebrafishrelatively relaxedmutants have a ryanodine receptor defect, show slow swimming and provide a model of multi-minicore disease
Hirata, H., Watanabe, T., Hatakeyama, J., Sprague, S. M., Saint‐Amant, L., Nagashima, A., Cui, W. W., Zhou, W., & Kuwada, J. Y. (2007) · Development · doi:10.1242/dev.004531 · Cited by 124
A Smooth Muscle Cav1.2 Calcium Channel Splice Variant Underlies Hyperpolarized Window Current and Enhanced State-dependent Inhibition by Nifedipine
Liao, P. H., Yu, D., Li, G., Yong, T. F., Soon, J.-L., Chua, Y. L., & Soong, T. W. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m705478200 · Cited by 125
Splicing for alternative structures of Ca1.2 Ca channels in cardiac and smooth muscles
Liao, P. H., Yong, T. A., Liang, M. C., Yue, D. N., & Soong, T. W. (2005) · Cardiovascular Research · doi:10.1016/j.cardiores.2005.06.024 · Cited by 124
Schistosome Calcium Channel β Subunits
Kohn, A. B., Anderson, P. A. V., ROBERTS-MISTERLY, J. M., & Greenberg, R. M. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.c100273200 · Cited by 125
Declining Into Failure
Jones, S. A., Boyett, M. R., & Lancaster, M. K. (2007) · Circulation · doi:10.1161/circulationaha.106.663070 · Cited by 125
Transsynaptic Control of Presynaptic Ca2+ Influx Achieves Homeostatic Potentiation of Neurotransmitter Release
Müller, M., & Davis, G. W. (2012) · Current Biology · doi:10.1016/j.cub.2012.04.018 · Cited by 129
Basic roles of key molecules connected with NMDAR signaling pathway on regulating learning and memory and synaptic plasticity
Wang, H., & Peng, R. (2016) · Military Medical Research · doi:10.1186/s40779-016-0095-0 · Cited by 129
From modulator to mediator: rapid effects of BDNF on ion channels
Rose, C. R., Blum, R., Kafitz, K. W., Kovalchuk, Y., & Konnerth, A. (2004) · BioEssays · doi:10.1002/bies.20118 · Cited by 106
β-Subunits Promote the Expression of CaV2.2 Channels by Reducing Their Proteasomal Degradation
Waithe, D., Ferron, L., Page, K. M., Chaggar, K., & DOLPHIN, A. C. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.195909 · Cited by 122
Alternative splicing: Functional diversity among voltage-gated calcium channels and behavioral consequences
Lipscombe, D., Andrade, A., & Allen, S. E. (2012) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2012.09.018 · Cited by 126
Ser1928 Is a Common Site for Cav1.2 Phosphorylation by Protein Kinase C Isoforms
Yang, L., Liu, G., Zakharov, S. I., Morrow, J., Rybin, V. O., Steinberg, S. F., & Marx, S. O. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m410509200 · Cited by 122
β-Adrenergic Stimulation of L-type Ca 2+ Channels in Cardiac Myocytes Requires the Distal Carboxyl Terminus of α 1C but Not Serine 1928
Ganesan, A. N., Maack, C., Johns, D. C., Sidor, A., & O'Rourke, B. P. (2006) · Circulation Research · doi:10.1161/01.res.0000202692.23001.e2 · Cited by 122
Redox regulation of calcium ion channels: Chemical and physiological aspects
Bogeski, I., Kappl, R., Kummerow, C., Gulaboski, R., Hoth, M., & Niemeyer, B. A. (2011) · Cell Calcium · doi:10.1016/j.ceca.2011.07.006 · Cited by 123
A Scaffold Protein, AHNAK1, Is Required for Calcium Signaling during T Cell Activation
Matza, D., Badou, A., Kobayashi, K. S., Goldsmith‐Pestana, K., Masuda, Y., Komuro, A., McMahon‐Pratt, D., Marchesi, V. T., & Flavell, R. A. (2008) · Immunity · doi:10.1016/j.immuni.2007.11.020 · Cited by 126
Voltage-dependent calcium channels and cardiac pacemaker activity: From ionic currents to genes
Mangoni, M. E., Couette, B., Marger, L., Bourinet, E., Striessnig, J., & Nargeot, J. (2005) · Progress in Biophysics and Molecular Biology · doi:10.1016/j.pbiomolbio.2005.05.003 · Cited by 121
Effects of Radiofrequency Electromagnetic Radiation on Neurotransmitters in the Brain
Hu, C., Zuo, H., & Yang, L. (2021) · Frontiers in Public Health · doi:10.3389/fpubh.2021.691880 · Cited by 120
Functional roles of cytoplasmic loops and pore lining transmembrane helices in the voltage‐dependent inactivation of HVA calcium channels
Stotz, S. C., Jarvis, S. E., & Zamponi, G. W. (2004) · The Journal of Physiology · doi:10.1113/jphysiol.2003.047068 · Cited by 120
Modulation of ion channels by reactive oxygen and nitrogen species: a pathophysiological role in brain aging?
Annunziato, L., Pannaccione, A., Cataldi, M., Secondo, A., Castaldo, P., Renzo, G. F. D., & Taglialatela, M. (2002) · Neurobiology of Aging · doi:10.1016/s0197-4580(02)00069-6 · Cited by 120
Voltage- and calcium-dependent inactivation in high voltage-gated Ca2+ channels
Cens, T., Rousset, M., Leyris, J.-P., FESQUET, P., & Charnet, P. (2005) · Progress in Biophysics and Molecular Biology · doi:10.1016/j.pbiomolbio.2005.05.013 · Cited by 120
D5 (Not D1) Dopamine Receptors Potentiate Burst-Firing in Neurons of the Subthalamic Nucleus by Modulating an L-Type Calcium Conductance
Baufreton, J., Garret, M., Rivera, A., de la Calle, A., Gonon, F., DUFY, B., Bioulac, B. H., & Taupignon, A. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-03-00816.2003 · Cited by 120
D1 Receptors Physically Interact with N-Type Calcium Channels to Regulate Channel Distribution and Dendritic Calcium Entry
Kisilevsky, A. E., Mulligan, S. J., Altier, C., Iftinca, M., Varela, D., Tai, C., Chen, L., Hameed, S., Hamid, J., MacVicar, B. A., et al. (2008) · Neuron · doi:10.1016/j.neuron.2008.03.002 · Cited by 127
Painful Channels in Sensory Neurons
Lee, Y., Lee, C., & Oh, U. (2005) · Molecules and Cells · doi:10.1016/s1016-8478(23)25242-5 · Cited by 120
Molecular aspects of adrenergic modulation of cardiac L-type Ca channels
van der Heyden, M. A. G., Wijnhoven, T. J. M., & Tobias Opthof, A. (2004) · Cardiovascular Research · doi:10.1016/j.cardiores.2004.09.028 · Cited by 119
Calmodulin Kinase II Is Involved in Voltage-dependent Facilitation of the L-type Cav1.2 Calcium Channel
Lee, T., Karl, R., Moosmang, S., Lenhardt, P., Klugbauer, N., Hofmann, F. B., Kleppisch, T., & Welling, A. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m508661200 · Cited by 118
Ser 1928 phosphorylation by PKA stimulates the L-type Ca 2+ channel Ca V 1.2 and vasoconstriction during acute hyperglycemia and diabetes
Nystoriak, M. A., Nieves‐Cintrón, M., Patriarchi, T., Buonarati, O. R., Prada, M. P., Morotti, S., Grandi, E., Fernandes, J. D. S., Forbush, K. A., Hofmann, F. B., et al. (2017) · Science Signaling · doi:10.1126/scisignal.aaf9647 · Cited by 117
New gain-of-function mutation shows CACNA1D as recurrently mutated gene in autism spectrum disorders and epilepsy
Pinggera, A., Mackenroth, L., Rump, A., Schallner, J., Beleggia, F., Wollnik, B., & Striessnig, J. (2017) · Human Molecular Genetics · doi:10.1093/hmg/ddx175 · Cited by 116
Amyloid Precursor Protein Regulates Ca v 1.2 L-type Calcium Channel Levels and Function to Influence GABAergic Short-Term Plasticity
Yang, L., Wang, Z., Wang, B., Justice, N. J., & Zheng, H. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.4104-09.2009 · Cited by 122
Increased phosphorylation of the neuronal L-type Ca 2+ channel Ca v 1.2 during aging
Davare, M. A., & Hell, J. W. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2236970100 · Cited by 121
The Transcription Factor NFAT3 Mediates Neuronal Survival
Benedito, A. B., Lehtinen, M. K., Massol, R., Lopes, U. G., Kirchhausen, T. L., Rao, A., & Bonni, A. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m408741200 · Cited by 118
Molecular heterogeneity of calcium channel β-subunits in canine and human heart: evidence for differential subcellular localization
Foell, J. D., Balijepalli, R. C., Delisle, B. P., Yunker, A. M. R., Robia, S. L., Walker, J. W., McEnery, M. W., January, C. T., & Kamp, T. J. (2004) · Physiological Genomics · doi:10.1152/physiolgenomics.00207.2003 · Cited by 117
Graded Ca2+/calmodulin-dependent coupling of voltage-gated CaV1.2 channels
Dixon, R. E., Moreno, C. M., Yuan, C., Opitz-Araya, X., Binder, M. D., Navedo, M. F., & Santana, L. F. (2015) · eLife · doi:10.7554/elife.05608 · Cited by 116
Identification of Intracellular and Plasma Membrane Calcium Channel Homologues in Pathogenic Parasites
Prole, D. L., & Taylor, C. W. (2011) · PLoS ONE · doi:10.1371/journal.pone.0026218 · Cited by 115
Distinctive Modulatory Effects of Five Human Auxiliary β2 Subunit Splice Variants on L-Type Calcium Channel Gating
Takahashi, S. X., Mittman, S., & Colecraft, H. M. (2003) · Biophysical Journal · doi:10.1016/s0006-3495(03)70027-7 · Cited by 115
Functional Characterization of the L-type Ca 2+ Channel Ca v 1.4α1 from Mouse Retina
Baumann, L., Gerstner, A., Zong, X., Biel, M., & Wahl‐Schott, C. (2004) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.03-0937 · Cited by 115
Mechanosensitivity of N-Type Calcium Channel Currents
Calabrese, B., Tabarean, I. V., Juranka, P. F., & Morris, C. E. (2002) · Biophysical Journal · doi:10.1016/s0006-3495(02)75267-3 · Cited by 115
Susceptibility to calcium dysregulation during brain aging
Kumar, A. (2009) · Frontiers in Aging Neuroscience · doi:10.3389/neuro.24.002.2009 · Cited by 119
Binding of Protein Phosphatase 2A to the L-Type Calcium Channel Ca v 1.2 next to Ser1928, Its Main PKA Site, Is Critical for Ser1928 Dephosphorylation
Hall, D. D., Feekes, J. A., Don, A. S. A., Shi, M., Hamid, J., Chen, L., Strack, S., Zamponi, G. W., Horne, M. C., & Hell, J. W. (2006) · Biochemistry · doi:10.1021/bi051593z · Cited by 114
Functional interactions between presynaptic calcium channels and the neurotransmitter release machinery
Spafford, J. D., & Zamponi, G. W. (2003) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(03)00061-8 · Cited by 114
Visualization of the Domain Structure of an L-type Ca2+ Channel Using Electron Cryo-microscopy
Wolf, M., Eberhart, A., Glossmann, H. H., Striessnig, J., & Grigorieff, N. (2003) · Journal of Molecular Biology · doi:10.1016/s0022-2836(03)00899-4 · Cited by 114
NLF-1 Delivers a Sodium Leak Channel to Regulate Neuronal Excitability and Modulate Rhythmic Locomotion
Xie, L., Gao, S., Alcaire, S., Aoyagi, K., Wang, Y., Griffin, J. K., Štagljar, I., Nagamatsu, S., & Zhen, M. (2013) · Neuron · doi:10.1016/j.neuron.2013.01.018 · Cited by 113
Pain as a channelopathy
Raouf, R., Quick, K., & Wood, J. N. (2010) · Journal of Clinical Investigation · doi:10.1172/jci43158 · Cited by 121
Ca2+-dependent modulation of voltage-gated Ca2+ channels
Christel, C., & Lee, A. (2012) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2011.12.012 · Cited by 112
Phosphorylation of Ser 1928 mediates the enhanced activity of the L-type Ca 2+ channel Ca v 1.2 by the β 2 -adrenergic receptor in neurons
Qian, H., Patriarchi, T., Price, J. L., Matt, L., Lee, B. R., Nieves‐Cintrón, M., Buonarati, O. R., Chowdhury, D., Nanou, E., Nystoriak, M. A., et al. (2017) · Science Signaling · doi:10.1126/scisignal.aaf9659 · Cited by 115
Self-citation
Protein Kinase G Phosphorylates Cav1.2 α1cand β2Subunits
Yang, L., Liu, G., Zakharov, S. I., Bellinger, A. M., Mongillo, M., & Marx, S. O. (2007) · Circulation Research · doi:10.1161/circresaha.107.156976 · Cited by 112
Regulation of Presynaptic Calcium Channels by Synaptic Proteins
Zamponi, G. W. (2003) · Journal of Pharmacological Sciences · doi:10.1254/jphs.92.79 · Cited by 111
Calcium ion currents mediating oocyte maturation events
Tosti, E. (2006) · Reproductive Biology and Endocrinology · doi:10.1186/1477-7827-4-26 · Cited by 112
Removal of Ca2+ Channel β3 Subunit Enhances Ca2+ Oscillation Frequency and Insulin Exocytosis
Berggren, P.-O., Yang, S.-N., Murakami, M., Efanov, A. M., Uhles, S., Köhler, M., Moede, T., Fernström, A., Appelskog, I. B., Aspinwall, C. A., et al. (2004) · Cell · doi:10.1016/j.cell.2004.09.033 · Cited by 114
Clinical Relevance of Ion Channels for Diagnosis and Therapy of Cancer
Schönherr, R. (2005) · The Journal of Membrane Biology · doi:10.1007/s00232-005-0782-3 · Cited by 110
A voltage-gated sodium channel is essential for the positive selection of CD4+ T cells
Lo, W., Donermeyer, D. L., & Allen, P. M. (2012) · Nature Immunology · doi:10.1038/ni.2379 · Cited by 110
Cortical hyperexcitability and epileptogenesis: Understanding the mechanisms of epilepsy – Part 1
Badawy, R. A. B., Harvey, A. S., & Macdonell, R. A. L. (2009) · Journal of Clinical Neuroscience · doi:10.1016/j.jocn.2008.08.026 · Cited by 110
SNAREing Voltage-Gated K+ and ATP-Sensitive K+ Channels: Tuning β-Cell Excitability with Syntaxin-1A and Other Exocytotic Proteins
Leung, Y. M., Kwan, E. P., Ng, B., Kang, Y., & Gaisano, H. Y. (2007) · Endocrine Reviews · doi:10.1210/er.2007-0010 · Cited by 106
Cav1.4α1 Subunits Can Form Slowly Inactivating Dihydropyridine-Sensitive L-Type Ca2+Channels Lacking Ca2+-Dependent Inactivation
Koschak, A., Reimer, D., Walter, D., Hoda, J., Heinzle, T., Grabner, M., & Striessnig, J. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-14-06041.2003 · Cited by 108

Authors: Catterall, W. A.
Affiliations: University of Washington (US)
Corresponding author: Catterall, William A.
ORCID: Catterall, William A.
Venue: Annual Review of Cell and Developmental Biology
Publisher: Annual Reviews
Published: 2000-11
Volume: 16
Issue: 1
Pages: 521-555
ISSN: 1081-0706 (ISSN-L)
1530-8995
DOI: 10.1146/annurev.cellbio.16.1.521
OpenAlex: W2112520390
Cited by: 2,344
References: 226
Citations by year: 2026: 20 · 2025: 24 · 2024: 38 · 2023: 37 · 2022: 60 · 2021: 47 · 2020: 90 · 2019: 57 · 2018: 55 · 2017: 71 · 2016: 65 · 2015: 72 · 2014: 122 · 2013: 123 · 2012: 134
FWCI: 5.88
Type: journal article
Language: en
Open access: closed
Locations: Annual Review of Cell and Developmental Biology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
Keywords: voltage-gated calcium channels, calcium channel subunits, L-type calcium current, N-type calcium current, T-type calcium current, alpha1 subunit, alpha2delta subunit, beta subunit, gamma subunit, protein phosphorylation, second messenger signaling, G protein coupling, SNARE proteins, synaptic transmission, calcium influx
MeSH terms: Animals, Calcium, Electrophysiology, Humans, Intracellular Fluid, Phosphorylation, Proteins, Calcium Channels, GTP-Binding Proteins

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Structure and Regulation of Voltage-Gated Ca 2+ Channels

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks